5 Matching Annotations
  1. Apr 2022
  2. Jan 2021
  3. Oct 2020
  4. May 2019
    1. While more traditional therapies such as chemotherapy and radiotherapy lack tumor specificity targeting all replicating cells, and other immunotherapies have limited scope by relying on the presence of a specific ligand/receptor, oncolytic viruses are postulated to be both specific to neoplastic cells and have an expansive immunostimulatory latitude. The

      Chemo and Radiation lack specificity in targetting cancerous cells, instead targeting a large scope or rapidly dividing cells.

      Immunotherapies are limited to the presence of ligand and receptors for activation.

      Oncolytic viruses are specific to neoplastic (cancerous, specific) cells and have a large amount of immunostimulatory range----> can activate tumor immunity, stimulate immune system......

    1. a genetically engineered or naturally occurring virus that can selectively replicate in and kill cancer cells without harming the normal tissues

      Contrasting to gene therapy, where a virus is used as a mere vector (carrier of a gene), oncolytic virotherapy uses the virus as a drug agent.