Aortic dissection typically presents acutely with sudden, severe tearing chest or back pain, often described as lancinating in quality. [5-6] Approximately 50% of patients with thoracic aortic aneurysm may progress to dissection without timely intervention. [5] In contrast, thoracic aortic aneurysm is usually asymptomatic and discovered incidentally during physical examination or imaging for other indications. [5]
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- CT angiography is the imaging modality of choice for differentiating these conditions in the emergency setting, with very high sensitivity and specificity for acute aortic syndromes
- Recent evidence suggests that inflammatory biomarkers may aid differentiation. The neutrophil-to-lymphocyte ratio (NLR) shows high diagnostic accuracy for distinguishing dissection from controls (AUC 0.933), while the fibrinogen-to-d-dimer ratio best differentiates dissection from aneurysm (AUC 0.898, sensitivity 77%, specificity 84%). [10] D-dimer levels below 500 ng/mL make acute aortic syndrome unlikely in low-risk patients
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- May 2021
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Gagne, Christopher, and Peter Dayan. ‘Peril, Prudence and Planning as Risk, Avoidance and Worry’. PsyArXiv, 11 May 2021. https://doi.org/10.31234/osf.io/tcn7e.
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- Feb 2021
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twitter.com twitter.com
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Carl T. Bergstrom. (2021, January 31). A somewhat technical thread about measuring vaccine efficacy. We’re used to the notion that certain properties of tests for disease depend on prevalence: Positive and negative predictive value do, for example, whereas sensitivity and specificity do not. [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1355762090078703621
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- Aug 2020
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Manski, C. F. (2020). Bounding the Predictive Values of COVID-19 Antibody Tests (Working Paper No. 27226; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27226
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- May 2020
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Radulescu, A., Holmes, K., & Niv, Y. (2020). On the convergent validity of risk sensitivity measures [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/qdhx4
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