47 Matching Annotations
  1. Apr 2026
    1. Urgent treatment for neoplasm consists of (1) cautious use of intravenous diuretics and (2) mediastinal irradiation, starting within 24 hours, with a treatment plan designed to give a high daily dose of radiation but a short total course of therapy to rapidly shrink the local tumor. Intensive radiation therapy combined with chemotherapy will palliate the process in up to 90% of patients. In patients with a subacute presentation, radiation therapy alone usually suffices. Chemotherapy is added if lymphoma or small-cell carcinoma is diagnosed

      endovascular stenting emerging as first-line therapy for rapid symptom relief, while definitive treatment targets the underlying cause

      Glucocorticoids (dexamethasone 4 mg every 6 hours) are commonly prescribed but lack robust supporting data; they may be more beneficial in lymphoma or thymoma and as prophylaxis against radiation-induced edema. [2-4] Importantly, SVC syndrome is no longer considered a medical emergency except in rare cases with life-threatening cerebral edema, laryngeal edema, or altered mental status. When thrombosis is present, catheter-directed thrombolysis or aspiration thrombectomy should be performed within 2-5 days of symptom onset before thrombus organization occurs. [3] The role of long-term anticoagulation after stenting remains unclear, though it is standard when significant thrombosis is present The American College of Chest Physicians recommends obtaining histologic diagnosis before treatment in suspected lung cancer cases, as stenting does not interfere with tissue diagnosis. [2] For small cell lung cancer (SCLC), chemotherapy alone is recommended as first-line treatment given rapid response rates. [2] For non-small cell lung cancer (NSCLC), radiation therapy and/or stent insertion are recommended, with response rates of 59% for chemotherapy and 63% for radiation therapy. [2] Patients with chemotherapy- or radiation-refractory disease should receive vascular stents For device-related thrombosis (catheters, pacemakers), catheter removal should be considered in conjunction with anticoagulation. [4] Endovascular therapy is first-line for device-related obstruction, while surgical bypass may be preferred for mediastinal fibrosis. [7] Both approaches show good mid-term patency, though secondary interventions are common (approximately 27-28%

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  2. Feb 2026
  3. Jan 2026
  4. Jun 2025
    1. Even at the current level of about 1.5C, the impacts of warming are emerging on the worst side of the range of possible outcomes and there is growing concern of tipping points for the

      Scientists warn that we are nearing or have already crossed several environmental tipping points (e.g. AMOC, Antarctic sea ice, coral reefs).

    2. In his models, he does not account for climate damages to labour productivity, buildings, infrastructure, transportation, non-coastal real estate, insurance, communication, government services and other sectors.

      Criticism of the economic models that ignore environmental externalities, like the true cost of greenhouse gas emissions.

  5. Apr 2025
  6. Sep 2024
  7. Jun 2023
    1. Have you ever: Been disappointed, surprised or hurt by a library etc. that had a bug that could have been fixed with inheritance and few lines of code, but due to private / final methods and classes were forced to wait for an official patch that might never come? I have. Wanted to use a library for a slightly different use case than was imagined by the authors but were unable to do so because of private / final methods and classes? I have.
  8. May 2022
  9. Mar 2022
  10. Sep 2021
    1. Some researchers worry that a major crackdown on Juul and other manufacturers would simply send teenagers reaching for traditional cigarettes instead.

      This seems to be an argument against banning the vapes, which could be less harmful than traditional cigarettes.

    1. Orwell in this instance is a rather large narcissist

      I think narcissist is the perfect description of Orwell's tone in this text, as he clearly acts as if his method of tea drinking is superior, despite there being other valid methods that could improve taste or realizing that it is all personal preference. There is more than one way to make tea and if he wants people to accept his methods then he has to accept the validity of their's

    1. I think the fact that there is a “right” way to drink tea is controversial and subjective, but I also believe that the steps in order to drink tea properly have reasons that relate to how the first people who drank tea drank tea.

      This is a very well worded description of George Orwell's judgement of tea drinkers and I think your point about tea drinking methods being right or wrong being subjective is a very valid point

  11. May 2021
  12. Apr 2021
  13. Feb 2021
    1. To give a little more context, structures like this often come up in my work when dealing with NoSQL datastores, especially ones that rely heavily on JSON, like Firebase, where a records unique ID isn't part of the record itself, just a key that points to it. I think most Ruby/Rails projects tend towards use cases where these sort of datastores aren't appropriate/necessary, so it makes sense that this wouldn't come up as quickly as other structures.
  14. Jan 2021
    1. Systemd problems might not have mattered that much, except that GNOME has a similar attitude; they only care for a small subset of the Linux desktop users, and they have historically abandoned some ways of interacting the Desktop in the interest of supporting touchscreen devices and to try to attract less technically sophisticated users. If you don't fall in the demographic of what GNOME supports, you're sadly out of luck.
  15. Nov 2020
    1. Capacity models acknowledge individual differences in attentional resources and the ability to allocate these resources between multiple tasks. In addition, and according to the capacity model, some individuals have greater attentional resources than others to begin with (Kane & Engle, 2002).

      This may help to explain some of the variation we saw in students.

    2. The top of the figure represents posttest scores in the no-distraction condition, and thus the bars reflect the amount of impairment from a student’s normal level of performance. Conversation had the largest negative effect, impairing performance by 30% from baseline, followed by high-arousal video, video game, and texting/social media. Unexpectedly, folding laundry impaired posttest performance by over 20%, which is equivalent to two full letter grades. Least impairing was the low-arousal video, yet this condition still lowered scores by 15%, or one and a half letter grades. These results indicate that the presence of distraction during learning can lower subsequent test scores by multiple letter grades.

      This study illustrates the educational impact of different types of distractions during learning. Conversation was the most distracting and resulted in the lowest levels of learning compared to a mild distraction like low-arousal video.

    3. Older students tended to do better than younger students in the distraction conditions (r[109] = .21, p = .003). However, there was no significant relationship between age and performance on the baseline posttest (r[109] = .08, p = .24), indicating that age may play specifically a role in the level of impairment caused by distraction during learning

      Adults may be better able to manage distractions as their lives becoming increasingly more complex with more responsibilities.

    4. One notable exception to the agreement between objective and subjective measures of learning was the high-arousal video, which was an exciting sword-fighting scene. Although students did not feel distracted by the high-arousal video, their performance was very poor. This indicates that students are unaware of how certain TV programs can capture attention and induce deficits in learning

      This is an important finding as students are not always a good judge of their learning and the impact of the distractions.

  16. Oct 2020
  17. Sep 2020
  18. Apr 2020
    1. Less than 1% of users in the world have Javascript turned off. So honestly, it's not worth anyones time accommodating for such a small audience when a large majority of websites rely on Javascript. Been developing websites for a very long time now, and 100% of my sites use Javascript and rely on it heavily. If users have Javascript turned off, that's their own problem and choice, not mine. They'll be unable to visit or use at least 90% of websites online with it turned off.
    1. How does HIBP handle "plus aliasing" in email addresses? Some people choose to create accounts using a pattern known as "plus aliasing" in their email addresses. This allows them to express their email address with an additional piece of data in the alias, usually reflecting the site they've signed up to such as test+netflix@example.com or test+amazon@example.com. There is presently a UserVoice suggestion requesting support of this pattern in HIBP. However, as explained in that suggestion, usage of plus aliasing is extremely rare, appearing in approximately only 0.03% of addresses loaded into HIBP. Vote for the suggestion and follow its progress if this feature is important to you.
  19. Jun 2019