422 Matching Annotations
  1. Apr 2023
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    Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells
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    biorxiv.org/content/10.1101/2022.08.15.503960v1
  3. Mar 2023
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    Peroxisomes contribute to intracellular calcium dynamics
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    biorxiv.org/content/10.1101/2020.09.02.279174v1
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    An extended DNA-free intranuclear compartment organizes centrosomal microtubules in Plasmodium falciparum
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    biorxiv.org/content/10.1101/2021.03.12.435157v2
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    Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16
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    biorxiv.org/content/10.1101/2021.11.30.470499v1
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    The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation, epithelial repair, and tumor growth
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    biorxiv.org/content/10.1101/2022.04.11.487842v1
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    Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition
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    biorxiv.org/content/10.1101/2021.10.03.462949v4
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    Lack of peroxisomal catalase affects heat shock response in C. elegans
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    biorxiv.org/content/10.1101/2021.07.13.452156v1
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    Lineage Tracing Reveals Fate Bias and Transcriptional Memory in Human B cells
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    biorxiv.org/content/10.1101/2022.07.14.499766v2
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    Critical roles of ICOS in controlling Foxp3-expressing T follicular cell subsets during early-stage germinal center reactions
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    biorxiv.org/content/10.1101/2021.09.14.460384v2
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    The human MRS2 magnesium binding domain is a regulatory feedback switch for channel activity.
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    biorxiv.org/content/10.1101/2022.09.27.509701v1
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    Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases
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    biorxiv.org/content/10.1101/2022.02.18.481032v1
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    Segregation of pathways leading to pexophagy
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    biorxiv.org/content/10.1101/2022.11.08.515582v1
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    New algorithms for accurate and efficient de-novo genome assembly from long DNA sequencing reads
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    biorxiv.org/content/10.1101/2022.08.30.505891v1
  16. Feb 2023
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    Adenylyl cyclase 9 is auto-stimulated by its isoform-specific carboxyl terminal domain and equipped with paradigm-switching mechanisms.
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    biorxiv.org/content/10.1101/2022.06.05.494885v3
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    Lung macrophages utilize cathepsin K-dependent phagosomal machinery to degrade intracellular collagen
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    biorxiv.org/content/10.1101/2022.05.16.492085v1
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    SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology
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    biorxiv.org/content/10.1101/2022.07.26.501499v1
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    The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex
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    biorxiv.org/content/10.1101/2021.09.20.461067v1
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    Human RNA Nm-MTase FTSJ1: new tRNA targets and role in the regulation of brain-specific genes.
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    biorxiv.org/content/10.1101/2021.02.06.430044v4
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    A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
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    biorxiv.org/content/10.1101/2022.09.08.507072v1
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    Epigenetic signals that direct cell type specific interferon beta response in mouse cells
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    biorxiv.org/content/10.1101/2022.02.26.481127v1
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    Convergent evolution and horizontal gene transfer in Arctic Ocean microalgae
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    biorxiv.org/content/10.1101/2021.07.31.454568v1
  25. Jan 2023
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    Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing
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    biorxiv.org/content/10.1101/2022.06.02.494495v2
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    Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2
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    biorxiv.org/content/10.1101/2022.08.31.506132v1
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    SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.
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    biorxiv.org/content/10.1101/2022.02.13.480288v1
  29. www.biorxiv.org www.biorxiv.org
    Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely specified among human cells
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    biorxiv.org/content/10.1101/2022.09.07.506974v1
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    Identifying novel regulators of placental development using time series transcriptomic data and network analyses
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    biorxiv.org/content/10.1101/2022.05.17.492330v1
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    De novo discovery of traits co-occurring with chronic obstructive pulmonary disease
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    biorxiv.org/content/10.1101/2022.07.20.500731v1
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    An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation
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    biorxiv.org/content/10.1101/2022.07.01.498448v1
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    Comparative analysis of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing
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    biorxiv.org/content/10.1101/2022.03.04.483068v3
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    A synergistic activation of RARb and RARg nuclear receptors restores cell-types specialization during stem cells differentiation by hijacking RARa-controlled program
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    biorxiv.org/content/10.1101/2022.05.31.494116v2
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    Nuclear envelope reshaping around the vacuole determines the morphology of the ribosomal DNA
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    biorxiv.org/content/10.1101/2021.06.23.449658v1
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    Porcine intestinal innate lymphoid cells and lymphocyte spatial context revealed through single-cell RNA sequencing
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    biorxiv.org/content/10.1101/2022.01.09.475571v1
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    Sibling rivalry among the ZBTB transcription factor family: homo vs. heterodimers
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    biorxiv.org/content/10.1101/2021.12.17.472994v2
  38. Dec 2022
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    Stage-specific gene and transcript dynamics in human male germ cells
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    biorxiv.org/content/10.1101/2022.03.22.485121v1
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    Cdh5-lineage independent origin of dermal lymphatic vessels revealed by temporally restricted lineage tracing
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    biorxiv.org/content/10.1101/2022.06.08.495310v1
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    Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces
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    biorxiv.org/content/10.1101/2022.05.14.491942v1
  42. www.biorxiv.org www.biorxiv.org
    Genome-wide Profiling of Histone Modifications in Plasmodium falciparum using CUT&RUN.
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    biorxiv.org/content/10.1101/2022.08.01.502378v2
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    Systematic analysis of ADP-ribose detection reagents and optimisation of sample preparation to detect ADP-ribosylation in vitro and in cells
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    biorxiv.org/content/10.1101/2022.02.22.481411v1
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    Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes
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    biorxiv.org/content/10.1101/2022.08.12.503771v2
  45. Nov 2022
  46. www.biorxiv.org www.biorxiv.org
    Actin binding domain of Rng2 strongly inhibits actin movement on myosin II HMM through structural changes of actin filaments
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    biorxiv.org/content/10.1101/2020.04.14.041046v4
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    Miro GTPase domains regulate assembly of the mitochondrial motor-adaptor complex
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    biorxiv.org/content/10.1101/2022.05.13.491728v1
  48. www.biorxiv.org www.biorxiv.org
    Improving the computation efficiency of polygenic risk score modeling: Faster in Julia
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    biorxiv.org/content/10.1101/2021.12.27.474263v1
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    Structure of mammalian V-ATPase with the TLDc domain protein mEAK7 bound
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    biorxiv.org/content/10.1101/2021.11.03.466369v2
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    Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish
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    biorxiv.org/content/10.1101/2021.12.22.473872v1
  51. Oct 2022
  52. www.biorxiv.org www.biorxiv.org
    https://biorxiv.org/cgi/content/10.1101/2022.03.06.483172
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    biorxiv.org/content/10.1101/2022.03.06.483172v1
  53. www.biorxiv.org www.biorxiv.org
    Replication-associated inversions are the dominant form of bacterial chromosome structural variation
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    biorxiv.org/content/10.1101/2022.02.15.480581v1
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    Contribution of the Golgi apparatus in morphogenesis of a virus induced cytopathic vacuolar system
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    biorxiv.org/content/10.1101/2022.03.14.484265v1
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    Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain
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    biorxiv.org/content/10.1101/2022.04.21.489014v1
  56. www.biorxiv.org www.biorxiv.org
    Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions
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    biorxiv.org/content/10.1101/2022.04.03.486870v1
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    Synthetic evolution of herbicide resistance using a T7 RNAP-based random DNA base editor
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    biorxiv.org/content/10.1101/2021.11.30.470689v1
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    Evaluation of CA repeat arrays as targets for MeCP2 function in the brain
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    biorxiv.org/content/10.1101/2022.04.26.489598v2
  59. Sep 2022
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    Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein level changes
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    biorxiv.org/content/10.1101/2022.02.24.481857v1
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    Human gene function publications that describe wrongly identified nucleotide sequence reagents are unacceptably frequent within the genetics literature
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    biorxiv.org/content/10.1101/2021.07.29.453321v1
  62. Aug 2022
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    Decreasing pdzd8-mediated mitochondrial-ER contacts in neurons improves fitness by increasing mitophagy
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    biorxiv.org/content/10.1101/2020.11.14.382861v1
  64. www.biorxiv.org www.biorxiv.org
    Islet Gene View - a tool to facilitate islet research
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    biorxiv.org/content/10.1101/435743v3
  65. www.biorxiv.org www.biorxiv.org
    Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis
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    biorxiv.org/content/10.1101/2022.05.02.490246v1
  66. www.biorxiv.org www.biorxiv.org
    CFTR modulator response measurements in subjects with cystic fibrosis using 2D differentiated nasal epithelia converted into spheroids
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    biorxiv.org/content/10.1101/2021.07.20.453105v2
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    A minimal hepatocyte growth factor mimic acting as a powerful agonist of the MET receptor tyrosine kinase for regeneration of epithelial tissues and organs.
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    biorxiv.org/content/10.1101/2020.07.20.212654v3
  68. www.biorxiv.org www.biorxiv.org
    Drosophila insulator proteins exhibit in-vivo liquid-liquid phase separation properties
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    biorxiv.org/content/10.1101/2022.05.27.493687v1
  69. www.biorxiv.org www.biorxiv.org
    ScRNA-seq Expression of APOC2 and IFI27 Identifies Four Families of Alveolar Macrophage Superclusters in Cystic Fibrosis and Healthy BALF
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    biorxiv.org/content/10.1101/2022.01.30.478325v3
  70. www.biorxiv.org www.biorxiv.org
    ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
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    biorxiv.org/content/10.1101/2021.12.22.473898v2
  71. Jul 2022
  72. www.biorxiv.org www.biorxiv.org
    LncRNA RUS shapes the gene expression program towards neurogenesis
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    biorxiv.org/content/10.1101/2022.02.17.480853v1
  73. Jun 2022
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    Negative curvature-promoting lipids instruct nuclear ingression of low autophagic potential vacuoles
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    biorxiv.org/content/10.1101/2021.06.26.450031v1
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    OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection
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    biorxiv.org/content/10.1101/2021.04.21.440692v1
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    Genetic and compound screens uncover factors modulating cancer cell response to indisulam
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    biorxiv.org/content/10.1101/2021.12.20.473451v1
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    Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms to control cell motility and neurite outgrowth.
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    biorxiv.org/content/10.1101/2021.10.27.466197v3
  78. May 2022
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    Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26
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    biorxiv.org/content/10.1101/2021.09.20.461029v1
  80. Apr 2022
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    Tricalbin proteins regulate plasma membrane phospholipid homeostasis
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    biorxiv.org/content/10.1101/2021.06.04.447076v1
  82. www.biorxiv.org www.biorxiv.org
    Polycomb Group Ring Finger Protein 6 suppresses Myc-induced lymphomagenesis
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    biorxiv.org/content/10.1101/2021.12.02.470967v1
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    Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe
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    biorxiv.org/content/10.1101/2021.08.11.455278v1
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    TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis
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    biorxiv.org/content/10.1101/2021.10.27.466063v1
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    https://biorxiv.org/cgi/content/10.1101/2021.10.18.464926
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    biorxiv.org/content/10.1101/2021.10.18.464926v1
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    Conserved exchange of paralog proteins during neuronal differentiation
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    biorxiv.org/content/10.1101/2021.07.22.453347v1
  87. Mar 2022
  88. www.biorxiv.org www.biorxiv.org
    AGO1 regulates major satellite transcripts and H3K9me3 distribution at pericentromeric regions in mESCs
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    biorxiv.org/content/10.1101/2021.07.26.453733v2
  89. www.biorxiv.org www.biorxiv.org
    GROWTH-RATE DEPENDENT AND NUTRIENT-SPECIFIC GENE EXPRESSION RESOURCE ALLOCATION IN FISSION YEAST
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    biorxiv.org/content/10.1101/2021.03.16.435638v1
  90. www.biorxiv.org www.biorxiv.org
    The expression of essential selenoproteins during zebrafish development requires SECIS binding protein 2-like
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    biorxiv.org/content/10.1101/2021.11.01.466845v1
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    Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.
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    biorxiv.org/content/10.1101/2020.03.02.972950v5
  92. www.biorxiv.org www.biorxiv.org
    ETV2 regulates PARP-1 binding protein to induce ER stress-mediated cell death in tuberin-deficient cells
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    biorxiv.org/content/10.1101/2021.11.08.467714v1
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    Quantitative Profiling of Adaptation to Cyclin E Overproduction
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    biorxiv.org/content/10.1101/2021.07.26.453751v3
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    https://biorxiv.org/cgi/content/10.1101/2021.09.08.459430
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    biorxiv.org/content/10.1101/2021.09.08.459430v1
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    https://biorxiv.org/cgi/content/10.1101/2021.04.23.440619
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    biorxiv.org/content/10.1101/2021.04.23.440619v2
  96. www.biorxiv.org www.biorxiv.org
    Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6
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    biorxiv.org/content/10.1101/2021.07.01.450801v1
  97. www.biorxiv.org www.biorxiv.org
    Redundant and specific roles of EGFR ligands in the ERK activation waves during collective cell migration of MDCK cells
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    biorxiv.org/content/10.1101/2021.05.25.445569v1
  98. www.biorxiv.org www.biorxiv.org
    Nonsense-mediated mRNA decay utilizes complementary mechanisms to suppress mRNA and protein accumulation
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    biorxiv.org/content/10.1101/2021.05.24.445486v1
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    Recruitment of Scc2/4 to double strand breaks depends on γH2A and DNA end resection
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    biorxiv.org/content/10.1101/2021.07.09.451733v1
  100. Feb 2022
  101. www.biorxiv.org www.biorxiv.org
    Refining the domain architecture model of the replication origin firing factor Treslin/TICRR
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    biorxiv.org/content/10.1101/2021.07.24.453613v1
  102. www.biorxiv.org www.biorxiv.org
    Small disulfide loops in peptide hormones mediate self-aggregation and secretory granule sorting
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    Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegans
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    The structure and flexibility analysis of the Arabidopsis Synaptotagmin 1 reveal the basis of its regulation at membrane contact sites
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    On the Relation of Gene Essentiality to Intron Structure: A Computational and Deep Learning Approach
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  149. Apr 2021
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  160. Feb 2021
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  186. Jul 2020
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    An unexpected contribution of lincRNA splicing to enhancer function.
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    Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells
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    A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus
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  195. Jun 2020
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    Dynamic changes in the regulatory T cell heterogeneity and function by murine IL-2 mutein
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    BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression
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    The structure of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR-fold
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  201. Nov 2019
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    Unfolded protein-independent IRE1 activation contributes to multifaceted developmental processes in Arabidopsis
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    Detecting Novel Sequence Signals in Targeting Peptides Using Deep Learning
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    Mechanistic Insights into the Protective Roles of Polyphosphate Against Amyloid Cytotoxicity
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  208. Sep 2019
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    Endogenous RNAi pathway evolutionarily shapes the destiny of the antisense lncRNAs transcriptome
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  210. www.biorxiv.org www.biorxiv.org
    let-7 controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41
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    Ncl1 mediated metabolic rewiring is critical during metabolic stress
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    Kinesin-8B controls basal body function and flagellum formation and is key to malaria parasite transmission
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  213. www.biorxiv.org www.biorxiv.org
    XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures
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  214. www.biorxiv.org www.biorxiv.org
    Tumor-Intrinsic Response to IFNgamma Shapes the Tumor Microenvironment and Anti-PD-1 Response in NSCLC
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    The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells
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    Molecular characterization of Chlamydomonas reinhardtii telomeres and telomerase mutants
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    Molecular characterization of CHAD domains as inorganic polyphosphate binding modules
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    Hierarchical organization of the human cell from a cancer coessentiality network
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    BZLF1 interacts with the chromatin remodeler INO80 promoting escape from latent infections with Epstein-Barr virus
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    The chaperone-client network subordinates cell-cycle entry to growth and stress
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    Maternal Circulating MicroRNAs Control the Placental Response to Alcohol
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    Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association
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    Intra-individual methylomics detects the impact of early-life adversity
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    Human DNA polymerase delta is a pentameric complex with dimeric p12 subunit: Implications in enzyme architecture and PCNA interaction
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    PISD is a mitochondrial disease gene causing skeletal dysplasia, cataracts and white matter changes
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    Expanding the repertoire of glucocorticoid receptor target genes by engineering genomic response elements
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    Worldwide genetic variation of the IGHV and TRBV immune receptor gene families in humans
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    Main constraints for RNAi induced by expressed long dsRNA in mouse cells
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