1,082 Matching Annotations
  1. Jul 2024
  2. www.biorxiv.org www.biorxiv.org
    Exploring the molecular composition of the multipass translocon in its native membrane environment
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    1. EMBOpress 02 Jul 2024

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    biorxiv.org/content/10.1101/2023.11.28.569136v1
  3. www.biorxiv.org www.biorxiv.org
    Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activity
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    1. EMBOpress 02 Jul 2024

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    biorxiv.org/content/10.1101/2023.12.18.572154v1
  4. Jun 2024
  5. www.biorxiv.org www.biorxiv.org
    Translation inhibition efficacy does not determine the Plasmodium berghei liver stage antiplasmodial efficacy of protein synthesis inhibitors
    1
    1. EMBOpress 27 Jun 2024

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    biorxiv.org/content/10.1101/2023.12.07.570699v1
  6. www.biorxiv.org www.biorxiv.org
    The type of DNA damage response after Decitabine treatment depends on the level of DNMT activity
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    1. EMBOpress 26 Jun 2024

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    biorxiv.org/content/10.1101/2023.09.02.556017v2
  7. www.biorxiv.org www.biorxiv.org
    Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
    1
    1. EMBOpress 05 Jun 2024

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    biorxiv.org/content/10.1101/2022.06.14.495968v1
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    Trim66 paternal deficiency causes intrauterine overgrowth
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    1. EMBOpress 04 Jun 2024

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    biorxiv.org/content/10.1101/2024.02.12.579976v1
  9. www.biorxiv.org www.biorxiv.org
    The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts
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    1. EMBOpress 04 Jun 2024

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    biorxiv.org/content/10.1101/2022.08.08.503265v1
  10. May 2024
  11. www.biorxiv.org www.biorxiv.org
    DNA binding site II is required for RAD51 recombinogenic activity in Arabidopsis thaliana
    1
    1. EMBOpress 31 May 2024

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    biorxiv.org/content/10.1101/2024.03.07.583932v1
  12. www.biorxiv.org www.biorxiv.org
    Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
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    1. EMBOpress 31 May 2024

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    biorxiv.org/content/10.1101/2022.12.20.521247v1
  13. www.biorxiv.org www.biorxiv.org
    ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
    1
    1. EMBOpress 30 May 2024

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    biorxiv.org/content/10.1101/2024.01.17.576039v1
  14. www.biorxiv.org www.biorxiv.org
    K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific interactors.
    1
    1. EMBOpress 29 May 2024

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    biorxiv.org/content/10.1101/2024.01.08.574586v1
  15. www.biorxiv.org www.biorxiv.org
    IGHMBP2 deletion suppresses translation and activates the integrated stress response
    1
    1. EMBOpress 29 May 2024

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    biorxiv.org/content/10.1101/2023.12.11.571166v2
  16. www.biorxiv.org www.biorxiv.org
    http://biorxiv.org/cgi/content/short/2020.10.26.356014
    1
    1. EMBOpress 29 May 2024

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      PeerReviewed EMBOPress Molecular Systems Biology systems biology
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    biorxiv.org/content/10.1101/2020.10.26.356014v3
  17. www.biorxiv.org www.biorxiv.org
    Control of mammalian brain aging by the unfolded protein response (UPR)
    1
    1. EMBOpress 22 May 2024

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      PeerReviewed EMBOPress The EMBO Journal neuroscience
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    biorxiv.org/content/10.1101/2020.04.13.039172v1
  18. www.biorxiv.org www.biorxiv.org
    Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome: mechanism of action and therapeutic potential
    1
    1. EMBOpress 15 May 2024

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    biorxiv.org/content/10.1101/2023.03.30.534977v2
  19. www.biorxiv.org www.biorxiv.org
    Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia
    1
    1. EMBOpress 08 May 2024

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    biorxiv.org/content/10.1101/2023.10.18.562916v1
  20. Apr 2024
  21. www.biorxiv.org www.biorxiv.org
    Integrative DNA methylation analysis of pediatric brain tumors reveals tumor type-specific developmental trajectories and epigenetic signatures of malignancy
    1
    1. EMBOpress 27 Apr 2024

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    biorxiv.org/content/10.1101/2022.03.14.483566v2
  22. www.biorxiv.org www.biorxiv.org
    pADP-ribosylation Regulates the Cytoplasmic Localization, Cleavage and Pro-apoptotic Function of HuR
    1
    1. EMBOpress 25 Apr 2024

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    biorxiv.org/content/10.1101/2023.08.07.552262v1
  23. www.biorxiv.org www.biorxiv.org
    Condensate functionalization with motors directs their nucleation in space and allows manipulating RNA localization
    1
    1. EMBOpress 23 Apr 2024

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    biorxiv.org/content/10.1101/2022.07.10.499452v1
  24. Mar 2024
  25. www.biorxiv.org www.biorxiv.org
    The P4-ATPase Drs2 regulates the homeostasis of Atg9
    1
    1. EMBOpress 29 Mar 2024

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    biorxiv.org/content/10.1101/2020.12.25.417865v3
  26. www.biorxiv.org www.biorxiv.org
    A YTHDF-PABP axis is required for m6A-mediated organogenesis in plants
    1
    1. EMBOpress 22 Mar 2024

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    biorxiv.org/content/10.1101/2023.07.03.547513v2
  27. www.biorxiv.org www.biorxiv.org
    Plant YTHDF proteins are direct effectors of antiviral immunity against an m6A-containing RNA virus
    1
    1. EMBOpress 20 Mar 2024

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      PeerReviewed EMBOPress The EMBO Journal plant biology
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    biorxiv.org/content/10.1101/2022.10.19.512835v1
  28. www.biorxiv.org www.biorxiv.org
    Circadian Transcriptomic and Epigenomic Remodeling in Response to Lipid Overload and Human Obesity
    1
    1. EMBOpress 09 Mar 2024

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    biorxiv.org/content/10.1101/2021.02.23.432336v4
  29. www.biorxiv.org www.biorxiv.org
    Regulation of branched versus linear Arp2/3-generated actin filaments
    1
    1. EMBOpress 07 Mar 2024

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      PeerReviewed EMBOPress The EMBO Journal biochemistry
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    biorxiv.org/content/10.1101/2022.05.06.490861v1
  30. www.biorxiv.org www.biorxiv.org
    Extracellular vesicles and co-isolated endogenous retroviruses differently affect dendritic cells
    1
    1. EMBOpress 06 Mar 2024

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    biorxiv.org/content/10.1101/2023.01.27.525863v1
  31. www.biorxiv.org www.biorxiv.org
    Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors
    1
    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2023.08.25.554811v1
  32. www.biorxiv.org www.biorxiv.org
    Structural and biochemical insights into heterotetramer formation between human oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
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    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2022.10.10.511529v8
  33. www.biorxiv.org www.biorxiv.org
    The memory of airway epithelium damage in smokers and COPD patients
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    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2021.04.21.439437v3
  34. www.biorxiv.org www.biorxiv.org
    Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography
    1
    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2023.10.05.560879v1
  35. www.biorxiv.org www.biorxiv.org
    Micronucleus Is Not a Potent Inducer of cGAS-STING Pathway
    1
    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2023.10.16.561322v1
  36. www.biorxiv.org www.biorxiv.org
    CLN3 deficiency leads to neurological and metabolic perturbations during early development
    1
    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2023.03.17.533107v1
  37. www.biorxiv.org www.biorxiv.org
    A nuclear signal in prophase determines centrosome positioning and ensures efficient mitotic spindle assembly
    1
    1. EMBOpress 01 Mar 2024

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    biorxiv.org/content/10.1101/2023.06.14.544905v2
  38. www.biorxiv.org www.biorxiv.org
    The origin, evolution and molecular diversity of the chemokine system
    1
    1. EMBOpress 01 Mar 2024

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    biorxiv.org/content/10.1101/2023.05.17.541135v2
  39. Feb 2024
  40. www.biorxiv.org www.biorxiv.org
    Cryo-EM structure of lipid embedded human ABCA7 at 3.6 &Aring resolution
    1
    1. EMBOpress 27 Feb 2024

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      PeerReviewed EMBOPress The EMBO Journal biophysics
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    biorxiv.org/content/10.1101/2021.03.01.433448v2
  41. www.biorxiv.org www.biorxiv.org
    Canalisation and plasticity on the developmental manifold of Caenorhabditis elegans
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    1. EMBOpress 24 Feb 2024

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    biorxiv.org/content/10.1101/2023.04.14.536891v2
  42. www.biorxiv.org www.biorxiv.org
    Histology-associated transcriptomic heterogeneity in ovarian folliculogenesis revealed by quantitative single-cell RNA-sequencing for tissue sections with DRaqL
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    1. EMBOpress 21 Feb 2024

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    biorxiv.org/content/10.1101/2022.12.14.520513v1
  43. www.biorxiv.org www.biorxiv.org
    Pioneer activity distinguishes activating from non-activating pluripotency transcription factor binding sites
    1
    1. EMBOpress 07 Feb 2024

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    biorxiv.org/content/10.1101/2022.07.27.501606v1
  44. www.biorxiv.org www.biorxiv.org
    CRISPR-Cas9-mediated genome engineering exaggerates genomic deletion at 10q23.31 including the PTEN gene locus mimicking cancer profiles
    1
    1. EMBOpress 03 Feb 2024

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    biorxiv.org/content/10.1101/2023.04.05.535680v1
  45. Jan 2024
  46. www.biorxiv.org www.biorxiv.org
    Convergent Insulin and TGF-β signalling drives cancer cachexia by promoting aberrant fatbody ECM accumulation in a Drosophila tumour model
    1
    1. EMBOpress 31 Jan 2024

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    biorxiv.org/content/10.1101/2023.06.10.544444v1
  47. www.biorxiv.org www.biorxiv.org
    Proteomic-based stratification of intermediate-risk prostate cancer patients
    1
    1. EMBOpress 26 Jan 2024

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    biorxiv.org/content/10.1101/2023.03.03.530910v1
  48. www.biorxiv.org www.biorxiv.org
    Human RAD52 stimulates the RAD51-mediated homology search
    1
    1. EMBOpress 25 Jan 2024

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    biorxiv.org/content/10.1101/2022.06.27.497340v1
  49. www.biorxiv.org www.biorxiv.org
    The structural basis for deubiquitination by the fingerless USP-type effector TssM
    1
    1. EMBOpress 25 Jan 2024

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    biorxiv.org/content/10.1101/2023.08.01.551441v1
  50. www.biorxiv.org www.biorxiv.org
    Changes in searching behaviour of CSL transcription complexes in Notch active conditions
    1
    1. EMBOpress 23 Jan 2024

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    biorxiv.org/content/10.1101/2023.08.10.552734v2
  51. www.biorxiv.org www.biorxiv.org
    Human liver organoids model progressive inflammatory and fibrotic injury in non-alcoholic fatty liver disease
    1
    1. EMBOpress 17 Jan 2024

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    biorxiv.org/content/10.1101/2022.07.19.500693v2
  52. www.biorxiv.org www.biorxiv.org
    Arp2/3 inhibition switches Eps8’s network associations to favour longer actin filament formation necessary for tunneling nanotubes
    1
    1. EMBOpress 06 Jan 2024

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    biorxiv.org/content/10.1101/2022.08.24.504515v2
  53. Dec 2023
  54. www.biorxiv.org www.biorxiv.org
    Monomeric α-Synuclein activates the Plasma Membrane Calcium Pump
    1
    1. EMBOpress 19 Dec 2023

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    biorxiv.org/content/10.1101/2022.02.21.481193v2
  55. www.biorxiv.org www.biorxiv.org
    RIF1 ensures the organization of replication factories upon DNA replicative stress.
    1
    1. EMBOpress 16 Dec 2023

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    biorxiv.org/content/10.1101/669234v3
  56. www.biorxiv.org www.biorxiv.org
    TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA
    1
    1. EMBOpress 16 Dec 2023

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    biorxiv.org/content/10.1101/2023.04.21.537799v2
  57. www.biorxiv.org www.biorxiv.org
    Decline of DNA damage response along with myogenic differentiation
    1
    1. EMBOpress 15 Dec 2023

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    biorxiv.org/content/10.1101/2023.06.27.546688v1
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    Enhancer-driven local 3D chromatin domain folding modulates transcription in human mammary tumor cells
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    Structural analysis shows that the BIR2 domain of E3 ligase XIAP binds across the RIP2 kinase dimer interface
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    The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
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    Adult neural stem cells and neurogenesis are resilient to intermittent fasting
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    Adaptive Pathfinding by Nucleokinesis during Amoeboid Migration
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    Molecular view of ER membrane remodeling by the Sec61/TRAP translocon
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    Mitochondrial phosphoproteomes are functionally specialized across tissues
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    Protein phosphatase 1 regulates core PCP signaling
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    Circadian oscillation in primary cilium length by clock genes regulate fibroblast cell migration
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    Propylene glycol inactivates respiratory viruses and prevents airborne transmission
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    The nucleolar protein GNL3 prevents resection of stalled replication forks.
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    The Response of the Eukaryotic Replisome to G-quadruplex- and i-motif-forming Sequences
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    Thiol reductive stress activates the hypoxia response pathway
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    Paralog dispensability shapes homozygous deletion patterns in tumor genomes
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    Enucleation of the C. elegans embryo revealed the mechanism of dynein-dependent spacing between microtubule asters
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    Epithelial lumen development requires differential participation of the vertebrate clathrin light chain isoforms with dominance of CLCa in vivo
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    Identification of FAM53C as a suppressive binding protein of a neurodevelopmental disorders-related kinase DYRK1A
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    Modeling of Aberrant Epithelial Reprogramming in Idiopathic Pulmonary Fibrosis using Human Induced Pluripotent Stem Cell-derived Alveolar Organoids
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    Downregulation of stromal syntenin sustains AML development
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    Multi-omic network analysis identified betacellulin as a novel target of omega-3 fatty acid attenuation of western diet-induced nonalcoholic steatohepatitis
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    NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma
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    MICA: A multi-omics method to predict gene regulatory networks in early human embryos
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    Tetraspanner-based nanodomains modulate BAR domain-induced membrane curvature
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    YAP antagonizes TEAD-mediated AR signaling and prostate cancer growth
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    A bifunctional kinase-phosphatase module integrates mitotic checkpoint and error-correction signalling to ensure mitotic fidelity
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    Dimensionality reduction methods for extracting functional networks from large-scale CRISPR screens
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    Comprehensive comparison of female germ cell development in vitro and in vivo identifies epigenetic gene regulation crucial for oocyte development and embryonic competence
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    EMBRYO-UTERINE INTERACTION COORDINATES MOUSE EMBRYOGENESIS DURING IMPLANTATION
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    A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance
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    PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.
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    Identification of a novel enhancer essential for Satb1 expression in TH2 cells and activated ILC2s.
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    MAP4K3 inhibits Sirtuin-1 to repress LKB1-AMPK to promote amino acid dependent activation of mTORC1
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    Distant sequence regions of JBP1 contribute to J-DNA binding
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    IKBKB reduces huntingtin aggregation by phosphorylating Serine 13 via a non-canonical IKK pathway
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    Germinal Centers Convergent Evolution and B cell Recirculation in Human Lymph Nodes
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    Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis
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    Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
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    Robust dimethyl-based multiplex-DIA workflow doubles single-cell proteome depth via a reference channel
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    A metabolic map of the DNA damage response identifies PRDX1 in nuclear ROS scavenging and aspartate synthesis
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    Targeting CD301+ macrophage inhibits endometrial fibrosis and improves pregnancy outcome
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    PRMT5 links lipid metabolism to contractile function of skeletal muscles
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    Senescent cell death as an aging resistance mechanism in naked mole-rat
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    Principles for Systematic Optimization of an Orthogonal Translation System with Enhanced Biological Tolerance
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    Synaptotagmin 1 mediates toxicity of botulinum neurotoxin type A
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    The C-terminal tail of CSNAP attenuates the CSN complex
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    Direct observation of coordinated assembly of individual native centromeric nucleosomes
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    Consistency across multi-omics layers in a drug-perturbed gut microbial community
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    ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer
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    Terminal differentiation of enterocytes is governed by distinct members of Tgfβ superfamily
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    Evolutionary transcriptomics reveals longevity mostly driven by polygenic and indirect selection in mammals
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    Comparative membrane proteomics reveals diverse cell regulators concentrated at the nuclear envelope
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    Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20
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    Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation
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    Extracellular matrix sensing via modulation of orientational order of integrins and F-actin in focal adhesions
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    DOT1L bridges transcription and heterochromatin formation at pericentromeres
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    Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase
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    PARK15/FBXO7 is dispensable for PINK1/Parkin-dependent mitophagy in iNeuron and HeLa cell systems
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    MATR3-antisense LINE1 RNA meshwork scaffolds higher-order chromatin organization
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    Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation
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    The cytochrome b carboxyl-terminal region is necessary for mitochondrial Complex III assembly
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    arfA antisense RNA regulates MscL excretory activity
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    Antibody reliability influences observed mRNA-protein correlations in tumour samples
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    N-terminal proteoforms may engage in different protein complexes
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    PI3P dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase
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    Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
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    Centrosome amplification fine-tunes tubulin acetylation to differentially control intracellular organization
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    ENGRAILED-1 transcription factor exerts a paracrine neurotrophic activity on adult spinal cord &#x03B1;-motoneurons.
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    A tissue-aware machine learning framework enhances the mechanistic understanding and genetic diagnosis of Mendelian and rare diseases
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  168. Jun 2023
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    Accurate genotype-based demultiplexing of single cell RNA sequencing samples from non-human animals
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    HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion
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    Structural basis of ubiquitin-independent PP1 complex disassembly by p97
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    Maternal diet and gut microbiome composition modulate early life immune responses
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    Structure-based design and characterization of Parkin activating mutations
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    Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins
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    Upf3a is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells
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    Structural insights into ubiquitin chain cleavage by Legionella ovarian tumor deubiquitinases
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    The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells
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    Missense variant interaction scanning reveals a critical role of the FERM-F3 domain for tumor suppressor protein NF2 conformation and function
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    Multivalent BARD1-nucleosome interactions facilitate H2A ubiquitylation by BRCA1/BARD1
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    PERK Signaling Promotes Mitochondrial Elongation By Remodeling Membrane Phosphatidic Acid
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    Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response
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    Updated benchmarking of variant effect predictors using deep mutational scanning
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    Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia
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    Pseudomonas aeruginosa mechanosensing controls cell polarity during twitching by activating two antagonistic response regulators
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    Two distinct mechanisms underlie dosage sensitivity in Pumilio1-associated diseases
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    Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 binding
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    Deterministic and probabilistic fate decisions co-exist in a single retinal lineage
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    Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns
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    A case of mistaken identity: structurally similar ligand inhibits Thymidylate Kinase causing reversible filamentation of E. coli
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    Highly multiplexed quantitative phosphosite assay for biology and preclinical studies
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    The histone methyltransferase DOT1L regulates chromatin reorganization and gene expression during the postmeiotic differentiation of male germ cells
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    Age-dependent lipid droplet-rich microglia worsen stroke outcome in old mice
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    Systems-level transcriptional regulation of Caenorhabditis elegans metabolism
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  194. May 2023
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    BAZ2A-RNA mediated association with TOP2A and KDM1A represses gene expression in prostate cancer
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    Recursive splicing discovery using lariats in total RNA sequencing
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    Exploratory Meta-Analysis of Hypoxic Transcriptomes Using a Precise Transcript Reference Sequence Set
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    VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome
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    Telescoping bimodal latent Dirichlet allocation to identify expression QTLs across tissues
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    RAS and PP2A activities converge on epigenetic gene regulation
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    Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
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    Gapless provides combined scaffolding, gap filling and assembly correction with long reads
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    A quantitative fluorescence-based approach to study mitochondrial protein import
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    Ubiquitination occurs in the mitochondrial matrix by eclipsed components of the ubiquitin machinery
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    The transcriptional regulator Sin3A balances IL-17A and Foxp3 expression in primary CD4 T cells
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    Inhibition of the ATM kinase rescues planarian regeneration after lethal radiation
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    Ubx5-Cdc48 assists the protease Wss1 at DNA-protein crosslink sites in yeast
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    Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain
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    Nirmatrelvir treatment blunts the development of antiviral adaptive immune responses in SARS-CoV-2 infected mice
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    Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury
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    eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content
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    Z-Flipon Variants reveal the many roles of Z-DNA and Z-RNA in health and disease
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    A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes
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    biorxiv.org/lookup/doi/10.1101/2022.08.11.503561
  214. www.biorxiv.org www.biorxiv.org
    Automated assembly of molecular mechanisms at scale from text mining and curated databases
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    biorxiv.org/lookup/doi/10.1101/2022.08.30.505688
  215. www.biorxiv.org www.biorxiv.org
    Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung
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    biorxiv.org/lookup/doi/10.1101/2022.09.29.510220