- Apr 2024
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Local file Local file
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Set you down this,And say besides that in Aleppo once,Where a malignant and a turbaned TurkBeat a Venetian and traduced the state,I took by the throat the circumcisèd dog,And smote him, thus
By killing himself, he is cleansing the world of his "inner darkness" being a Turk, the beastliness that ruined the superior and ordered Venetian society. It is this, himself, who he kills -- showing he is, at heart, still a Turk, and not the driving motivation that causes all these events to unfold (Iago) -- as Iago is stabbed but has not died. This signifies the curse of suspicion and reason cannot be eliminated -- reason preys on individual people and is not something one can rid. In the end, he chooses once again to rid the tumor of society (which he believes first is his wife, Desdemona, now it is him, the Turk), following honor rather than personal desire.
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- May 2022
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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DICER1 syndrome is a rare genetic condition predisposing to hereditary cancer and caused by variants in the DICER1
GeneName: DICER1 PMCID: PMC7859642 HGNCID: Unavailable Inheritance Pattern: Autosomal dominant. Disease Entity: Familial pleuropulmonary blastoma (PPB), cervix embryonal rhabdomyosarcoma, multinodular goiter, nasal chondromesenchymal hemartoma, Ciliary body medulloepithelioma, Sertoli-Leydig Cell Tumor (SLCT), differentiated thyroid carcinoma, pituitary blastoma, pineoblastoma, cystic nephroma, Wilm's tumor and sarcomas of different sites including, amongst others, the uterine cervix, kidney and brain. Mutation: Germline Zygosity: Heterozygose Variant: No ClinVarID present. Family Information: No family outline Case: No specified information of patients included. CasePresentingHPO's: n/a CasePrevious Testing: n/a gnomAD: n/a Mutation Type: nonsense, frameshift, or splice affected.
Tags
- Mutation type: Frameshift
- Gene: DICER1
- Multinodular goiter
- Zygosity: Heterozygous
- Ciliary body medulloepitheliomma
- Inheritance Pattern: Autosomal dominant
- Differentiated thyroid carcinoma
- Mutation type: Nonsense
- Mutation: Germline
- Wilm's tumor
- PMCID: PMC7859642
- Sertoli-Letdig Cell Tumor(SLCT)
- Nasal chondromesenchymal hemartoma
- Familial pleuropulmonary blastoma (PPB)
- Cervix embryonal rhabdomyosarcoma
Annotators
URL
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Pathogenic germline variants in DICER1 underlie an autosomal dominant, pleiotropic tumor-predisposition disorder.
gene name: DICER 1 PMID (PubMed ID): 33570641 HGNCID: n/a Inheritance Pattern: autosomal dominant Disease Entity: benign and malignant tumor mutation Mutation: somatic Zygosity: heterozygous Variant: n/a Family Information: n/a Case: people of all sexes, ages, ethnicities and races participated CasePresentingHPOs: individuals with DICER1-associated tumors or pathogenic germline DICER1 variants were recruited to participate CasePreviousTesting: n/a gnomAD: n/a
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- Apr 2022
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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DICER1 syndrome is a rare genetic condition predisposing to hereditary cancer and caused by variants in the DICER1 gene.
Gene Name: DICER1 PMID:33552988 HGNCID: Unavailable Inheritance Pattern:Autosomal Dominant Disease Entity: familial pleuropulmonary blastoma (PPB),cystic nephroma, ovarian Sertoli-Leydig cell tumor (SLCT), multinodular goiter, cervix embryonal rhabdomyosarcoma, Wilms’ tumor, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, differentiated thyroid carcinoma, pituitary blastoma, pineoblastoma, and sarcomas of different sites. Mutation: Nonsense, Frameshift<br /> Zygosity: Heterosygosity Variant:No ClinVar ID present Family Information:no diseases mentioned in family Case: no specified case in this article gnomAD: n/a Mutation type: Nonsense. frameshift
Tags
- familial pleuropulmonary blastoma
- PMID:33552988
- multinodular goiter
- Zygosity: Heterosygosity
- PPB
- Mutation: Nonsense
- pituitary blastoma
- sarcomas
- pineoblastoma
- ovarian Sertoli-Leydig cell tumor
- cervix embryonal rhabdomyosarcoma
- nasal chondromesenchymal hamartoma
- Gene: DICER1
- Inheritance Pattern: Autosomal Dominant
- ciliary body medulloepithelioma
- SLCT
- Mutation: Frameshift
- cystic nephroma
- Wilms’ tumor
- differentiated thyroid carcinoma
Annotators
URL
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pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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DICER1 syndrome is a rare genetic disorder that predisposes individuals to multiple cancer
GeneName: DICER1 PMID: 29762508 HGNCID: Can't find Inheritance: Autosomal Dominant Disease Entities: Endocrine and Reproductive Tumors Mutation: Somatic and germline Zygosity: Heterozygous Mutant: Can't find Family: Can't find
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- Jun 2021
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www.migrationencounters.org www.migrationencounters.org
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Anita: Was the tumor benign?Luisa: Yes, it was benign. Thank God for that. But she had an encounter with TB and then she was on medication for that. You know what I think it was? I think that all this negativity affected her [Chuckles], or I don't know if you believe this, but the law of attraction. I think that she really did not want to keep going and that affected her quite a bit.
Time in the US, Illness
Tags
Annotators
URL
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- Nov 2020
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www.plymouth.edu www.plymouth.edu
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Tumor suppressor genes
These are genes that slow down cell division, repair DNA errors, and/or tell cells to terminate. If these Tumor Suppressor Genes fail to function properly, they go rouge and become cancer cells.
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- Jan 2019
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Adipose tissue is no longer considered to be an inert tissue that stores fat. This tissue is capable of expanding to accommodate increased lipids through hypertrophy of existing adipocytes and by initiating differentiation of pre-adipocytes. Adipose tissue metabolism exerts an impact on whole-body metabolism. As an endocrine organ, adipose tissue is responsible for the synthesis and secretion of several hormones. These are active in a range of processes, such as control of nutritional intake (leptin, angiotensin), control of sensitivity to insulin and inflammatory process mediators (tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), resistin, visfatin, adiponectin, among others) and pathways (plasminogen activator inhibitor 1 (PAI-1) and acylation stimulating protein (ASP) for example). This paper reviews some of the biochemical and metabolic aspects of adipose tissue and its relationship to inflammatory disease and insulin resistance.
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