1,207 Matching Annotations
  1. Oct 2026
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    Mechanism and consequence of daily modulation of cortical parvalbumin-positive inhibitory neurons
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    biorxiv.org/content/10.1101/2022.03.30.486351v1
  3. Sep 2026
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    Cross comparison of imaging strategies of mitochondria in C. elegans during aging
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    biorxiv.org/content/10.1101/2024.12.24.630282v1
  5. Aug 2026
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    Fishing with Two Lines: A Hybrid Approach to Spatial Transcriptomic Discovery
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    biorxiv.org/content/10.64898/2026.01.07.698201v1
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    Investigating the role of CpG island DNA methylation at 3'UTRs in cancer
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    biorxiv.org/content/10.1101/2024.10.18.619008v1
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    RAFTER: a releasing factor tethered RNA editing system for quantifying mRNA translation
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    biorxiv.org/content/10.64898/2025.12.12.693956v1
  9. Jul 2026
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    Septin7 is essential in early hematopoiesis, but redundant at later stages
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    biorxiv.org/content/10.1101/2025.04.22.649981v4
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    Lack of motor defects and ALS-like neuropathology in heterozygous Sptlc1 Exon 2 deletion mice
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    biorxiv.org/content/10.1101/2025.02.18.638951v1
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    Vav2 is a master regulator of repair against bacterial pore-forming toxins
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    biorxiv.org/content/10.1101/2025.07.31.668026v2
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    A Spinal Muscular Atrophy Model Reveals Both Developmental and Degenerative Neuronal Defects in C. elegans
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    biorxiv.org/content/10.64898/2026.01.22.701008v1
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    DiffMethylTools: a toolbox of the detection, annotation and visualization of differential DNA methylation
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    biorxiv.org/content/10.1101/2025.07.01.662655v1
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    TERT drives liver tumorigenesis beyond telomere elongation
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    biorxiv.org/content/10.64898/2026.02.02.703327v2
  16. Jun 2026
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    GPLD1 functions as a scavenger chaperone mediating lysosomal degradation of extracellular aberrant proteins
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    biorxiv.org/lookup/doi/10.1101/2025.07.16.665076
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    Optimization of systemic AAV9 gene therapy in Niemann-Pick disease type C1 mice
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    biorxiv.org/lookup/doi/10.1101/2024.06.07.597901
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    The chromatin remodeler DEK promotes proliferation of mammary epithelium and is associated with H3K27me3 epigenetic modifications
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    biorxiv.org/content/10.1101/2024.09.09.612116v1
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    Cross-Species Transcriptomic Integration Reveals a MIRO1-Mediated Macrophage-to-T Cell Signaling Axis Alginging with Immunosuppression in Glioma
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    biorxiv.org/lookup/doi/10.1101/2025.11.10.686781
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    Vsb1, Ypq1 and Ypq2 control dynamic cationic amino acid storage in the yeast vacuole
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    biorxiv.org/lookup/doi/10.1101/2025.09.11.675521
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    Sterile triggers drive joint inflammation in TNF and IL-1beta dependent mouse arthritis models
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    biorxiv.org/lookup/doi/10.1101/2023.01.31.526410
  23. May 2026
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    Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets
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    biorxiv.org/lookup/doi/10.1101/2025.09.05.674429
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    The mechanosensitive Ca2+-permeable ion channel PIEZO1 promotes satellite cell function in skeletal muscle regeneration
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    biorxiv.org/lookup/doi/10.1101/2021.03.18.435982
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    In vitro approaches to study centriole and cilium function in early mouse embryogenesis
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    biorxiv.org/lookup/doi/10.1101/2025.03.21.644416
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    GPR88 localization to primary cilia in neurons is cell-type specific.
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    biorxiv.org/lookup/doi/10.1101/2025.05.28.656656
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    Chromatin states contribute to coordinated allelic transcriptional bursting to drive iPSC reprogramming
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    biorxiv.org/lookup/doi/10.1101/2023.07.13.548864
  29. Apr 2026
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    Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathways
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    biorxiv.org/lookup/doi/10.1101/2024.12.27.630542
  31. Mar 2026
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    Tissue-specific I-Smad mechanisms revealed by structure-function analysis in Drosophila
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    biorxiv.org/lookup/doi/10.1101/2025.06.20.660739
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    TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner
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    biorxiv.org/lookup/doi/10.1101/2024.12.04.626765
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    The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress
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    biorxiv.org/lookup/doi/10.1101/2025.07.13.663563
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    Syk activation during FcγR-mediated phagocytosis involves Syk palmitoylation and desulfenylation
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    biorxiv.org/lookup/doi/10.1101/2025.05.26.656092
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    TBK1 activity regulates the directionality of axonal transport of signalling endosomes
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    biorxiv.org/lookup/doi/10.1101/2025.09.03.674015
  37. Feb 2026
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    Cryo-EM structure of the tetra-phosphorylated R-domain in Ycf1 reveals key interactions for transport regulation
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    biorxiv.org/content/10.1101/2024.03.06.583773v2
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    Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung
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    biorxiv.org/content/10.1101/2024.12.12.628112v1
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    Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation.
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    biorxiv.org/content/10.1101/2025.11.07.687309v1
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    Amyloid-β fibrils accumulated in preeclamptic placentas suppress syncytialization of cytotrophoblasts
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    biorxiv.org/content/10.1101/2025.03.06.641957v1
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    Tonic GluD1 channel current is independent of G protein activity in the dorsal raphe nucleus
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    biorxiv.org/content/10.1101/2022.01.20.477055v1
  43. Jan 2026
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    Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation
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    biorxiv.org/lookup/doi/10.1101/2025.02.06.636644
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    Intravital imaging the formation and resolution of MHC class II-positive T cell activation niches
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    biorxiv.org/lookup/doi/10.1101/2025.08.05.668796
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    Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD
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    biorxiv.org/lookup/doi/10.1101/2025.10.29.685259
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    RB dependent transcriptional regulation at mitotic centromeres preserves genome stability
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    Development of a pipeline to evaluate YAP-TEAD inhibitor potential - direct TEAD inhibition represses cancerous growth in a NF2-mutant model of mesothelioma
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    biorxiv.org/lookup/doi/10.1101/2024.11.12.622964
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    Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer
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    biorxiv.org/lookup/doi/10.1101/2025.04.23.650265
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    An integrated stress response-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation
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    biorxiv.org/lookup/doi/10.1101/2024.09.10.611650
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    Propionate reinforces epithelial identity and reduces aggressiveness of non-small cell lung carcinoma via chromatin remodelling
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    biorxiv.org/lookup/doi/10.1101/2023.01.19.524677
  52. Dec 2025
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    Identification of M-Sec as a unique cellular regulator of CSF-1 receptor activation
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    biorxiv.org/lookup/doi/10.1101/2024.09.03.610939
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    Conformational change of the Plasmodium TRAP I domain is essential for sporozoite migration and transmission of malaria
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    biorxiv.org/content/10.1101/2022.08.24.505106v1
  55. Nov 2025
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    PARP10 is Critical for Stress Granule Initiation
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    biorxiv.org/lookup/doi/10.1101/2023.10.13.562236
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    Beneficial and detrimental consequences of AHR activation in intestinal infection
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    biorxiv.org/lookup/doi/10.1101/2025.05.28.656570
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    Antioxidant properties of dihydroxy B-ring flavonoids modulate circadian amplitude in Arabidopsis
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    biorxiv.org/lookup/doi/10.1101/2025.03.09.641856
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    Bassoon controls synaptic vesicle pools via regulation of presynaptic phosphorylation and cAMP homeostasis
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    biorxiv.org/content/10.1101/2021.07.22.453360v1
  60. Oct 2025
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    Comparison of Infinium MethylationEPIC v2.0 to v1.0 for human population epigenetics: considerations for addressing EPIC version differences in DNA methylation-based tools
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    biorxiv.org/lookup/doi/10.1101/2024.07.02.600461
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    Genome-scale prediction of gene ontology from mass fingerprints reveals new metabolic gene functions
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    biorxiv.org/lookup/doi/10.1101/2024.11.27.625594
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    Hepatitis E Virus-induced antiviral response by plasmacytoid dendritic cells is modulated by the ORF2 protein
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    biorxiv.org/lookup/doi/10.1101/2024.04.12.589258
  64. Sep 2025
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    Differential cell survival outcomes in response to diverseamino acid stress
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    Co-occurrence of essential gene dispensability and bypass suppressor mutations across species
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    biorxiv.org/lookup/doi/10.1101/2022.11.11.516117
  67. Aug 2025
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    Gut microbiome remains stable following COVID-19 vaccination in healthy and immuno-compromised individuals
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    biorxiv.org/lookup/doi/10.1101/2023.08.23.554506
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    Chondrodysplasia-inducing COL2A1 p.Gly1170Ser causes an ER storage defect without associated unfolded protein response in a human cartilage model
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    biorxiv.org/content/10.1101/2023.10.19.562780v4
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    Computing hematopoiesis plasticity in response to genetic mutations and environmental stimulations
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    biorxiv.org/lookup/doi/10.1101/2024.08.02.606315
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    The nucleocytoplasmic translocation of HINT1 regulates the maturation of cell density
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    biorxiv.org/lookup/doi/10.1101/2025.01.13.632869
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    In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals
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    biorxiv.org/lookup/doi/10.1101/2024.12.06.627170
  73. Jul 2025
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    Multiple domains of scaffold Tudor protein play non-redundant roles in Drosophila germline
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    biorxiv.org/lookup/doi/10.1101/2025.03.13.643173
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    PSME3 Regulates Migration and Differentiation of Myoblasts
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    biorxiv.org/content/10.1101/2025.01.08.632048v1
  76. Jun 2025
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    Wound closure after brain injury relies on force generation by microglia in zebrafish
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  78. May 2025
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    AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation
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    biorxiv.org/content/10.1101/2024.11.01.621527v1
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    Lipid-driven SRC self-association modulates its transformation capacity
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    biorxiv.org/content/10.1101/2024.11.12.623151v1
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    STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs
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    biorxiv.org/content/10.1101/2024.12.20.629685v1
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    Optogenetic control of pheromone gradients reveals functional limits of mating behavior in budding yeast
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    biorxiv.org/content/10.1101/2024.02.06.578657v2
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    DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance
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    biorxiv.org/content/10.1101/2025.02.17.638677v1
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    Shared requirement for MYC upstream super-enhancer in tissue regeneration and cancer
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    biorxiv.org/content/10.1101/2022.11.04.515076v2
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    Predicting cell cycle stage from 3D single-cell nuclear-stained images
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    biorxiv.org/content/10.1101/2024.08.30.610553v2
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    Matrix-driven jamming dynamics mediates transition of ovarian cancer spheroids to stable morphologies
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    biorxiv.org/content/10.1101/2022.02.09.479678v3
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    Molecular mechanism of bacteriophage tail contraction- structure of an S-layer-penetrating bacteriophage
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    biorxiv.org/content/10.1101/2023.08.04.551987v1
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    Divergent Plasmodium protein kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
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    biorxiv.org/content/10.1101/2024.09.22.613647v1
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    The late onset Alzheimer’s disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis
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    biorxiv.org/content/10.1101/2024.09.13.612888v1
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    Diversification of Dentate Gyrus Granule Cell Subtypes is Regulated by Neuregulin1 Nuclear Back Signaling.
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    biorxiv.org/content/10.1101/2024.10.15.618334v1
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    Variety in the USP deubiquitinase catalytic mechanism
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    biorxiv.org/content/10.1101/2023.07.24.550302v2
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    Mechanical forces and ligand-binding modulate Pseudomonas aeruginosa PilY1 mechanosensitive protein
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    biorxiv.org/content/10.1101/2023.08.03.551776v3
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    MDC1 mediates Pellino recruitment to sites of DNA double-strand breaks
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    biorxiv.org/content/10.1101/2024.07.20.604390v1
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    Novel determinants of NOTCH1 trafficking and signaling in breast epithelial cells
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    biorxiv.org/content/10.1101/2023.03.05.531156v2
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    DICE: Fast and Accurate Distance-Based Reconstruction of Single-Cell Copy Number Phylogenies
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    biorxiv.org/content/10.1101/2024.06.03.597037v1
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    Canonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate
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    biorxiv.org/content/10.1101/2024.08.07.606990v1
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    Mitochondrial Signatures Shape Phenotype Switching and Apoptosis in Response to PLK1 and RSK Inhibitors in Melanoma
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    biorxiv.org/content/10.1101/2024.06.14.599035v1
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    Transcription Factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress
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    biorxiv.org/content/10.1101/2023.05.30.542913v1
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    Loss-of-function cancer-associated mutations in the EIF4G2 non-canonical translation initiation factor
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    biorxiv.org/content/10.1101/2023.08.22.554280v2
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    Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal Parvalbumin interneurons
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    biorxiv.org/content/10.1101/2024.06.17.599289v2
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    FAM172A controls the nuclear import and alternative splicing function of AGO2
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    biorxiv.org/content/10.1101/2022.03.04.482948v2
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    Specific vulnerability of long telomeres to undergo end fusions revealed by mutational analysis of Rap1
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    biorxiv.org/content/10.1101/2021.12.16.472883v1
  103. www.biorxiv.org www.biorxiv.org
    STAT1 is required to establish but not maintain IFNγ-induced transcriptional memory
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    biorxiv.org/content/10.1101/2022.09.17.508285v1
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    RNA sensing via LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency
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    Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish
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  125. Oct 2024
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    TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44
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    Metabolic resistance of Abeta3pE-42, epitope of the anti-Alzheimer therapeutic antibody, donanemab.
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    FAM111A regulates replication origin activation and cell fitness
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    Differential Modulation of Polycomb-Associated Histone Marks by cBAF, pBAF, and gBAF Complexes
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    A Novel Role for CSA in the Regulation of Nuclear Envelope Integrity: Uncovering a Non-Canonical Function
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  135. Sep 2024
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    Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons
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    The mitotic surveillance pathway requires PLK1-dependent 53BP1 displacement from kinetochores
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    Passive diffusion accounts for the majority of intracellular vesicle transport
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  145. Jul 2024
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    Global Huntingtin Knockout in Adult Mice Leads to Fatal Neurodegeneration that Spares the Pancreas
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    Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain
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    Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activity
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  152. Jun 2024
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    Translation inhibition efficacy does not determine the Plasmodium berghei liver stage antiplasmodial efficacy of protein synthesis inhibitors
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    The type of DNA damage response after Decitabine treatment depends on the level of DNMT activity
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    Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
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    Trim66 paternal deficiency causes intrauterine overgrowth
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    The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts
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  158. May 2024
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    DNA binding site II is required for RAD51 recombinogenic activity in Arabidopsis thaliana
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    Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
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    ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
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    K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific interactors.
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    IGHMBP2 deletion suppresses translation and activates the integrated stress response
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    Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome: mechanism of action and therapeutic potential
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    Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia
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  168. Apr 2024
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    Integrative DNA methylation analysis of pediatric brain tumors reveals tumor type-specific developmental trajectories and epigenetic signatures of malignancy
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    pADP-ribosylation Regulates the Cytoplasmic Localization, Cleavage and Pro-apoptotic Function of HuR
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    Condensate functionalization with motors directs their nucleation in space and allows manipulating RNA localization
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  172. Mar 2024
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    The P4-ATPase Drs2 regulates the homeostasis of Atg9
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    Plant YTHDF proteins are direct effectors of antiviral immunity against an m6A-containing RNA virus
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    Circadian Transcriptomic and Epigenomic Remodeling in Response to Lipid Overload and Human Obesity
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    Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors
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    Structural and biochemical insights into heterotetramer formation between human oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
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    The memory of airway epithelium damage in smokers and COPD patients
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    Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography
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    Micronucleus Is Not a Potent Inducer of cGAS-STING Pathway
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    CLN3 deficiency leads to neurological and metabolic perturbations during early development
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    A nuclear signal in prophase determines centrosome positioning and ensures efficient mitotic spindle assembly
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    The origin, evolution and molecular diversity of the chemokine system
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  187. Feb 2024
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    Cryo-EM structure of lipid embedded human ABCA7 at 3.6 &Aring resolution
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    Canalisation and plasticity on the developmental manifold of Caenorhabditis elegans
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    Histology-associated transcriptomic heterogeneity in ovarian folliculogenesis revealed by quantitative single-cell RNA-sequencing for tissue sections with DRaqL
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    Pioneer activity distinguishes activating from non-activating pluripotency transcription factor binding sites
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    CRISPR-Cas9-mediated genome engineering exaggerates genomic deletion at 10q23.31 including the PTEN gene locus mimicking cancer profiles
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  193. Jan 2024
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    Convergent Insulin and TGF-β signalling drives cancer cachexia by promoting aberrant fatbody ECM accumulation in a Drosophila tumour model
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    Proteomic-based stratification of intermediate-risk prostate cancer patients
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    Human RAD52 stimulates the RAD51-mediated homology search
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    The structural basis for deubiquitination by the fingerless USP-type effector TssM
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    Changes in searching behaviour of CSL transcription complexes in Notch active conditions
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    Human liver organoids model progressive inflammatory and fibrotic injury in non-alcoholic fatty liver disease
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    Arp2/3 inhibition switches Eps8’s network associations to favour longer actin filament formation necessary for tunneling nanotubes
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  201. Dec 2023
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    Monomeric α-Synuclein activates the Plasma Membrane Calcium Pump
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    RIF1 ensures the organization of replication factories upon DNA replicative stress.
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    TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA
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    biorxiv.org/content/10.1101/2023.04.21.537799v2
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    Decline of DNA damage response along with myogenic differentiation
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    biorxiv.org/content/10.1101/2023.06.27.546688v1
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    Enhancer-driven local 3D chromatin domain folding modulates transcription in human mammary tumor cells
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    biorxiv.org/content/10.1101/2023.10.17.562690v1
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    Structural analysis shows that the BIR2 domain of E3 ligase XIAP binds across the RIP2 kinase dimer interface
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    biorxiv.org/content/10.1101/2022.10.14.512215v1
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    The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
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    biorxiv.org/content/10.1101/2022.10.03.510613v1
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    Adult neural stem cells and neurogenesis are resilient to intermittent fasting
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    biorxiv.org/content/10.1101/2022.07.08.499318v2
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    Adaptive Pathfinding by Nucleokinesis during Amoeboid Migration
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    biorxiv.org/content/10.1101/2023.05.19.540965v1
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    The ribosome-associated chaperone Zuo1 controls translation upon TORC1 inhibition
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    biorxiv.org/content/10.1101/2022.12.09.519716v1
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    Molecular view of ER membrane remodeling by the Sec61/TRAP translocon
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    biorxiv.org/content/10.1101/2022.09.30.510141v1
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    Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex
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    biorxiv.org/content/10.1101/2023.06.06.543957v1
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    Mitochondrial phosphoproteomes are functionally specialized across tissues
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    biorxiv.org/content/10.1101/2022.03.23.485457v1
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    Protein phosphatase 1 regulates core PCP signaling
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    biorxiv.org/content/10.1101/2023.09.12.556998v1
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    Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis
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    biorxiv.org/content/10.1101/2022.12.19.521008v1
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    Circadian oscillation in primary cilium length by clock genes regulate fibroblast cell migration
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    biorxiv.org/content/10.1101/2023.01.24.525311v2
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    Propylene glycol inactivates respiratory viruses and prevents airborne transmission
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    biorxiv.org/content/10.1101/2023.02.13.528349v1
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    The nucleolar protein GNL3 prevents resection of stalled replication forks.
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    biorxiv.org/content/10.1101/2022.10.27.514025v2
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    The Response of the Eukaryotic Replisome to G-quadruplex- and i-motif-forming Sequences
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    biorxiv.org/content/10.1101/2022.11.18.517070v2
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    Thiol reductive stress activates the hypoxia response pathway
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    biorxiv.org/content/10.1101/2023.03.06.531274v2
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    Paralog dispensability shapes homozygous deletion patterns in tumor genomes
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    biorxiv.org/content/10.1101/2022.06.20.496722v3
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    Enucleation of the C. elegans embryo revealed the mechanism of dynein-dependent spacing between microtubule asters
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    Epithelial lumen development requires differential participation of the vertebrate clathrin light chain isoforms with dominance of CLCa in vivo
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    biorxiv.org/content/10.1101/2023.04.25.538235v2
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    Identification of FAM53C as a suppressive binding protein of a neurodevelopmental disorders-related kinase DYRK1A
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    biorxiv.org/content/10.1101/2023.04.21.537794v2
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    Modeling of Aberrant Epithelial Reprogramming in Idiopathic Pulmonary Fibrosis using Human Induced Pluripotent Stem Cell-derived Alveolar Organoids
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    biorxiv.org/content/10.1101/2022.06.15.496102v1
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    Detecting Cell Contact-dependent Gene Expression from Spatial Transcriptomics Data
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    biorxiv.org/content/10.1101/2022.02.16.480673v2
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    Downregulation of stromal syntenin sustains AML development
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    Multi-omic network analysis identified betacellulin as a novel target of omega-3 fatty acid attenuation of western diet-induced nonalcoholic steatohepatitis
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    biorxiv.org/content/10.1101/2022.10.03.510635v2
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    Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion
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    biorxiv.org/content/10.1101/2023.03.13.532401v1
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    DONSON is required for CMG helicase assembly in the mammalian cell cycle
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    biorxiv.org/content/10.1101/2023.08.16.553614v1