416 Matching Annotations
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    GPLD1 functions as a scavenger chaperone mediating lysosomal degradation of extracellular aberrant proteins
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    biorxiv.org/lookup/doi/10.1101/2025.07.16.665076
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    Optimization of systemic AAV9 gene therapy in Niemann-Pick disease type C1 mice
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    biorxiv.org/lookup/doi/10.1101/2024.06.07.597901
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    The chromatin remodeler DEK promotes proliferation of mammary epithelium and is associated with H3K27me3 epigenetic modifications
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    biorxiv.org/content/10.1101/2024.09.09.612116v1
  5. Jun 2026
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    Cross-Species Transcriptomic Integration Reveals a MIRO1-Mediated Macrophage-to-T Cell Signaling Axis Alginging with Immunosuppression in Glioma
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    biorxiv.org/lookup/doi/10.1101/2025.11.10.686781
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    Vsb1, Ypq1 and Ypq2 control dynamic cationic amino acid storage in the yeast vacuole
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    biorxiv.org/lookup/doi/10.1101/2025.09.11.675521
  8. May 2026
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    Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets
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    biorxiv.org/lookup/doi/10.1101/2025.09.05.674429
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    The mechanosensitive Ca2+-permeable ion channel PIEZO1 promotes satellite cell function in skeletal muscle regeneration
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    biorxiv.org/lookup/doi/10.1101/2021.03.18.435982
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    In vitro approaches to study centriole and cilium function in early mouse embryogenesis
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    biorxiv.org/lookup/doi/10.1101/2025.03.21.644416
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    GPR88 localization to primary cilia in neurons is cell-type specific.
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    biorxiv.org/lookup/doi/10.1101/2025.05.28.656656
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    Chromatin states contribute to coordinated allelic transcriptional bursting to drive iPSC reprogramming
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    biorxiv.org/lookup/doi/10.1101/2023.07.13.548864
  14. Apr 2026
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    Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathways
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    biorxiv.org/lookup/doi/10.1101/2024.12.27.630542
  16. Mar 2026
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    Tissue-specific I-Smad mechanisms revealed by structure-function analysis in Drosophila
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    biorxiv.org/lookup/doi/10.1101/2025.06.20.660739
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    TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner
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    biorxiv.org/lookup/doi/10.1101/2024.12.04.626765
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    The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress
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    Syk activation during FcγR-mediated phagocytosis involves Syk palmitoylation and desulfenylation
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    biorxiv.org/lookup/doi/10.1101/2025.05.26.656092
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    TBK1 activity regulates the directionality of axonal transport of signalling endosomes
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    biorxiv.org/lookup/doi/10.1101/2025.09.03.674015
  22. Feb 2026
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    Cryo-EM structure of the tetra-phosphorylated R-domain in Ycf1 reveals key interactions for transport regulation
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    biorxiv.org/content/10.1101/2024.03.06.583773v2
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    Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung
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    biorxiv.org/content/10.1101/2024.12.12.628112v1
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    Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation.
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    Amyloid-β fibrils accumulated in preeclamptic placentas suppress syncytialization of cytotrophoblasts
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    biorxiv.org/content/10.1101/2025.03.06.641957v1
  27. Jan 2026
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    Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation
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    Intravital imaging the formation and resolution of MHC class II-positive T cell activation niches
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    biorxiv.org/lookup/doi/10.1101/2025.08.05.668796
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    Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD
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    RB dependent transcriptional regulation at mitotic centromeres preserves genome stability
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    Development of a pipeline to evaluate YAP-TEAD inhibitor potential - direct TEAD inhibition represses cancerous growth in a NF2-mutant model of mesothelioma
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    Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer
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    An integrated stress response-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation
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  35. Dec 2025
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    Identification of M-Sec as a unique cellular regulator of CSF-1 receptor activation
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  37. Nov 2025
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    PARP10 is Critical for Stress Granule Initiation
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    Beneficial and detrimental consequences of AHR activation in intestinal infection
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    Antioxidant properties of dihydroxy B-ring flavonoids modulate circadian amplitude in Arabidopsis
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  41. Oct 2025
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    Comparison of Infinium MethylationEPIC v2.0 to v1.0 for human population epigenetics: considerations for addressing EPIC version differences in DNA methylation-based tools
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    biorxiv.org/lookup/doi/10.1101/2024.07.02.600461
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    Genome-scale prediction of gene ontology from mass fingerprints reveals new metabolic gene functions
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    biorxiv.org/lookup/doi/10.1101/2024.11.27.625594
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    Hepatitis E Virus-induced antiviral response by plasmacytoid dendritic cells is modulated by the ORF2 protein
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  45. Sep 2025
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    Differential cell survival outcomes in response to diverseamino acid stress
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    Co-occurrence of essential gene dispensability and bypass suppressor mutations across species
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  48. Aug 2025
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    Gut microbiome remains stable following COVID-19 vaccination in healthy and immuno-compromised individuals
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    Chondrodysplasia-inducing COL2A1 p.Gly1170Ser causes an ER storage defect without associated unfolded protein response in a human cartilage model
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    biorxiv.org/content/10.1101/2023.10.19.562780v4
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    Computing hematopoiesis plasticity in response to genetic mutations and environmental stimulations
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    The nucleocytoplasmic translocation of HINT1 regulates the maturation of cell density
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    In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals
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    biorxiv.org/lookup/doi/10.1101/2024.12.06.627170
  54. Jul 2025
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    Multiple domains of scaffold Tudor protein play non-redundant roles in Drosophila germline
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    biorxiv.org/lookup/doi/10.1101/2025.03.13.643173
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    PSME3 Regulates Migration and Differentiation of Myoblasts
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    biorxiv.org/content/10.1101/2025.01.08.632048v1
  57. Jun 2025
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    Wound closure after brain injury relies on force generation by microglia in zebrafish
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  59. May 2025
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    AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation
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    Lipid-driven SRC self-association modulates its transformation capacity
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    biorxiv.org/content/10.1101/2024.11.12.623151v1
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    STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs
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    biorxiv.org/content/10.1101/2024.12.20.629685v1
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    Optogenetic control of pheromone gradients reveals functional limits of mating behavior in budding yeast
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    DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance
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    Shared requirement for MYC upstream super-enhancer in tissue regeneration and cancer
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    biorxiv.org/content/10.1101/2022.11.04.515076v2
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    Predicting cell cycle stage from 3D single-cell nuclear-stained images
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    Matrix-driven jamming dynamics mediates transition of ovarian cancer spheroids to stable morphologies
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    Molecular mechanism of bacteriophage tail contraction- structure of an S-layer-penetrating bacteriophage
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    Divergent Plasmodium protein kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
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    The late onset Alzheimer’s disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis
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    Diversification of Dentate Gyrus Granule Cell Subtypes is Regulated by Neuregulin1 Nuclear Back Signaling.
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    Variety in the USP deubiquitinase catalytic mechanism
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    Mechanical forces and ligand-binding modulate Pseudomonas aeruginosa PilY1 mechanosensitive protein
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    MDC1 mediates Pellino recruitment to sites of DNA double-strand breaks
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    Novel determinants of NOTCH1 trafficking and signaling in breast epithelial cells
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    DICE: Fast and Accurate Distance-Based Reconstruction of Single-Cell Copy Number Phylogenies
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    biorxiv.org/content/10.1101/2024.06.03.597037v1
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    Canonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate
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    Mitochondrial Signatures Shape Phenotype Switching and Apoptosis in Response to PLK1 and RSK Inhibitors in Melanoma
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    Transcription Factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress
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    Loss-of-function cancer-associated mutations in the EIF4G2 non-canonical translation initiation factor
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    biorxiv.org/content/10.1101/2023.08.22.554280v2
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    Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal Parvalbumin interneurons
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    FAM172A controls the nuclear import and alternative splicing function of AGO2
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  83. Dec 2024
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    N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs
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    4G cloning: rapid gene assembly for expression of multisubunit protein complexes in diverse hosts
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    Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor-tumor connections
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    Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in mice
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    A complete digital karyotype of the B-cell leukemia REH cell line resolved by long-read sequencing
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    biorxiv.org/content/10.1101/2023.03.08.531483v1
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    Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice
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    Transcriptional regulators ensuring specific gene expression and decision making at high TGFβ doses
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    biorxiv.org/content/10.1101/2024.04.23.590740v1
  91. Nov 2024
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    Mass spectrometry-based proteomic exploration of diverse murine macrophage cellular models
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    Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein
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    biorxiv.org/content/10.1101/2024.06.10.598172v2
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    Cell–cell adhesion drives patterning in stratified epithelia
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    Deregulation of multiple mechanisms shapes the onset of LAMA2-congenital muscular dystrophy
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    CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation
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    The hGID GID4 E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration
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    Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish
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  99. Oct 2024
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    TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44
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    Metabolic resistance of Abeta3pE-42, epitope of the anti-Alzheimer therapeutic antibody, donanemab.
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    Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis
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    Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1b
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    biorxiv.org/content/10.1101/2023.10.19.563039v1
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    FAM111A regulates replication origin activation and cell fitness
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    Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins
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    biorxiv.org/content/10.1101/2022.10.27.514032v1
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    Upf3a is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells
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    biorxiv.org/content/10.1101/2022.07.04.495064v2
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    Structural insights into ubiquitin chain cleavage by Legionella ovarian tumor deubiquitinases
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    Missense variant interaction scanning reveals a critical role of the FERM-F3 domain for tumor suppressor protein NF2 conformation and function
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  213. May 2023
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    BAZ2A-RNA mediated association with TOP2A and KDM1A represses gene expression in prostate cancer
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    Exploratory Meta-Analysis of Hypoxic Transcriptomes Using a Precise Transcript Reference Sequence Set
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    VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome
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    biorxiv.org/content/10.1101/2022.03.16.484566v1
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    RAS and PP2A activities converge on epigenetic gene regulation
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    Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
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    Gapless provides combined scaffolding, gap filling and assembly correction with long reads
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    Z-Flipon Variants reveal the many roles of Z-DNA and Z-RNA in health and disease
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    The value of genotype-specific reference for transcriptome analyses
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    Genome-wide CRISPRi screening reveals regulators of Alzheimee's tau pathology shared between exosomal and vesicle-free tau seeds.
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    Small non-coding vault RNA1-2 modulate expression of cell membrane proteins through nascent RNA silencing
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    LuminoCell: a versatile and affordable luminometer platform for monitoring in-cell luciferase-based reporters
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  227. Apr 2023
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    Efficient knock-in method enabling lineage tracing in zebrafish
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    The TUDOR domain of SMN is an H3K79me1 histone mark reader
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    Preference of CAMSAP3 for microtubules with expanded lattice contributes to stabilization of the minus end
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    Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells
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  232. Mar 2023
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    Peroxisomes contribute to intracellular calcium dynamics
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    An extended DNA-free intranuclear compartment organizes centrosomal microtubules in Plasmodium falciparum
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    Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16
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    The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation, epithelial repair, and tumor growth
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    Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition
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    biorxiv.org/content/10.1101/2021.10.03.462949v4