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  1. Oct 2025
    1. Zjadł 720 jajek w miesiąc! Efekt? Nikt się tego nie spodziewał

      Based on YT video I Ate 720 Eggs in 1 Month. Here's What Happened to my Cholesterol:

      • Nick Norwitz, a Harvard medical student with a doctorate in human cerebral metabolism, ate 720 eggs in one month, averaging 24 eggs per day, to test the effects on his cholesterol levels.
      • Contrary to popular belief that eggs increase bad cholesterol (LDL), his LDL cholesterol dropped during the experiment. It decreased by 2% in the first two weeks and then by an additional 18% in the next two weeks.
      • The high cholesterol intake (about 133,000 mg from eggs) did not raise his blood cholesterol. This was explained by a hormone called cholesin, released when cholesterol binds to receptors in the gut, which signals the liver to reduce cholesterol production, maintaining balance in the body.
      • During the last two weeks, he also increased carbohydrate intake slightly, which further helped reduce LDL levels, possibly in combination with other dietary elements like fruits.
      • The experiment challenges the long-held medical advice limiting egg consumption due to cholesterol concerns, suggesting that dietary cholesterol may not significantly impact blood cholesterol levels in healthy individuals.
      • Norwitz documented his experiment publicly on YouTube, sparking discussions on nutrition and metabolism and encouraging re-evaluation of egg consumption guidelines.
      • Eggs are a veritable treasure trove of nutrients: harmful vitamins A, D, E, and K, harmful B vitamins, calcium, phosphorus, iron, sodium, and potassium. However, even such a valuable product should not replace other essential nutrients.
  2. Oct 2023
  3. Nov 2021
  4. Oct 2020
  5. Mar 2017
    1. Findings In a meta-regression analysis of 49 clinical trials with 312 175 participants, each 1-mmol/L (38.7-mg/dL) reduction in LDL-C level was associated with a relative risk (RR) of major vascular events of 0.77 (95% CI, 0.71-0.84; P < .001) for statins and 0.75 (95% CI, 0.66-0.86; P = .002) for established nonstatin interventions that act primarily via upregulation of LDL receptor expression.Meaning These data suggest statins and nonstatin therapies that act through upregulation of LDL receptor expression are associated with similar cardiovascular risk reduction per decrease in LDL-C. The clinical value of adding specific nonstatin interventions to lower LDL-C to background statin therapy should be confirmed in appropriately powered clinical trials.
    1. In addition, the vast majority of animal studies have shown that oral administration of PS reduces the progression atherosclerosis. However, it has been recently suggested that an increase in PS plasma concentrations may increase CV risk. Evidence to support this hypothesis come mainly from observations in sitosterolemic patients who hyperabsorb PS and cholesterol and display very high levels of PS, which may be associated with a premature atherosclerosis. Some epidemiological studies in non-sitosterolemic subjects have shown a positive correlation between PS plasma levels and coronary heart disease. However, these are observational studies and some of them present major methodological bias. In addition, recent studies with a larger number of subjects have indicated, either an absence or a negative relationship between PS and the incidence of CV disease.