• Siwienie jako mechanizm obronny przed rakiem:
  • Proces siwienia nie jest jedynie biernym symptomem starzenia, lecz aktywną odpowiedzią przeciwnowotworową chroniącą organizm przed czerniakiem (agresywnym nowotworem skóry).
  • Badania prowadzone przez naukowców z Uniwersytetu Tokijskiego (zespół pod kierunkiem prof. Emi Nishimury, opublikowane m.in. w Nature Cell Biology) wykazały, że utrata barwnika to uboczny skutek eliminacji potencjalnie groźnych komórek.
• Rola melanocytarnych komórek macierzystych (McSCs):
  • Za pigmentację odpowiadają komórki macierzyste melanocytów zlokalizowane w niszach mieszków włosowych.
  • W sytuacji poważnego uszkodzenia DNA (np. wywołanego stresem oksydacyjnym, chemikaliami czy promieniowaniem UV) komórki stają przed wyborem: dalszy podział z mutacjami lub zatrzymanie cyklu.
• Proces seno-dyferencjacji (ang. seno-differentiation):
  • Poważne pęknięcia nici DNA aktywują szlak obronny p53–p21, który zmusza uszkodzone McSCs do nieodwracalnego zróżnicowania i wejścia w stan senescencji zamiast samoodnawiania.
  • Choć komórki te ostatecznie wymierają i wyczerpują pulę barwnika (co powoduje wyrastanie siwych włosów), uniemożliwia im to akumulację mutacji onkogennych i przekształcenie w komórki nowotworowe.
• Ryzyko w przypadku zablokowania mechanizmu:
  • Gdy sygnały mikrośrodowiska (np. nadmiar czynnika SCF i aktywacja receptora KIT) sztucznie podtrzymują przeżycie i podziały uszkodzonych komórek macierzystych, włosy dłużej zachowują kolor, lecz drastycznie rośnie ryzyko rozwoju czerniaka.
  • Same siwe włosy nie chronią bezpośrednio przed nowotworem – stanowią widoczny, zewnętrzny biomarker skutecznie przeprowadzonego procesu eliminacji uszkodzonych komórek.

https://axminsterheritage.org/industry-commerce/

J H Shand Ltd.<br /> From 1940 until the late 1980s J H Shand Ltd employed highly-skilled engineers and technicians, designing and manufacturing steel type used in office equipment and industrial marking systems; and the manufacture of tools and equipment for use by other manufacturing companies. The company’s original role was to supply individual letter type blocks to manufacturers of manual typewriters which they could build into their machines. As electric typewriters took over, the company specialised in the manufacture of plastic ‘daisy wheels’. As well as producing raised characters for use in typewriters etc , the company made embossing type to produce raised letters or numbers when pressed into metal or plastic. This technique was used to make credit cards, many millions of which have been issued. Another side to the business made larger equipment including precision machine tools.

https://www.reddit.com/r/rs_x/comments/1npjd4t/if_i_may_be_so_bold/

These comments...

for - post - LinkedIn - hair - is biologically active

Parchment has two distinguishable sides:<br /> hair, which is usually darker and may show follicles (and even hair itself when poorly scraped) and<br /> flesh, which is usually lighter.

Most planned manuscripts' bindings have the hair side of the parchment facing hair sides of opposing leaf and similarly the flesh facing flesh.

Because of additions and potential mistakes in binding there are places in LJS 101 in which hair faces flesh and vice-versa. This "mistake" can provide an indication of binding procedures or mistakes in them.

https://elifesciences.org/articles/67437

Researchers have shown that some types of greying hair are reversible.

—Proverbs 16:31

Naturally as someone who went gray prematurely, I'm in total agreement with this! 😁

https://www.theguardian.com/politics/2013/nov/25/mapping-redheads-which-country-has-the-most

Trousers should shiver on the shoe but not break. —Arnold Bennett’s tailor

A gentleman: superficially perhaps, a man who never looks as if he’d just had his hair cut.

No gentleman can be without three copies of a book; one for show (and this he will probably keep at his country house), another for use, and a third at the service of his friends. —Richard Heber

Some great examples from Geoffrey Madan's notebooks

SO the women who realized that they didn't need to be strong were able to fully recover from depression

the women who manage the depression by being strong still experienced this periodically- maybe even more so.

Sarah was trying to manage by being strong- so strong that she didn't need her father "quote from landlady" but in her attempt to be strong she was losing her mind, will to live, and hair

because sarah couldn't be stronger this made her hair fall out. not necesarily the cause but its a factor. her lack of blackness devoids her of her "strength". "the cultural way of doing things was to be stronger" Sarah didn't have that mindset to be stronger. furthermore, neither did the queen. She is the dominant culture and she seem's to be one of the dominant "selves" in sarah.

Sarah's loss of crown is because she was dwelling on her life as a caucasion

The marriage between the mother and father crumpled and the mother slowly lost her mind and her hair.

This can fit with her hair being symbolized as her strength. because her hair is quite literally an exact opposite of her other very white-passing demeaner. She states thats the one prominent thing of her african american heritage. When she loses that, she loses her strength to go on.

Another reason why hair is a good symbolism for strength: both kinky curly hair and strength are "natural qualities" to being a black woman.

As said, when she begins to lack that she doesn't feel as though she deserves to even live.

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Well, this is just great....

https://www.youtube.com/watch?v=8vpDIobFALk Jeremy Werner Anja Glumicic Hawken Paul Mark Chipollo

From article: Temp not higher than 175 C, flat iron should not be used more than once a week (oops) "If there is a temperature setting on the device, it should be set no higher than 175C or on the low/medium setting. How frequently the flat iron can be used depends on the individual’s hair type, but should probably not be used more than one time per week."