71 Matching Annotations
  1. Jun 2026
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    Sterile triggers drive joint inflammation in TNF and IL-1beta dependent mouse arthritis models
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    biorxiv.org/lookup/doi/10.1101/2023.01.31.526410
  3. Jan 2026
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    Propionate reinforces epithelial identity and reduces aggressiveness of non-small cell lung carcinoma via chromatin remodelling
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    biorxiv.org/lookup/doi/10.1101/2023.01.19.524677
  5. May 2024
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    Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome: mechanism of action and therapeutic potential
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    biorxiv.org/content/10.1101/2023.03.30.534977v2
  7. Dec 2023
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    TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA
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    biorxiv.org/content/10.1101/2023.04.21.537799v2
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    Propylene glycol inactivates respiratory viruses and prevents airborne transmission
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    biorxiv.org/content/10.1101/2023.02.13.528349v1
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    Downregulation of stromal syntenin sustains AML development
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    biorxiv.org/content/10.1101/2023.02.15.527799v1
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    Multi-omic network analysis identified betacellulin as a novel target of omega-3 fatty acid attenuation of western diet-induced nonalcoholic steatohepatitis
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    biorxiv.org/content/10.1101/2022.10.03.510635v2
  12. Sep 2023
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    M-CSF induces a coordinated myeloid and NK cell differentiation program protecting against CMV after hematopoietic cell transplantation
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    biorxiv.org/content/10.1101/2023.01.30.526105v1
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    Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
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    biorxiv.org/content/10.1101/2022.12.27.521482v1
  15. Aug 2023
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    Targeting CD301+ macrophage inhibits endometrial fibrosis and improves pregnancy outcome
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    biorxiv.org/content/10.1101/2023.06.09.544336v1
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    ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer
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    biorxiv.org/content/10.1101/2022.12.16.520783v1
  18. Jun 2023
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    Maternal diet and gut microbiome composition modulate early life immune responses
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    biorxiv.org/content/10.1101/2023.03.06.531289v2
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    Age-dependent lipid droplet-rich microglia worsen stroke outcome in old mice
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    biorxiv.org/content/10.1101/2022.03.14.484305v1
  21. May 2023
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    Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain
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    biorxiv.org/content/10.1101/2022.03.01.482519v1
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    Nirmatrelvir treatment blunts the development of antiviral adaptive immune responses in SARS-CoV-2 infected mice
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    biorxiv.org/content/10.1101/2022.11.22.517465v2
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    Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung
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    biorxiv.org/lookup/doi/10.1101/2022.09.29.510220
  25. Apr 2023
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    β-catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia
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    biorxiv.org/content/10.1101/2022.07.07.499249v1
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    An innovative hematopoietic stem cell gene therapy approach benefits CLN1 disease in the mouse model
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    biorxiv.org/content/10.1101/2022.03.03.482460v1
  28. Mar 2023
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    Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and delays resistance in melanoma
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    biorxiv.org/content/10.1101/2021.07.02.450838v1
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    iPSC-based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation
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    biorxiv.org/content/10.1101/2022.02.24.481741v1
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    Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever
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    biorxiv.org/content/10.1101/2022.05.10.491306v1
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    Nanobody-mediated Complement Activation to Kill HIV-infected Cells
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    biorxiv.org/content/10.1101/2022.06.09.495439v1
  33. Jan 2023
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    NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
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    biorxiv.org/content/10.1101/2022.07.11.499563v1
  35. Nov 2022
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    Bleeding in patients and mice with Alagille syndrome: sex differences and risk factors
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    biorxiv.org/content/10.1101/2021.04.13.439679v2
  37. www.biorxiv.org www.biorxiv.org
    Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes
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    biorxiv.org/content/10.1101/2022.01.03.474504v1
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    Genetically-Modified Macrophages Accelerate Myelin Repair
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    biorxiv.org/content/10.1101/2020.10.28.358705v3
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    Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models
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    biorxiv.org/content/10.1101/2022.01.15.476442v1
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    THEM6-mediated lipid remodelling sustains stress resistance in cancer
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    biorxiv.org/content/10.1101/2021.04.04.438378v1
  41. Mar 2022
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    Early Disruption of Photoreceptor Cell Architecture and Loss of Vision in a Humanized Pig Model of Usher Syndrome
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    biorxiv.org/content/10.1101/2021.05.31.446123v1
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    Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes
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    biorxiv.org/content/10.1101/2021.04.27.441575v1
  44. Feb 2022
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    A census of cell types and paracrine interactions in colorectal cancer
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    biorxiv.org/content/10.1101/2020.01.10.901579v3
  46. Jan 2022
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    The Sec61 translocon is a therapeutic vulnerability in Multiple Myeloma
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    biorxiv.org/content/10.1101/2021.09.05.459026v1
  48. www.biorxiv.org www.biorxiv.org
    LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies
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    biorxiv.org/content/10.1101/2021.04.25.441302v1
  49. Dec 2021
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    CCG*CGG interruptions in high penetrance SCA8 families increase RAN translation and protein toxicity
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    biorxiv.org/content/10.1101/2021.02.08.430311v1
  51. Nov 2021
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    Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress
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    biorxiv.org/lookup/doi/10.1101/2020.12.30.424810
  53. www.biorxiv.org www.biorxiv.org
    Loss of PIKfyve drives the spongiform degeneration in prion diseases
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    biorxiv.org/lookup/doi/10.1101/2021.01.08.425896
  54. Sep 2021
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    Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice
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    biorxiv.org/content/10.1101/2020.12.17.419531v1
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    Independent information from PET, CSF and plasma biomarkers of tau pathology in Alzheimer's disease
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    biorxiv.org/content/10.1101/2021.04.19.440402v1
  57. Aug 2021
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    Modeling Genetic Epileptic Encephalopathies using Brain Organoids
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    biorxiv.org/content/10.1101/2020.08.23.263236v1
  59. Jul 2021
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    Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51
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    biorxiv.org/content/10.1101/2020.06.09.137612v1
  61. www.biorxiv.org www.biorxiv.org
    http://biorxiv.org/cgi/content/short/2020.11.21.392639
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    biorxiv.org/content/10.1101/2020.11.21.392639v1
  62. www.biorxiv.org www.biorxiv.org
    Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth
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    biorxiv.org/content/10.1101/2020.10.06.327882v1
  63. Jun 2021
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    Pancreatic Cancer Intrinsic PI3Kα Activity accelerates Metastasis and rewires Macrophage Component
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    biorxiv.org/content/10.1101/2020.09.23.307884v1
  65. Apr 2021
  66. www.biorxiv.org www.biorxiv.org
    Urinary proteome profiling for stratifying patients with familial Parkinsons disease
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    biorxiv.org/content/10.1101/2020.08.09.243584v1
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    The enhancement of activity rescues the establishment of Mecp2 null neuronal phenotypes
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    biorxiv.org/content/10.1101/2020.04.06.027995v1
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    Malaria parasites differentially sense environmental elasticity during transmission
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    biorxiv.org/content/10.1101/2020.09.29.319020v1
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    NF45/NF90-mediated rDNA transcription provides a novel target for immunosuppressant development
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    biorxiv.org/content/10.1101/2020.05.26.116897v3
  70. www.biorxiv.org www.biorxiv.org
    Antioxidant nanozyme counteracts HIV-1 by modulating intracellular redox potential
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    biorxiv.org/content/10.1101/2020.08.15.252098v1
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    TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin stability
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    biorxiv.org/content/10.1101/2020.09.03.281097v1
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    Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
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    biorxiv.org/content/10.1101/2020.07.26.217661v1
  73. www.biorxiv.org www.biorxiv.org
    WNT inhibition creates a BRCA-like state in Wnt-addicted cancer
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    biorxiv.org/content/10.1101/2020.06.17.157024v1
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    Biofabricating murine and human myo-substitutes for rapid volumetric muscle loss restoration
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    biorxiv.org/content/10.1101/2020.05.25.114819v1
  75. Feb 2021
  76. www.biorxiv.org www.biorxiv.org
    Epigenetic gene-expression links heart failure to memory impairment
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    biorxiv.org/content/10.1101/2020.01.22.915637v1
  77. www.biorxiv.org www.biorxiv.org
    Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson's disease
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    biorxiv.org/content/10.1101/2020.02.13.947465v1
  78. www.biorxiv.org www.biorxiv.org
    Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders.
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    biorxiv.org/content/10.1101/2020.07.22.216382v1
  79. www.biorxiv.org www.biorxiv.org
    MicroRNA-574 Regulates FAM210A Expression and Influences Pathological Cardiac Remodeling
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    biorxiv.org/content/10.1101/2020.01.09.900712v1
  80. www.biorxiv.org www.biorxiv.org
    ALX1-related Frontonasal Dysplasia Results From Defective Neural Crest Cell Development and Migration
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    biorxiv.org/content/10.1101/2020.06.12.148262v1
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    LSD1 inhibitors induce neuronal differentiation of Merkel cell carcinoma by disrupting the LSD1-CoREST complex and activating TGFβ signaling
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    biorxiv.org/content/10.1101/2020.04.14.041657v1
  82. www.biorxiv.org www.biorxiv.org
    The Mutational Landscape of the SCAN-B Real-World Primary Breast Cancer Transcriptome
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    biorxiv.org/content/10.1101/2020.01.30.926733v1
  83. Oct 2020
  84. www.biorxiv.org www.biorxiv.org
    Protective anti-prion antibodies in human immunoglobulin repertoires
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    biorxiv.org/content/10.1101/2020.02.05.933721v1
  85. www.biorxiv.org www.biorxiv.org
    PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS
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    biorxiv.org/content/10.1101/787994v2
  86. Jul 2020
  87. www.biorxiv.org www.biorxiv.org
    Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress
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    biorxiv.org/content/10.1101/836015v1
  88. Jun 2020
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    The USP28-{triangleup}Np63 axis is a vulnerability of squamous tumours
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    biorxiv.org/content/10.1101/683508v1
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    Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry
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    biorxiv.org/content/10.1101/792671v3
  91. www.biorxiv.org www.biorxiv.org
    Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology
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    biorxiv.org/content/10.1101/491902v2
  92. www.biorxiv.org www.biorxiv.org
    Huntington phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice
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    biorxiv.org/content/10.1101/643312v2
  93. Nov 2019
  94. www.biorxiv.org www.biorxiv.org
    High affinity interactions and signal transduction between Aβ oligomers and TREM2
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    biorxiv.org/content/10.1101/269787v1
  95. www.biorxiv.org www.biorxiv.org
    Plasma proteome profiling to detect and avoid sample-related biases in biomarker studies
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    biorxiv.org/content/10.1101/478305v1
  96. Sep 2019
  97. www.biorxiv.org www.biorxiv.org
    Functional systemic CD4 immunity is a differential factor for clinical responses to PD-L1/PD-1 blockade therapy in lung cancer
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    biorxiv.org/content/early/2019/01/09/508739
  98. www.biorxiv.org www.biorxiv.org
    Murine MPDZ-Linked Hydrocephalus is Caused by Hyperpermeability of the Choroid Plexus
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    biorxiv.org/content/early/2018/11/05/446500
  99. www.biorxiv.org www.biorxiv.org
    Household triclosan and triclocarban exposure impacts the adult intestinal microbiome but not the infant intestinal microbiome
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    biorxiv.org/content/10.1101/126334v1