82 Matching Annotations
  1. Jan 2026
  2. www.biorxiv.org www.biorxiv.org
    Development of a pipeline to evaluate YAP-TEAD inhibitor potential - direct TEAD inhibition represses cancerous growth in a NF2-mutant model of mesothelioma
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    biorxiv.org/lookup/doi/10.1101/2024.11.12.622964
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    An integrated stress response-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation
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    biorxiv.org/lookup/doi/10.1101/2024.09.10.611650
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    Propionate reinforces epithelial identity and reduces aggressiveness of non-small cell lung carcinoma via chromatin remodelling
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    biorxiv.org/lookup/doi/10.1101/2023.01.19.524677
  5. May 2025
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    Shared requirement for MYC upstream super-enhancer in tissue regeneration and cancer
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    biorxiv.org/content/10.1101/2022.11.04.515076v2
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    Mitochondrial Signatures Shape Phenotype Switching and Apoptosis in Response to PLK1 and RSK Inhibitors in Melanoma
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    biorxiv.org/content/10.1101/2024.06.14.599035v1
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    Transcription Factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress
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    biorxiv.org/content/10.1101/2023.05.30.542913v1
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    Loss-of-function cancer-associated mutations in the EIF4G2 non-canonical translation initiation factor
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    biorxiv.org/content/10.1101/2023.08.22.554280v2
  10. Dec 2024
  11. www.biorxiv.org www.biorxiv.org
    A complete digital karyotype of the B-cell leukemia REH cell line resolved by long-read sequencing
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    biorxiv.org/content/10.1101/2023.03.08.531483v1
  12. Oct 2024
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    Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism
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    biorxiv.org/content/10.1101/2023.08.22.554238v1
  14. Sep 2024
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    Proteomic analysis reveals microvesicles containing NAMPT as mediators of radiation resistance in glioma
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    biorxiv.org/lookup/doi/10.1101/2022.03.23.485479
  16. Apr 2024
  17. www.biorxiv.org www.biorxiv.org
    Integrative DNA methylation analysis of pediatric brain tumors reveals tumor type-specific developmental trajectories and epigenetic signatures of malignancy
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    biorxiv.org/content/10.1101/2022.03.14.483566v2
  18. Feb 2024
  19. www.biorxiv.org www.biorxiv.org
    CRISPR-Cas9-mediated genome engineering exaggerates genomic deletion at 10q23.31 including the PTEN gene locus mimicking cancer profiles
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    biorxiv.org/content/10.1101/2023.04.05.535680v1
  20. Jan 2024
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    Proteomic-based stratification of intermediate-risk prostate cancer patients
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    biorxiv.org/content/10.1101/2023.03.03.530910v1
  22. docdrop.org docdrop.org
    Video: Let Food Be Thy Medicine: EAT THIS To Heal The Body & STARVE CANCER! | Dr. William Li (DocDrop)
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    1. stopresetgo 25 Jan 2024

      for - healthy eating - Dr. William Li - nutrition - healthy food - inflammation - angiogenesis

      summary - A good interview about human health and healthy diet. William Li begins by talking about angiogenesis as a key aspect of human health - and how pathology of angiogenesis is at the root of many major diseases. - The interviewer then asks Dr. Li about the connection between another keystone disease, and angiogenesis. - Dr. Li then describes some healthy foods and good dietary practices including extra virgin olive oil.

      adjacency - between - angiogenesis - inflammation - Micheal Levine's work - evolutionary biology - adjacency statement - they all seem related, as evolutionary biology has created legacy subsystems within the human body

      adjacency - Michael Levine - angiogenesis - inflammation angiogenesis inflammation adjacency - cancer - inflammation - angiogenesis adjacency - food - angiogenesis - cancer adjacency - michael levine - evolutionary biology - angiogenesis
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    docdrop.org/video/cNPV_5stNLo/
  23. Dec 2023
  24. www.biorxiv.org www.biorxiv.org
    TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA
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    biorxiv.org/content/10.1101/2023.04.21.537799v2
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    Paralog dispensability shapes homozygous deletion patterns in tumor genomes
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    biorxiv.org/content/10.1101/2022.06.20.496722v3
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    Downregulation of stromal syntenin sustains AML development
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    biorxiv.org/content/10.1101/2023.02.15.527799v1
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    NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma
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    biorxiv.org/content/10.1101/2023.05.08.539792v1
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    YAP antagonizes TEAD-mediated AR signaling and prostate cancer growth
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    biorxiv.org/content/10.1101/2022.08.01.502314v1
  29. Sep 2023
  30. www.biorxiv.org www.biorxiv.org
    PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.
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    biorxiv.org/content/10.1101/2022.11.29.518198v1
  31. www.biorxiv.org www.biorxiv.org
    Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
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    biorxiv.org/content/10.1101/2022.12.27.521482v1
  32. Aug 2023
  33. www.biorxiv.org www.biorxiv.org
    NLRP3 controls ATM activation in response to DNA damage.
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    biorxiv.org/content/10.1101/2020.05.12.087015v1
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    ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer
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    biorxiv.org/content/10.1101/2022.12.16.520783v1
  35. Jun 2023
  36. www.biorxiv.org www.biorxiv.org
    Highly multiplexed quantitative phosphosite assay for biology and preclinical studies
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    biorxiv.org/content/10.1101/2020.12.08.415281v1
  37. May 2023
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    RAS and PP2A activities converge on epigenetic gene regulation
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    biorxiv.org/content/10.1101/2022.05.11.491459v1
  39. www.biorxiv.org www.biorxiv.org
    ROR1 plays a critical role in pancreatic tumor-initiating cells with a partial EMT signature.
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    biorxiv.org/content/10.1101/2022.07.13.499868v1
  40. Apr 2023
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    β-catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia
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    biorxiv.org/content/10.1101/2022.07.07.499249v1
  42. www.biorxiv.org www.biorxiv.org
    An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene
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    biorxiv.org/content/10.1101/2021.12.16.472890v3
  43. Mar 2023
  44. www.biorxiv.org www.biorxiv.org
    Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16
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    biorxiv.org/content/10.1101/2021.11.30.470499v1
  45. www.biorxiv.org www.biorxiv.org
    Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and delays resistance in melanoma
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    biorxiv.org/content/10.1101/2021.07.02.450838v1
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    The eukaryotic translation initiation factor eIF4E reprogrammes the splicing machinery anddrives alternative splicing
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    biorxiv.org/content/10.1101/2021.12.07.471666v4
  47. Feb 2023
  48. www.biorxiv.org www.biorxiv.org
    The mechanosensitive TRPV2 calcium channel controls melanoma invasiveness and metastatic potential.
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    biorxiv.org/content/10.1101/2021.10.22.465391v1
  49. www.biorxiv.org www.biorxiv.org
    TSC2 regulates tumor susceptibility to TRAIL-mediated T cell killing by orchestrating mTOR signaling
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    biorxiv.org/content/10.1101/2022.05.09.491124v1
  50. Jan 2023
  51. www.biorxiv.org www.biorxiv.org
    Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival
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    biorxiv.org/content/10.1101/2021.06.09.447741v1
  52. Nov 2022
  53. www.biorxiv.org www.biorxiv.org
    Heterogeneity of the Cancer Cell Line Metabolic Landscape
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    biorxiv.org/content/10.1101/2021.08.19.456093v1
  54. www.biorxiv.org www.biorxiv.org
    Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes
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    biorxiv.org/content/10.1101/2022.01.03.474504v1
  55. www.biorxiv.org www.biorxiv.org
    Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models
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    biorxiv.org/content/10.1101/2022.01.15.476442v1
  56. www.biorxiv.org www.biorxiv.org
    THEM6-mediated lipid remodelling sustains stress resistance in cancer
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    biorxiv.org/content/10.1101/2021.04.04.438378v1
  57. Jun 2022
  58. www.biorxiv.org www.biorxiv.org
    Genetic and compound screens uncover factors modulating cancer cell response to indisulam
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    biorxiv.org/content/10.1101/2021.12.20.473451v1
  59. Apr 2022
  60. www.biorxiv.org www.biorxiv.org
    Polycomb Group Ring Finger Protein 6 suppresses Myc-induced lymphomagenesis
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    biorxiv.org/content/10.1101/2021.12.02.470967v1
  61. www.biorxiv.org www.biorxiv.org
    TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis
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    biorxiv.org/content/10.1101/2021.10.27.466063v1
  62. Mar 2022
  63. www.biorxiv.org www.biorxiv.org
    REDUCED ER-MITOCHONDRIA CONNECTIVITY PROMOTES NEUROBLASTOMA MULTIDRUG RESISTANCE
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    biorxiv.org/content/10.1101/2021.03.01.433120v1
  64. Feb 2022
  65. www.biorxiv.org www.biorxiv.org
    A census of cell types and paracrine interactions in colorectal cancer
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    biorxiv.org/content/10.1101/2020.01.10.901579v3
  66. www.biorxiv.org www.biorxiv.org
    CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal
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    biorxiv.org/content/10.1101/2021.02.03.428245v1
  67. www.biorxiv.org www.biorxiv.org
    Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma
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    biorxiv.org/content/10.1101/2021.02.23.432584v3
  68. www.biorxiv.org www.biorxiv.org
    Nucleotide Biosynthesis Links Glutathione Metabolism to Ferroptosis Sensitivity
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    biorxiv.org/content/10.1101/2021.07.14.452394v1
  69. Jan 2022
  70. www.biorxiv.org www.biorxiv.org
    The Sec61 translocon is a therapeutic vulnerability in Multiple Myeloma
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    biorxiv.org/content/10.1101/2021.09.05.459026v1
  71. Dec 2021
  72. www.nature.com www.nature.com
    Replicating scientific results is tough — but essential
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    nature.com/articles/d41586-021-03736-4
  73. Nov 2021
  74. www.biorxiv.org www.biorxiv.org
    The unfolded protein response links tumor aneuploidy to local immune dysregulation
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    biorxiv.org/content/10.1101/2020.11.10.377358v1
  75. Oct 2021
  76. www.biorxiv.org www.biorxiv.org
    RASSF1C oncogene elicits amoeboid invasion, cancer stemness and invasive EVs via a novel SRC/Rho axis
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    biorxiv.org/lookup/doi/10.1101/2021.01.05.425393
  77. Jul 2021
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    Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51
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    biorxiv.org/content/10.1101/2020.06.09.137612v1
  79. www.biorxiv.org www.biorxiv.org
    Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth
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    biorxiv.org/content/10.1101/2020.10.06.327882v1
  80. Jun 2021
  81. www.biorxiv.org www.biorxiv.org
    Aneuploid cells activate NF-κB to promote their immune clearance by NK cells
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    biorxiv.org/content/10.1101/2020.06.25.172239v1
  82. www.biorxiv.org www.biorxiv.org
    Pancreatic Cancer Intrinsic PI3Kα Activity accelerates Metastasis and rewires Macrophage Component
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    biorxiv.org/content/10.1101/2020.09.23.307884v1
  83. Apr 2021
  84. www.biorxiv.org www.biorxiv.org
    Identifying Modules of Cooperating Cancer Drivers
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    biorxiv.org/content/10.1101/2020.06.29.168229v1
  85. www.biorxiv.org www.biorxiv.org
    Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor
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    biorxiv.org/content/10.1101/2020.01.31.929372v1
  86. www.biorxiv.org www.biorxiv.org
    WNT inhibition creates a BRCA-like state in Wnt-addicted cancer
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    biorxiv.org/content/10.1101/2020.06.17.157024v1
  87. Feb 2021
  88. www.biorxiv.org www.biorxiv.org
    A FIJI Macro for quantifying pattern in extracellular matrix
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    biorxiv.org/content/10.1101/867507v4
  89. www.biorxiv.org www.biorxiv.org
    IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling
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    biorxiv.org/content/10.1101/2020.05.25.114660v1
  90. www.biorxiv.org www.biorxiv.org
    Helicobacter pylori accelerates KRAS-dependent gastric dysplasia
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    biorxiv.org/content/10.1101/2020.10.06.328518v1
  91. www.biorxiv.org www.biorxiv.org
    LSD1 inhibitors induce neuronal differentiation of Merkel cell carcinoma by disrupting the LSD1-CoREST complex and activating TGFβ signaling
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    biorxiv.org/content/10.1101/2020.04.14.041657v1
  92. www.biorxiv.org www.biorxiv.org
    The Mutational Landscape of the SCAN-B Real-World Primary Breast Cancer Transcriptome
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    biorxiv.org/content/10.1101/2020.01.30.926733v1
  93. Oct 2020
  94. www.biorxiv.org www.biorxiv.org
    DDX5 targets tissue-specific RNAs to promote intestine tumorigenesis
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    biorxiv.org/content/10.1101/2020.03.25.006668v1
  95. www.biorxiv.org www.biorxiv.org
    Reprogrammed mRNA translation drives metabolic response to therapeutic targeting of ribosome biogenesis
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    biorxiv.org/content/10.1101/847723v3
  96. www.biorxiv.org www.biorxiv.org
    The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism
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    biorxiv.org/content/10.1101/855361v1
  97. Jul 2020
  98. www.biorxiv.org www.biorxiv.org
    Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells
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    biorxiv.org/content/10.1101/2020.01.21.913467v1
  99. www.biorxiv.org www.biorxiv.org
    STAT3-dependent systems-level analysis reveals PDK4 as an independent predictor of biochemical recurrence in prostate cancer
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    biorxiv.org/content/10.1101/770701v1
  100. www.biorxiv.org www.biorxiv.org
    Stromal ISLR promotes intestinal regeneration and cancer by suppressing epithelial Hippo signaling
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    biorxiv.org/content/10.1101/740472v1
  101. www.biorxiv.org www.biorxiv.org
    An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation
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    biorxiv.org/content/10.1101/561464v2
  102. www.biorxiv.org www.biorxiv.org
    Hippo Pathway Deregulation Drives Tissue Stiffness and Cancer Stem-like Cells in Lung Adenocarcinoma
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    biorxiv.org/content/10.1101/390849v1
  103. www.biorxiv.org www.biorxiv.org
    EZH2 co-opts gain-of-function p53 mutants to promote cancer growth and metastasis
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    biorxiv.org/content/10.1101/298737v1
  104. Jun 2020
  105. www.biorxiv.org www.biorxiv.org
    Ubiquitin and SUMO conjugation as biomarkers of Acute Myeloid Leukemias response to chemotherapies
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    biorxiv.org/content/10.1101/825182v1
  106. www.biorxiv.org www.biorxiv.org
    The USP28-{triangleup}Np63 axis is a vulnerability of squamous tumours
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    biorxiv.org/content/10.1101/683508v1
  107. www.biorxiv.org www.biorxiv.org
    Preservation of stemness in high-grade serous ovarian cancer organoids requires low Wnt environment
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    biorxiv.org/content/10.1101/741397v1
  108. Sep 2019
  109. www.biorxiv.org www.biorxiv.org
    Tumor-Intrinsic Response to IFNgamma Shapes the Tumor Microenvironment and Anti-PD-1 Response in NSCLC
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    biorxiv.org/content/10.1101/531236v1
  110. www.biorxiv.org www.biorxiv.org
    Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy
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    biorxiv.org/content/10.1101/284240v2
  111. www.biorxiv.org www.biorxiv.org
    Fibroblasts from metastatic sites induce broad-spectrum drug desensitization via modulation of mitochondrial priming
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    biorxiv.org/content/10.1101/197376v1
  112. www.biorxiv.org www.biorxiv.org
    Whole chromosome loss in tetraploid cells confers tumorigenic potential in a mouse allograft model
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    biorxiv.org/content/10.1101/172668v1
  113. www.biorxiv.org www.biorxiv.org
    FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.
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    biorxiv.org/content/10.1101/365460v1
  114. www.biorxiv.org www.biorxiv.org
    Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib
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    biorxiv.org/content/10.1101/202770v1
  115. www.biorxiv.org www.biorxiv.org
    Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells
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    biorxiv.org/content/10.1101/247429v1
  116. www.biorxiv.org www.biorxiv.org
    Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations
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    biorxiv.org/content/10.1101/124446v1