a change towards climate-friendly behavior by citizens can reduce greenhouse gas (GHG) emissions substantially: up to one-third of the total EU mitigation target pledged

Treaty of Ghent

Olivetti Lettera 31 (Another name for the Dora -- or is it the opposite?) olivetti Dora (the actual base model if I'm not mistaken, with a bunch of rebrands worldwide) ETON (naturally this belongs on this list, I've even seen 2 others for sale online since) Underwood 315 (rebrand) Montgomery Ward Escort 33 (rebrand) Olivetti Underwood 310 (pretty sure this is a rebrand too, or at least very closely related) Olivetti Index (this is the closest thing I've found to my ETON branded one. It s PRACTICALLY the same in every regard - seen two online for sale) Montgomery ward escort 44 (also a rebrand of the DORA?!) Mercedes Super T (rebrand as well, seen one for sale) Montomery Ward Escort 77 (pretty close to being the same model again again... But not quite?) Neckermann BRILLANT Special T (DEFINITELY a rebrand. The manual is a dead give-away among other things) JUPITER (A typewriter 100% identical to the IDEX or ETON, but rebranded again again) Underwood 314 (no idea on this one. I gave up at this point)

Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

SUPPLEMENTARY DATA

To this end, 44 missense variants found in breast cancer patients were identified in the ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar) and/or selected by literature curation based on their frequency of description or amino acid substitution position in the protein (Supplemental Table S1).

Source Data

Source Data

We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.

Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

Supplemental material

Supplemental material

We analysed a total of 82 blood samples derived from 77 individuals (online supplemental table 3). These 77 individuals corresponded either to new index cases suspected to harbour a pathogenic TP53 variant or to relatives of index cases harbouring TP53 variants.

In order to protect local interests, and to prevent sectional jealousies, it was found requisite that the three great divisions into which British North America is separated, should be represented in the Upper House on the principle of equality. There are three great sections, having different interests, in this proposed Confederation.

To the Upper House is to be confided the protection of sectional interests ; therefore is it that the three great divisions are there equally represented, for the purpose of defending such interests against the combinations of majorities in the Assembly.

But the very essence of our compact is that the union shall be federal and not legislative. Our Lower Canada friends have agreed to give us representation by population in the Lower House, on the express condition that they shall have equality in the Upper House. On no other condition could we have advanced a step ; and, for my part, I am quite willing they should have it. In maintaining the existing sectional boundaries and handing over the control of local matters to local bodies, we recognize, to a certain extent, a diversity of interests ; and it was quite natural that the protection for those interests, by equality in the Upper Chamber, should be demanded by the less numerous provinces.

It is quite right that the General Government should have such powers; but the very fact of our having to make a reservation of this kind, is an unpleasant recognition of the fact, in itself the reverse of encouraging, of the all darkening neighborhood of the United States.

It would not become them to object to the nominative plan, because the members for the Upper House would be nominated by the Crown on the recommendation of the General Government. He might say it here, because it was said by everybody outside, that in the event of any thing like injustice being attempted towards the British population of Lower Canada by their French Canadian fellow-subjects, —they would moat unquestionably look for remedy and redress at the hands of the General Government, who would hare the power of causing their interests to be represented in the Upper House of the General Legislature.

so that the blessed news had to circulate from individual to individual