Moldova is formally leaving the CIS agreements. In practice they left in 2023. Read some comments asking 'why only now'. Part of it is that Moldova has Russian troops on its territory, depended for exports on Russia and wasn't clearly on an European path. With the EU path better locked in and having spent time on reducing exposure, it seems the recent elections marked that now the time is ready to make the formal renouncements. Vgl [[Chisinau Moldova 2012]] when I worked there

Disease: Von-willebrand Disorder Type 2B, Noncanonical

Patient: 55 YO, Italian male

Note: these heterozygous variants are in cis mutations

Variant1: VWF NM_000552.5 c.2771G>A p.(R924Q), in exon 21, D'D3 domain affected

Variant2: VWF NM_000552.5 c.6532G>T p.(A2178S), in exon 37, D4 domain affected

Phenotypes: Mucosal and cutaneous bleeding, low VWF antigent and VWF activity, mild thrombocytopenia, increased ristocetin-induced platelet aggregation, deficiency in high-molecular-weight multimers. Epistaxis, repeated GI bleeding, easy bruising, ISTH BAT score of 7.

Note: Proband initially diagnosed with VWD type 1 in 2010 but later re-diagnosed as VWD-Type 2.

Family: No reported family history of bleeding, parents unable to be included in family work-up as they were deceased by time of study. Paternity test was performed for family, parental link established. Patient's daughter does not present the same mutation noted in proband but has heterozygous polymorphic variant inherited from mother which is: VWF NM_000552.5 c.3379C>T p.(P1127S), in exon 25. Daughter did not show menorrhagia or hemorrhagic disorder except for large hematoma on the thigh after trauma of moderate intensity.

Molecular workup: Paternity test, Sanger-sequencing to validate genetic variants, multimer analysis with electrophoresis, platelet aggregation analysis with Ristocetin, electron micrographs to observe conformation differences.

Prediction workup: Structural analysis with I-TASSER modeling program to identify perturbed structure. A2178S is predicted as tolerated in all in-silico systems used.

Database Information: Effect of the R924Q mutation is noted in literature database but has contradicting reports of effects altering VWF levels. Some studies do report it as a polymorphic variant

Variant is present in dbSNP database (rs33978901). MAF in European population 0.01< MAF< 0.02

Effect of A2178S variant is present in dbSNP database (rs34230288), MAF = 0.02 in European population.

"interoperable and openly accessible European data processing ecosystem, known as IPCEI-CIS. This initiative aims to reduce reliance on external providers and promote open source technologies" "The European Union has approved a €1.2 billion investment" - [ ] zoek het IPCEI-ICS project op #geonovumtb en kijk nr relevantie voor bijv SIMPL en andere DS initiatieven. #10mins #elaag #pmiddel

Look at beliefs held in the subculture and how they affect choices and livestyle

Provide a description of where your group is located. This may include describing the building or area that the group meets

This is also, to myself, indicative of the main problem with Wikipedia: most editors are white men in a certain age span.

When abuse is added like this, non-men are more likely to stay away, and watch Wikipedia wither into a reason for staying with professionally edited encyclopedias.

oh, so it seems you already understand!