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Medical Onotologies. They had to take out CPT codes a few years ago..
294 Matching Annotations
- May 2025
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bioportal.bioontology.org bioportal.bioontology.org
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URL
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- Jan 2025
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www.sfu.ca www.sfu.ca
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for - Dr. Julian Somers - SFU Health Sciences - substance use & mental health, primary heath care reform, homelessness, clinical psychology - home page - from - Youtube - Tyler Oliviera Vancouver - Disneyland for Drug Addicts - 2024, Dec - https://hyp.is/6va49soNEe-OwyvA2lPThw/www.youtube.com/watch?v=ggfZwBdaiYk
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- Apr 2024
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www.nicabm.com www.nicabm.com
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for - trauma treatment - National Institute for the Clinical Application of Behavioral Medicine - NICABM
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- Oct 2023
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postlab.psych.wisc.edu postlab.psych.wisc.edu
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C
bottom-horizontal fMRI images of someone wo experienced anoxic lesions to their posterior corpus callosum, resulting in permanent coma following head trauma.
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F
Sagittal fMRI image of an individual who displayed content-specific changes in experience (feeling of intention to move) following electrical stimulation of the temporoparietal cortex.
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D
Mid-sagittal fMRI image of an individual who displayed content-specific changes in experience (intrusive thoughts) following electrical stimulation of the ACC.
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E
Bottom-horizontal fMRI image of an individual who displayed content-specific changes in experience (inability to perceive faces) following electrical stimulation of the fusiform gyrus.
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Together, stimulation studies support the idea that some pos-terior cortical regions may contribute directly to specific contentsof experience, but the evidence for prefrontal regions is scarceand indirect.
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Many studies have demonstrated that electrical stimulation of the posterior cortex induces discrete changes in the content-specific NCC more reliably than electrical stimulation of the anterior cortex. Hence, most evidence suggests that posterior regions of the brain contribute more to the content-specific NCC than do anterior regions of the brain.
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For the most part, electrical and TMS stimulation of the frontal cortex does not elicit content-specific changes in experience. Stimulation of the ACC and MCC (posterior areas), however, does elicit some content-specific changes in experience, suggesting that posterior area stimulation is more likely to excite content-specific NCC than frontal area stimulation.
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Several studies have shown that electrical stimulation and EEG activation of posterior cortical areas is effective at restoring consciousness in subjects where it is impaired, demonstrating that the excitability of the full NCC can be modulated through arousal systems.
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Electrical stimulation during neurosurgery is an important source ofevidence for a direct contribution of different brain areas to con-sciousness (Penfield, 1959; Desmurget et al., 2013), as indicatedby its superior value in predicting postoperative deficits com-pared with fMRI or diffusion tensor imaging (Borchers et al.,2011).
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diffusion tensor imaging
A technique that detects how water travels along the white matter tracts in the brain.
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Figure 2.
anatomical images depicting clinical evidence for the full (A, B, C) and content-specific (D, E, F) NCC.
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Although frontal injuries can slightlyincrease the threshold for perceiving some brief (16 ms) andmasked visual stimuli, patients still experience them (Del Cul etal., 2009), suggesting that these frontal regions may modulate theNCC (i.e., act as background conditions) rather than contribut-ing directly to consciousness (Kozuch, 2014).
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By contrast, there is little evidence for loss of specific con-scious contents after frontal damage (Penfield and Jasper, 1954).
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prosody
Patterns of rhythm and sound used in poetry.
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With regards to content-specific NCC, there is abundant neu-rological evidence that lesions in the posterior cortex can cause aloss of specific contents of experience (Farah, 2004).
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B
mid-sagittal fMRI image of someone who experienced anoxic lesions to their posterior corpus callosum, resulting in permanent VS following head trauma.
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traumatic lesions to the posterior corpus callosum appear to permanently cause states of VS (coma, or impeded consciousness), whereas traumatic lesions to the frontal lobe do not seem to do this.
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VS
Behavioral state similar to coma.
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A,
Bilateral view of the left and right frontal lobes of someone who experienced extensive prefrontal lobe damage without a noticeable change in consciousness, with certain anatomical regions labeled (top). Lateral view of the left and right hemispheres of that same individual, with certain anatomical regions labeled (bottom).
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There are many examples of people who have experienced bilateral lesions to the frontal lobe and still retained most, if not all aspects of consciousness. These instances lend credence to the idea that the anterior cortex may not account for the full NCC. Even when such damage causes deficits in cognition, perception, or executive function, consciousness does not appear to be significantly altered and effected individuals still seem capable of living normal lives.
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- May 2023
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accessphysiotherapy.mhmedical.com accessphysiotherapy.mhmedical.com
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The clinical application of the work of these disciplines is performed to improve and maintain an individual's functional capacities for physical labor, exercise, and sports. Sports medicine also includes the prevention and treatment of diseases and injuries related to exercise and sports.
Ask a question in class
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- Apr 2023
- Aug 2022
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www.mavenclinic.com www.mavenclinic.com
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With Only 26% of Pregnant People in the United States Vaccinated Against COVID-19, New Survey Sheds Light on the Reasons Why. (n.d.). Retrieved November 1, 2021, from https://www.mavenclinic.com/post/covid-19-vaccine-survey-pregnant-people?utm_content=185156625&utm_medium=social&utm_source=twitter&hss_channel=tw-2236392565
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www.livemint.com www.livemint.com
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Banerjee, P. (2022, February 13). Biological E seeks EUA for its Corbevax vaccine for 12-18 yrs age group. Mint. https://www.livemint.com/news/india/biological-e-seeks-eua-for-its-corbevax-vaccine-for-12-18-yrs-age-group-11644746753338.html
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Monto, A. S. (2021). The Future of SARS-CoV-2 Vaccination—Lessons from Influenza. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMp2113403
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Varmus, H. (2021, August 31). Covid has revealed the need for genomic sequencing around the world. Financial Times. https://www.ft.com/content/342fd3c3-5a22-49a0-9cef-135f2ccd8700
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www.bmj.com www.bmj.com
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Lauring, A. S., Tenforde, M. W., Chappell, J. D., Gaglani, M., Ginde, A. A., McNeal, T., Ghamande, S., Douin, D. J., Talbot, H. K., Casey, J. D., Mohr, N. M., Zepeski, A., Shapiro, N. I., Gibbs, K. W., Files, D. C., Hager, D. N., Shehu, A., Prekker, M. E., Erickson, H. L., … Self, W. H. (2022). Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: Prospective observational study. BMJ, 376, e069761. https://doi.org/10.1136/bmj-2021-069761
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www.medrxiv.org www.medrxiv.org
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Regev-Yochay, G., Gonen, T., Gilboa, M., Mandelboim, M., Indenbaum, V., Amit, S., Meltzer, L., Asraf, K., Cohen, C., Fluss, R., Biber, A., Nemet, I., Kliker, L., Joseph, G., Doolman, R., Mendelson, E., Freedman, L. S., Harats, D., Kreiss, Y., & Lustig, Y. (2022). 4th Dose COVID mRNA Vaccines’ Immunogenicity & Efficacy Against Omicron VOC (p. 2022.02.15.22270948). medRxiv. https://doi.org/10.1101/2022.02.15.22270948
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twitter.com twitter.com
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ReconfigBehSci. (2021, April 21). RT @covidoneyearago: One year ago today: A paper in Clinical Infectious Diseases identifies a 16.3% rate of in-household COVID-19 infection… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1384784541873737729
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twitter.com twitter.com
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Gavi, the Vaccine Alliance. (2021, November 25). Around the world, there are now 132 COVID-19 vaccine candidates undergoing clinical trials and 194 candidates in pre-clinical development. Read our latest #COVID19 vaccine race update: Https://t.co/ETtHP6XmYI [Tweet]. @gavi. https://twitter.com/gavi/status/1463953132120010753
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- Apr 2022
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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airflow limitation and irreversible decline in lung function.
COPD characterised by
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www.nature.com www.nature.com
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Tao, K., Tzou, P. L., Nouhin, J., Gupta, R. K., de Oliveira, T., Kosakovsky Pond, S. L., Fera, D., & Shafer, R. W. (2021). The biological and clinical significance of emerging SARS-CoV-2 variants. Nature Reviews Genetics, 1–17. https://doi.org/10.1038/s41576-021-00408-x
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www.scientificamerican.com www.scientificamerican.com
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Wallis, C. (n.d.). COVID Has Pushed Medical Research into Remote Trials, Benefiting Patients and Scientists. Scientific American. https://doi.org/10.1038/scientificamerican0521-24
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twitter.com twitter.com
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The Lancet. (2021, April 16). Quantity > quality? The magnitude of #COVID19 research of questionable methodological quality reveals an urgent need to optimise clinical trial research—But how? A new @LancetGH Series discusses challenges and solutions. Read https://t.co/z4SluR3yuh 1/5 https://t.co/94RRVT0qhF [Tweet]. @TheLancet. https://twitter.com/TheLancet/status/1383027527233515520
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twitter.com twitter.com
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Kai Kupferschmidt. (2021, March 16). “I’m not here to give you the outcome of any scientific review”, says EMA director Emer Cooke at start of press conference on AstraZeneca vaccine safety. ‘I’m here to explain the steps in the process, what we’re doing, and when you can expect us to come to a conclusion.’ [Tweet]. @kakape. https://twitter.com/kakape/status/1371811123197001729
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www.ema.europa.eu www.ema.europa.eu
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EMA. (2020, October 27). COVID-19 vaccines: Development, evaluation, approval and monitoring [Text]. European Medicines Agency. https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19/treatments-vaccines/vaccines-covid-19/covid-19-vaccines-development-evaluation-approval-monitoring
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- Mar 2022
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www.cnn.com www.cnn.com
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CNN, A. S. (n.d.). Pfizer begins Phase 2 and 3 trial of Covid-19 antiviral Paxlovid in children ages 6 to 17. CNN. Retrieved 22 March 2022, from https://www.cnn.com/2022/03/09/health/pfizer-paxlovid-pediatric-trial/index.html
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- Feb 2022
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psyarxiv.com psyarxiv.com
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Inasaridze, K. (2022). COVID-19-related symptoms’ assessment tool. PsyArXiv. https://doi.org/10.31234/osf.io/wf8rv
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Mancini, D. P., & Smyth, J. (2022, February 16). Merck struggles to win European approval for Covid-19 antiviral pill. Financial Times. https://www.ft.com/content/2cf0b6cc-b07b-4ff9-a833-42eb1798a576
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www.cdc.gov www.cdc.gov
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Hause, A. M. (2021). COVID-19 Vaccine Safety in Children Aged 5–11 Years—United States, November 3–December 19, 2021. MMWR. Morbidity and Mortality Weekly Report, 70. https://doi.org/10.15585/mmwr.mm705152a1
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jamanetwork.com jamanetwork.com
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Heesakkers, H., van der Hoeven, J. G., Corsten, S., Janssen, I., Ewalds, E., Simons, K. S., Westerhof, B., Rettig, T. C. D., Jacobs, C., van Santen, S., Slooter, A. J. C., van der Woude, M. C. E., van den Boogaard, M., & Zegers, M. (2022). Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19. JAMA, 327(6), 559–565. https://doi.org/10.1001/jama.2022.0040
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twitter.com twitter.com
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Prof. Akiko Iwasaki. (2022, January 27). Vaccines that reduce infection & disease are needed to combat the pandemic. Here, @tianyangmao @BenIsraelow et al. Describe our new mucosal booster strategy, Prime and Spike, to induce such immunity via nasal delivery of unadjuvanted spike vaccine 🧵 (1/) https://biorxiv.org/content/10.1101/2022.01.24.477597v1 https://t.co/bcB5MFph9F [Tweet]. @VirusesImmunity. https://twitter.com/VirusesImmunity/status/1486510697332842498
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www.theguardian.com www.theguardian.com
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Devlin, H., & correspondent, H. D. S. (2022, February 3). Novavax Covid vaccine approved for use in over-18s in UK. The Guardian. https://www.theguardian.com/society/2022/feb/03/novavax-covid-vaccine-approved-for-use-in-over-18s-in-uk
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twitter.com twitter.com
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Deepti Gurdasani. (2022, January 29). Going to say this again because it’s important. Case-control studies to determine prevalence of long COVID are completely flawed science, but are often presented as being scientifically robust. This is not how we can define clinical syndromes or their prevalence! A thread. [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1487366920508694529
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- Jan 2022
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skimsci.netlify.app skimsci.netlify.app
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A Prospective Trial with Long Term Follow-up of Patients With Severe, Steroid-Resistant Ulcerative Colitis Who Received Induction Therapy With Cyclosporine and Were Maintained With Vedolizumab.
17 patients only
At week 52 of follow-up, 10 (71%) of 14 of these patients continued to be in endoscopic remission and 11 (79%) of 14 were in clinical remission
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medicalxpress.com medicalxpress.com
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Tong-Hyung, K. (n.d.). South Korea gets first supply of Pfizer’s COVID-19 pills. Retrieved January 20, 2022, from https://medicalxpress.com/news/2022-01-south-korea-pfizer-covid-pills.html
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twitter.com twitter.com
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Shematologist, MD. (2022, January 13). In medicine this is what we call a conflict of interest. Https://t.co/DNk0pDdz6Y [Tweet]. @acweyand. https://twitter.com/acweyand/status/1481480271254138880
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psyarxiv.com psyarxiv.com
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Williams, M., Anderson, R. C., Fox, N., Skinner, C. M., & McMurtrie, B. (2022). Evidence for a positive relationship between perceived stress and belief in conspiracy theories. PsyArXiv. https://doi.org/10.31234/osf.io/gca56
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psyarxiv.com psyarxiv.com
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Strickland, J. C., Stoops, W., Banks, M., & Gipson-Reichardt, C. D. (2022). Logical Fallacies and Misinterpretations that Hinder Progress in Translational Addiction Neuroscience. PsyArXiv. https://doi.org/10.31234/osf.io/frd5e
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- Dec 2021
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medicalxpress.com medicalxpress.com
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Convalescent plasma not efficacious in hospitalized COVID-19 patients. (n.d.). Retrieved December 17, 2021, from https://medicalxpress.com/news/2021-12-convalescent-plasma-efficacious-hospitalized-covid-.html
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erictopol.substack.com erictopol.substack.com
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Topol, E. (2021, December 16). Why Paxlovid is a Just-in-Time Breakthrough [Substack newsletter]. Ground Truths. https://erictopol.substack.com/p/why-paxlovid-is-a-just-in-time-breakthrough
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www.medrxiv.org www.medrxiv.org
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Simon, M. A., Luginbuhl, R. D., & Parker, R. (2021). Reduced Incidence of Long-COVID Symptoms Related to Administration of COVID-19 Vaccines Both Before COVID-19 Diagnosis and Up to 12 Weeks After (p. 2021.11.17.21263608). https://doi.org/10.1101/2021.11.17.21263608
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www.nature.com www.nature.com
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Heitmann, J. S., Bilich, T., Tandler, C., Nelde, A., Maringer, Y., Marconato, M., Reusch, J., Jäger, S., Denk, M., Richter, M., Anton, L., Weber, L. M., Roerden, M., Bauer, J., Rieth, J., Wacker, M., Hörber, S., Peter, A., Meisner, C., … Walz, J. S. (2021). A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity. Nature, 1–9. https://doi.org/10.1038/s41586-021-04232-5
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www.theguardian.com www.theguardian.com
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Devlin, H., & Kollewe, J. (2021, November 26). BioNTech says it could tweak Covid vaccine in 100 days if needed. The Guardian. https://www.theguardian.com/society/2021/nov/26/biontech-says-it-could-tweak-covid-vaccine-in-100-days-if-needed
Tags
- booster
- clinical trials
- COVID-19
- escape variant
- vaccine
- development
- variant
- immunity
- Omicron
- spike protein
- variant-specific booster
- BioNTech
- Pfizer
- mutation
- research
- is:news
- transmissibility
- lang:en
- protection
- effectiveness
- science
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theguardian.com/society/2021/nov/26/biontech-says-it-could-tweak-covid-vaccine-in-100-days-if-needed -
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jamanetwork.com jamanetwork.com
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Jabagi, M. J., Botton, J., Bertrand, M., Weill, A., Farrington, P., Zureik, M., & Dray-Spira, R. (2021). Myocardial Infarction, Stroke, and Pulmonary Embolism After BNT162b2 mRNA COVID-19 Vaccine in People Aged 75 Years or Older. JAMA. https://doi.org/10.1001/jama.2021.21699
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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COVID-19 vaccine surveillance report—Week 47. (n.d.). 46.
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- clinical trials
- COVID-19
- immune response
- vaccine
- data
- research
- UKHSA
- UK
- approval
- safety profile
- delta
- lang:en
- protection
- vaccine efficacy
- is:report
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URL
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- Nov 2021
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www.theguardian.com www.theguardian.com
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Yang, M. (2021, November 23). Seven doctors contract Covid after attending Florida anti-vaccine summit. The Guardian. https://www.theguardian.com/us-news/2021/nov/23/florida-doctors-covid-coronavirus-bruce-boros
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www.nature.com www.nature.com
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Reardon, S. (2021). Cuba’s bet on home-grown COVID vaccines is paying off. Nature. https://doi.org/10.1038/d41586-021-03470-x
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Forbes, P., Pronizius, E., Feneberg, A. C., Nater, U., Piperno, G., Silani, G., Stijovic, A., & Lamm, C. (2021). The benefits and limits of social interactions during COVID-19 lockdown. PsyArXiv. https://doi.org/10.31234/osf.io/ae6t9
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www.science.org www.science.org
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Couzin-Frankel, J. (2021). Antiviral pills could change pandemic’s course. Science, 374(6569), 799–800. https://doi.org/10.1126/science.acx9605
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www.nejm.org www.nejm.org
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Walter, E. B., Talaat, K. R., Sabharwal, C., Gurtman, A., Lockhart, S., Paulsen, G. C., Barnett, E. D., Muñoz, F. M., Maldonado, Y., Pahud, B. A., Domachowske, J. B., Simões, E. A. F., Sarwar, U. N., Kitchin, N., Cunliffe, L., Rojo, P., Kuchar, E., Rämet, M., Munjal, I., … Gruber, W. C. (2021). Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age. New England Journal of Medicine, NEJMoa2116298. https://doi.org/10.1056/NEJMoa2116298
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Tanzer, M., Campbell, C., Saunders, R., Luyten, P., Booker, T., & Fonagy, P. (2021). Acquiring knowledge: Epistemic trust in the age of fake news. PsyArXiv. https://doi.org/10.31234/osf.io/g2b6k
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journals.sagepub.com journals.sagepub.com
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Gurdasani, D., Bhatt, S., Costello, A., Denaxas, S., Flaxman, S., Greenhalgh, T., Griffin, S., Hyde, Z., Katzourakis, A., McKee, M., Michie, S., Ratmann, O., Reicher, S., Scally, G., Tomlinson, C., Yates, C., Ziauddeen, H., & Pagel, C. (2021). Vaccinating adolescents against SARS-CoV-2 in England: A risk–benefit analysis. Journal of the Royal Society of Medicine, 01410768211052589. https://doi.org/10.1177/01410768211052589
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- Oct 2021
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valneva.com valneva.com
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Valneva Reports Positive Phase 3 Results for Inactivated, Adjuvanted COVID-19 Vaccine Candidate VLA2001 – Valneva. (n.d.). Retrieved October 26, 2021, from https://valneva.com/press-release/valneva-reports-positive-phase-3-results-for-inactivated-adjuvanted-covid-19-vaccine-candidate-vla2001/
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www.nature.com www.nature.com
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Waltz, E. (2021). COVID vaccine makers brace for a variant worse than Delta. Nature, d41586-021-02854–3. https://doi.org/10.1038/d41586-021-02854-3
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Abbas-Hanif, A., Modi, N., Smith, S. K., & Majeed, A. (2021). Covid-19 treatments and vaccines must be evaluated in pregnancy. BMJ, n2377. https://doi.org/10.1136/bmj.n2377
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www.gavi.org www.gavi.org
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The COVID-19 vaccine race | Gavi, the Vaccine Alliance. (n.d.). Retrieved October 8, 2021, from https://www.gavi.org/vaccineswork/covid-19-vaccine-race
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jamanetwork.com jamanetwork.com
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Simone, A., Herald, J., Chen, A., Gulati, N., Shen, A. Y.-J., Lewin, B., & Lee, M.-S. (2021). Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Years or Older. JAMA Internal Medicine. https://doi.org/10.1001/jamainternmed.2021.5511
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www.science.org www.science.org
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Mateus, J., Dan, J. M., Zhang, Z., Rydyznski Moderbacher, C., Lammers, M., Goodwin, B., Sette, A., Crotty, S., & Weiskopf, D. (n.d.). Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells. Science, 0(0), eabj9853. https://doi.org/10.1126/science.abj9853
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www.cloverbiopharma.com www.cloverbiopharma.com
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Clover’s COVID-19 Vaccine Candidate Demonstrates 79% Efficacy Against Delta in Global Phase 2/3 SPECTRA Trial Dominated by Variants of Concern and Interest—Clover Biopharmaceuticals. (n.d.). Retrieved 4 October 2021, from https://www.cloverbiopharma.com/news/83.html
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www.theguardian.com www.theguardian.com
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Flu and Covid jabs safe to be given at same time, study finds | Vaccines and immunisation | The Guardian. (n.d.). Retrieved October 1, 2021, from https://www.theguardian.com/society/2021/sep/30/flu-covid-jabs-safe-same-time-study?CMP=Share_iOSApp_Other
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- Sep 2021
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www.nytimes.com www.nytimes.com
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Zimmer, C., Corum, J., & Wee, S.-L. (2020, June 10). Coronavirus Vaccine Tracker. The New York Times. https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html
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www.newscientist.com www.newscientist.com
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Klein, Alice. “Cheap Covid-19 Antibody Test Shows If You Have Immunity in 5 Minutes.” New Scientist. Accessed September 20, 2021. https://www.newscientist.com/article/2290120-cheap-covid-19-antibody-test-shows-if-you-have-immunity-in-5-minutes/.
Tags
- COVID-19
- infection
- fast
- immunity
- antibody
- clinical trial
- blood
- vaccination
- is:news
- Coronavirus
- accuracy
- lang:en
- protection
- saliva
- cheap
- approval
Annotators
URL
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www.nature.com www.nature.com
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Lee, J. W., Su, Y., Baloni, P., Chen, D., Pavlovitch-Bedzyk, A. J., Yuan, D., Duvvuri, V. R., Ng, R. H., Choi, J., Xie, J., Zhang, R., Murray, K., Kornilov, S., Smith, B., Magis, A. T., Hoon, D. S. B., Hadlock, J. J., Goldman, J. D., Price, N. D., … Heath, J. R. (2021). Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19. Nature Biotechnology, 1–11. https://doi.org/10.1038/s41587-021-01020-4
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- Aug 2021
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twitter.com twitter.com
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Mel 💉🩹❤️Get Vaccinated! On Twitter: “#GetVaccinatedNow https://t.co/ewb1vQCvWw” / Twitter. (n.d.). Retrieved August 27, 2021, from https://twitter.com/ScientistMel/status/1430927342361137156
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www.thelancet.com www.thelancet.com
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Kadambari, S., & Vanderslott, S. (2021). Lessons about COVID-19 vaccine hesitancy among minority ethnic people in the UK. The Lancet Infectious Diseases, S1473309921004047. https://doi.org/10.1016/S1473-3099(21)00404-7
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www.nytimes.com www.nytimes.com
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Mandavilli, A. (2021, August 6). New data suggest J. & J. vaccine works against Delta and recipients don’t need a booster shot. The New York Times. https://www.nytimes.com/2021/08/06/science/johnson-delta-vaccine-booster.html
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psyarxiv.com psyarxiv.com
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PsyArXiv Preprints | Anti-Asian Discrimination and Antiracist Bystander Behaviors amid the COVID-19 Outbreak. (n.d.). Retrieved 4 August 2021, from https://psyarxiv.com/tfsqh/
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- Jul 2021
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www.ema.europa.eu www.ema.europa.eu
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PINHO, A. C. (2021, March 10). EMA starts rolling review of Eli Lilly antibodies bamlanivimab and etesevimab for COVID-19 [Text]. European Medicines Agency. https://www.ema.europa.eu/en/news/ema-starts-rolling-review-eli-lilly-antibodies-bamlanivimab-etesevimab-covid-19
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Short interview that covers the findings of a systematic review that aimed to identify the number of studies trying to replicate the outcomes of clinical decision support systems.
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Stoddard, J., Reynolds, E. K., Paris, R., Haller, S., Johnson, S., Zik, J., Elliote, E., Maru, M., Jaffe, A., Mallidi, A., Smith, A., Hernandez, R. G., Volk, H. E., Brotman, M. A., & Kaufman, J. (2021). The Coronavirus Impact Scale: Construction, Validation, and Comparisons in Diverse Clinical Samples [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/kz4pg
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Franceschini, C., Musetti, A., Zenesini, C., Palagini, L., Pelosi, A., Quattropani, M. C., Lenzo, V., Freda, M. F., Lemmo, D., Vegni, E., Borghi, L., Saita, E., Cattivelli, R., De Gennaro, L., Plazzi, G., Riemann, D., & Castelnuovo, G. (2020). Poor quality of sleep and its consequences on mental health during COVID-19 lockdown in Italy [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/ah6j3
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Eric Topol. (2021, February 17). New reports @NEJM today confirming some immune evasion of the B.1.351 variant (identified in South Africa) to both the mRNA vaccines, in vitro data @BioNTech_Group/@Pfizer and @moderna_tx. Less vaccine efficacy vs B.1.351 has been confirmed in clinical trials for 3 vaccines https://t.co/2N7eKDllso [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1362160675913568256
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Park, J. J. H., Mogg, R., Smith, G. E., Nakimuli-Mpungu, E., Jehan, F., Rayner, C. R., Condo, J., Decloedt, E. H., Nachega, J. B., Reis, G., & Mills, E. J. (2021). How COVID-19 has fundamentally changed clinical research in global health. The Lancet Global Health, 9(5), e711–e720. https://doi.org/10.1016/S2214-109X(20)30542-8
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Park, J. J. H., Grais, R. F., Taljaard, M., Nakimuli-Mpungu, E., Jehan, F., Nachega, J. B., Ford, N., Xavier, D., Kengne, A. P., Ashorn, P., Socias, M. E., Bhutta, Z. A., & Mills, E. J. (2021). Urgently seeking efficiency and sustainability of clinical trials in global health. The Lancet Global Health, 9(5), e681–e690. https://doi.org/10.1016/S2214-109X(20)30539-8
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Moderna Provides Clinical and Supply Updates on COVID-19 Vaccine Program Ahead of 2nd Annual Vaccines Day. (2021, April 13). Moderna, Inc. https://investors.modernatx.com/news-releases/news-release-details/moderna-provides-clinical-and-supply-updates-covid-19-vaccine
Tags
- booster
- COVID-19
- clinical
- press release
- variant
- antibody
- dose
- efficacy
- supply
- biotechnology
- is:webpage
- vaccination
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- global
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Annotators
URL
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Dr Lea Merone MBChB (hons) MPH&TM MSc FAFPHM Ⓥ. ‘I’m an Introvert and Being Thrust into the Centre of This Controversy Has Been Quite Confronting. I’ve Had a Little Processing Time Right Now and I Have a Few Things to Say. I Won’t Repeat @GidMK and His Wonderful Thread but I Will Say 1 This Slander of Us Both Has Been 1/n’. Tweet. @LeaMerone (blog), 29 March 2021. https://twitter.com/LeaMerone/status/1376365651892166658.
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Iversen, P. L., & Bavari, S. (2021). Is there space for a three-dose vaccine to fight the spread of SARS-CoV-2? The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00149-3
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Skalski, Sebastian, Karol Konaszewski, Paweł Dobrakowski, Janusz Surzykiewicz, and Sherman A. Lee. ‘Pandemic Grief in Poland: Adaptation of a Measure and Its Relationship with Social Support and Resilience’. PsyArXiv, 11 January 2021. https://doi.org/10.31234/osf.io/es3rd.
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Isaacson, Walter. ‘Opinion | I Was Part of a Trial for Pfizer’s Covid-19 Vaccine. It’s a Miracle for Genetic Medicine.’ Washington Post. Accessed 6 March 2021. https://www.washingtonpost.com/opinions/i-took-the-pfizer-covid-19-vaccine-its-a-miracle-for-genetic-medicine/2020/11/09/77e652d0-22bf-11eb-952e-0c475972cfc0_story.html.
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Abdelhafiz, Ahmed Samir, Samar Abd ElHafeez, Mohammad Adnan Khalil, Manal Shahrouri, Bandar Alosaim, Raneem O. Salem, Mohamed Alorabi, Fatma Abdelgawad, and Mamoun Ahram. ‘Factors Influencing Participation in COVID-19 Clinical Trials: A Multi-National Study’. Frontiers in Medicine 8 (2021). https://doi.org/10.3389/fmed.2021.608959.
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Dr Ellie Murray. (2020, December 3). Some really great resources & discussions in this thread. The tl;dr is (1) yes, the vaccine trials included some people who had previously had COVID; and (2) in general vaccination plans will include those who have previously been sick/infected. Thanks all! [Tweet]. @EpiEllie. https://twitter.com/EpiEllie/status/1334545373126389766
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Wilkinson, Jack, Kellyn F. Arnold, Eleanor J. Murray, Maarten van Smeden, Kareem Carr, Rachel Sippy, Marc de Kamps, et al. ‘Time to Reality Check the Promises of Machine Learning-Powered Precision Medicine’. The Lancet Digital Health 0, no. 0 (16 September 2020). https://doi.org/10.1016/S2589-7500(20)30200-4.
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erj.ersjournals.com erj.ersjournals.com
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Gupta, R. K., Marks, M., Samuels, T. H. A., Luintel, A., Rampling, T., Chowdhury, H., Quartagno, M., Nair, A., Lipman, M., Abubakar, I., Smeden, M. van, Wong, W. K., Williams, B., & Noursadeghi, M. (2020). Systematic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19: An observational cohort study. European Respiratory Journal. https://doi.org/10.1183/13993003.03498-2020
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Siemieniuk, R. A., Bartoszko, J. J., Ge, L., Zeraatkar, D., Izcovich, A., Kum, E., Pardo-Hernandez, H., Rochwerg, B., Lamontagne, F., Han, M. A., Liu, Q., Agarwal, A., Agoritsas, T., Chu, D. K., Couban, R., Darzi, A., Devji, T., Fang, B., Fang, C., … Brignardello-Petersen, R. (2020). Drug treatments for covid-19: Living systematic review and network meta-analysis. BMJ, 370. https://doi.org/10.1136/bmj.m2980
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Kouzy, R., Jaoude, J. A., Garcia, C. J. G., Alam, M. B. E., Taniguchi, C. M., & Ludmir, E. B. (2020). Characteristics of the Multiplicity of Randomized Clinical Trials for Coronavirus Disease 2019 Launched During the Pandemic. JAMA Network Open, 3(7), e2015100–e2015100. https://doi.org/10.1001/jamanetworkopen.2020.15100
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Ponchner, D. (n.d.). Costa Rica Readies Horse Antibodies for Trials as an Inexpensive COVID-19 Therapy. Scientific American. Retrieved September 8, 2020, from https://www.scientificamerican.com/article/costa-rica-readies-horse-antibodies-for-trials-as-an-inexpensive-covid-19-therapy/
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Emanuel, E. J., & Offit, P. A. (2020, June 8). Opinion | Could Trump Turn a Vaccine Into a Campaign Stunt? The New York Times. https://www.nytimes.com/2020/06/08/opinion/trump-coronavirus-vaccine.html
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Lancet, T. (2020). Research and higher education in the time of COVID-19. The Lancet, 396(10251), 583. https://doi.org/10.1016/S0140-6736(20)31818-3
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Yang, B. Y., Barnard, L. M., Emert, J. M., Drucker, C., Schwarcz, L., Counts, C. R., Murphy, D. L., Guan, S., Kume, K., Rodriquez, K., Jacinto, T., May, S., Sayre, M. R., & Rea, T. (2020). Clinical Characteristics of Patients With Coronavirus Disease 2019 (COVID-19) Receiving Emergency Medical Services in King County, Washington. JAMA Network Open, 3(7), e2014549–e2014549. https://doi.org/10.1001/jamanetworkopen.2020.14549
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Shan, B., Broza, Y. Y., Li, W., Wang, Y., Wu, S., Liu, Z., Wang, J., Gui, S., Wang, L., Zhang, Z., Liu, W., Zhou, S., Jin, W., Zhang, Q., Hu, D., Lin, L., Zhang, Q., Li, W., Wang, J., … Haick, H. (2020). Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath. ACS Nano. https://doi.org/10.1021/acsnano.0c05657
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Mohana, A., Suliman, T., Mahmoud, N., Hassanein, M., Alfaifi, A., Alenazi, E., Radwan, N., Alkhalifah, N., Elkady, E., Almohaizeie, A., AboGazalah, F., AbdulKareem, K., AlGhofaili, F., Jokhdar, H., & Alrabiah, F. (2020). Hydroxychloroquine Safety Outcome within Approved Therapeutic Protocol for COVID-19 Outpatients in Saudi Arabia. MedRxiv, 2020.08.16.20175752. https://doi.org/10.1101/2020.08.16.20175752
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Yonker, L. M., Neilan, A. M., Bartsch, Y., Patel, A. B., Regan, J., Arya, P., Gootkind, E., Park, G., Hardcastle, M., John, A. S., Appleman, L., Chiu, M. L., Fialkowski, A., Flor, D. D. la, Lima, R., Bordt, E. A., Yockey, L. J., D’Avino, P., Fischinger, S., … Fasano, A. (2020). Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses. The Journal of Pediatrics, 0(0). https://doi.org/10.1016/j.jpeds.2020.08.037
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Facebook, Twitter, options, S. more sharing, Facebook, Twitter, LinkedIn, Email, URLCopied!, C. L., & Print. (2020, August 22). Researchers show that COVID-19 racial disparities aren’t inevitable. Los Angeles Times. https://www.latimes.com/science/story/2020-08-22/researchers-show-that-covid-19-racial-disparities-arent-inevitable
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Califf, Robert M., Adrian F. Hernandez, and Martin Landray. ‘Weighing the Benefits and Risks of Proliferating Observational Treatment Assessments: Observational Cacophony, Randomized Harmony’. JAMA 324, no. 7 (18 August 2020): 625–26. https://doi.org/10.1001/jama.2020.13319.
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www.biorxiv.org www.biorxiv.org
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Sun, W., McCroskery, S., Liu, W.-C., Leist, S. R., Liu, Y., Albrecht, R. A., Slamanig, S., Oliva, J., Amanat, F., Schäfer, A., Dinnon, K. H., Innis, B. L., García-Sastre, A., Krammer, F., Baric, R. S., & Palese, P. (2020). A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine. BioRxiv, 2020.07.30.229120. https://doi.org/10.1101/2020.07.30.229120
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Monforte, A. d’Arminio, Tavelli, A., Bai, F., Marchetti, G., & Cozzi-Lepri, A. (2020). Effectiveness of hydroxychloroquine in COVID-19 disease: A done and dusted deal? International Journal of Infectious Diseases, 99, 75–76. https://doi.org/10.1016/j.ijid.2020.07.056
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Yan, Q., Zuo, P., Cheng, L., Li, Y., Song, K., Chen, Y., Dai, Y., Yang, Y., Zhou, L., Yu, W., Li, Y., Xie, M., Zhang, C., & Gao, H. (n.d.). Acute Kidney Injury Is Associated With In-hospital Mortality in Older Patients With COVID-19. The Journals of Gerontology: Series A. https://doi.org/10.1093/gerona/glaa181
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Mather, N. (2020). How we accelerated clinical trials in the age of coronavirus. Nature, 584(7821), 326–326. https://doi.org/10.1038/d41586-020-02416-z
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Lo, A. W., Siah, K. W., & Wong, C. H. (2020). Estimating Probabilities of Success of Vaccine and Other Anti-Infective Therapeutic Development Programs (Working Paper No. 27176; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27176
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Manski, C. F. (2020). Bounding the Predictive Values of COVID-19 Antibody Tests (Working Paper No. 27226; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27226
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Chaudhuri, S., Lo, A. W., Xiao, D., & Xu, Q. (2020). Bayesian Adaptive Clinical Trials for Anti‐Infective Therapeutics during Epidemic Outbreaks (Working Paper No. 27175; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27175
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Khan MS, Fonarow GC, Friede T, et al. Application of the Reverse Fragility Index to Statistically Nonsignificant Randomized Clinical Trial Results. JAMA Netw Open. 2020;3(8):e2012469. doi:10.1001/jamanetworkopen.2020.12469
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Hewitt, J., Carter, B., Vilches-Moraga, A., Quinn, T. J., Braude, P., Verduri, A., Pearce, L., Stechman, M., Short, R., Price, A., Collins, J. T., Bruce, E., Einarsson, A., Rickard, F., Mitchell, E., Holloway, M., Hesford, J., Barlow-Pay, F., Clini, E., … Guaraldi, G. (2020). The effect of frailty on survival in patients with COVID-19 (COPE): A multicentre, European, observational cohort study. The Lancet Public Health, 5(8), e444–e451. https://doi.org/10.1016/S2468-2667(20)30146-8
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Salvatore, C. M., Han, J.-Y., Acker, K. P., Tiwari, P., Jin, J., Brandler, M., Cangemi, C., Gordon, L., Parow, A., DiPace, J., & DeLaMora, P. (2020). Neonatal management and outcomes during the COVID-19 pandemic: An observation cohort study. The Lancet Child & Adolescent Health, 0(0). https://doi.org/10.1016/S2352-4642(20)30235-2
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Taraborelli, D., Taraborelli, D., & Taraborelli, D. (2020, August 5). How the COVID-19 crisis has prompted a revolution in scientific publishing. Fast Company. https://www.fastcompany.com/90537072/how-the-covid-19-crisis-has-prompted-a-revolution-in-scientific-publishing
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Kominers, S. D., Pathak, P. A., Sönmez, T., & Ünver, M. U. (2020). Paying It Backward and Forward: Expanding Access to Convalescent Plasma Therapy Through Market Design (Working Paper No. 27143; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27143
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Horby, P., Mafham, M., Linsell, L., Bell, J. L., Staplin, N., Emberson, J. R., Wiselka, M., Ustianowski, A., Elmahi, E., Prudon, B., Whitehouse, A., Felton, T., Williams, J., Faccenda, J., Underwood, J., Baillie, J. K., Chappell, L., Faust, S. N., Jaki, T., … Landray, M. J. (2020). Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial. MedRxiv, 2020.07.15.20151852. https://doi.org/10.1101/2020.07.15.20151852
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