a-Genotype designations are as in (Berlyn, 1998).b-Strains DH5α, MC4100andMG1655 were from the laboratory stock collection.FRT-indicates FLP recognition target, a sequence that is recognized by FLP recombinase and is left as a scar at the indicated sites after excision of an antibiotic marker that is flanked by the FRT sites

The E. coli strains used in this study with their genotypes are shown in the table below. Bacterial strains were routinely stored on solid agar plates at 4ºC and also as thick suspensions in 20% glycerolat –80ºC. Plasmid harbouring strains were freshly prepared by transformation of the required plasmid. The bacteriophage P1kc was used for routine transduction to move a locus from one strain to another and is referred to as P1 throughout this thesis.Bacterial Strains Table 2.1: E. coli strains used and constructed in this study:

'That colour's very good on you,' she said, smiling professio­nally.Sayako said, 'I take it and also I take it in strawberry and navy and primrose.'3The manageress inwardly rejoiced. She would now reach this week's target.4 Her job would be safe for at least another month. God bless the Japanese!Sayako walked over on stockinged feet5 to a display of suede loafers.'And these shoes to match all suits in size four,' she said. Her role model was the fibreglass mannequin6 which lolled convincingly against the shop counter, wearing the same cream suit that Sayako was wearing, the loafers that Sayako had just ordered and a bag that Sayako was about to order in navy, strawberry, cream and primrose. The mannequin's blonde nylon wig shone under the spotlights. Her blue eyes were half closed as though she were encaptured by her own beauty.She is so beautiful, thought Sayako. She took the wig from the mannequin's head and placed it on her own. It fitted perfectly.'And I take this,' she said.She then handed over a platinum card which bore the name of her father, the Emperor of Japan.

'That colour's very good on you,' she said, smiling professio­nally.Sayako said, 'I take it and also I take it in strawberry and navy and primrose.'3The manageress inwardly rejoiced. She would now reach this week's target.4 Her job would be safe for at least another month. God bless the Japanese!Sayako walked over on stockinged feet5 to a display of suede loafers.'And these shoes to match all suits in size four,' she said. Her role model was the fibreglass mannequin6 which lolled convincingly against the shop counter, wearing the same cream suit that Sayako was wearing, the loafers that Sayako had just ordered and a bag that Sayako was about to order in navy, strawberry, cream and primrose. The mannequin's blonde nylon wig shone under the spotlights. Her blue eyes were half closed as though she were encaptured by her own beauty.She is so beautiful, thought Sayako. She took the wig from the mannequin's head and placed it on her own. It fitted perfectly.'And I take this,' she said.

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Finally, and for the encouragement of people troubled with accents that cut them off from all high employment,

But if the play makes the public aware that there are such people as phoneticians, and that they are among the most important people in England at present, it will serve its turn.

Pygmalion needs, not a preface, but a sequel,

IammyselfastudentofIndiandia-lects

THEMOTHER.Howdoyouknowthatmyson'snameisFreddy,prayrTHEFLOWE

Cabwhistlesblowijigfranticallyinalldirections.Pedes-triansrunningforshelterintothemarketandundertheporticoofSt.Paul'sChurch,wheretherearealreadyseveralpeople,

CoventGardenat11.15p.m.Torrentsofheavysummerrain

Pygmalion:aRomanceinFiveActs:byBernardShaw

Pygmalion:aRomanceinFiveActs:byBernardShaw

Eons upon eons ago, when human life could last up to twenty thousand years, the Blessed One Kashyapa appeared in the world.

ancient story

previous century

Adipose tissue is no longer considered to be an inert tissue that stores fat. This tissue is capable of expanding to accommodate increased lipids through hypertrophy of existing adipocytes and by initiating differentiation of pre-adipocytes. Adipose tissue metabolism exerts an impact on whole-body metabolism. As an endocrine organ, adipose tissue is responsible for the synthesis and secretion of several hormones. These are active in a range of processes, such as control of nutritional intake (leptin, angiotensin), control of sensitivity to insulin and inflammatory process mediators (tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), resistin, visfatin, adiponectin, among others) and pathways (plasminogen activator inhibitor 1 (PAI-1) and acylation stimulating protein (ASP) for example). This paper reviews some of the biochemical and metabolic aspects of adipose tissue and its relationship to inflammatory disease and insulin resistance.

Drugs may also interact with genetic pathways of disease to elicit or exacerbate symptoms of the underlying conditions. In the porphyrias,

foolish imaginations of his heart

prayed unto the Lord, yea, even with all his heart

and his whole heart was filled

But an increasing hostility on the part of the non-slaveholding States to the institution of slavery, has led to a disregard of their obligations, and the laws of the General Government have ceased to effect the objects of the Constitution.

Questions for our first 1:1

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It will be observed that the basis of confederation now proposed differs from that of-the-United States in several important particulars. It does not profess to be derived from the people, but would be the Constitution provided by the Imperial Parliament; thus affording the means of remedying any defect, which is now practically impossible under the American Constitution.

Fra. This is most strange,That she, who even but now, was your best object,The argument of your praise, balm of your age,The best, the dearest, should in this trice of timeCommit a thing so monstrous, to dismantleSo many folds of favour: sure her offenceMust be of such unnatural degree,That monsters it: Or your fore-voucht affectionFall into Taint; which to believe of herMust be a faith, that reason without miracleShould never plant in me.

ng some text a

Import duty on air conditioners, refrigerators and washing machines under 10-kilogram capacity has been doubled to 20 percent each from 10 percent earlier. The basic customs duty on radial tyres is now 15 percent compared with 10 percent earlier,

It appears therefore that the only alternative which now offers itself to the inhabitants of Lower Canada is a choice between dissolution pure and simple, or Confederation on one side, and representation by population on the other. And however opposed Lower Canada may be to representation by population, is there not imminent danger that it may be finally imposed upon it, if it resist all measures of reform, the object of which is to leave to the local authorities of each section the control of its own interests and institutions. We should not forget that the same authority which imposed on us the Act of Union, or which altered it without our consent, by repealing the clause which required the concurrence of two thirds of the members of both Houses in order to change the representation respecting the two sections, may again intervene to impose upon us this new change.

In order to protect local interests, and to prevent sectional jealousies, it was found requisite that the three great divisions into which British North America is separated, should be represented in the Upper House on the principle of equality. There are three great sections, having different interests, in this proposed Confederation.

To the Upper House is to be confided the protection of sectional interests ; therefore is it that the three great divisions are there equally represented, for the purpose of defending such interests against the combinations of majorities in the Assembly.

But the very essence of our compact is that the union shall be federal and not legislative. Our Lower Canada friends have agreed to give us representation by population in the Lower House, on the express condition that they shall have equality in the Upper House. On no other condition could we have advanced a step ; and, for my part, I am quite willing they should have it. In maintaining the existing sectional boundaries and handing over the control of local matters to local bodies, we recognize, to a certain extent, a diversity of interests ; and it was quite natural that the protection for those interests, by equality in the Upper Chamber, should be demanded by the less numerous provinces.

the Lieutenant-Governor, who will enjoy the right of reserving the bills of the Local Parliament for the sanction of the Governor General, will be appointed by the Governor General in Council, that is to say, by the Federal Government, and, as a matter of course, it must be expected that he will act in conformity with the views of the Federal Government. Any bill reserved by him will require to be sanctioned by the Federal Government, which may refuse such sanction if they think proper, as they undoubtedly will as regards any bill the object of which might be to give responsible government to Lower Canada, whilst all the other provinces would only have governments which were not responsible. And the militia,—it will be exclusively under the control of the Federal Government. Have the honorable the French-Canadian members, to whom I more particularly address myself at this moment, reflected on the danger to us that is contained in this provision ?

My hon. friend from Wellington admits that under the Constitution we have the power to alter the constitution of this House in so far as it relates to Canada, but he says we are not authorized to extend our action to the other provinces, in a scheme of Federal union. That is begging the question. I answer his objection that any change affecting the elective principle is a breach of trust. Besides, we do not propose to enact a system of Government embracing all British North America We have not the power to do so. We merely propose to address Her Majesty on the subject. The Imperial Parliament alone has that power ; but if we have power without a breach of trust to alter the constitution of the Legislative Council of Canada (and my hon. friend admits this), then, certainly, we cannot be guilty of a breach of trust in suggesting a change embraced in a Constitution for the various provinces.

and dissent from others, of his opinions. The essential conditions of a valid trust to express particular opinions in Parliament are then wanting. The persons nominating him to his office, do not concur as to the opinions which he is to express. How then can a trust exist which it is impossible to define. The real trust imposed on the representative is co-extensive with those obligations, which alone the trust-makers can generally confer on him,—namely, to exercise his representative power honestly and discreetly. This argument, of course, assumes that the candidate has not defined his parliamentary obligations by unconditional pledges.

That the elective members had received a sacred trust to exercise ; that they were seut here by their constituencies to represent them, and to do that only. Under these circumstances, how could they conceive they had the power to vote away the rights of their electors? That was not their mandate, and if they did, they would be doing that which they had no authority to do ; they would be doing that which they could not do without going beyond the authority con faded to them. Now, it must be frankly admitted that if the hon. gentleman’s position’ be correct, then his objection would be fatal to any elected member giving his concurrence to the scheme of the Conference. But , hon. gentlemen, let us enquire what is the position of a representative. Two elements enter into the idea of representation— namely, power and duty. A representative derives the former from his constituents acting by their majority, under the Constitution. From what source does he derive the latter ? Obviously not from his constituents, because even the majority are not agreed on all points connected with the discharge of his duty. My hon. friend (Hon. Mr. SANBORN) has spoken of the position of a representative, as being that of a trustee. I shall quote from a very able work on the British Commonwealth, in which that position is, to my mind, very fully and very satisfactorily proved to be incorrect. Cox says :— Any trust, to be obligatory in conscience, must be defined by the self-same persons who appoint the trustee, or the person who is to fulfil the trust. His powers and duties must be derived from identically the same authority, for it obviously would be contrary to morals, as it is to law, that a man would be bound in conscience to exercise, in a particular way, powers delegated to him by several others, when trey themselves, while delegating those powers, differ as to the mode in which they are to be exercised. For, which of the different ways is the trustee to choose? By whom of those who appoint him is he to be guided in preference to the rest ? At the most he is bound to exercise his trust in a particular way in those particulars only respecting which the trust makers are agreed. Let us now apply this abstract principle of equity to the relations between a representative and his constituents. Regard him as their trustee. With respect to the source of his power there is no ambiguity ; it is derived from his constituents acting by their majority. But from whom does he derive the duty of expressing this or that opinion in Parliament ? In what particular are the trust-makers agreed? The very majority who voted for him are rarely, perhaps never, all agreed on any one point on which their opinions have been compared with his. Some of them differ from him on some points, some on others, but they all voted for him, from personal consideration, or because of their agreement with him on those points which they respectively deemed most important. In the minority, also, are probably some electors who assent to some,

HON. MR. CHRISTIE—A number of the representatives in the Federal Congress who voted for it were democrats, and without their concurrence and support it could not have been carried. Besides, that was only an amendment, not a revision of the Constitution. The Constitution of the United States was not the work of a party. The revision of the Constitution of the State of New York, in 1846, was not the work of a party I t is not desirable that any Constitution should be the work of a party ; in so important an undertaking all party spirit should be laid aside. (Hear, hear.) Why ? Because men of all parties are alike interested in the formation of a Constitution, and because in the construction of such an instrument , the collective wisdom of the leading men of all parties is needed. Besides, a Constitution so framed will be more likely, as my hon. friend from Wellington has so well said, to live in the hearts and affections of the people. (Hear, hear.) To show the good sense of our neighbors on this point, they do not give the revision of a Constitution—and the work of the Conference was a revision of our Constitution—to any party, but to men specially chosen for the purpose, irom all parties ; and I think the Governor General, and the Lieutenant-Governors of the Lower Provinces acted most wisely when they selected men of all shades of political opinion to compose this Conference and to prepare this Constitution, because all party views and feelings being laid aside, the whole object and motive of the members of the body was to devise a scheme which would best tend to promote the good of their common country. (Hear , hear.)

HON. MR. CHRISTIE—The hon. gentleman, I see, has not changed the ground which he took the other day, and which is precisely as I stated it. He thinks it would have been to the public advantage if this question had been taken up and discussed by a party. In this, in my judgment, he is entirely wrong; and I say he can find no instance of a constitution having been revised by a party.

The honorable gentleman very correctly stated the manner in which the Federal Constitution may be amended, but he is in error as to the mode in which state constitutions may be revised. One of the most important of the States revised its Constitution in 1846. I refer to the State of New York. The modus operandi on that occasion was as follows :—An act was passed in the State Legislature authorizing the electors at large to choose delegates to a convention, for the express purpose of revising the Constitution. The instrument passed by the convention was then submitted to the Legislature for approval ; but the Legislature had no power to alter it. It had either to be rejected or accepted as a whole. It was so accepted, none of the details being altered. My hon. friend will see that while the Conference was composed of leading representatives of the people in the various provinces, those conventions are composed of gentlemen elected by the people for that special purpose; and that the only difference between them is in the mode of selection. However, in both cases, all political parties are represented.

Whenever a majority of the House of Representatives shall deem it necessary to alter or amend this Constitution, they may propose such alterations and amendments, which proposed amendments shall be continued to the next General Assembly, and be published with the laws which may have been passed at the same session, and if two-thirds of each house, at the next ses-

sion of said Assembly, shall approve the amendments proposed, by yeas and nays, said amendments shall, by the Secretary, be transmitted to the town, clerk in each town in this State, whose duty it shall be to present the same to the inhabitants thereof, for their consideration, at a town meeting legally warned and held for that purpose ; and if it shall appear in a manner provided by law, that a majority of the electors present at such meetings shall have approved such amendments, the same shall be valid, to all intents and purposes, as a part of this Constitution. That is the way one of the oldest states guards the rights and liberties of its people. Then here is another extract from the Constitution of the State of Mississippi, one of the new states, showing how the people there are protected against hasty innovation :— Whenever two-thirds of the General Assembly shall deem it necessary to amend or change this Constitution, they shall recommend to the electors, at the next election for members of the General Assembly, to vote for or against a convention; and if it shall appear that a majority of the citizens of the state, voting for representatives, have voted for a convention, the General Assembly shall, at their next session, call a convention, to consist of as many members as there may be in the General Assembly, to be chosen by the qualified electors in the manner, and at the times and places of choosing members of the General Assembly ; which convention shall meet within three months after the said election, for the purpose of revising, amending, or changing the Constitution.

alluded the other day to the conservative feature of the Senate in the United States, in allowing the same representation to small states as to the larger states. But this does not at all affect the general arrangement, because the large majority are large states. But while my honorable friend approves of this portion, he should have expressed an opinion on the whole system. In the United States, no change of Constitution can be effected without the consent of two-thirds of both branches of the Legislature, and that must afterwards be sanctioned by three fourths of the state governments. This is a conservative feature also.

We have had the Constitution of 1841 altered more than once—twice at least—since the union. If we find that some parts of the machinery do not work—if, after the establishment of the Confederation, we find some little error has been made—-we will then, no doubt, have power and authority also to alter it.

Smart Cities: Stockholm Royal Seaport Project Update

Urban Green Space

Last week Stefka Wiese from GreenGasDrive was with us. The startup wants to make GreenCNG available nationwide for public and private fleet customers in the CNG filling station network. It should be made climate neutral, especially from waste biogas. In addition, GreenGasDrive advises on upcoming investment decisions and utilization optimization

The DIGINET-PS research project involves the development and implementation of a connected urban infrastructure test field along a stretch of Straße des 17. Juni between Ernst-Reuter Platz and the Brandenburg Gate, designed to advance and validate automated and autonomous driving and its broad range of individual areas under real-life traffic circumstances. The test infrastructure is intended to provide central, regional and supra-regional companies and R&D institutes with the opportunity to field test automated driving within an authentic urban setting. This will establish Germany’s first pilot project to build a digital test field for automated driving in highly complex traffic situations. DIGINET-PS will contribute to implementing Berlin’s smart city strategy in the area of mobility and will also support the state’s Digital Agenda.

The ELEKTRA research project seeks to develop an energy-efficient, hybrid-powered inland push boat. The project will demonstrate hydrogen and fuel cell technologies in combination with accumulators on inland waterway vessels in order to test the technology under operating conditions. Focus AreasElectric heavy-cargo shipsBZ drive

The research project eMobility-Scout deals with the conceptualization, implementation and testing of a cloud-based IT solution for the operation of electric vehicles and for sharing charging infrastructures among different businesses. In doing so, eMobility-Scout is considering the interest shown by many companies and institutions for simple and smart integration of electric vehicles into their fleets. Solutions for diverse areas of application in commercial mobility are being developed and tested, while taking logistical, economic and ecological aspects into account. Experienced project partners and affiliates, as well as renowned end users, are contributing extensive knowledge to the project. The results of the research project for IKT EM III should also gain substantial recognition in the public sphere.

A fully integrated logistics concept to establish environment and climate friendly supply chains in urban districts is going to evolve from the project. Co-creation processes, which are supported by online tools, are being used to develop the concept. The development and testing of sustainable business and deployment models is the goal of Distribut(e) and this will be addressed through the development of a shared e-logistics system in Klausenerplatz and at Mierendorff-Insel. The system will relate to a specific district (Kiez) in Berlin. A digital dialogue platform will be set up for the purpose of ordering local goods and for the booking of cargo bikes. Other low-threshold service offerings will be developed using Urban Design Thinking and will be integrated into the operating model.Focus Areas Integrated shared e-logistics at Mierendorff-Insel and at KlausenerplatzUrban Design Thinking: Formats for the co-creation process for sustainable urban district logisticsEfficiency enhancement in the delivery of goods in the ‘last mile’Mobile and online participation: Promotion of local production chains and activation of local stakeholders such as small to medium sized companies and local residentsIdentification of new sharing and value-in-use conceptsHigher standards in terms of the transparency, sovereignty, security and efficiency of data on the online platform

if any Legislative Councillor shall, for two consecutive sessions of Parliament, fail to give his attendance in the said Council, his seat shall thereby become vacant.

4

Charlotte's Web

I am very careful to make sure the books I have come from reputable publishers, I read everything before I put it on the shelf, and I am watching out for your kids,”

build great confidence in new readers

Prose books and comics are challenged for the same reasons,” Brownstein says. “Content addressing the facts of life about growing up, like sexuality, sexual orientation, race issues, challenging authority, and drug and alcohol use are causes for challenges. [Profanity] is often a factor,” as is violence.

pedagogical

youth prepare for a “performance of possibilities”(Madison,2005) as they share their writing publicly; that is, they use classroom forums, micro-phones, and stages as a way to (re)present themselves to the world

Alternative splicing: regulation of HIV‐1 multiplication as a target for therapeutic action

let's just look at why the Earth orbits the sun. it's because it's just gradually being pulled around by the gravity of the sun. you know,

With globalization, Taiwanese farmers are forced to compete with cheap agricultural goods from China and Southeast Asia. And although Taiwan has a strong organic and local food movement, it’s easy to imagine why farmers might feel fearful of the trend toward globalization. Exhibitions at the Southern Branch serve at least two important functions: to educate viewers about other cultures, and to reveal that cultural purity is a myth.

HOW TO PRODUCE LENTIVECTOR PARTICLES

Eleusinccoracana

$59,320.00

People are just foolish and believe what they want to believe. They weretalking behind my back, accusing me of being a witch, pointing at me, andspreading all kinds of gossip. But all of this was just a plan by mybrother-in-law and his wife to kick me off the shamba because they knewthere was not enough land to support all of us. Even if I agreed to marry [mybrother-in-law] he would not have taken me as his second wife because itwas not possible to support us, and [his first wife] would not have allowed itanyway. It was good for him to say I was a witch and that I gave myhusband AIDS. I lost everything in this way...the shamba just rotted awaybeneath my feet. [Juma’s mother, November

And unlike public institutions (like the library), Google and Facebook have no transparent curation process by which the public can judge the credibility or legitimacy of the information they propagate.

Populous, developing countries like Vietnam are where the company is looking to add its next billion customers — and to bolster its ad business.

Coherence

Details

Designing

La tradición textual Presentación La Parte IX El autógrafo El manuscrito de memorión Las sueltas El manuscrito de Parma Tipología de las variantes Errores Otras características Conclusiones Ediciones modernas La edición crítica Criterios de edición Texto crítico(pdf) Apéndice lingüístico

La obra Presentación Argumento Versificación Segmentación

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His mother is a very anxious woman, very very anxious....

to try to understand what is human by nature and what is human by social convention. It is always risky to think one under­stands the true intentions of great t

Rousseau was brilliantly correct in certain of his observations, such as his view that human inequality had its origins in the development of met­allurgy, agriculture, and, above all, private property.

He talks about man's perfectibility, and speculates on how human thoughts, passions, and behavior have evolved over time.

they are also timid, fearful, and more likely to flee one another than to fight.

Unregulated liberty in the state of nature leads to the state of war, necessitating, as for Hobbes, a social contract for the preservation of natural liberty and property.

solitary, poore, nasty, brutish, and short

state of nature

Plato and Aristotle argued that a just city had to exist in conformity with man's permanent nature and not what was ephemeral and changing.

Everything that modern biology and anthropology tell us about the state of nature suggests the opposite: there was never a period in human evolution when human beings existed as isolated individuals

Mutual human dependence comes about almost accidentally, as a result of technological innovations like agriculture that require greater cooperation.

Savage man's ''desires never extend beyond his physical wants; he knows no goods but food, a female, and rest"; he fears pain and hunger but not the abstraction of death

Aristotle differed from Hobbes, Locke, and Rousseau in one critical respect.

communication

but I think the stereotype is wrong—dead wrong.

Give a millennial employee a research assignment on your competitors and you’ll get the project back in 24 hours. Twenty years ago the same project might have taken a month to complete

They’ve been encouraged to follow their dreams and passions

1950s

So where some see entitlement, I see greater authenticity and audacity. Millennials will shoot for the stars—and if they fall down, they’ll get right back up and try it a different way.

which is a huge plus for companies that are spread out globally and interact primarily in a virtual environment.

Fukuyama is being modest, if not disingenuous.

By chance, these three elements were united for the first time in Britain, although other northwestern European countries that were influenced by the Reformation, like the Netherlands, Denmark and Sweden

epistemological

Some readers, however, may think that Fukuyama goes too far in de-emphasizing the natural rights tradition that inspired the Renaissance and Enlightenment liberalism. Here Fukuyama’s historicism and his insistence that ideas themselves shape political order are arguably at odds

Human

Mechanism

We present a case studythat illustrates challenges and potential solutions tomaximize data validity and describe these behaviorsand experiences as closely as possible.

The capacity of game environments to produce spatially complex structures as well as respond to players’ location within them helps to generate what Calleja (2011) calls “spatial involvementȄ in the space of the image, whereby movement and navigation rešuire effort and skill. This effort and skill then produce a sense of exploration: ȃwhen a player plots a route through a geographical expanse and then navigates it, it is more likely that she will feel a sense of habitation within the game environment” (

a geometric understanding of screen space assumes that space is a property of the screen and that different forms of space are dependent on how geometry and graphical lines are presented on the screen. Space is therefore a bounded property of the distance between the lines and polygons that delimit the edges of the game environment and serves to separate and partition how and where the player can move within this space through the joining of straight lines and polygons.

This chapter has examined various ways of conceptualizing video-game space and place. It has argued that what makes video-game spaces and places unique is that, as digital simulations, video games are possibility spaces – spaces of potential opened up between the rules that limit players’ actions and the freedom that is available within these spaces.

representations of people and places. As a number of writers are now highlighting, there is a clear representational politics to video-game images and how they shape the geographical imagination of users. This politics has two clearly identifiable strands: representations of conĚict and militarism and representations of human identity.

Sometimes the view is from outside looking in, but more common, as in this photograph, is the interior view showing the world beyond.

rough photographs, the world was ȃmade familiarȄ and ȃbrought in intense reality to our very hearthsȄ (

his constant tension between photography and reality – a slippery relationship at once straightforward and enigmatic – can be found at the extreme ends of the photographic spectrum: from modest snapshots emerging from a Brownie camera or cell phone to the most serious ȃartȄ photographs.

we repeatedly encounter the power of media to transform the places in which they are used. This power is not a mere conceit of human audiencesDz animals and even plants respond to the presence of media in their environments (see lulka, this volume). Media transform a place from within, whether the place in šuestion is the nation-state, the neighborhood, or the home

A third feature of Geography, the Media and Popular Culture was its attention to power, whether in the form of the power to produce cheap television programming (Gould and lyew-Ayee 1985), the power to define notions like risk and danger (liverman and sherman 1985Dz Burgess 1985), the power to articulate a particular structure of space and time (Brooker-Gross 1985), or more generally the power to propagate dominant ideologies. Power remains a central concern in media geography,

Up-regulation of glycolysis is proposed to endow cancer cells withseveral selective advantages, in particular the incorporation ofnutrients into biomass to sustain high rates of proliferation (2,3). Deregulation of certain cancer-related genes has been linkedto the acquisition of the glycolytic phenotype (4). The phospha-tase and tensin homolog, PTEN,2is a tumor suppressor mostwell known for its ability to oppose the PI3K/Akt signalingpathway through the dephosphorylation of phosphatidylino

This has beentraditionally attributed to the hyperactivation of PI3K/Akt sig-naling that results from PTEN loss. Here, we propose a novelmechanism whereby the loss of PTEN negatively affects theactivity of the E3 ligase APC/C-Cdh1, resulting in the stabiliza-tion of the enzyme PFKFB3 and increased synthesis of its prod-uct fructose 2,6-bisphosphate (F2,6P2)

Unlike normal differentiated cells, tumor cells metabolizeglucose via glycolysis under aerobic conditions, a hallmark ofcancer known as the Warburg effect

Our results suggest animportant role for F2,6P2in the metabolic reprogramming ofPTEN-deficient cells that has important consequences forcell proliferation.

a beat divided into 3 parts instead of two

Koromanti

from

La AMAI es la única asociación profesional en Latinoamérica enfocada al sector de inteligencia aplicada a negocios y asuntos sociales. Fundada en 1992, la AMAI surgió originalmente para ser el centro institucional de la comunidad mexicana de investigación de mercados, opinión y comunicación; ahora engloba a toda la industria de generación y transformación de datos para la toma de decisiones.

mujer muy rica

ever more prominen

working to support solidarity and justice-based relationships​with Indigenous peoples