380 Matching Annotations
  1. Aug 2025
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    Gut microbiome remains stable following COVID-19 vaccination in healthy and immuno-compromised individuals
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    biorxiv.org/lookup/doi/10.1101/2023.08.23.554506
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    Chondrodysplasia-inducing COL2A1 p.Gly1170Ser causes an ER storage defect without associated unfolded protein response in a human cartilage model
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    biorxiv.org/lookup/doi/10.1101/2023.10.19.562780
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    Computing hematopoiesis plasticity in response to genetic mutations and environmental stimulations
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    biorxiv.org/lookup/doi/10.1101/2024.08.02.606315
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    The nucleocytoplasmic translocation of HINT1 regulates the maturation of cell density
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    biorxiv.org/lookup/doi/10.1101/2025.01.13.632869
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    In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals
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    biorxiv.org/lookup/doi/10.1101/2024.12.06.627170
  7. Jul 2025
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    Multiple domains of scaffold Tudor protein play non-redundant roles in Drosophila germline
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    biorxiv.org/lookup/doi/10.1101/2025.03.13.643173
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    PSME3 Regulates Migration and Differentiation of Myoblasts
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    biorxiv.org/content/10.1101/2025.01.08.632048v1
  10. Jun 2025
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    Wound closure after brain injury relies on force generation by microglia in zebrafish
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    biorxiv.org/lookup/doi/10.1101/2024.06.04.597300
  12. May 2025
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    AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation
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    biorxiv.org/content/10.1101/2024.11.01.621527v1
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    Lipid-driven SRC self-association modulates its transformation capacity
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    biorxiv.org/content/10.1101/2024.11.12.623151v1
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    STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs
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    biorxiv.org/content/10.1101/2024.12.20.629685v1
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    Optogenetic control of pheromone gradients reveals functional limits of mating behavior in budding yeast
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    biorxiv.org/content/10.1101/2024.02.06.578657v2
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    DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance
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    biorxiv.org/content/10.1101/2025.02.17.638677v1
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    Shared requirement for MYC upstream super-enhancer in tissue regeneration and cancer
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    biorxiv.org/content/10.1101/2022.11.04.515076v2
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    Predicting cell cycle stage from 3D single-cell nuclear-stained images
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    biorxiv.org/content/10.1101/2024.08.30.610553v2
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    Matrix-driven jamming dynamics mediates transition of ovarian cancer spheroids to stable morphologies
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    biorxiv.org/content/10.1101/2022.02.09.479678v3
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    Molecular mechanism of bacteriophage tail contraction- structure of an S-layer-penetrating bacteriophage
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    biorxiv.org/content/10.1101/2023.08.04.551987v1
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    Divergent Plasmodium protein kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
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    biorxiv.org/content/10.1101/2024.09.22.613647v1
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    The late onset Alzheimer’s disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis
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    biorxiv.org/content/10.1101/2024.09.13.612888v1
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    Diversification of Dentate Gyrus Granule Cell Subtypes is Regulated by Neuregulin1 Nuclear Back Signaling.
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    biorxiv.org/content/10.1101/2024.10.15.618334v1
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    Variety in the USP deubiquitinase catalytic mechanism
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    biorxiv.org/content/10.1101/2023.07.24.550302v2
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    Mechanical forces and ligand-binding modulate Pseudomonas aeruginosa PilY1 mechanosensitive protein
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    biorxiv.org/content/10.1101/2023.08.03.551776v3
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    MDC1 mediates Pellino recruitment to sites of DNA double-strand breaks
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    biorxiv.org/content/10.1101/2024.07.20.604390v1
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    Novel determinants of NOTCH1 trafficking and signaling in breast epithelial cells
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    biorxiv.org/content/10.1101/2023.03.05.531156v2
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    DICE: Fast and Accurate Distance-Based Reconstruction of Single-Cell Copy Number Phylogenies
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    biorxiv.org/content/10.1101/2024.06.03.597037v1
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    Canonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate
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    biorxiv.org/content/10.1101/2024.08.07.606990v1
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    Mitochondrial Signatures Shape Phenotype Switching and Apoptosis in Response to PLK1 and RSK Inhibitors in Melanoma
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    biorxiv.org/content/10.1101/2024.06.14.599035v1
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    Transcription Factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress
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    biorxiv.org/content/10.1101/2023.05.30.542913v1
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    Loss-of-function cancer-associated mutations in the EIF4G2 non-canonical translation initiation factor
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    biorxiv.org/content/10.1101/2023.08.22.554280v2
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    Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal Parvalbumin interneurons
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    biorxiv.org/content/10.1101/2024.06.17.599289v2
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    FAM172A controls the nuclear import and alternative splicing function of AGO2
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    biorxiv.org/content/10.1101/2022.03.04.482948v2
  36. Dec 2024
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    N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs
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    biorxiv.org/content/10.1101/2023.06.20.545713v4
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    4G cloning: rapid gene assembly for expression of multisubunit protein complexes in diverse hosts
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    biorxiv.org/content/10.1101/2024.06.17.599261v1
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    Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor-tumor connections
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    biorxiv.org/content/10.1101/2024.03.26.586725v1
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    Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in mice
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    biorxiv.org/content/10.1101/2024.04.09.588709v1
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    A complete digital karyotype of the B-cell leukemia REH cell line resolved by long-read sequencing
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    biorxiv.org/content/10.1101/2023.03.08.531483v1
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    Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice
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    biorxiv.org/content/10.1101/2023.03.14.532682v2
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    Transcriptional regulators ensuring specific gene expression and decision making at high TGFβ doses
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    biorxiv.org/content/10.1101/2024.04.23.590740v1
  44. Nov 2024
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    Mass spectrometry-based proteomic exploration of diverse murine macrophage cellular models
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    biorxiv.org/content/10.1101/2024.04.09.588684v1
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    Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein
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    biorxiv.org/content/10.1101/2024.06.10.598172v2
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    Cell–cell adhesion drives patterning in stratified epithelia
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    biorxiv.org/content/10.1101/2023.11.24.567740v1
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    Deregulation of multiple mechanisms shapes the onset of LAMA2-congenital muscular dystrophy
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    biorxiv.org/content/10.1101/2024.01.20.576409v1
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    CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation
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    biorxiv.org/content/10.1101/2024.05.29.596395v1
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    The hGID GID4 E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration
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    biorxiv.org/content/10.1101/2023.07.20.549906v1
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    Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish
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    biorxiv.org/content/10.1101/2024.03.17.585386v1
  52. Oct 2024
  53. www.biorxiv.org www.biorxiv.org
    TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44
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    biorxiv.org/content/10.1101/2024.06.12.598629v1
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    Metabolic resistance of Abeta3pE-42, epitope of the anti-Alzheimer therapeutic antibody, donanemab.
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    biorxiv.org/content/10.1101/2024.01.30.578111v1
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    Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis
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    biorxiv.org/content/10.1101/2024.03.18.585508v1
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    Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1b
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    biorxiv.org/content/10.1101/2023.10.19.563039v1
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    FAM111A regulates replication origin activation and cell fitness
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    biorxiv.org/content/10.1101/2020.04.22.055574v1
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    Regulation of proteostasis by sleep through autophagy in Drosophila models of Alzheimer's Disease
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    biorxiv.org/content/10.1101/2024.07.01.601554v1
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    Differential Modulation of Polycomb-Associated Histone Marks by cBAF, pBAF, and gBAF Complexes
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    biorxiv.org/content/10.1101/2023.09.23.557848v2
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    A Novel Role for CSA in the Regulation of Nuclear Envelope Integrity: Uncovering a Non-Canonical Function
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    biorxiv.org/content/10.1101/2023.12.14.571633v1
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    Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism
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    biorxiv.org/content/10.1101/2023.08.22.554238v1
  62. Sep 2024
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    Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons
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    Proteomic analysis reveals microvesicles containing NAMPT as mediators of radiation resistance in glioma
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    biorxiv.org/lookup/doi/10.1101/2022.03.23.485479
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    De-tensioning of collagen fibers optimizes endometrial receptivity and improves the rate of embryo implantation
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    biorxiv.org/lookup/doi/10.1101/2022.01.18.476712
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    A highly scalable approach to topic modelling in single-cell data by approximate pseudobulk projection
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    biorxiv.org/lookup/doi/10.1101/2024.02.21.581497
  67. Aug 2024
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    Passive diffusion accounts for the majority of intracellular vesicle transport
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    biorxiv.org/content/10.1101/2023.05.10.540182v1
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    RedRibbon: A new rank-rank hypergeometric overlap pipeline to compare gene and transcript expression signatures
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    biorxiv.org/content/10.1101/2022.08.31.505818v1
  70. Jul 2024
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    Global Huntingtin Knockout in Adult Mice Leads to Fatal Neurodegeneration that Spares the Pancreas
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    biorxiv.org/content/10.1101/2024.01.11.575238v1
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    Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis
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    biorxiv.org/content/10.1101/2023.11.24.568591v2
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    A large-scale cancer-specific protein-DNA interaction network
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    biorxiv.org/content/10.1101/2024.01.24.577099v1
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    Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain
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    biorxiv.org/content/10.1101/2023.12.21.572875v2
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    Exploring the molecular composition of the multipass translocon in its native membrane environment
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    biorxiv.org/content/10.1101/2023.11.28.569136v1
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    Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activity
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    biorxiv.org/content/10.1101/2023.12.18.572154v1
  77. Jun 2024
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    Translation inhibition efficacy does not determine the Plasmodium berghei liver stage antiplasmodial efficacy of protein synthesis inhibitors
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    biorxiv.org/content/10.1101/2023.12.07.570699v1
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    The type of DNA damage response after Decitabine treatment depends on the level of DNMT activity
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    biorxiv.org/content/10.1101/2023.09.02.556017v2
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    Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
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    biorxiv.org/content/10.1101/2022.06.14.495968v1
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    Trim66 paternal deficiency causes intrauterine overgrowth
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    biorxiv.org/content/10.1101/2024.02.12.579976v1
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    The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts
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    biorxiv.org/content/10.1101/2022.08.08.503265v1
  83. May 2024
  84. www.biorxiv.org www.biorxiv.org
    DNA binding site II is required for RAD51 recombinogenic activity in Arabidopsis thaliana
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    biorxiv.org/content/10.1101/2024.03.07.583932v1
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    Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
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    biorxiv.org/content/10.1101/2022.12.20.521247v1
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    ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
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    biorxiv.org/content/10.1101/2024.01.17.576039v1
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    K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific interactors.
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    biorxiv.org/content/10.1101/2024.01.08.574586v1
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    IGHMBP2 deletion suppresses translation and activates the integrated stress response
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    biorxiv.org/content/10.1101/2023.12.11.571166v2
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    Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia
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    biorxiv.org/content/10.1101/2023.10.18.562916v1
  90. Apr 2024
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    Integrative DNA methylation analysis of pediatric brain tumors reveals tumor type-specific developmental trajectories and epigenetic signatures of malignancy
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    biorxiv.org/content/10.1101/2022.03.14.483566v2
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    pADP-ribosylation Regulates the Cytoplasmic Localization, Cleavage and Pro-apoptotic Function of HuR
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    biorxiv.org/content/10.1101/2023.08.07.552262v1
  93. Mar 2024
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    Circadian Transcriptomic and Epigenomic Remodeling in Response to Lipid Overload and Human Obesity
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    biorxiv.org/content/10.1101/2021.02.23.432336v4
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    Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors
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    biorxiv.org/content/10.1101/2023.08.25.554811v1
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    Structural and biochemical insights into heterotetramer formation between human oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
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    biorxiv.org/content/10.1101/2022.10.10.511529v8
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    The memory of airway epithelium damage in smokers and COPD patients
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    biorxiv.org/content/10.1101/2021.04.21.439437v3
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    Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography
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    biorxiv.org/content/10.1101/2023.10.05.560879v1
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    Micronucleus Is Not a Potent Inducer of cGAS-STING Pathway
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    biorxiv.org/content/10.1101/2023.10.16.561322v1
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    CLN3 deficiency leads to neurological and metabolic perturbations during early development
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    Lineage Tracing Reveals Fate Bias and Transcriptional Memory in Human B cells
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    biorxiv.org/content/10.1101/2022.07.26.501499v1
  202. www.biorxiv.org www.biorxiv.org
    The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex
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    biorxiv.org/content/10.1101/2021.09.20.461067v1
  203. www.biorxiv.org www.biorxiv.org
    Human RNA Nm-MTase FTSJ1: new tRNA targets and role in the regulation of brain-specific genes.
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    biorxiv.org/content/10.1101/2021.02.06.430044v4
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    A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
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    biorxiv.org/content/10.1101/2022.09.08.507072v1
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    Epigenetic signals that direct cell type specific interferon beta response in mouse cells
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    biorxiv.org/content/10.1101/2022.02.26.481127v1
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    Convergent evolution and horizontal gene transfer in Arctic Ocean microalgae
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    biorxiv.org/content/10.1101/2021.07.31.454568v1
  207. Jan 2023
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    Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing
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    biorxiv.org/content/10.1101/2022.06.02.494495v2
  209. www.biorxiv.org www.biorxiv.org
    Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2
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    biorxiv.org/content/10.1101/2022.08.31.506132v1
  210. www.biorxiv.org www.biorxiv.org
    SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.
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    biorxiv.org/content/10.1101/2022.02.13.480288v1
  211. www.biorxiv.org www.biorxiv.org
    Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely specified among human cells
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    biorxiv.org/content/10.1101/2022.09.07.506974v1
  212. www.biorxiv.org www.biorxiv.org
    Identifying novel regulators of placental development using time series transcriptomic data and network analyses
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    biorxiv.org/content/10.1101/2022.05.17.492330v1
  213. www.biorxiv.org www.biorxiv.org
    De novo discovery of traits co-occurring with chronic obstructive pulmonary disease
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    biorxiv.org/content/10.1101/2022.07.20.500731v1
  214. www.biorxiv.org www.biorxiv.org
    An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation
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    biorxiv.org/content/10.1101/2022.07.01.498448v1
  215. www.biorxiv.org www.biorxiv.org
    Comparative analysis of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing
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    biorxiv.org/content/10.1101/2022.03.04.483068v3
  216. www.biorxiv.org www.biorxiv.org
    A synergistic activation of RARb and RARg nuclear receptors restores cell-types specialization during stem cells differentiation by hijacking RARa-controlled program
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    biorxiv.org/content/10.1101/2022.05.31.494116v2
  217. www.biorxiv.org www.biorxiv.org
    Nuclear envelope reshaping around the vacuole determines the morphology of the ribosomal DNA
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    biorxiv.org/content/10.1101/2021.06.23.449658v1
  218. www.biorxiv.org www.biorxiv.org
    Porcine intestinal innate lymphoid cells and lymphocyte spatial context revealed through single-cell RNA sequencing
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    biorxiv.org/content/10.1101/2022.01.09.475571v1
  219. www.biorxiv.org www.biorxiv.org
    Sibling rivalry among the ZBTB transcription factor family: homo vs. heterodimers
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    biorxiv.org/content/10.1101/2021.12.17.472994v2
  220. Dec 2022
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    Stage-specific gene and transcript dynamics in human male germ cells
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    biorxiv.org/content/10.1101/2022.03.22.485121v1
  222. www.biorxiv.org www.biorxiv.org
    Cdh5-lineage independent origin of dermal lymphatic vessels revealed by temporally restricted lineage tracing
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    biorxiv.org/content/10.1101/2022.06.08.495310v1
  223. www.biorxiv.org www.biorxiv.org
    Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces
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    biorxiv.org/content/10.1101/2022.05.14.491942v1
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    Genome-wide Profiling of Histone Modifications in Plasmodium falciparum using CUT&RUN.
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    biorxiv.org/content/10.1101/2022.08.01.502378v2
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    Systematic analysis of ADP-ribose detection reagents and optimisation of sample preparation to detect ADP-ribosylation in vitro and in cells
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    biorxiv.org/content/10.1101/2022.02.22.481411v1
  226. www.biorxiv.org www.biorxiv.org
    Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes
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    biorxiv.org/content/10.1101/2022.08.12.503771v2
  227. Nov 2022
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    Actin binding domain of Rng2 strongly inhibits actin movement on myosin II HMM through structural changes of actin filaments
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    biorxiv.org/content/10.1101/2020.04.14.041046v4
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    Miro GTPase domains regulate assembly of the mitochondrial motor-adaptor complex
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    biorxiv.org/content/10.1101/2022.05.13.491728v1
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    Improving the computation efficiency of polygenic risk score modeling: Faster in Julia
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    biorxiv.org/content/10.1101/2021.12.27.474263v1