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  1. Last 7 days
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    YAP antagonizes TEAD-mediated AR signaling and prostate cancer growth
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    1. EMBOpress 01 Dec 2023

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    biorxiv.org/content/10.1101/2022.08.01.502314v1
  3. Sep 2023
  4. www.biorxiv.org www.biorxiv.org
    PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.
    1
    1. EMBOpress 06 Sep 2023

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    biorxiv.org/content/10.1101/2022.11.29.518198v1
  5. www.biorxiv.org www.biorxiv.org
    Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
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    1. EMBOpress 02 Sep 2023

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    biorxiv.org/content/10.1101/2022.12.27.521482v1
  6. Aug 2023
  7. www.biorxiv.org www.biorxiv.org
    NLRP3 controls ATM activation in response to DNA damage.
    1
    1. EMBOpress 26 Aug 2023

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    biorxiv.org/content/10.1101/2020.05.12.087015v1
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    ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer
    1
    1. EMBOpress 02 Aug 2023

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    biorxiv.org/content/10.1101/2022.12.16.520783v1
  9. Jun 2023
  10. www.biorxiv.org www.biorxiv.org
    Highly multiplexed quantitative phosphosite assay for biology and preclinical studies
    1
    1. EMBOpress 10 Jun 2023

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    biorxiv.org/content/10.1101/2020.12.08.415281v1
  11. May 2023
  12. www.biorxiv.org www.biorxiv.org
    RAS and PP2A activities converge on epigenetic gene regulation
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    1. EMBOpress 26 May 2023

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    biorxiv.org/content/10.1101/2022.05.11.491459v1
  13. www.biorxiv.org www.biorxiv.org
    ROR1 plays a critical role in pancreatic tumor-initiating cells with a partial EMT signature.
    1
    1. EMBOpress 19 May 2023

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    biorxiv.org/content/10.1101/2022.07.13.499868v1
  14. Apr 2023
  15. www.biorxiv.org www.biorxiv.org
    β-catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia
    1
    1. EMBOpress 27 Apr 2023

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    biorxiv.org/content/10.1101/2022.07.07.499249v1
  16. www.biorxiv.org www.biorxiv.org
    An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene
    1
    1. EMBOpress 25 Apr 2023

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    biorxiv.org/content/10.1101/2021.12.16.472890v3
  17. Mar 2023
  18. www.biorxiv.org www.biorxiv.org
    Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16
    1
    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.11.30.470499v1
  19. www.biorxiv.org www.biorxiv.org
    Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and delays resistance in melanoma
    1
    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.07.02.450838v1
  20. www.biorxiv.org www.biorxiv.org
    The eukaryotic translation initiation factor eIF4E reprogrammes the splicing machinery anddrives alternative splicing
    1
    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.12.07.471666v4
  21. Feb 2023
  22. www.biorxiv.org www.biorxiv.org
    The mechanosensitive TRPV2 calcium channel controls melanoma invasiveness and metastatic potential.
    1
    1. EMBOpress 28 Feb 2023

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    biorxiv.org/content/10.1101/2021.10.22.465391v1
  23. www.biorxiv.org www.biorxiv.org
    TSC2 regulates tumor susceptibility to TRAIL-mediated T cell killing by orchestrating mTOR signaling
    1
    1. EMBOpress 15 Feb 2023

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    biorxiv.org/content/10.1101/2022.05.09.491124v1
  24. Jan 2023
  25. www.biorxiv.org www.biorxiv.org
    Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival
    1
    1. EMBOpress 28 Jan 2023

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    biorxiv.org/content/10.1101/2021.06.09.447741v1
  26. Nov 2022
  27. www.biorxiv.org www.biorxiv.org
    Heterogeneity of the Cancer Cell Line Metabolic Landscape
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2021.08.19.456093v1
  28. www.biorxiv.org www.biorxiv.org
    Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2022.01.03.474504v1
  29. www.biorxiv.org www.biorxiv.org
    Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2022.01.15.476442v1
  30. www.biorxiv.org www.biorxiv.org
    THEM6-mediated lipid remodelling sustains stress resistance in cancer
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2021.04.04.438378v1
  31. Jun 2022
  32. www.biorxiv.org www.biorxiv.org
    Genetic and compound screens uncover factors modulating cancer cell response to indisulam
    1
    1. EMBOpress 02 Jun 2022

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    biorxiv.org/content/10.1101/2021.12.20.473451v1
  33. Apr 2022
  34. www.biorxiv.org www.biorxiv.org
    Polycomb Group Ring Finger Protein 6 suppresses Myc-induced lymphomagenesis
    1
    1. EMBOpress 23 Apr 2022

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    biorxiv.org/content/10.1101/2021.12.02.470967v1
  35. www.biorxiv.org www.biorxiv.org
    TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis
    1
    1. EMBOpress 22 Apr 2022

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    biorxiv.org/content/10.1101/2021.10.27.466063v1
  36. Mar 2022
  37. www.biorxiv.org www.biorxiv.org
    REDUCED ER-MITOCHONDRIA CONNECTIVITY PROMOTES NEUROBLASTOMA MULTIDRUG RESISTANCE
    1
    1. EMBOpress 29 Mar 2022

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    biorxiv.org/content/10.1101/2021.03.01.433120v1
  38. Feb 2022
  39. www.biorxiv.org www.biorxiv.org
    A census of cell types and paracrine interactions in colorectal cancer
    1
    1. EMBOpress 25 Feb 2022

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    biorxiv.org/content/10.1101/2020.01.10.901579v3
  40. www.biorxiv.org www.biorxiv.org
    CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal
    1
    1. EMBOpress 11 Feb 2022

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    biorxiv.org/content/10.1101/2021.02.03.428245v1
  41. www.biorxiv.org www.biorxiv.org
    Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma
    1
    1. EMBOpress 09 Feb 2022

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    biorxiv.org/content/10.1101/2021.02.23.432584v3
  42. www.biorxiv.org www.biorxiv.org
    Nucleotide Biosynthesis Links Glutathione Metabolism to Ferroptosis Sensitivity
    1
    1. EMBOpress 03 Feb 2022

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    biorxiv.org/content/10.1101/2021.07.14.452394v1
  43. Jan 2022
  44. www.biorxiv.org www.biorxiv.org
    The Sec61 translocon is a therapeutic vulnerability in Multiple Myeloma
    1
    1. EMBOpress 28 Jan 2022

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    biorxiv.org/content/10.1101/2021.09.05.459026v1
  45. Dec 2021
  46. www.nature.com www.nature.com
    Replicating scientific results is tough — but essential
    1
    1. lucyparfitt16 15 Dec 2021

      Replicating scientific results is tough—But essential. (2021). Nature, 600(7889), 359–360. https://doi.org/10.1038/d41586-021-03736-4

      is:article lang:en science replication research cancer biology scientific journal Reproducibility Project experimental treatment bias time consuming detail open science scientific method methodology data peer review funding publishing investment progress
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    nature.com/articles/d41586-021-03736-4
  47. Nov 2021
  48. www.biorxiv.org www.biorxiv.org
    The unfolded protein response links tumor aneuploidy to local immune dysregulation
    1
    1. EMBOpress 24 Nov 2021

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    biorxiv.org/content/10.1101/2020.11.10.377358v1
  49. Oct 2021
  50. www.biorxiv.org www.biorxiv.org
    RASSF1C oncogene elicits amoeboid invasion, cancer stemness and invasive EVs via a novel SRC/Rho axis
    1
    1. EMBOpress 26 Oct 2021

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    biorxiv.org/lookup/doi/10.1101/2021.01.05.425393
  51. Jul 2021
  52. www.biorxiv.org www.biorxiv.org
    Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51
    1
    1. EMBOpress 17 Jul 2021

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    biorxiv.org/content/10.1101/2020.06.09.137612v1
  53. www.biorxiv.org www.biorxiv.org
    Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth
    1
    1. EMBOpress 16 Jul 2021

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    biorxiv.org/content/10.1101/2020.10.06.327882v1
  54. Jun 2021
  55. www.biorxiv.org www.biorxiv.org
    Aneuploid cells activate NF-κB to promote their immune clearance by NK cells
    1
    1. EMBOpress 30 Jun 2021

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    biorxiv.org/content/10.1101/2020.06.25.172239v1
  56. www.biorxiv.org www.biorxiv.org
    Pancreatic Cancer Intrinsic PI3Kα Activity accelerates Metastasis and rewires Macrophage Component
    1
    1. EMBOpress 08 Jun 2021

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    biorxiv.org/content/10.1101/2020.09.23.307884v1
  57. Apr 2021
  58. www.biorxiv.org www.biorxiv.org
    Identifying Modules of Cooperating Cancer Drivers
    1
    1. EMBOpress 05 Apr 2021

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    biorxiv.org/content/10.1101/2020.06.29.168229v1
  59. www.biorxiv.org www.biorxiv.org
    Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor
    1
    1. EMBOpress 02 Apr 2021

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    biorxiv.org/content/10.1101/2020.01.31.929372v1
  60. www.biorxiv.org www.biorxiv.org
    WNT inhibition creates a BRCA-like state in Wnt-addicted cancer
    1
    1. EMBOpress 02 Apr 2021

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    biorxiv.org/content/10.1101/2020.06.17.157024v1
  61. Feb 2021
  62. www.biorxiv.org www.biorxiv.org
    A FIJI Macro for quantifying pattern in extracellular matrix
    1
    1. EMBOpress 25 Feb 2021

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    biorxiv.org/content/10.1101/867507v4
  63. www.biorxiv.org www.biorxiv.org
    IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling
    1
    1. EMBOpress 25 Feb 2021

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    biorxiv.org/content/10.1101/2020.05.25.114660v1
  64. www.biorxiv.org www.biorxiv.org
    Helicobacter pylori accelerates KRAS-dependent gastric dysplasia
    1
    1. EMBOpress 25 Feb 2021

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    biorxiv.org/content/10.1101/2020.10.06.328518v1
  65. www.biorxiv.org www.biorxiv.org
    LSD1 inhibitors induce neuronal differentiation of Merkel cell carcinoma by disrupting the LSD1-CoREST complex and activating TGFβ signaling
    1
    1. EMBOpress 25 Feb 2021

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    biorxiv.org/content/10.1101/2020.04.14.041657v1
  66. www.biorxiv.org www.biorxiv.org
    The Mutational Landscape of the SCAN-B Real-World Primary Breast Cancer Transcriptome
    1
    1. EMBOpress 25 Feb 2021

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    biorxiv.org/content/10.1101/2020.01.30.926733v1
  67. Oct 2020
  68. www.biorxiv.org www.biorxiv.org
    DDX5 targets tissue-specific RNAs to promote intestine tumorigenesis
    1
    1. EMBOpress 06 Oct 2020

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    biorxiv.org/content/10.1101/2020.03.25.006668v1
  69. www.biorxiv.org www.biorxiv.org
    Reprogrammed mRNA translation drives metabolic response to therapeutic targeting of ribosome biogenesis
    1
    1. EMBOpress 06 Oct 2020

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    biorxiv.org/content/10.1101/847723v3
  70. www.biorxiv.org www.biorxiv.org
    The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism
    1
    1. EMBOpress 06 Oct 2020

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    biorxiv.org/content/10.1101/855361v1
  71. Jul 2020
  72. www.biorxiv.org www.biorxiv.org
    Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells
    1
    1. EMBOpress 15 Jul 2020

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    biorxiv.org/content/10.1101/2020.01.21.913467v1
  73. www.biorxiv.org www.biorxiv.org
    STAT3-dependent systems-level analysis reveals PDK4 as an independent predictor of biochemical recurrence in prostate cancer
    1
    1. EMBOpress 15 Jul 2020

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    biorxiv.org/content/10.1101/770701v1
  74. www.biorxiv.org www.biorxiv.org
    Stromal ISLR promotes intestinal regeneration and cancer by suppressing epithelial Hippo signaling
    1
    1. EMBOpress 15 Jul 2020

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    biorxiv.org/content/10.1101/740472v1
  75. www.biorxiv.org www.biorxiv.org
    An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation
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    1. EMBOpress 15 Jul 2020

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    biorxiv.org/content/10.1101/561464v2
  76. www.biorxiv.org www.biorxiv.org
    Hippo Pathway Deregulation Drives Tissue Stiffness and Cancer Stem-like Cells in Lung Adenocarcinoma
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    1. EMBOpress 15 Jul 2020

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    biorxiv.org/content/10.1101/390849v1
  77. www.biorxiv.org www.biorxiv.org
    EZH2 co-opts gain-of-function p53 mutants to promote cancer growth and metastasis
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    1. EMBOpress 15 Jul 2020

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    biorxiv.org/content/10.1101/298737v1
  78. Jun 2020
  79. www.biorxiv.org www.biorxiv.org
    Ubiquitin and SUMO conjugation as biomarkers of Acute Myeloid Leukemias response to chemotherapies
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    1. EMBOpress 04 Jun 2020

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    biorxiv.org/content/10.1101/825182v1
  80. www.biorxiv.org www.biorxiv.org
    The USP28-{triangleup}Np63 axis is a vulnerability of squamous tumours
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    1. EMBOpress 04 Jun 2020

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    biorxiv.org/content/10.1101/683508v1
  81. www.biorxiv.org www.biorxiv.org
    Preservation of stemness in high-grade serous ovarian cancer organoids requires low Wnt environment
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    biorxiv.org/content/10.1101/741397v1
  82. Sep 2019
  83. www.biorxiv.org www.biorxiv.org
    Tumor-Intrinsic Response to IFNgamma Shapes the Tumor Microenvironment and Anti-PD-1 Response in NSCLC
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    1. EMBOpress 22 Sep 2019

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    biorxiv.org/content/10.1101/531236v1
  84. www.biorxiv.org www.biorxiv.org
    Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy
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    1. EMBOpress 22 Sep 2019

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    biorxiv.org/content/10.1101/284240v2
  85. www.biorxiv.org www.biorxiv.org
    Fibroblasts from metastatic sites induce broad-spectrum drug desensitization via modulation of mitochondrial priming
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    1. EMBOpress 22 Sep 2019

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    biorxiv.org/content/10.1101/197376v1
  86. www.biorxiv.org www.biorxiv.org
    Whole chromosome loss in tetraploid cells confers tumorigenic potential in a mouse allograft model
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    1. EMBOpress 22 Sep 2019

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    biorxiv.org/content/10.1101/172668v1
  87. www.biorxiv.org www.biorxiv.org
    FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.
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    1. EMBOpress 22 Sep 2019

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    biorxiv.org/content/10.1101/365460v1
  88. www.biorxiv.org www.biorxiv.org
    Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib
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    1. EMBOpress 22 Sep 2019

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    biorxiv.org/content/10.1101/202770v1
  89. www.biorxiv.org www.biorxiv.org
    Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells
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    1. EMBOpress 22 Sep 2019

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    biorxiv.org/content/10.1101/247429v1
  90. www.biorxiv.org www.biorxiv.org
    Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations
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    biorxiv.org/content/10.1101/124446v1