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    Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1b
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    1. EMBOpress 04 Oct 2024

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    biorxiv.org/content/10.1101/2023.10.19.563039v1
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    FAM111A regulates replication origin activation and cell fitness
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    1. EMBOpress 04 Oct 2024

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    biorxiv.org/content/10.1101/2020.04.22.055574v1
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    Regulation of proteostasis by sleep through autophagy in Drosophila models of Alzheimer's Disease
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    1. EMBOpress 04 Oct 2024

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    biorxiv.org/content/10.1101/2024.07.01.601554v1
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    Differential Modulation of Polycomb-Associated Histone Marks by cBAF, pBAF, and gBAF Complexes
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    1. EMBOpress 03 Oct 2024

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    biorxiv.org/content/10.1101/2023.09.23.557848v2
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    A Novel Role for CSA in the Regulation of Nuclear Envelope Integrity: Uncovering a Non-Canonical Function
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    1. EMBOpress 03 Oct 2024

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    biorxiv.org/content/10.1101/2023.12.14.571633v1
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    Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism
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    1. EMBOpress 03 Oct 2024

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    biorxiv.org/content/10.1101/2023.08.22.554238v1
  8. Sep 2024
  9. www.biorxiv.org www.biorxiv.org
    Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons
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    1. EMBOpress 24 Sep 2024

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    biorxiv.org/lookup/doi/10.1101/2023.10.02.560439
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    Proteomic analysis reveals microvesicles containing NAMPT as mediators of radiation resistance in glioma
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    1. EMBOpress 11 Sep 2024

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    biorxiv.org/lookup/doi/10.1101/2022.03.23.485479
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    De-tensioning of collagen fibers optimizes endometrial receptivity and improves the rate of embryo implantation
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    1. EMBOpress 10 Sep 2024

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    biorxiv.org/lookup/doi/10.1101/2022.01.18.476712
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    A highly scalable approach to topic modelling in single-cell data by approximate pseudobulk projection
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    1. EMBOpress 10 Sep 2024

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    biorxiv.org/lookup/doi/10.1101/2024.02.21.581497
  13. Aug 2024
  14. www.biorxiv.org www.biorxiv.org
    Passive diffusion accounts for the majority of intracellular vesicle transport
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    1. EMBOpress 20 Aug 2024

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    biorxiv.org/content/10.1101/2023.05.10.540182v1
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    RedRibbon: A new rank-rank hypergeometric overlap pipeline to compare gene and transcript expression signatures
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    1. EMBOpress 01 Aug 2024

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    biorxiv.org/content/10.1101/2022.08.31.505818v1
  16. Jul 2024
  17. www.biorxiv.org www.biorxiv.org
    Global Huntingtin Knockout in Adult Mice Leads to Fatal Neurodegeneration that Spares the Pancreas
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    1. EMBOpress 31 Jul 2024

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    biorxiv.org/content/10.1101/2024.01.11.575238v1
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    Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis
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    1. EMBOpress 30 Jul 2024

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    biorxiv.org/content/10.1101/2023.11.24.568591v2
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    A large-scale cancer-specific protein-DNA interaction network
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    1. EMBOpress 30 Jul 2024

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    biorxiv.org/content/10.1101/2024.01.24.577099v1
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    Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain
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    1. EMBOpress 24 Jul 2024

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    biorxiv.org/content/10.1101/2023.12.21.572875v2
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    Exploring the molecular composition of the multipass translocon in its native membrane environment
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    1. EMBOpress 02 Jul 2024

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    biorxiv.org/content/10.1101/2023.11.28.569136v1
  22. www.biorxiv.org www.biorxiv.org
    Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activity
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    1. EMBOpress 02 Jul 2024

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    biorxiv.org/content/10.1101/2023.12.18.572154v1
  23. Jun 2024
  24. www.biorxiv.org www.biorxiv.org
    Translation inhibition efficacy does not determine the Plasmodium berghei liver stage antiplasmodial efficacy of protein synthesis inhibitors
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    1. EMBOpress 27 Jun 2024

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    biorxiv.org/content/10.1101/2023.12.07.570699v1
  25. www.biorxiv.org www.biorxiv.org
    The type of DNA damage response after Decitabine treatment depends on the level of DNMT activity
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    1. EMBOpress 26 Jun 2024

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    biorxiv.org/content/10.1101/2023.09.02.556017v2
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    Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
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    1. EMBOpress 05 Jun 2024

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    biorxiv.org/content/10.1101/2022.06.14.495968v1
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    Trim66 paternal deficiency causes intrauterine overgrowth
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    biorxiv.org/content/10.1101/2024.02.12.579976v1
  28. www.biorxiv.org www.biorxiv.org
    The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts
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    biorxiv.org/content/10.1101/2022.08.08.503265v1
  29. May 2024
  30. www.biorxiv.org www.biorxiv.org
    DNA binding site II is required for RAD51 recombinogenic activity in Arabidopsis thaliana
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    1. EMBOpress 31 May 2024

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    biorxiv.org/content/10.1101/2024.03.07.583932v1
  31. www.biorxiv.org www.biorxiv.org
    Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
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    1. EMBOpress 31 May 2024

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    biorxiv.org/content/10.1101/2022.12.20.521247v1
  32. www.biorxiv.org www.biorxiv.org
    ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
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    1. EMBOpress 30 May 2024

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    biorxiv.org/content/10.1101/2024.01.17.576039v1
  33. www.biorxiv.org www.biorxiv.org
    K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific interactors.
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    1. EMBOpress 29 May 2024

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    biorxiv.org/content/10.1101/2024.01.08.574586v1
  34. www.biorxiv.org www.biorxiv.org
    IGHMBP2 deletion suppresses translation and activates the integrated stress response
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    1. EMBOpress 29 May 2024

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    biorxiv.org/content/10.1101/2023.12.11.571166v2
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    Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia
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    1. EMBOpress 08 May 2024

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    biorxiv.org/content/10.1101/2023.10.18.562916v1
  36. Apr 2024
  37. www.biorxiv.org www.biorxiv.org
    Integrative DNA methylation analysis of pediatric brain tumors reveals tumor type-specific developmental trajectories and epigenetic signatures of malignancy
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    1. EMBOpress 27 Apr 2024

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    biorxiv.org/content/10.1101/2022.03.14.483566v2
  38. www.biorxiv.org www.biorxiv.org
    pADP-ribosylation Regulates the Cytoplasmic Localization, Cleavage and Pro-apoptotic Function of HuR
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    1. EMBOpress 25 Apr 2024

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    biorxiv.org/content/10.1101/2023.08.07.552262v1
  39. Mar 2024
  40. www.biorxiv.org www.biorxiv.org
    Circadian Transcriptomic and Epigenomic Remodeling in Response to Lipid Overload and Human Obesity
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    1. EMBOpress 09 Mar 2024

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    biorxiv.org/content/10.1101/2021.02.23.432336v4
  41. www.biorxiv.org www.biorxiv.org
    Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors
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    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2023.08.25.554811v1
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    Structural and biochemical insights into heterotetramer formation between human oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
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    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2022.10.10.511529v8
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    The memory of airway epithelium damage in smokers and COPD patients
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    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2021.04.21.439437v3
  44. www.biorxiv.org www.biorxiv.org
    Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography
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    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2023.10.05.560879v1
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    Micronucleus Is Not a Potent Inducer of cGAS-STING Pathway
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    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2023.10.16.561322v1
  46. www.biorxiv.org www.biorxiv.org
    CLN3 deficiency leads to neurological and metabolic perturbations during early development
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    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2023.03.17.533107v1
  47. www.biorxiv.org www.biorxiv.org
    A nuclear signal in prophase determines centrosome positioning and ensures efficient mitotic spindle assembly
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    1. EMBOpress 01 Mar 2024

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    biorxiv.org/content/10.1101/2023.06.14.544905v2
  48. www.biorxiv.org www.biorxiv.org
    The origin, evolution and molecular diversity of the chemokine system
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    1. EMBOpress 01 Mar 2024

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    biorxiv.org/content/10.1101/2023.05.17.541135v2
  49. Feb 2024
  50. www.biorxiv.org www.biorxiv.org
    Histology-associated transcriptomic heterogeneity in ovarian folliculogenesis revealed by quantitative single-cell RNA-sequencing for tissue sections with DRaqL
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    1. EMBOpress 21 Feb 2024

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    biorxiv.org/content/10.1101/2022.12.14.520513v1
  51. www.biorxiv.org www.biorxiv.org
    CRISPR-Cas9-mediated genome engineering exaggerates genomic deletion at 10q23.31 including the PTEN gene locus mimicking cancer profiles
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    1. EMBOpress 03 Feb 2024

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    biorxiv.org/content/10.1101/2023.04.05.535680v1
  52. Jan 2024
  53. www.biorxiv.org www.biorxiv.org
    Proteomic-based stratification of intermediate-risk prostate cancer patients
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    1. EMBOpress 26 Jan 2024

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    biorxiv.org/content/10.1101/2023.03.03.530910v1
  54. www.biorxiv.org www.biorxiv.org
    Human RAD52 stimulates the RAD51-mediated homology search
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    1. EMBOpress 25 Jan 2024

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    biorxiv.org/content/10.1101/2022.06.27.497340v1
  55. www.biorxiv.org www.biorxiv.org
    The structural basis for deubiquitination by the fingerless USP-type effector TssM
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    1. EMBOpress 25 Jan 2024

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    biorxiv.org/content/10.1101/2023.08.01.551441v1
  56. www.biorxiv.org www.biorxiv.org
    Changes in searching behaviour of CSL transcription complexes in Notch active conditions
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    1. EMBOpress 23 Jan 2024

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    biorxiv.org/content/10.1101/2023.08.10.552734v2
  57. Dec 2023
  58. www.biorxiv.org www.biorxiv.org
    RIF1 ensures the organization of replication factories upon DNA replicative stress.
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    1. EMBOpress 16 Dec 2023

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    biorxiv.org/content/10.1101/669234v3
  59. www.biorxiv.org www.biorxiv.org
    Decline of DNA damage response along with myogenic differentiation
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    1. EMBOpress 15 Dec 2023

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    biorxiv.org/content/10.1101/2023.06.27.546688v1
  60. www.biorxiv.org www.biorxiv.org
    Enhancer-driven local 3D chromatin domain folding modulates transcription in human mammary tumor cells
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    1. EMBOpress 15 Dec 2023

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    biorxiv.org/content/10.1101/2023.10.17.562690v1
  61. www.biorxiv.org www.biorxiv.org
    Structural analysis shows that the BIR2 domain of E3 ligase XIAP binds across the RIP2 kinase dimer interface
    1
    1. EMBOpress 15 Dec 2023

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  62. www.biorxiv.org www.biorxiv.org
    Mitochondrial phosphoproteomes are functionally specialized across tissues
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    1. EMBOpress 14 Dec 2023

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    biorxiv.org/content/10.1101/2022.03.23.485457v1
  63. www.biorxiv.org www.biorxiv.org
    Enucleation of the C. elegans embryo revealed the mechanism of dynein-dependent spacing between microtubule asters
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    1. EMBOpress 12 Dec 2023

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    Epithelial lumen development requires differential participation of the vertebrate clathrin light chain isoforms with dominance of CLCa in vivo
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    biorxiv.org/content/10.1101/2023.04.25.538235v2
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    Identification of FAM53C as a suppressive binding protein of a neurodevelopmental disorders-related kinase DYRK1A
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    Modeling of Aberrant Epithelial Reprogramming in Idiopathic Pulmonary Fibrosis using Human Induced Pluripotent Stem Cell-derived Alveolar Organoids
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    Automated staging of zebrafish embryos with deep learning
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    NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma
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    MICA: A multi-omics method to predict gene regulatory networks in early human embryos
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    1. EMBOpress 09 Dec 2023

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  70. Nov 2023
  71. www.biorxiv.org www.biorxiv.org
    Expansion microscopy reveals subdomains in C. elegans germ granules
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    Revisiting degron motifs in human AURKA required for its targeting by APC/C-FZR1
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  73. Oct 2023
  74. www.biorxiv.org www.biorxiv.org
    High Resolution Kinetic Characterization and Dynamic Mathematical Modeling of the RIG-I Signaling Pathway and the Antiviral Responses
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  75. Sep 2023
  76. www.biorxiv.org www.biorxiv.org
    Caspase-4 dimerisation and D289 auto-processing elicits an interleukin-1β converting enzyme
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    Neuroprotective effects of hepatoma-derived growth factor in models of Huntington's disease
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    Structural evidence for elastic tethers connecting separating chromosomes in crane-fly spermatocytes
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  79. www.biorxiv.org www.biorxiv.org
    A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance
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    Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generation
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    Identification of a novel enhancer essential for Satb1 expression in TH2 cells and activated ILC2s.
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  82. www.biorxiv.org www.biorxiv.org
    Spatial metabolomics for symbiotic marine invertebrates
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  83. www.biorxiv.org www.biorxiv.org
    MAP4K3 inhibits Sirtuin-1 to repress LKB1-AMPK to promote amino acid dependent activation of mTORC1
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    biorxiv.org/content/10.1101/2021.11.08.467702v2
  84. www.biorxiv.org www.biorxiv.org
    Origin and segregation of the human germline
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    biorxiv.org/content/10.1101/2022.07.06.498671v1
  85. www.biorxiv.org www.biorxiv.org
    Apolipoprotein E intersects with amyloid-β within neurons
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  86. www.biorxiv.org www.biorxiv.org
    Distant sequence regions of JBP1 contribute to J-DNA binding
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    biorxiv.org/content/10.1101/2023.01.23.525147v1
  87. www.biorxiv.org www.biorxiv.org
    IKBKB reduces huntingtin aggregation by phosphorylating Serine 13 via a non-canonical IKK pathway
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  88. www.biorxiv.org www.biorxiv.org
    Germinal Centers Convergent Evolution and B cell Recirculation in Human Lymph Nodes
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    biorxiv.org/content/10.1101/2022.11.09.463832v9
  89. Aug 2023
  90. www.biorxiv.org www.biorxiv.org
    NLRP3 controls ATM activation in response to DNA damage.
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    biorxiv.org/content/10.1101/2020.05.12.087015v1
  91. www.biorxiv.org www.biorxiv.org
    The C-terminal tail of CSNAP attenuates the CSN complex
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  92. Jul 2023
  93. www.biorxiv.org www.biorxiv.org
    Comparative membrane proteomics reveals diverse cell regulators concentrated at the nuclear envelope
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  94. www.biorxiv.org www.biorxiv.org
    Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20
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    biorxiv.org/content/10.1101/2022.08.22.504726v1
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    Extracellular matrix sensing via modulation of orientational order of integrins and F-actin in focal adhesions
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  96. www.biorxiv.org www.biorxiv.org
    https://biorxiv.org/cgi/content/10.1101/2021.11.16.468777
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  97. www.biorxiv.org www.biorxiv.org
    Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation
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    The cytochrome b carboxyl-terminal region is necessary for mitochondrial Complex III assembly
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    biorxiv.org/content/10.1101/2022.11.25.517933v1
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    arfA antisense RNA regulates MscL excretory activity
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    Antibody reliability influences observed mRNA-protein correlations in tumour samples
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    N-terminal proteoforms may engage in different protein complexes
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  102. www.biorxiv.org www.biorxiv.org
    PI3P dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase
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  103. www.biorxiv.org www.biorxiv.org
    Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
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    biorxiv.org/content/10.1101/2022.10.14.512296v1
  104. Jun 2023
  105. www.biorxiv.org www.biorxiv.org
    Accurate genotype-based demultiplexing of single cell RNA sequencing samples from non-human animals
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  106. www.biorxiv.org www.biorxiv.org
    Structure-based design and characterization of Parkin activating mutations
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    Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins
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    biorxiv.org/content/10.1101/2022.10.27.514032v1
  108. www.biorxiv.org www.biorxiv.org
    Upf3a is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells
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  109. www.biorxiv.org www.biorxiv.org
    Structural insights into ubiquitin chain cleavage by Legionella ovarian tumor deubiquitinases
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    The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells
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    biorxiv.org/content/10.1101/2022.08.19.504520v1
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    Missense variant interaction scanning reveals a critical role of the FERM-F3 domain for tumor suppressor protein NF2 conformation and function
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  112. May 2023
  113. www.biorxiv.org www.biorxiv.org
    BAZ2A-RNA mediated association with TOP2A and KDM1A represses gene expression in prostate cancer
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    biorxiv.org/content/10.1101/2021.07.15.452487v2
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    Recursive splicing discovery using lariats in total RNA sequencing
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    Exploratory Meta-Analysis of Hypoxic Transcriptomes Using a Precise Transcript Reference Sequence Set
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    biorxiv.org/content/10.1101/2022.05.01.489280v2
  116. www.biorxiv.org www.biorxiv.org
    VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome
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    biorxiv.org/content/10.1101/2022.03.16.484566v1
  117. www.biorxiv.org www.biorxiv.org
    Telescoping bimodal latent Dirichlet allocation to identify expression QTLs across tissues
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    1. EMBOpress 26 May 2023

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      PeerReviewed EMBOPress Life Science Alliance genomics
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    biorxiv.org/content/10.1101/2021.10.27.466156v2
  118. www.biorxiv.org www.biorxiv.org
    RAS and PP2A activities converge on epigenetic gene regulation
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    1. EMBOpress 26 May 2023

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      PeerReviewed EMBOPress Life Science Alliance cancer biology
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    biorxiv.org/content/10.1101/2022.05.11.491459v1
  119. www.biorxiv.org www.biorxiv.org
    Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
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    1. EMBOpress 26 May 2023

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      PeerReviewed EMBOPress Life Science Alliance developmental biology
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    biorxiv.org/content/10.1101/2022.05.09.491247v1
  120. www.biorxiv.org www.biorxiv.org
    Gapless provides combined scaffolding, gap filling and assembly correction with long reads
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    1. EMBOpress 26 May 2023

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      PeerReviewed EMBOPress Life Science Alliance bioinformatics
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    biorxiv.org/content/10.1101/2022.03.08.483466v2
  121. www.biorxiv.org www.biorxiv.org
    Z-Flipon Variants reveal the many roles of Z-DNA and Z-RNA in health and disease
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    1. EMBOpress 24 May 2023

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    biorxiv.org/lookup/doi/10.1101/2023.01.12.523822
  122. www.biorxiv.org www.biorxiv.org
    The value of genotype-specific reference for transcriptome analyses
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    1. EMBOpress 14 May 2023

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    biorxiv.org/content/10.1101/2021.09.14.460213v1
  123. www.biorxiv.org www.biorxiv.org
    Genome-wide CRISPRi screening reveals regulators of Alzheimee's tau pathology shared between exosomal and vesicle-free tau seeds.
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    1. EMBOpress 14 May 2023

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      PeerReviewed EMBOPress Life Science Alliance neuroscience
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    biorxiv.org/content/10.1101/2022.04.26.489622v1
  124. www.biorxiv.org www.biorxiv.org
    Small non-coding vault RNA1-2 modulate expression of cell membrane proteins through nascent RNA silencing
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    1. EMBOpress 11 May 2023

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      PeerReviewed EMBOPress Life Science Alliance molecular biology
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    biorxiv.org/content/10.1101/2022.08.12.503724v2
  125. www.biorxiv.org www.biorxiv.org
    LuminoCell: a versatile and affordable luminometer platform for monitoring in-cell luciferase-based reporters
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    1. EMBOpress 11 May 2023

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    biorxiv.org/content/10.1101/2022.01.28.478134v1
  126. Apr 2023
  127. www.biorxiv.org www.biorxiv.org
    Efficient knock-in method enabling lineage tracing in zebrafish
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    1. EMBOpress 12 Apr 2023

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    biorxiv.org/content/10.1101/2022.07.15.500272v1
  128. www.biorxiv.org www.biorxiv.org
    The TUDOR domain of SMN is an H3K79me1 histone mark reader
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    1. EMBOpress 11 Apr 2023

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      PeerReviewed EMBOPress Life Science Alliance biochemistry
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    biorxiv.org/content/10.1101/2022.10.06.511070v1
  129. www.biorxiv.org www.biorxiv.org
    Preference of CAMSAP3 for microtubules with expanded lattice contributes to stabilization of the minus end
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    1. EMBOpress 11 Apr 2023

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      PeerReviewed EMBOPress Life Science Alliance biophysics
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    biorxiv.org/content/10.1101/2022.08.21.504720v2
  130. www.biorxiv.org www.biorxiv.org
    Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells
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    1. EMBOpress 11 Apr 2023

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      PeerReviewed EMBOPress Life Science Alliance systems biology
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    biorxiv.org/content/10.1101/2022.08.15.503960v1