21 Matching Annotations
  1. Last 7 days
    1. I started to use in the 00:58:01 little book the music of Life a way of exploring that metaphor

      for - follow up - book - The Music of Life - Biology Beyond Genes

      to - book - The Music of Life - Biology Beyond Genes - https://hyp.is/OI8RVBYIEe-t-rObPCPKoQ/www.univ.ox.ac.uk/book/the-music-of-life-biology-beyond-genes/

    2. the real answer doesn't lie there because all they can do is to go on associating groups of gene expression with particular proteins or particular diseases or whatever and with 00:28:39 the tiniest associations and um that creates all sorts of problems and biomedical sense it creates all sorts of ethical problems

      for - problem with gene therapy - Very little association between genes and disease - very complex associations

    3. I said a little while ago at at another meeting I said that I don't know what it is that controls Richard Dawkins but it isn't his jeans

      for - quote - genes don't control Richard Dawkins - Ray Noble

    4. ghost in the machine

      for - metaphor - genes - ghost in that machine

    1. you've used a metaphor in the past of thinking of genes not as a as a code as you said but as a kind of musical score

      for - metaphor - genes - musical scores - Denis Noble

    1. there are no genes for any of those membranes all the lipids that form the membranes and the complicated 00:07:27 structures that you can see in a typical cell none of that is coded for in the genome all of that is inherited

      for - key insight - decision-making structures are in the cell membrane, not the genes

      key insight - The codes that enable us to make choices are located in - the membranes of our cells and - their protein channels - There are no genes for - any of those membranes - all the lipids that form the membranes and the complicated structures that you can see in a typical cell - None of that is coded for in the genome - All of that is inherited

  2. Jan 2023
    1. Darwin knew nothing of genes. He was unaware of the work of Gregor Mendel, the Austrian monk who worked in his monastery garden and did experiments on the inheritance of pod-color in peas. Mendel discovered that heritable traits such as pod-color are inherited in discrete packages which he called genes. Any act of sexual reproduction of two parents with different genes results in offspring with a random distribution of the parental genes. Heredity in any population is a random process, resulting in a redistribution of genes between parents and offspring. The numbers of genes of various types are maintained on the average from generation to generation, but the numbers in each individual offspring are random. Mendel made this discovery and published it in the journal of the Brünn Natural History Society, only seven years after Darwin published The Origin of Species. Mendel had read Darwin's book, but Darwin never read Mendel's paper. In 1866, the year when Mendel's paper was published, Darwin did a very similar experiment, using snap-dragons instead of peas, and testing the inheritance of flower-shape instead of pod-color. Like Mendel, he bred three generations of plants, and observed the ratio of normal-shaped to star-shaped flowers in the third generation. Unlike Mendel, he had no understanding of the mathematics of statistical variations. He used only 125 third-generation plants and obtained a value of 2.4 for the ratio of normal to star-shaped offspring. This result did not suggest any clear picture of the way flower-shapes are inherited. He stopped the experiment and explored the question no further. Darwin did not understand that he would need a much larger sample to obtain a statistically significant result. Mendel understood statistics. His sample was sixty-four times larger than Darwin's, so that his statistical uncertainty was eight times smaller. He used 8023 plants. Mendel's essential insight was to see that sexual reproduction is a system for introducing randomness into inheritance. In peas as in humans, inheritance is carried by genes that are handed down from parents to offspring. His simple theory of inheritance carried by genes predicted a ratio of three between green and yellow pods in the third generation. He found a ratio of 3.01 with the big sample. This gave him confidence that the theory was correct. His experiment required immense patience, continuing for eight years with meticulous attention to detail. Every plant was carefully isolated to prevent any intruding bee from causing an unintended fertilization. A monastery garden was an ideal place for such experiments. Unfortunately, his experiments ended when his monastic order promoted him to the rank of abbot. Obedient to his vows, he ceased to be an explorer and became an administrator. His life-work lay hidden in an obscure German-language journal in Brünn, the city that later became Brno and is now in the Czech Republic.

      !- history of science : Mendel and Darwin - Mendel’s training in statistics helped Mendel construct his experiment differently from Darwin’s and also to interpret the results differently

    1. the neo-Darwinists were practically driven to their conclusions by their initial assumption: that science demands a rational explanation, that this means attributing rational motives to all behavior, and that a truly rational motivation can only be one that, if observed in humans, would normally be described as selfishness or greed.
  3. Mar 2022
  4. Dec 2021
    1. In other words, the palette of social organization was rich and diverse from the beginning: early humans, like us, were constantly in the business of shaping and reshaping their social arrangements, with evidence of conscious embracing and rejection of all sorts of social forms.

      In an ever-evolving manner, humans are constantly working at shaping and reshaping ourselves.

      How does our drive to have and establish identity cause us to evolve as a species? Is identity the root gene that is driving change within society? Is there an identeme (a tacit portmanteau of identity + gene) that works at both the local level as well as at the group level? How might this fit into the selfish gene theory?

  5. Mar 2021
  6. Feb 2021
  7. Nov 2020
    1. trait

      A trait is a characteristic of an organism. These can be determined by the environment, genes, or interactions within the traits. A genotype is the trait being genetically passed on to the offspring.

    1. Tumor suppressor genes

      These are genes that slow down cell division, repair DNA errors, and/or tell cells to terminate. If these Tumor Suppressor Genes fail to function properly, they go rouge and become cancer cells.

  8. Oct 2020
  9. Dec 2019
    1. Th ough cautions are oft en expressed [e.g., Plomin, DeFries, McClearn, & Rutter, 1997], the fact that reported biological mothers-adopted children correlations are higher than adoptive mothers-adopted children correlations has had a big impact in psychology and on theories of development. Most usually, the correlations have been computed into heritability

      This does suggest some of the supposed heritability is actually prenatal environment (or some other analogous factor). It's also possible that e.g. mitochondrial DNA plays a bigger role than previously recognized, much how thyroid status is the #1 predictor of mental retardation. Perhaps IVF will shed further light on the issue.

  10. May 2016