- Nov 2024
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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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Disorder studied: Type 1 von Willebrand disease (T1-VWD).
Type of study: Translational
Model organism: Mouse (inbred strains) Obtained from Jackson Laboratory
Analyses:
VWF plasma protein quantitation (ELISA)
Hertiability calculations
PCR genotyping
QTL analysis
Allele-specific primer extension analysis
Results:
Identified new modifier of VWF known as (Mvwf5). Also found two loci unliked to Vwf known as (Mvwf6-7)
Mice with this variant displayed statistically significant decrease in VWF levels, recapitulating the decreasing patterns displayed in humans.
However, another strain of inbred mice with a different mutation did not show an age-dependent decrease in VWF. Suggests strain-specific differences in regulation of VWF levels over time.
Mvwf5 is a cis-regulatory variant altering Vwf mRNA expression.
This is a natural variant of the Vwf allele among inbred strains of mice. Found this variant causes elevation in steady-state levels of Vwf mRNA.
Authors state findings show equivalent of of type 1 VWD is remarkably common in mice and humans. ALso state the Mvwf1 analysis in wild mouse populations suggest this locus is under selective pressure.
Of the 5 potential modifier loci identified, 3 display conservation of synteny with potential human modifier loci.
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- Dec 2023
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alangalangkumitir.wordpress.com alangalangkumitir.wordpress.com
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Tegesipun kang ngilo iku Hyang Ngagung, anapon semunya, kang wawayangngan sayekti, ya iku kang ingarannan dzatullah. Tegesipun aran sipattullah iku, iya sipattira, pasthiné kang dén aranni, apngallullah pan iya panggawénira. Dén tuwajuh, poma aja saksiréku, aja kumalamar, lawan aja pindha kardi, krana wong kang makrifatté wus sampurna.
Dzat = Materiality Sifat = Attributes, Characters Apngal, af'al = Act/ Action/ Actor
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Kang dén ilo, lawan kang ngilo puniku, anapon wayangngan anané kang ngilo pasthi, iya iku tannana prabédanira.
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nenggih antukkira nukil saking kitab. Akya ngulumudin lan saking puniku, tefsir Ibnu Ngabas ngélmu khak kang dén rasani, kang wus takhsis nenggih, masalah paéssan.
Serat Pamejang Ngelmi merupakan contoh bagaimana pujangga Jawa melakukan translasi pemikiran Ihya Ulumuddin dan tafsir Ibnu Abbas terutama dalam tema etika (paesan).
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- Feb 2023
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www.technologynetworks.com www.technologynetworks.com
- Jun 2022
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www.scientificamerican.com www.scientificamerican.com
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Second, the application of the scientific method matters: what works for ants and other nonhuman species is not always relevant for health and/or human outcomes. For example, the associations of Black people with poor health outcomes, economic disadvantage and reduced life expectancy can be explained by structural racism, yet Blackness or Black culture is frequently cited as the driver of those health disparities. Ant culture is hierarchal and matriarchal, based on human understandings of gender. And the descriptions and importance of ant societies existing as colonies is a component of Wilson’s work that should have been critiqued. Context matters.
The author is going in two opposite directions here and neither match up. A massive swath of our medicine research is wholly based on translational genetics. (That is, our basic research on organisms like flies (drosophila), worms (C. elegans), zebrafish, mice, rats, primates, etc. is contingent on moving medicines applicable to simpler genetic models in these animals will also work for humans who share large amounts of genetic material as the result of evolutionary dynamics. Sure some of it may not be relevant for humans because of both genetic and epigenetic (environmental) factors, but generally we expect that more will than won't.
This basic fact is wholly separate from the health disparities issue. While there are some (and few of these are generally scientists in my experience) who believe that culture is the driving factor, there is enough proof to show that structural racism is the driving factor in almost all cases. I'm unaware of any translational genetic work on ant culture into human culture in any of the scientific literature and she certainly doesn't cite any to provide any sort of evidence to the contrary. As a result, she isn't providing any context at all.
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- Nov 2021
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psyarxiv.com psyarxiv.com
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Racine, N., Madigan, S., Cardinal, S., Hartwick, C., Leslie, M., Motz, M., & Pepler, D. (2021). Community-Based Research: Perspectives of Psychology Researchers and Community Partners. PsyArXiv. https://doi.org/10.31234/osf.io/cxrmt
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