Meta-analysis statistical procedures provide a measure of the difference between two groups thatis expressed in quantitative units that are comparable across studies
The units are only "comparable across studies" if there weren't any mishaps (eg, clinical or methodological heterogeneity). If there's clinical heterogeneity, then we're probably comparing apples to oranges (ie, either participants, interventions, or outcomes are different among studies). If there's methodological heterogeneity, then that means there's a difference in study design