19 Matching Annotations
  1. Jul 2024
  2. May 2024
    1. if you could correct this Gene would we have the future reassured and we can then avoid all of these diseases I very much doubt it and I think it's very dangerous 00:23:49 because

      for - adjacency - progress trap - Crispr - gene therapy - Denis Noble - human genome project

      adjacency - between - human genome project - gene therapy - Crispr - progress trap - adjacency relationship - The idea that we can find specific causal relationships between genes and disease and use gene therapy to cure disease, - an envisioned goal of the human genome project - can be very dangerous because - usually one gene collaborates with many other genes to bring about an effect - If we don't know all the relationships, we can bring about a progress trap

  3. Jul 2022
    1. In just a decade, CRISPR has become one of the most celebrated inventions in modern biology. It is swiftly changing how medical researchers study diseases: Cancer biologists are using the method to discover hidden vulnerabilities of tumor cells. Doctors are using CRISPR to edit genes that cause hereditary diseases.
  4. Nov 2020
    1. Cas3 systems raises the possibility of its development as a tool for large genomic deletions, such as the targeted removal of entire genes, gene clusters, islands, prophages or plasmids
  5. May 2020
  6. Mar 2020
  7. Dec 2019
  8. Jul 2019
  9. Jan 2019
    1. ethical ramifications of widely accessible tools for altering genomes.

      Is this the philosophical problem underlying CRISPR? Isn't anything else beyond the widespread availability of the technology that is troublesome? It also reiterates the dual use problem: good and bad people can have access to the technology and we need to make sure only good people have access to it

      For the dual use, see Bennett et al 2009

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    1. Some worry that this is the first step toward using gene editing to create people with extreme intelligence, beauty or athletic ability. But that, for now, is not possible. Such traits are thought to be affected by possibly hundreds of genes acting in concert, and affected in turn by the environment. The biggest ethical concerns for now are with rogue scientists enticing couples who do not realize the risks to babies that might result from the experiments. And when those children grow up, the altered genes will be passed on to their children, and to their children’s children, for generations to come

      Is that how we should portray He Jiankui? Like a "rogue scientists enticing couples who do not realize the risks to babies that might result from the experiments"? But what if the current values (in the sense of a virtue ethics for example) that we uphold for the life sciences, are the ones that brought He to take these actions? Values that do not correspond to what we should think regarding science's values, but rather to the values that are usually uphold in corporations.

      See Shorett et al 2003

    1. This is a very important piece in the discussion of the ethical issues of CRISPR-Cas9. Instead on focusing only on the aspect of editing of human germ-line, the authors focus on more pressing aspects such as the use on foods, gene drives to decimate vector species, and biofuels, pharmaceuticals.

      Some of the outstanding issues are:

      • More transparent and accountable regulatory processes
      • Risks on ecological balance and unforeseeable effects on decimating vector species
      • Need to assign liability for ecological damage
      • Measures to halt the effects of edited animals if they prove harmful
  10. Jul 2018
    1. The MGEs are less abundant in archaea and bacteria, conceivably due to the intense purifying selection that constrains the spread of selfish elements but nevertheless constitute up to 30% of some bacterial genomes ( Casjens 2003 ; Carle et al. 2010 ).

      This is interesting!

  11. Apr 2018
  12. Feb 2018
  13. Nov 2017
    1. CRISPR screening has emerged as a powerful method for identifying critical functional dependencies in vitro (Koike-Yusa et al., 2014xGenome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library. Koike-Yusa, H., Li, Y., Tan, E.-P., Velasco-Herrera, Mdel.C., and Yusa, K. Nat. Biotechnol. 2014; 32: 267–273Crossref | PubMed | Scopus (285)See all References, Shalem et al., 2014xGenome-scale CRISPR-Cas9 knockout screening in human cells. Shalem, O., Sanjana, N.E., Hartenian, E., Shi, X., Scott, D.A., Mikkelson, T., Heckl, D., Ebert, B.L., Root, D.E., Doench, J.G., and Zhang, F. Science. 2014; 343: 84–87Crossref | PubMed | Scopus (936)See all References)
  14. Feb 2017
    1. Where should we draw the ethical and moral lines? Will CRISPR mean people are making designer babies and eliminating genetic diseases, and is that acceptable? We can wipe out whole species, like the mosquitos that carry the malaria parasite. But should we?

      All good questions.

    2. The controversial gene editing technique CRISPR could help scientists solve antimicrobial resistance, cure genetic diseases and much more

      I'm so excited to learn more about this!