4 Matching Annotations
  1. Sep 2023
    1. Defections from large-scale anatomical goals, such as those that occur due to an inappropriate reduction of gap junctional connectivity [74], present as cancer, cause reversions of cell behavior to ancient unicellular concerns which lead to metastasis and over-proliferation as the cells treat the rest of the body as external environment.
      • fresh perspective

        • cancer can be interpreted as a breakdown in the bodies multiscale competency architecture causing cancerous cells to lose their higher level synchronizing signals and revert to their more evolutionarily primitive forms as individuals that see the body as simply an external environment
      • adjacency between

        • gap junction coupling
        • cancer
        • healthy tissue coherence
        • multiscale competency architecture
      • adjacency statement
        • gap junction coupling appears to be an evolutionary means of cohering individuals together to form a larger group
        • hence, they seem to play a critical role in the continued evolution of more complex multicellular organisms
        • their pathologies within multicellular beings destroy multicellular structures and create disease, reverting the organism, or competent multicellular structures of the organism such as tissues and organs back to individualistic behavior, as in cancers
    2. gap junctions
      • for: gap junctions, multicellular cohesion, multicellular unity, MET, major evolutionary transition, group to individual, group glue
      • comment

        • gap junctions play a critical role in cohering a group of cells together
        • hence they might be considered a kind of "cellular glue" which fosters evolutionary fitness by incentifying individual organisms to beneficially socially interact with other individual organisms
      • question

        • do gap junctions play a role in major evolutionary transition (MET)?
      • adjacency between

        • gap junction
        • cancer
        • MET
        • individual to group
      • adjacency statement
        • gap junctions may play a role in major evolutionary transition, enabling individual cells to unite into a group, leading to the evolution of multicellular organisms. Investigate and do literature review to see if this is the case.
    3. It is hard to maintain the I-you distinction, and cooperation is massively favored. This is not because the agents have become less selfish, but because the size of the self (to which they are committed) has grown. For properly coupled cells, it is impossible to hide information from each other (from yourself) and it is impossible to do anything injurious to your neighbor because the same effects (consequences) will affect you within seconds.
      • for: cellular collaboration, gap junction, bioelectrical networks, bioelectric network

      • interesting fact: multicellular mechanisms to create coherence in competent constituent subunit cells

      • more research
        • very interesting mechanisms that mediate benefits of collective behavior of competent subunits within the biological body.
  2. Jan 2019