Asimov’s Foundation series, which is fascinating because of the spoiler that you first need planetary scale populations to model the future, but then a mutant mule appears who can change behavior and must be opposed by Second Foundation operators leveraging his own emotions against him to get the project back on track
Asimov in his fiction was fascinated by the advent of statistics, so let's not read things into it wrt predicting futures. We know that's not what statistics do, and still are committed to the waving of invisible hands like it's the 18th century. Connecting this to memetics is likely a fruitless path.