1,661 Matching Annotations
  1. Jun 2024
    1. no two long COVID patients are alike."

      Completely fucking false. Lazy avoidant pussy rhetoric from an ignorant coward

    2. Perry Wilson

      Whiny, lazy, arrogant, bitching, ignorant, dipshit

    1. are linked
    2. mental health services,
    3. some individuals have extensive behavioral health needs. In these cases, we partner with local mental health agencies on a referral basis to ensure all the medical and emotional needs of our patients are met.
    4. also has a case manager
    5. side-by-side with your primary care
    6. family-related issues
    7. behavioral health care as part of any medical appointment.
    8. behavioral health professional,
    9. dental care
    10. full-service
  2. May 2024
    1. but their confidence level is still below that of high performers


    2. Nor does it claim that people lacking a given skill are as confident as high performers


    3. which people with limited competence


    4. positive prior beliefs about one's skills are the source of false self-assessment


    5. inhibit people from addressing their shortcomings


    6. engaging in dangerous behavior


    7. systematic tendency to engage in erroneous forms of thinking and judging


    8. the tendency of highly skilled people to underestimate their abilities relative to the abilities of others


    9. incompetence often includes being unable to tell the difference between competence and incompetence


    10. people with low intelligence


  3. Feb 2024
    1. key role in causing the various pathologies; it can activate clotting factors [13], it is itself amyloidogenic [14], and it may have direct protein-protein interactions with the main plasma clotting protein, fibrinogen [2,15].
    2. presence of clotting pathology in the form of fibrinaloid microclots, hyperactivated platelets and endothelial dysfunction represents a key target for both the diagnosis and the treatment of the condition [1,8,11,12].
    3. signals indicating the presence of microclots should be easily detectable using a conventional flow cytometer
    4. combining cell imaging and the high-event-rate and full-sample analysis nature of a conventional flow cytometer, imaging flow cytometry can eliminate erroneous results and increase accuracy in gating and analysis beyond what pure quantitative measurements from conventional flow cytometry can provide.
    5. we have used imaging flow cytometry for the first time to show a significantly increased concentration and size of these microclots
    6. demonstrated a significant amyloid microclot load in Long COVID patients
    7. One of the major pathophysiological factors contributing to Long COVID is the presence of hypercoagulability; this results in insoluble amyloid microclots that are resistant to fibrinolysis
    1. This suggests that there may be a replicating viral reservoir remaining long term, in some cases.
    2. Various adjuvant medications may also assist
    3. clinicians have embarked upon clinician-initiated treatment regimens that include such treatments
    4. Oral anticoagulants
    5. treatments will be to prevent microclots from forming and to prevent platelet hyperactivation
    6. easy place to break it is the microclots because they’re really the chief bad guys
    7. got to break the cycle somewhere
    8. due directly to hypoxia, but also ischemia reperfusion injury, which causes so-called post-exertional malaise
    9. a lot of sequelae is caused by microclots that lead to a variety of problems
    10. The microclots account for all the obvious symptoms like fatigue, where patients are gasping for oxygen
    11. If you’ve got these microclots, they block up the microcapillaries, preventing red blood cells from going through so oxygen doesn’t get to the tissues. The tissues that have been blocked from getting oxygen are the ones that are going to manifest disease
    12. hese microclots are the central element to everything,
    13. The general principle is that if you acquire a scientific understanding of what’s gone wrong with a disease, you can use that knowledge to fix it
    14. P-selectin on CD40L-activated platelet surfaces can form complexes with monocytes and neutrophils.
    15. platelets express P-selectin
    16. form a platelet-T cell complex
    17. found that microclots and platelet pathologies were present in all 80 patients
    18. All patients were experiencing lingering symptoms of shortness of breath, low oxygen levels, heart palpitations, constant fatigue, joint and muscle pain, brain fog, sleep disturbances, digestive problems, or kidney problems.
    19. samples from 80 patients
    20. Long COVID, they found that no thrombin was needed to start the fibrinogen amyloid microclot process because the SARS-CoV-2 Spike protein was capable of starting the microclot process.
    21. when we added thrombin to a blood sample from someone with asthma, it induced clotting into the amyloid form
    22. We found that this was happening in a variety of chronic inflammatory diseases, such as Alzheimer disease or Parkinson disease
    23. these deposits could be induced by things like unliganded iron, and later, we discovered, also by very low concentrations of bacterial cell wall components.
    24. University of Liverpool
    25. Stellenbosch Universit
    26. dense matted deposits resulting from fibrin polymerization
    27. had been looking at clots with an electron microscope
    28. Over 10 years ago now
    29. help to explain why some patients experience long-term symptoms and why COVID-19 affects so many tissues and organ systems
    30. vascular4,8 disease
    31. However, it is now accepted that COVID-19 is primarily an endothelial4,
    32. was thought to be a typical viral pneumonia with acute disseminated intravascular coagulopathy
    33. known as Long COVID
    34. persistent sequelae, typically manifesting as fatigue, shortness of beath, sleep difficulties, and central nervous system symptoms.
    35. respiratory failure and hypoxia
    36. multi-organ failure
    37. Thrombotic Disorders Are Amyloid Fibrin Microclots Central to Long COVID? Jessica Nye, PhD | July 8, 2022

      Hematology Advisor

    1. understanding and treatment of Long COVID
    2. it has been shown that suitable and closely monitored ‘triple’ anticoagulant therapy that leads to the removal of the microclots also removes the other symptoms
    3. Consistent with
    4. Although the symptoms of Long COVID are multifarious, we here argue that the ability of these fibrin amyloid microclots (fibrinaloids) to block up capillaries, and thus to limit the passage of red blood cells and hence O2 exchange, can actually underpin the majority of these symptoms
    5. microclots are more-or-less easily measured in PPP with the stain thioflavin T and a simple fluorescence microscope
    6. extensive fibrin amyloid microclots that can persist, can entrap other proteins, and that may lead to the production of various autoantibodies.
    7. result, as is strongly manifested
    8. A few years ago, we discovered that fibrinogen in blood can clot into an anomalous ‘amyloid’ form of fibrin
    9. bears similarities to other post-viral syndromes, and to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
    10. symptoms such as breathlessness, fatigue, ‘brain fog’, tissue damage, inflammation, and coagulopathies (dysfunctions of the blood coagulation system) persist long after the initial infection
    11. Biochem J. 2022 Feb 25; 479(4): 537–559. Published online 2022 Feb 23. doi: 10.1042/BCJ20220016PMCID: PMC8883497PMID: 35195253A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
    12. A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
    1. Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC) Etheresia Pretorius  ORCID: orcid.org/0000-0002-9108-23841,5, Chantelle Venter1, Gert Jacobus Laubscher2, Maritha J Kotze3, Sunday O. Oladejo4, Liam R. Watson  ORCID: orcid.org/0000-0002-7016-92294, Kanshu Rajaratnam4, Bruce W. Watson  ORCID: orcid.org/0000-0003-0511-18374 & …Douglas B. Kell  ORCID: orcid.org/0000-0001-5838-79631,5,6 Show authors Cardiovascular Diabetology volume 21, Article number: 148 (2022) Cite this article
    1. Research Article| August 20 2021 SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19 In Collection Coronavirus Lize M. Grobbelaar; Lize M. Grobbelaar Sample analysis, Visualization, Writing—original draft 1Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, Private Bag X1, Matieland 7602, South Africa Search for other works by this author on: This Site PubMed Google Scholar Chantelle Venter; Chantelle Venter Data curation, Project administration 1Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, Private Bag X1, Matieland 7602, South Africa Search for other works by this author on: This Site PubMed Google Scholar Mare Vlok; Mare Vlok Software, Formal analysis, Investigation 2Central Analytical Facility: Mass Spectrometry Stellenbosch University, Tygerberg Campus, Room 6054, Clinical Building, Francie van Zijl Drive, Tygerberg, Cape Town 7505, South Africa Search for other works by this author on: This Site PubMed Google Scholar Malebogo Ngoepe 0000-0002-3639-9063 ; Malebogo Ngoepe Methodology 3Department of Mechanical Engineering, Faculty of Engineering and the Built Environment, University of Cape Town, Cape Town, Rondebosch 7701, South Africa4Stellenbosch Institute for Advanced Study, Wallenberg Research Centre, Stellenbosch University, Stellenbosch, South Africa Search for other works by this author on: This Site PubMed Google Scholar Gert Jacobus Laubscher; Gert Jacobus Laubscher Writing—review and editing 5Private practice clinician, Mediclinic Stellenbosch, Stellenbosch 7600, South Africa Search for other works by this author on: This Site PubMed Google Scholar Petrus Johannes Lourens; Petrus Johannes Lourens Writing—review and editing 5Private practice clinician, Mediclinic Stellenbosch, Stellenbosch 7600, South Africa Search for other works by this author on: This Site PubMed Google Scholar Janami Steenkamp; Janami Steenkamp Project administration, Writing—review and editing 1Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, Private Bag X1, Matieland 7602, South Africa6PathCare Laboratories, PathCare Business Centre, PathCare Park, Neels Bothma Street, N1 City 7460, South Africa Search for other works by this author on: This Site PubMed Google Scholar Douglas B. Kell 0000-0001-5838-7963 ; Douglas B. Kell Writing—review and editing 1Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, Private Bag X1, Matieland 7602, South Africa7Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZB, U.K.8The Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Kemitorvet 200, Kgs Lyngby 2800, Denmark Correspondence: Etheresia Pretorius (resiap@sun.ac.za) or Douglas B. Kell (dbk@liv.ac.uk) Search for other works by this author on: This Site PubMed Google Scholar Etheresia Pretorius
    2. However, there was a complete failure to dislodge or disturb COVID-19 PPP clots from the channels.

      Complete failure. Could not even get it off. …. The first suspect is that the COVID plasma is richer in various coagulation factors. Raising the question of a need for anticoagulant therapy.

    3. COVID-19 clots, on the contrary, could not be displaced or dislodged and remained intact, even with the force of high-speed water flow in a small flow channel.

      WTF. Something is critically different about post COVID plasma beyond just spike clothing that makes these clots super sticky. And to naked plastic. What are these tubes made of? Is it polyethylene? See polyalanine tract fibrin amyloid pathology studies

    4. Clots also formed with the PPP with the addition of the spike protein, but not as disruptive as the COVID-19 PPP clots

      So this is saying….PPP of never infected people showed clotting when spike S1 was added, but it was worse in PPP (i.e. clear and clean of clots or masses) of prior COVID infected people? So meaning, not only is spike bad, but COVID adds/changes/induces introduction of something to or into the plasma (eg protein, antibody, altered protein, viral accessory protein, ions, molecules, etc)?

    5. Interestingly, these clots did not propagate much after the initial burst, indicating that most of the thrombin was consumed in a short period of time
    6. reaction between thrombin and PPP occurred rapidly, resulting in large clots after approximately 90 s
    7. disorderly clots that cover the bulk of the channel and often protruding into the center of the flow channel and disrupting flow
    8. PPP with added spike protein showed a combination of a fibrous laminar clot and disorderly clotted mass
    9. clot formation was also less frequent
    10. clot had orderly layers that did not disrupt flow through the centre of the channel
    11. Clots formed in healthy PPP were relatively small and were limited to the walls of the flow channel
    12. In healthy plasma, clot formation was a relatively slow and gradual process, resulting in the formation of a modest clot
    13. anomalous deposits that is amyloid in nature
    14. spontaneously formed fibrin network
    15. Whole blood sample of healthy volunteers, before and after exposure to spike protein
    16. formation of spontaneous and anomalous fibrin(ogen) deposits with an amyloid nature, were prominent in all the samples incubated with spike protein, without the addition of thrombin
    17. An increase in platelet hyperactivation, membrane spreading
    18. WB incubated with spike protein showed erythrocyte agglutination, despite the very low concentration of the spike protein
    19. targeting it directly, whether via vaccines or antibodies, is likely to be of therapeutic benefit.


    20. conclude that the spike protein may have pathological effects directly, without being taken up by cells
    21. comparing naïve healthy platelet-poor plasma (PPP) samples, with and without added spike protein
    22. also determine if the spike protein may interfere with blood flow
    23. directly interact with platelets and fibrin(ogen) to cause fibrin(ogen) protein changes and blood hypercoagulation
    24. infected cells liberates free receptor binding domain-containing S1 particles
    25. Free spike protein can potentially be released due to spontaneous ‘firing’ of the S protein trimers on the surface of virions
    26. Free S1 particles may also play a role in the pathogenesis of the disease
    27. S1 proteins can also cross the blood–brain barrier
    28. Spike protein, can however be shed
    29. spike proteins are the key factors for virus attachment
    30. inflammatory biomarkers
    31. platelets
    32. numerous reports of damage to erythrocytes
    33. Plasma of COVID-19 patients also carries a massive load of preformed amyloid clots
    34. substantial deposition of microclots in the lungs
    35. Endotheliopathies are therefore a key clinical feature of the condition
    36. directly bind to endothelial receptors
    37. dysregulated inflammatory coagulation biomarkers,
    38. hypercoagulation and thrombosis
    39. Phenotypic vascular characteristics are strongly associated with various coagulopathies
    40. important clinical relevance in the treatment of hypercoagulability in COVID-19 patients.
    41. lytic impairment may result in the persistent large microclots
    42. cause substantial impairment of fibrinolysis
    43. we suggest that, in part, the presence of spike protein in circulation may contribute to the hypercoagulation in COVID-19
    44. roteins were substantially resistant to trypsinization, in the presence of spike protein S1
    45. prothrombin
    46. complement 3
    47. β and γ fibrin(ogen)
    48. Mass spectrometry also showed that when spike protein S1 is added to healthy PPP, it results in structural changes
    49. we show that spike protein may interfere with blood flow
    50. directly
    51. cause blood hypercoagulation
    52. investigate the potential of this inflammagen to interact with platelets and fibrin(ogen)
    53. effect of isolated SARS-CoV-2 spike protein S1 subunit as potential inflammagen
    54. One of the most important pathologies, is hypercoagulation and microclots
    55. there is a significant difference in peptide structure before and after spike protein addition
    56. less resistant to trypsinization
    1. Is the Child’s Therapist Part of the Problem? What Judges, Attorneys, and Mental HealthProfessionals Need to Know About Court-related Treatment for ChildrenLYN R. GREENBERG, PH.D.*, JONATHAN W. GOULD,PH.D.**, DIANNA J. GOULD-SALTMAN, ESQ.***,PHILIP M. STAHL, PH.D.****I.

      Family Law Quarterly

    1. parents are provided legal representation to address a range of civil legal problems that could create family instability
    1. There is an increased likelihood of psychotic symptoms with lifetime PTSD diagnoses
    2. nTrauma exposure leads to various psychiatric disorders including depression, anxiety, bipolar disorders, personality disorders, psychotic disorders, and trauma related disorders, especially posttraumatic stress disorder (PTSD
    1. person with delusional disorder may be high functioning in daily life
    2. Apart from their delusion or delusions, people with delusional disorder may continue to socialize and function in a normal manner and their behavior does not necessarily generally seem odd.[
    3. Delusional disorder, traditionally synonymous with paranoia, is a mental illness in which a person has delusions, but with no accompanying prominent hallucinations, thought disorder, mood disorder, or significant flattening of affect.[7][8] Delusions are a specific symptom of psychosis. Delusions can be bizarre or non-bizarre in content;[8] non-bizarre delusions are fixed false beliefs that involve situations that could occur in real life, such as being harmed
    1. some children do not recover on their own.
    2. Explain to the child that he or she is not responsible for what happened. Children often blame themselves for events
    3. impact of child traumatic stress can last well beyond childhood.
    4. self-harming behaviors
    5. signs of traumatic stress are different in each child
    6. important to learn how traumatic events affect children
    7. reported experiencing multiple and repeated traumatic events
    8. violent loss of a loved one
    9. life-threatening illnes
    10. events overwhelm a child’s or adolescent’s ability to cope
    1. InvestigationReportDearMr.Furman:Asyouareaware,ourlawfirmservesasCountyAttorneyforWashingtonCounty,Colorado.Thisletterissenttoyouinyourcapacityas
    1. Andrea Marsh
    2. Alicia told me that the Bernhardts “can be victims, too.” Once the system “put this idea in their heads that adoption could be an achievable goal for them, it damaged our family, and my son, and the foster parents’ family.”

      Ridiculously "fit" and "capable". Something an ACTUAL EXPERT, could have assessed and testified to years ago, and would have done without competition as there wasn't 1 even nearly qualified provider involved, except for the one psychologist who was, who was not objecting the child be returned to the parents

    3. We didn’t do any of this for any reason other than to make sure that Carter has the best life,” J’Lyn told me later. “He deserves that.”

      Pathological. They were never assessed. Yet the biological and fit parents were repeatedly assessed by non-"experts"

    4. they’d paid around thirty-two thousand dollars to Eirich’s firm.
    5. he is on target developmentally, and even “potentially gifted.” When I mentioned to Baird that there is little sign of the attachment trauma she predicted, she said this just demonstrates that Carter knows he has to “hero on.”
    6. Can we tell Dad I slept so good?” he asked his mom with excitement one morning, and Alicia wondered if he knew or sensed that his sleep problems had been debated for years.
    7. could do anything about it.

      Not true. But the writer is trying to make a point. I get it

    8. February, the judge asked for an explanation of what, exactly, was still unfit about Alicia and Fred as parents


    9. Two days later, a letter from an attorney representing Washington County revealed that an internal investigation had found improprieties in the handling of Carter’s case. (The investigative report is under a gag order, and neither Smith nor the new director would elaborate on the resignation.) The trial was cancelled
    10. director of the Department of Human Services, Grant Smith, resigned.
    11. Washington County had spent more than three hundred and ten thousand dollars on Carter’s case: on his brain-mapping and medical exams, on the many expert evaluations, on Baird’s travel to and from Denver, on payments to the Bernhardts, and so on
    12. They filed a Colorado Open Records Act request, and soon received dozens of invoices.

      RPC, why are your clients having to do this? Is that not a clue to you? And if this actually was necessary, why aren't you doing it? Why aren't you adding an investigator to your case?

    13. Last year, the Kempe Center’s director asked Baird in an e-mail to stop using the Kempe name to describe her protocol an

      Now that is what an expert would do, because....see above

    14. Baird has long called her technique for evaluating

      Experts don't "create" techniques, at the very least which can be testified to as evidence backed clinical standards of care

    15. had again brought in an expert—Diane Baird—to assess

      Omg. "Expert"

    16. the judge did little but say that he would await responses to a motion and schedule another hearing

      ....again. see above

    17. judge, for his part, lamented all the medical tests. “We’re going to turn this kid into a lab rat,” he said

      So judge, why aren't you taking control and asking for what you need, let alone holding the county accountable. RPC, why aren't you arguing this fact?

    18. they couldn’t hear, let alone counter, much of what the county’s lawyer was saying about them

      RPC, you didn't motion a response regarding this?

    19. sitting cross-legged on their living-room floor,

      RPC, you didn't advise them to not do that?

    20. Janina Fariñas, another clinical psychologist who evaluated him for the county, told me, “There was almost a need for Carter to not be O.K.”

      Now finally only the 2nd arguable ACTUAL EXPERT in a case that's mentioned "lots of experts". An actual Clinical Psychologist. And she's CALLING BULLSHIT.

      And AGAIN, RPC?!?! How do you not have the competence to obliterate this case with the autumn of this expert witness, HIRED BY THE OPPOSITION?

    21. therapist

      Neither an expert nor an "assessment". And lots of "screenings" and "tests" are developed by people who arguably could serve as experts in a case, but the tests they created are neither intended to serve as an expert best interests assessment nor are they meant to be conducted by others who have the credentials to give such an assessment. Just like x ray techs aren't doctors.

    22. A clinical psychologist found that he had normal social functioning for his age but that the fuzz-eating could be attributed to pica, a condition marked by eating non-food items, and that other signs of distress might be caused by “upbringing away from parents.”

      So 1 or more people failed here. RPC did not ask CP to assess for "as an expert, is it medically in the best interest for the child to return to the parents and be raised by them and why or why not, and support that with heavily cited evidence and clinical justification", or this psychologist was not the right specialty, or this psychologist was negligent and did not advise RPC regardless of they were asked what was the ultimate best interest of the child or the need and the how or how to get to that assessment evaluation"

    23. experts

      Again ORPC, are we seeing yet the weight that these people hold and the complete misuse of the application of non-"experts"? And where are the services the RPC is advocating for? Not only are those of great value to the parents, but those workers would supply an abundance of supporting training to reinforce an actual EXPERT assessment

    24. tests

      Tests are not experts. Tests require experts, who can expertly interpret them, and will include them in expert created assessment reports and expert recommendations and expertly speak to how the results apply as evidence to support their findings and the tests limitations and risks.

    25. Paul Spragg, a Colorado forensic psychologist

      A forensic licensed psychologist is not necessarily an expert, but is the only one who could be argued as one in this story so far other than the AAP, and he is raising the bullshit flag because he actually is trained and licensed and likely actually qualified to assess and make recommendations that are truly healthful and not ridiculously dangerous.

    26. Foster Source

      Fucking spooky

    27. veteran nurse practitioner

      Not even close to an expert. Neither of course is eirich an expert

    28. What is the process at this point?” she wrote. “Will I hear from you or should I expect to hear from someone else? Is there anything else I can/should be doing to be prepared for baby and court? Should I plan a visit to Colorado to meet [the child] or to meet persons involved?”

      Misconduct. Didn't meet reasonable Efforts Standards.

    29. She has significant experience,” the judge said,

      RPC, and ORPC, are you seeing yet the lever that determines a judges decisions??? EXPERT TESTIMONY. As in GET AN EXPERT. An ACTUAL EXPERT.

    30. only a preference under state laws. The judge rule

      They have WAY MORE THAN PREFERENCE. A judge is mandated to know this. An RPC should be a magician with this.

    31. , as Eirich underlined to me, though parents have a constitutional right to their child until such right is terminated

      Jesus Christ. The opposing attorney knows this, WHY DOESN'T THE RPC?

    32. but you’re also being blamed
    33. in reality, children may be dysregulated for any number of reasons—perhaps they miss their parent, feel confused, or are simply behaving as toddlers do.” Green used to employ the dysregulation claim in her own cases, she said. She now regrets it.


    34. Allison Green, the legal director of the National Association of Counsel for Children,

      Dude... Allison Green....of the NACC....provider of THE CWLS CERTIFICATION

    35. gave his foster parents more time to make their central argument
    36. remained in foster care, with no transition home planned.

      RPC? Why?

    37. social worker had explained that Eirich and Baird “went around the state together,” arguing for the termination of birth-parents’ rights


    38. Another judge, recognizing Fred’s transformation, had recently granted him full custody of his other son, Robert, who was twelve years old.

      I mean what the fuck RPC, you can't win the case immediately armed with that alone?

    39. The problem was that Alicia and Fred would not give up.

      This is supposed to be, "the RPC would not give up and launched a storm of conditional law, judicial review, recruited actual experts, and complaints to oversight bodies and law enforcement....and the parents got their kids back immediately with funded ongoing support services and DHS responded they have begun a task force to review conduct and policy and the judges and caseworkers at a minimum in that district are on alert to not keep trying to pull this bullshit again and statewide all judges an attorneys know to get real serious when they see the names eirich or Baird"

    40. A healthy attachment trumps biology in the first three years of life, period,”

      Direct admission of unlawful intent!

    41. an attachment expert whom she has trained.

      A case worker is training an "attachment expert"? This is what an "attachment expert" is??? Holy shit

    42. intervenor-training sessions for judges and foster parents


    43. When the American Academy of Pediatrics reviewed

      This is an actual "expert"

    44. foster children were becoming a “hot commodity,” he said
    45. prominent local ranching family