5 Matching Annotations
  1. Mar 2021
    1. “The mRNA molecule is vulnerable to destruction. So, in order to protect the fragile mRNA strands while they are being inserted into our DNA they are coated with PEGylated lipid nanoparticles. This coating hides the mRNA from our immune system which ordinarily would kill any foreign material injected into the body. PEGylated lipid nanoparticles have been used in several different drugs for years. Because of their effect on immune system balance, several studies have shown them to induce allergies and autoimmune diseases. Additionally, PEGylated lipid nanoparticles have been shown to trigger their own immune reactions, and to cause damage to the liver.”

      LNP and PEG can cause autoimmune disease. They also damage the liver.

  2. Aug 2020
  3. Oct 2017
    1. . Although site-specific conjugation strategies have been developed that improve the yield and specificity of the conjugation site5,6, issues remain with the cost and intrinsic heterogeneity of the PEG itself7.

      peg heterogeneity

    2. Renally cleared PEGylated proteins or their metabolites may accumu-late in the kidney, causing formation of PEG hydrates that interfere with normal glomerular filtration. In addition, animals and humans can be induced to make antibodies to PEG9,10

      kidney accumulation, anti-peg antibodies



  4. Dec 2016
    1. Written by rchase, feel free to edit. It's an experiment.

      Since I took the notes using hypothesis, the password to edit is hypothesis.