- Dec 2015
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teaching.lfhanley.net teaching.lfhanley.net
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who ate fire in paint hotels or drank turpentine in Paradise Alley, death, or purgatoried their torsos night after night with dreams, with drugs, with waking nightmares, alcohol and cock and endless balls,
Fire and turpentine are destructive elements but are described as something of "paradise" and they fulfill the "dreams" of the subjects. It could also be described through the motif the beautiful and the sublime. The subjects search the vastness of life with the beautiful drugs, alcohol and experiences.
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- Nov 2015
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secure-media.collegeboard.org secure-media.collegeboard.org
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The rise of farmers’ markets — in city centers, college towns, and rural squares — is testament to a dramatic shift in American tastes. Consumers increasingly are seeking out the flavors of fresh, vine-ripened foods grown on local farms rather than those trucked to supermarkets from faraway lands. “This is not a fringe foodie culture,” says [Anthony] Flaccavento. “These are ordinary, middle-income folks who have become really engaged in food and really care about where their food comes from.
middle class citizens are becoming more involved in the Locavore movement. they are starting to take notice of their food.
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mfeldstein.com mfeldstein.com
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What is the correlation between levels of student responses to each other and outcomes?
Levels and types of responses. Just read such an analysis, based on Brookfield and Preskill’s “Conversational Moves”.
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- Oct 2015
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teaching.lfhanley.net teaching.lfhanley.net
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singing
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fiddled whisper music on those strings
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What the Thunder Said
The natural world deciding to make its opinion known
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frosty silence
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shouting and the crying
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cms.whittier.edu cms.whittier.edu
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Instead, the concentration of poverty has been paired with a concentration of melanin.
Poverty is concentrated among those with dark skin.
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- Sep 2015
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www.gutenberg.org www.gutenberg.org
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Him the Almighty Power Hurled headlong flaming from th' ethereal sky, With hideous ruin and combustion, down To bottomless perdition, there to dwell In adamantine chains and penal fire,
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Who first seduced them to that foul revolt?
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bullybloggers.wordpress.com bullybloggers.wordpress.com
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have come to think of themselves as communities of naked, shivering, quaking little selves – too vulnerable to take a joke, too damaged to make one
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any kind of representation or association that resembles or even merely represents the theme of the original painful experience
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a cultural event, a painting, a play, a speech, a casual use of slang, a characterization, a caricature and so on whether or not the “damaging” speech/characterization occurs within a complex aesthetic work
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focused on language, slang and naming.
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poorly phrased question, another person’s bad word choice
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humor is something that feminists in particular, but radical politics in general, are accused of lacking. Recent controversies within queer communities around language, slang, satirical or ironic representation and perceptions of harm or offensive have created much controversy with very little humor recently, leading to demands for bans, censorship and name changes
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netzpolitik.org netzpolitik.org
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Hahn: Welche BND-Selektoren hat NSA geprüft? W.O.: Alle, die in Bad Aibling waren und gesteuert werden sollen. Hahn: Wird ja Geheimnis um Auftragsprofil des BND (APB) gemacht. Aber USA können das ja aus BND-Selektoren ablesen? W.O.: USA wissen, wonach BND in Bad Aibling sucht, ja. Hahn: Aber es wird nicht alles eingespeist in Bad Aibling? W.O.: Nein, gibt Sperrvermerke. Darf ist das sagen? Wolff: Ja, grob. W.O.: Es gibt Sperrvermerke für Selektoren gegenüber bestimmten AND. (!)
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schepers.cc schepers.cc
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historical political boundaries of the native Americans
We view the world in these simplified 2D representations of clearcut political entities. Fredrik Barth and Benedict Anderson have said quite a few important things about these issues of maps and boundaries.
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- Aug 2015
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chronicle.com chronicle.com
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"What really is our role as professors?" he asks. "Is our role to simply give out information and people will use it as they wish? Or is our role to honestly and truly help guide people to be who they are and how they will live their life?"
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scienceintheclassroom.org scienceintheclassroom.org
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H. Wang, M. A. Winnik, I. Manners, Synthesis and self-assembly of poly(ferrocenyldimethylsilane- b -2-vinylpyridine) diblock copolymers. Macromolecules 40, 3784 (2007).
In this paper, the authors developed a new class of diblock copolymers that have a metal-containing hydrophobic block (PFS) and an organic hydrophilic block (P2VP): PFS = poly(ferrocenyldimethylsilane) and P2VP = poly(2-vinylpyridine). The authors of this publication discovered the ability to obtain spherical and cylindrical morphologies simply by using different alcohols. Having established the ability to obtain cylindrical micelles using the PFS-b-P2VP block copolymer system in isopropyl alcohol, the authors modified their approach in the current study to obtain supermicelles.
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P. A. Rupar, G. Cambridge, M. A. Winnik, I. Manners, Reversible cross-linking of polyisoprene coronas in micelles, block comicelles, and hierarchical micelle architectures using Pt(0)–olefin coordination. J. Am. Chem. Soc. 133, 16947 (2011).
This paper established that Karstedt's catalysts ability to cross-link the double bonds in polyisoprene in the absences of silicon-containing molecules. Besides acquiring a variety of morphologies, the authors also investigated their ability to use Karstedt's catalyst to synthesize reversible polymer gel networks.
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X. S. Wanget al., Shell-cross-linked cylindrical polyisoprene- b -polyferrocenylsilane (PI- b -PFS) block copolymer micelles: One-dimensional (1D) organometallic nanocylinders. J. Am. Chem. Soc. 129, 5630 (2007).
This reference investigates the development of 1D nano-structures through the use of cross-linked cylindrical micelles. This paper highlights possible applications for these 1D nanomaterials such as microfluidics.
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R. K. O’Reilly, C. J. Hawker, K. L. Wooley, Cross-linked block copolymer micelles: functional nanostructures of great potential and versatility. Chem. Soc. Rev. 35, 1068 (2006).
This review paper describes the uses and progress made in the field of cross-linked micelles. Concepts covered include stabilization as well chemical modification and functionalization.
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W. Zhanget al., Supramolecular linear heterojunction composed of graphite-like semiconducting nanotubular segments. Science 334, 340 (2011).
References: This paper describes the synthesis of semiconducting nanotubes through a process similar to CDSA by connecting dissimilar junctions, referred to as heterojuntions, to study the behaviors of photocarriers.
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Z.-X. Du, J.-T. Xu, Z.-Q. Fan, Micellar morphologies of poly(ε-caprolactone)- b -poly(ethylene oxide) block copolymers in water with a crystalline core. Macromolecules 40, 7633 (2007).
This paper describes the use of a biodegradable polymer in order to obtain a variety of micelle morphologies. A concept referred to as tethering density is used in this paper to explain unexpected morphologies.
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Schmelz, M. Karg, T. Hellweg, H. Schmalz, General pathway toward crystalline-core micelles with tunable morphology and corona segregation. ACS Nano 5, 9523 (2011).
This paper uses triblock copolymers to synthesize cylindrical and spherical micelles. By carefully controlling crystallization, the authors were able to control the micellar morphology in a highly selective fashion.
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T. Gädt, N. S. Ieong, G. Cambridge, M. A. Winnik, I. Manners, Complex and hierarchical micelle architectures from diblock copolymers using living, crystallization-driven polymerizations. Nat. Mater. 8, 144 (2009).
This paper utilizes CDSA to synthesize noncylindrical block co-micelles. The authors utilized plateletlike micelle and cylindrical micelles in order to form scarflike architectures using platelet-cylindrical and cylindrical-cylindrical connections.
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X. S. Wanget al., Cylindrical block copolymer micelles and co-micelles of controlled length and architecture. Science 317, 644 (2007)
This paper describes the discovery of CDSA. The authors draw a comparison to living polymerization and explain the phenomenon of epitaxial crystallization-induced co-micellization
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Y. Xia, B. D. Olsen, J. A. Kornfield, R. H. Grubbs, Efficient synthesis of narrowly dispersed brush copolymers and study of their assemblies: The importance of side chain arrangement. J. Am. Chem. Soc. 131, 18525 (2009).
This reference describes the synthesis of brush block and random copolymers. The polymers are referred to as a "brush" because pendant groups are dangling off the main chain. The brush polymers synthesized were amphiphilic and demonstrated self-assembly.
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Walther, M. Drechsler, A. H. E. Müller, Structures of amphiphilic Janus discs in aqueous media. Soft Matter 5, 385 (2009).
This paper describes the synthesis of amphiphilic Janus discs using a block terpolymer (three distinct blocks comprised of three distinct monomers). Two different size discs were made where, depending on size, the manner in which the hydrophobic side is "protected" from water can vary. The smaller discs are stabilized by the long hydrophilic polymer chains, protruding out of one side and shielding the hydrophobic side against water. The larger discs undergo aggregation as well as bending to again shield the hydrophobic side from the water by flipping over one part of the structure.
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J. Dupont, G. Liu, ABC triblock copolymer hamburger-like micelles, segmented cylinders, and Janus particles. Soft Matter 6, 3654 (2010).
This reference is an example where triblock copolymers were photo-crosslinked to create Janus particles which were classified as "hamburger-like" micelles.
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Walther, A. H. E. Müller, Janus particles. Soft Matter 4, 663 (2008)
This review paper discusses a class of noncentrosymmetric nanoparticles referred to as the Janus particle. These particles are rather challenging to synthesize because two different chemistries are present on the surface of the particle.
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H. Cui, Z. Chen, S. Zhong, K. L. Wooley, D. J. Pochan, Block copolymer assembly via kinetic control. Science 317, 647 (2007).
This paper utilized charged polymers as well as metal cations and a variety of solvents to kinetically trap unique micelle morphologies. The self-assembly systems were forced down a specific pathway in order to form morphologies that would not have typically occurred without assistance.
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L. Zhang, A. Eisenberg, Multiple morphologies of “crew-cut” aggregates of polystyrene-b-poly(acrylic acid) block copolymers. Science 268, 1728 (1995).
This paper was one of the first papers to establish the ability to form micelles of different morphologies (beyond just spherical) for systems using amphiphilic block copolymers
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semiconducting nanotubes
To read how semiconducting nanotubes can be used to potentially improve eyesight click here:
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nanotechnology
To read general information on nanotechnology click on the following link:
http://www.nano.gov/nanotech-101/what/definition
The following article is an interestng example of using nanotechnology to create jewelery:
http://www.nytimes.com/2014/11/18/style/international/jewelry-nanotechnology.html
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- Jul 2015
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www.sciencemag.org www.sciencemag.org
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J. F. Soderholm, S. L. Bird, P. Kalab, Y. Sampathkumar, K. Hasegawa, M. Uehara-Bingen, K. Weis, R. Heald, Importazole, a small molecule inhibitor of the transport receptor importin-β. ACS Chem. Biol. 6, 700–708 (2011).
Importazole is a small molecule inhibitor of the transport receptor importin-β. This inhibitor was identified by a screening assay developed by the authors of this paper.
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A. J. Firestone, J. S. Weinger, M. Maldonado, K. Barlan, L. D. Langston, M. O’Donnell, V. I. Gelfand, T. M. Kapoor, J. K. Chen, Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 484, 125–129 (2012). doi:10.1038/nature10936 pmid:22425997
This work reported the discovery of ciliobrevins, the first specific small-molecule antagonists of cytoplasmic dynein.
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K. V. Butler, J. Kalin, C. Brochier, G. Vistoli, B. Langley, A. P. Kozikowski, Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J. Am. Chem. Soc. 132, 10842–10846 (2010). doi:10.1021/ja102758v pmid:20614936
This paper reported the development of Tubastatin A, a potent and selective HDAC6 inhibitor.
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H. Ouyang, Y. O. Ali, M. Ravichandran, A. Dong, W. Qiu, F. MacKenzie, S. Dhe-Paganon, C. H. Arrowsmith, R. G. Zhai, Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini. J. Biol. Chem. 287, 2317–2327 (2012).
This work suggested a novel ubiquitin-mediated signaling pathway, where the exposure of ubiquitin C termini within protein aggregates enables HDAC6 recognition and transport to the aggresome. The authors found that the ubiquitin-binding domain (ZnF-UBP) of HDAC6, instead of recognizing protein aggregates by binding directly to polyubiquitinated proteins, binds exclusively to the unanchored C-terminal diglycine motif of ubiquitin.
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Y. Zhang, B. Gilquin, S. Khochbin, P. Matthias, Two catalytic domains are required for protein deacetylation. J. Biol. Chem. 281, 2401–2404 (2006).
In this report, the authors showed that both HDAC domains are required for the intact deacetylase activity of HDAC-6.
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Y. Zhang, S. Kwon, T. Yamaguchi, F. Cubizolles, S. Rousseaux, M. Kneissel, C. Cao, N. Li, H. L. Cheng, K. Chua, D. Lombard, A. Mizeracki, G. Matthias, F. W. Alt, S. Khochbin, P. Matthias, Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol. Cell. Biol. 28, 1688–1701 (2008). doi:10.1128/MCB.01154-06 pmid:18180281
In this study, the author generated HDAC6 knock out mice and investigated the in vivo functions of HDAC6 and the relevance of tubulin acetylation/deacetylation. they observed that HDAC6-deficient mice are viable and fertile and show hyperacetylated tubulin in most tissues.They concluded that mice survive well without HDAC6 and that tubulin hyperacetylation is not detrimental to normal mammalian development.
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I. Kemler, G. Whittaker, A. Helenius, Nuclear import of microinjected influenza virus ribonucleoproteins. Virology 202, 1028–1033 (1994).
This work showed that when influenza virus ribonucleoproteins (vRNPs), devoid of M1, were introduced into the cytoplasm of cells by microinjection, they were found to be imported into the nucleus, and the RNA was transcribed. Their uptake into the nucleus was ATP-dependent, inhibited by antibodies to the nuclear pore complex, unaffected by the prior acidification of the vRNPs, and not inhibited by an anti-virurs, called amantadine. These experiments demonstrated that for productive infection, all the early stages of the viral entry pathway can be bypassed.
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anerjee, Y. Yamauchi, A. Helenius, P. Horvath, High-content analysis of sequential events during the early phase of influenza A virus infection. PLOS ONE 8, e68450 (2013).
This study provides a powerful high-throughput platform to understand the host cell processes. The authors developed quantitative, imaging-based assays to dissect seven consecutive steps in the early phases of IAV infection in tissue culture cells.
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K. S. Matlin, H. Reggio, A. Helenius, K. Simons, Infectious entry pathway of influenza virus in a canine kidney cell line. J. Cell Biol. 91, 601–613 (1981).
This work investigated the cell fusion process of representatives of 3 families of enveloped viruses. it was discovered that hemagglutinin plays a role for the influenza in the low-pH-dependent membrane fusion activity. Low-pH-induced fusion is a widespread property of enveloped animal viruses and that it may play a role in the infective process.
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L. H. Pinto, L. J. Holsinger, R. A. Lamb, Influenza virus M2 protein has ion channel activity. Cell 69, 517–528 (1992).
The authors of this paper identified the ion channel activity of M2.
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J. White, K. Matlin, A. Helenius, Cell fusion by Semliki Forest, influenza, and vesicular stomatitis viruses. J. Cell Biol. 89, 674–679 (1981).
This work investigated the cell fusion process of representatives of 3 families of enveloped viruses. it was discovered that hemagglutinin plays a role for the influenza in the low-pH-dependent membrane fusion activity. Low-pH-induced fusion is a widespread property of enveloped animal viruses and that it may play a role in the infective process.
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K. Martin, A. Helenius, Nuclear transport of influenza virus ribonucleoproteins: The viral matrix protein (M1) promotes export and inhibits import. Cell 67, 117–130 (1991). doi:10.1016/0092-8674(91)90576-K pmid:1913813
This work described the nuclear transport of influenza virus ribonucleoproteins (vRNPs). Viral matrix protein (M1) associates with newly assembled vRNPs in the nucleus and escorts them to the cytoplasm through the nuclear pores. In contrast, during entry of the virus into a new host cell, M1 protein dissociates from the RNPs, allowing them to enter the nucleus.
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new antiviral strategies
Possible Therapy? Find out what the author Dr. Yamauchi says in this regard.
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www.sciencemag.org www.sciencemag.org
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G. Larson, J. Burger,Trends Genet.29, 197–205 (2013).
This study is about animal domestication. It explains that the dog is the only animal domesticated before the advent of agriculture. It also discuss the limits of mtDNA analysis.
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Nonetheless, ourmtDNA genome tree shows that three of four
Read more about this research in these two news articles: DNA Analysis Indicates Domesticated Dogs Originated In Europe
DNA hint of European origin for dogs
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Local file Local file
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Dogs are one of the best known examplesof domestication, the process of speciesmodification over time by human-inducedselection
Check out a Science special issue on Dogs: http://www.sciencemag.org/site/extra/dogs/
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onset of domesticationthere 18,800 to 32,100 years ago.
Wolves were domesticated much earlier than thought. Researchers discovered that wolves were domesticated by European hunter-gatherers between 19,000 and 32,000 years ago. The analysis cannot, however, be used to determine the origin of the dog, argues a Danish DNA scientist.
http://sciencenordic.com/wolves-became-domesticated-dogs-much-earlier-thought
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Local file Local file
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The cytoplasm of eukaryotic cells is a highlydynamic composite polymer material.
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www.theatlantic.com www.theatlantic.com
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most gorgeous dream
I'm wondering if "the dream" -- at least as Coates sketches it out in the remainder of this paragraph -- has become a "war with the known world" for people without education and money. Is it about race or class. Robert Putnam makes a good case for the problem being about rising economic inequality in America, even as racial and sexual divisions have been lessening.
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stopping and frisking you
Stop and frisk has ended, right? Not so fast: "The NYPD hasn’t ended its practice of stop-and-frisk...." It just stopped reporting the number of stops.
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lose my body
I'm just trying to imagine how it might make Coates son squirm to have his dad talk to him about his body. I guess I'm squirming a bit too. I'm expecting to hear about racism, but here I'm being asked to think about a body.
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- Jun 2015
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daringfireball.net daringfireball.net
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Apple’s superior position on privacy needs to be the icing on the cake, not their primary selling point.
Yeah... 'cause apparently no one actually cares...
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caseyboyle.net caseyboyle.net
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frequently attracted people who felt frustrated, suffocated by their family, and lacking other means of self-expression than private writing. This explains the over representation of women and homosexuals within the ranks of the diarists
I lol'd.
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- May 2015
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www.alasdairroberts.com www.alasdairroberts.com
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Lethe (Leith)
The River Lethe was one of the rivers of Hades in Greek mythology. Exposure to its waters was held to lead to loss of memory, or, more intriguingly, a state of "unmindfulness" and oblivion. From this origin, it has re-appeared throughout western culture, from Dante to Tony Banks's first solo album (River Lethe in popular culture, Wikipedia).
By providing the alternative spelling of Leith, Alasdair Roberts 'doubles' this meaning with the Water of Leith, a river that runs through Edinburgh, and co-locates ancient Greek and contemporary Scots mythology.
The idea of eternal return is bound up with memory, with cultures being compelled to repeat and confront the missteps of the past. So the oblivion of forgetfulness provided by the endless Lethe provides a form of antidote or escape.
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my sermons seven
In interview with Tyler Wilcox in 2009, Alasdair Roberts referred to the
specifically Jungian references to the "sermons seven" and mandalas... it's like a quest song against conflict and towards individuation. I know a lot of people with strong political or religious convictions whose musical and artistic practice is guided by that – in some ways I envy that kind of certitude, but I suppose my thing is always about flexibility, multiplicity, confusion wanting to reflect the turmoil of reality... always trying to remember that the oar in the ocean is a winnowing fan on dry land.'
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research.microsoft.com research.microsoft.com
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That is, the human annotators are likely to assign different relevance labels to a document, depending on the quality of the last document they had judged for the same query. In addi- tion to manually assigned labels, we further show that the implicit relevance labels inferred from click logs can also be affected by an- choring bias. Our experiments over the query logs of a commercial search engine suggested that searchers’ interaction with a document can be highly affected by the documents visited immediately be- forehand.
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- Sep 2014
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dev-stem-ethics.gotpantheon.com dev-stem-ethics.gotpantheon.com
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After all, don’t we tend to examine our motivations for doing something only when we have reason to doubt that we are doing the right thing?
change:
'only'
to:
'primarily'
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dev-stem-ethics.gotpantheon.com dev-stem-ethics.gotpantheon.com
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It migh
http://dev-stem-ethics.gotpantheon.com/node/53
Replace
"It might provide..."
With:
"This fatalistic attitude..."
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- Feb 2014
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www.justinhughes.net www.justinhughes.net
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The Philosophy of Intellectual Property
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