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   Transcription factor expression is the main determinant of variability in gene co-activity

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   FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

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   Mapping single-cell responses to population-level dynamics during antibiotic treatment

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   ROR1 plays a critical role in pancreatic tumor-initiating cells with a partial EMT signature.

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   The piRNA pathway sustains adult neurogenesis by repressing protein synthesis

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   DASH/Dam1 complex mutants stabilize ploidy by weakening kinetochore-microtubule attachments

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   The value of genotype-specific reference for transcriptome analyses

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   Genome-wide CRISPRi screening reveals regulators of Alzheimee's tau pathology shared between exosomal and vesicle-free tau seeds.

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    Small non-coding vault RNA1-2 modulate expression of cell membrane proteins through nascent RNA silencing

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    LuminoCell: a versatile and affordable luminometer platform for monitoring in-cell luciferase-based reporters

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    Caspase-dependent activation of Hedgehog-signalling sustains proliferation and differentiation of ovarian somatic stem cells.

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    TOR acts as metabolic gatekeeper for auxin-dependent lateral root initiation in Arabidopsis thaliana

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    β-catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia

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    UBAP2L-dependent coupling of PLK1 localization and stability during mitosis

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    An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene

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    Combined measurements of proteome and cell turnover reveal the influences of tissue context and pathological aging on protein and organelle lifetimes

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    Cell-extrinsic autophagy in mature adipocytes regulates anti-inflammatory response to intestinal tissue injury through lipid mobilization

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    Deregulations of miR-1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1

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    Efficient knock-in method enabling lineage tracing in zebrafish

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    An innovative hematopoietic stem cell gene therapy approach benefits CLN1 disease in the mouse model

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    Morphofunctional changes at the active zone during synaptic vesicle exocytosis

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    The TUDOR domain of SMN is an H3K79me1 histone mark reader

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    Preference of CAMSAP3 for microtubules with expanded lattice contributes to stabilization of the minus end

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    Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells

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    Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development

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    Peroxisomes contribute to intracellular calcium dynamics

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    An extended DNA-free intranuclear compartment organizes centrosomal microtubules in Plasmodium falciparum

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    Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16

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    The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation, epithelial repair, and tumor growth

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    Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition

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    Lineage Tracing Reveals Fate Bias and Transcriptional Memory in Human B cells

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    Critical roles of ICOS in controlling Foxp3-expressing T follicular cell subsets during early-stage germinal center reactions

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    The human MRS2 magnesium binding domain is a regulatory feedback switch for channel activity.

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    Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy

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    An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation

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    Uncoupling from transcription protects polyadenylation site cleavage from inhibition by DNA damage

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    Mild impairment of mitochondrial function increases longevity and pathogen resistance through ATFS-1-driven activation of p38-regulated innate immunity

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    Rabaptin5 targets autophagy to damaged early endosomes and Salmonella containing vacuoles by interaction with FIP200 and ATG16L1

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    Protein-coding potential of RNAs measured by potentially translated island scores

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    Production of offspring from azoospermic mice with meiotic failure: Precise biparental meiosis within halved oocytes

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    The Legionella-driven PtdIns(4)P gradient at LCV-ER membrane contact sites promotes Vap-, OSBP- and Sac1-dependent pathogen vacuole remodeling

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    The spindle orienting machinery requires activation, not just localization

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    Multinucleation resets human macrophages for specialized functions at the expense of mononuclear phagocyte identity

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    Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and delays resistance in melanoma

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    A spatial model of the plant circadian clock reveals design principles for coordinated timing under noisy environments

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    iPSC-based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation

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    The cryo-EM structure of the CENP-A nucleosome in complex with ggKNL2

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    Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever

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    The eukaryotic translation initiation factor eIF4E reprogrammes the splicing machinery anddrives alternative splicing

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    Nanobody-mediated Complement Activation to Kill HIV-infected Cells

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    Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases

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    Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism

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    The Proxitome of Arabidopsis Processing Bodies Reveals a Condensate-Membrane Interface Instructing Actin-Driven Directional Growth

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    Adenylyl cyclase 9 is auto-stimulated by its isoform-specific carboxyl terminal domain and equipped with paradigm-switching mechanisms.

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    The mechanosensitive TRPV2 calcium channel controls melanoma invasiveness and metastatic potential.

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    TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes

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    Single cell clonal analysis identifies an AID-dependent pathway of plasma cell differentiation

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    MitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol

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    SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology

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    The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex

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    Retromer oligomerization drives SNX-BAR coat assembly and membrane constriction

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    Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis

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    The blood vasculature instructs lymphatics patterning in a SOX7-dependent manner

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    TSC2 regulates tumor susceptibility to TRAIL-mediated T cell killing by orchestrating mTOR signaling

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    Transient ribosome slowdown at the decoding step triggers mRNA degradation independent of Znf598 in zebrafish

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    Human RNA Nm-MTase FTSJ1: new tRNA targets and role in the regulation of brain-specific genes.

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    A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery

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    Epigenetic signals that direct cell type specific interferon beta response in mouse cells

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    CDK9 and PP2A regulate the link between RNA polymerase II transcription termination and RNA maturation.

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    Constricted migration contributes to persistent 3D genome structure changes associated with an invasive phenotype in melanoma cells

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    NuRD independent Mi-2 activity represses ectopic gene expression during neuronal maturation.

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    Evolution of genome fragility enables microbial division of labor

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    Convergent evolution and horizontal gene transfer in Arctic Ocean microalgae

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    A molecular mechanism by which amyloid-β induces transcriptional inactivation of CREB in Alzheimer's Disease

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    A toolbox for systematic discovery of stable and transient protein interactors in baker's yeast

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    Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing

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    Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2

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    Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival

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    SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.

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    Plasma membrane topography governs the three-dimensional dynamic localization of IgM B cell receptor clusters

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    Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely specified among human cells

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    Identifying novel regulators of placental development using time series transcriptomic data and network analyses

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    De novo discovery of traits co-occurring with chronic obstructive pulmonary disease

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     An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation

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     CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium

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     Adaptation of bacterial proteome reveals a key role of the cell envelope in starvation survival

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     Condensin pinches a short negatively supercoiledDNA loop during each round of ATP usage

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     Comparative analysis of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing

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     A synergistic activation of RARb and RARg nuclear receptors restores cell-types specialization during stem cells differentiation by hijacking RARa-controlled program

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     NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

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     Nuclear envelope reshaping around the vacuole determines the morphology of the ribosomal DNA

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     Porcine intestinal innate lymphoid cells and lymphocyte spatial context revealed through single-cell RNA sequencing

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     Sibling rivalry among the ZBTB transcription factor family: homo vs. heterodimers

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     Stage-specific gene and transcript dynamics in human male germ cells

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     Cdh5-lineage independent origin of dermal lymphatic vessels revealed by temporally restricted lineage tracing

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     Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress

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     Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces

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     Genome-wide Profiling of Histone Modifications in Plasmodium falciparum using CUT&RUN.

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     When Yeast Cells Change their Mind: Cell Cycle 'Start' is Reversible under Starvation

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     Systematic analysis of ADP-ribose detection reagents and optimisation of sample preparation to detect ADP-ribosylation in vitro and in cells

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     Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination

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     Specific N-glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning

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     The dengue virus NS1 protein conveys pro-inflammatory signals by docking onto human high-density lipoproteins

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     Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes

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     Cue-specific remodeling of the neuronal transcriptome through intron retention programs

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     Dissecting the co-transcriptome landscape of plants and microbiota members

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     Epithelial-mesenchymal transition is the main driver of intrinsic metabolism in cancer cell lines

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     The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging

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     The AAA-ATPase Atad1 and its partners promote degradation of desmin intermediate filaments in muscle

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     Live-cell chromosome dynamics in Arabidopsis thaliana reveals increased chromatin mobility in response to DNA damage

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     Actin binding domain of Rng2 strongly inhibits actin movement on myosin II HMM through structural changes of actin filaments

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     Miro GTPase domains regulate assembly of the mitochondrial motor-adaptor complex

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     The E3 ligase RNF115 regulates phagosome maturation and host response to bacterial infection

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     Improving the computation efficiency of polygenic risk score modeling: Faster in Julia

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     Heterogeneity of the Cancer Cell Line Metabolic Landscape

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     A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

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     m6A is required for resolving progenitor identity during planarian stem cell differentiation

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     The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins

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     Structure and functional mapping of the KRAB-KAP1 repressor complex

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     Bleeding in patients and mice with Alagille syndrome: sex differences and risk factors

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     Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis

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     An ERAD-independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis

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     Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair

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     http://biorxiv.org/cgi/content/short/2020.11.10.376822

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     RNA-mediated nucleosome depletion is required for elimination of transposon-derived DNA.

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     Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity

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     Dynamic chromosomal interactions and control of heterochromatin positioning by Ki67

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     The chromatin factor ROW cooperates with BEAF-32 in regulating long-range genes

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     Parkin drives pS65-Ub turnover independently of canonical autophagy in Drosophila

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     Parkin coordinates mitochondrial lipid remodeling to execute mitophagy

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     Endothelial-immune crosstalk contributes to vasculopathy in non-alcoholic fatty liver disease

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     Cellular stress in brain organoids is limited to a distinct and bioinformatically removable subpopulation.

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     HEAT SHOCK FACTOR BINDING PROTEIN limits meiotic crossovers by repressing HEI10 transcription

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     Hedgehog signaling can enhance glycolytic ATP production in the Drosophila wing disc

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     The molecular architecture of cell cycle arrest

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     TSG101 Associates with PARP1 and is Essential for PARylation and DNA Damage-induced NF-κB Activation

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     A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage

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     http://biorxiv.org/cgi/content/short/2020.10.28.359356

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     Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions

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     Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

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     Growth-mediated negative feedback shapes quantitative antibiotic response

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     CRYPTOCHROME suppresses the circadian proteome and promotes protein homeostasis

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     Changes in chromatin accessibility are not concordant with transcriptional changes for single-factor perturbations

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     Vesalius: Tissue anatomy from spatial transcriptomic data.

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     Zika virus alters centrosome organization to suppress the innate immune response

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     https://biorxiv.org/cgi/content/10.1101/2021.02.25.432821

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     CellRegMap: A statistical framework for mapping context-specific regulatory variants using scRNA-seq

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     Quantifying the phenotypic information in mRNA abundance

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     Mechanistic insights into the enhancement or inhibition of phase separation by polyubiquitin chains of different lengths or linkages

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     Naked mole-rat hematopoietic stem and progenitors are highly quiescent with an inherent myeloid bias

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     Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

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     Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6-dependent pathway

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     Regulation of mitochondrial proteostasis by the proton gradient

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     Heterotypic Assembly Mechanism Regulates CHIP E3 Ligase Activity

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     Species richness determines C. difficile invasion outcome in synthetic human gut communities

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     Basal Neural Stem Cells in the Subventricular Zone Drive Postnatal Neurogenesis with Apical Stem Cells Acting as Proliferation Gatekeepers

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     Genetically-Modified Macrophages Accelerate Myelin Repair

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     Mitotic checkpoint gene expression is tuned by coding sequences

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     Lifespan can be extended during a specific time window early in life

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     IL-21 lowers the B cell receptor affinity threshold for participation in a T cell dependent immune response.

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     Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation

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     Structural mechanism underpinning Thermus oshimai Pif1-mediated G-quadruplex unfolding

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     ALS-linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain of function

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     Nuclear Pore Complex Acetylation Regulates mRNA Export and Cell Cycle Commitment in Budding Yeast

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     Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting

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     Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms

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     Cooperative Amyloid Fibre Binding and Disassembly by the Hsp70 disaggregase

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     Optogenetic actuator/biosensor circuits for large-scale interrogation of ERK dynamics identify sources of MAPK signaling robustness.

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     Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models

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     Precise control of microtubule disassembly in living cells

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     Proteome-scale amino-acid resolution footprinting of protein-binding sites in the intrinsically disordered regions of the human proteome

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     Varicella-Zoster Virus ORF9 Is an Antagonist of the DNA Sensor cGAS

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     External light dark cycle shapes gut microbiota through intrinsically photosensitive retinal ganglion cells

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     THEM6-mediated lipid remodelling sustains stress resistance in cancer

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     Growth-dependent heterogeneity in the DNA damage response in Escherichia coli

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     Dynamic human liver proteome atlas reveals functional insights into disease pathways

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     Self-ubiquitination of a pathogen type-III effector traps and blocks the autophagy machinery to promote disease

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     A temporally controlled sequence of X-chromosomeinactivation and reactivation defines female mouse in vitro germ cells with meiotic potential

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     TRiC activates the unfolded protein response and protects starved stem cells by modulating energy and lipid metabolism during planarian regeneration

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     Reproducibility in systems biology modelling

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     Structure of mammalian V-ATPase with the TLDc domain protein mEAK7 bound

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     Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish

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     https://biorxiv.org/cgi/content/10.1101/2022.03.06.483172

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     Replication-associated inversions are the dominant form of bacterial chromosome structural variation

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     Contribution of the Golgi apparatus in morphogenesis of a virus induced cytopathic vacuolar system

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     Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain

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     Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

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     Synthetic evolution of herbicide resistance using a T7 RNAP-based random DNA base editor

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     Evaluation of CA repeat arrays as targets for MeCP2 function in the brain

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