26 Matching Annotations
  1. Nov 2024
    1. 100-mile zone of Russian control over water off the coast of its northwest American territories to protect its shores from Americans smuggling to natives

      Ok... so this is an extra credit question worth 50 points. How much do you know about international waterways and how they are regulated? Why do countries care about this? Explain the current agreement between the USA and Russia. Since 1821, how many times have the two countries had a disagreement related to this?

      Cite your sources!

  2. Oct 2024
  3. Sep 2024
    1. Topic: Defining Distance Education Date: 1980 Course/Subject: Distance Education Studies

      Notes Main Idea The paper analyzes existing definitions of distance education and identifies six essential components that should be included in a comprehensive definition. The analysis covers different educational philosophies and institutional contexts for distance education.

      Key Definitions and Theorists Holmberg's Definition

      Distance education involves the separation of teacher and learner. Requires planned, structured learning materials and institutional support. French Law (Loi 71.556 du 12 juillet 1971)

      Defines distance education as learning where the teacher is not physically present, except for occasional tasks. Moore's Definition

      Highlights separation of teaching and learning behaviors. Emphasizes the use of technical media and the importance of two-way communication. Peters’ Definition

      Describes distance education as an industrialized form of education. Incorporates principles like division of labor, mass production, and mechanization in the teaching process. Six Essential Components of Distance Education Separation of Teacher and Student

      Physical and temporal separation in the teaching and learning process. Role of Educational Organization

      Planning, preparing, and providing learning materials and support. Use of Technical Media

      Communication between teacher and learner facilitated by print, radio, television, or computers. Provision of Two-Way Communication

      Opportunities for dialogue between teacher and learner. Possibility of Occasional Seminars

      Allowing for some face-to-face interaction for didactic or social purposes. Participation in an Industrialized Form of Education

      Incorporates aspects of industrial processes in the delivery of education, such as standardized materials and automated communication. Analysis and Discussion Educational Contexts and Models

      Different definitions cater to various levels and types of education (e.g., correspondence, open learning, external studies). Theoretical frameworks like Peters' focus on the structural separation and mechanization of distance education. Challenges and Misconceptions

      Confusion over terminology, such as correspondence study vs. distance education. Misunderstanding of the relationship between traditional and distance education models. Proposed Solution

      The term 'distance education' is suggested as the most suitable to encompass various forms and philosophies of education that involve separation of teacher and learner. Implications The need for clarity in defining distance education for consistent policy development and theoretical analysis. Importance of recognizing the distinct nature of distance education as an industrialized form of learning. Questions/Cues What are the key differences between Holmberg’s and Peters’ definitions of distance education? How does Keegan's six-component framework help in distinguishing distance education from other forms of non-traditional education? Why is Peters’ view on industrialization important in understanding distance education? Summary The paper provides a detailed analysis of distance education by examining prominent definitions and proposing a comprehensive framework. Keegan emphasizes the industrialized nature of distance education and the necessity for clear terminology to distinguish it from other educational forms.

      Reference Keegan, D. J. (1980). On defining distance education. Distance Education, 1(1), 13-36.

  4. Aug 2024
    1. The study analysedindirect dependencies on ecosystem services and concluded that EUR510 billion, or 36% ofthe EUR 1.4 trillion in investments held by Dutch financial institutions, is highly or very highlydependent on one or more ecosystem services.

      for - stats - ecosystem disruption and financial losses study - Dutch investors risk 510 billion EUR or 36% of the Dutch 1.4 trillion EURO investment is at risk

  5. Oct 2023
    1. https://en.wikipedia.org/wiki/Shmita

      During shmita, the land is left to lie fallow and all agricultural activity, including plowing, planting, pruning and harvesting, is forbidden by halakha (Jewish law).

      The sabbath year (shmita; Hebrew: שמיטה, literally "release"), also called the sabbatical year or shǝvi'it (שביעית‎, literally "seventh"), or "Sabbath of The Land", is the seventh year of the seven-year agricultural cycle mandated by the Torah in the Land of Israel and is observed in Judaism.

  6. Mar 2023
    1. Hisz bűnösök vagyunk mi, akár a többi nép, s tudjuk miben vétkeztünk, mikor, hol és mikép, de élnek dolgozók itt, költők is bűntelen, és csecsszopók, akikben megnő az értelem, világít bennük, őrzik, sötét pincékbe bújva, míg jelt nem ír hazánkra újból a béke ujja, s fojtott szavunkra majdan friss szóval ők felelnek. Nagy szárnyadat borítsd ránk virrasztó éji felleg.

      a harmadik részben megváltozik az elbeszélő, Radnóti immár az egész magyarság nevében szól. stílusában a régi prédikátorokat idézve szól Istenhez, Isten nagyságát dicsőítve és a bűnös emberiséget ostorozva. a szomszédos népek bűnösnek kiáltottak ki minket, a költő azonban békevágytól vezetve vallja, hogy egy egész nép nem lehet bűnös, hiszen számtalan ártatlan tagja van; csecsemőktől egészen magáig a költőig.

      az utolsó sor elkülönül az eddigiektől. ebben a sorban egy hatalmas szárnyú óvó madár képe jelenik meg. az éjji felleg a bibliában a Gondviselő Istent jelenti. az egész világot beborító szárnyas virrasztó csak Isten lehet, hiszen csak ő képes az abszolút virrasztásra, aki soha nem alszik el sem szellemében sem testi valójában. Radnóti védelemért könyörög az Úrhoz az egész szenvedő emberiség számára.

  7. Mar 2021
    1. Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 3.6

      AssayResultAssertion: Indeterminate

      StandardErrorMean: 0.11

    2. A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

      HGVS: NM_024675.3:c.2792T>G p.(Leu931Arg)

    1. SUPPLEMENTARY DATA

      AssayResult: 108.7

      AssayResultAssertion: Not reported

      PValue: > 0.9999

      Comment: Exact values reported in Table S3.

    2. To this end, 44 missense variants found in breast cancer patients were identified in the ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar) and/or selected by literature curation based on their frequency of description or amino acid substitution position in the protein (Supplemental Table S1).

      HGVS: NM_024675.3:c.371C>T p.(Thr124Ile)

    1. Source Data

      AssayResult: 12.77

      AssayResultAssertion: Abnormal

      ReplicateCount: 2

      StandardErrorMean: 5.34

      Comment: Exact values reported in “Source Data” file.

    2. Source Data

      AssayResult: 14.01

      AssayResultAssertion: Abnormal

      ReplicateCount: 2

      StandardDeviation: 0.53

      StandardErrorMean: 0.38

      Comment: Exact values reported in “Source Data” file.

    3. We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.

      HGVS: NM_024675.3:c.2915T>A p.(L972Q)

    1. Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 119.6

      AssayResultAssertion: Normal

      ReplicateCount: 22

      StandardErrorMean: 19.5

      Comment: This variant had normal function (75-125% of wildtype peak current, <1% late current, no large perturbations to other parameters). These in vitro features are consistent with non-disease causing variants. (Personal communication: A. Glazer)

    2. we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

      HGVS: NM_198056.2:c.327C>A p.(Asn109Lys)

  8. Feb 2021
    1. Supplemental material

      AssayResult: 56, 52

      AssayResultAssertion: Abnormal

      Comment: See Table S3 for details

    2. Supplemental material

      AssayResult: 3.1

      AssayResultAssertion: Abnormal

      Comment: See Table S3 for details; The blood sample used to test this variant was derived from an individual carrying the c.723del variant in combination with the c.*1175A>C variant in heterozygosity.

    3. Supplemental material

      AssayResult: 7.1, 6.0

      AssayResultAssertion: Abnormal

      Comment: See Table S3 for details

    4. We analysed a total of 82 blood samples derived from 77 individuals (online supplemental table 3). These 77 individuals corresponded either to new index cases suspected to harbour a pathogenic TP53 variant or to relatives of index cases harbouring TP53 variants.

      HGVS: NM_000546.5:c.723del p.(Cys242Alafs*5)

    5. Supplemental material

      AssayResult: 52

      AssayResultAssertion: Abnormal

      Comment: See Table S3 for details; The blood sample used to test this variant was derived from an individual carrying the c.723del variant in combination with the c.*1175A>C variant in heterozygosity.

  9. Dec 2018
    1. foolish imaginations of his heart

      Constructs which mistake the head as superior to the heart or as an adequate starting place for imaginings will always lead to destruction since the head can not handle nor is it designed for the necessary embedding and recursion which is a seed bearing fruit in itself. But it is sure that, before the brain breaks down and eventually falls/fails, those who mistake it as the best foundation will inevitably turn to mocking them who follow through with flow of spirit through and back to the heart. (see Lehi's Dream 1 Nephi 8:26-27 and Nephi's visitation of the same dream in 1 Nephi 11:35-36)

      This phrase,"foolish imaginations" can and ought to be read as the "FULLish imaginations of his heart." In earlier verses we see that a FULL rendering of Lehi's heart brought about fulfillment on several levels already. This "fulfillment" even took the immediate form of a "filament" (pillar of light which struck a rock in front of Lehi just as the communication struck his heart with overpowering energy). The electrical charging effects of Full Imagining can be transmitted beyond the individual and others can be made to feel these effects, however, unless they are allowed to take hold in the heart where embedding and recursion can take place, then they are short lived and sometimes can have disastrous overall effect upon others who rely on second-hand spirit and external motivation. (see 1 Nephi 3:28-31 and 1 Nephi 17:53-54)

  10. Sep 2018
    1. In order to protect local interests, and to prevent sectional jealousies, it was found requisite that the three great divisions into which British North America is separated, should be represented in the Upper House on the principle of equality. There are three great sections, having different interests, in this proposed Confederation.
    2. To the Upper House is to be confided the protection of sectional interests ; therefore is it that the three great divisions are there equally represented, for the purpose of defending such interests against the combinations of majorities in the Assembly.
    1. But the very essence of our compact is that the union shall be federal and not legislative. Our Lower Canada friends have agreed to give us representation by population in the Lower House, on the express condition that they shall have equality in the Upper House. On no other condition could we have advanced a step ; and, for my part, I am quite willing they should have it. In maintaining the existing sectional boundaries and handing over the control of local matters to local bodies, we recognize, to a certain extent, a diversity of interests ; and it was quite natural that the protection for those interests, by equality in the Upper Chamber, should be demanded by the less numerous provinces.
  11. Jan 2015
    1. Ahhoz azonban, hogy egy valóban ütőképes tényfeltáró központot hozzunk létre, szükségünk van minél több ember támogatására. Ha bővíteni tudjuk az egyelőre szűkös költségvetésünket, akkor több újságíróval tudunk dolgozni, és több, illetve mélyebb nyomozó munkát tudunk végezni.
    2. A Direkt36 egy új oknyomozó újságírói központ, amelynek célja, hogy kitartó kérdéseken és szilárd tényeken alapuló cikkekkel ellenőrizze a hatalom birtokosait, és rámutasson a mindannyiunkat megkárosító visszaélésekre.