Hypothesis: Scientists predicted that rearrangements in 3D chromatin organization can alter regulatory domains and affect gene expression. Methods: In genome comparisons, synteny breaks can identify rearrangements. Mole genomes were compared with full-chromosome assemblies from human, mouse, and shrew. These were used for comparison as they are the closest taxonomical outgroup with normal ovarian development. These comparisons were performed to identify rearrangements specific to moles. Moreover, Hi-C domain predictions were used to identify genes located in topologically associating domains (TAD) that were affected by a synteny break. They then filtered the located genes according to Gene Ontology (GO terms). Results: They found 286 synteny breaks, and 2,595 genes with altered 3D chromatin organization. Conclusion: After filtering candidates based on GO terms, the list was restricted to 39 genes that were possibly effected. Concept from Ainsworth 2015: A made a connection between female mole's genitalia and the DSD called, congenital adrenal hyperplasia, which causes the body to produce excessive amounts of male sex hormones. If you have this condition and are XX, you are born with an enlarged clitoris and fused labia that resemble a scrotum. In the study they compared the mole genome with humans, so I find this interesting. Concept from Ridnik 2021: In this paper, TAD's are described in a bit more detail, as well as the Hi-C domain. Hi-C is a genome-wide chromosome conformation capture technique. Investigation of Hi-C interaction maps reveled that genome is further organized into megabase-scale units. These are called TADs. TADs there are regulatory elements (enhancers) and they are predicted to interact with their promoters by forming a loop to control gene expression. In the Real paper, they use both Hi-C and TAD predictions for their 3D chromatin organization.

There seems to be a number of issues with the positive and negative feedback systems these social media companies are trying to create. What are they really measuring? The either aren't measuring well or aren't designing well (or both?)...

!- Global Capitalism's pathological behavior of maximizing profit : comment - Due to lack of global coordination and agreements, - global capitalism game played by multi-nationals is a whack-a-mole game that eludes any kind of attempts at individual state level regulation. - Any attempt by one country at social or ecological regulation will be met with a corporation exercising their right to pull out and find another country that has no such regulation in place.

I never knew you could have a cold-blooded mammal.

Seriously weird.