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  1. Apr 2026
    1. Cephalosporins or extended-spectrum penicillins are commonly used (eg, cephalexin, 0.5 g orally four times daily for 7–10 days; see Table 35–6). Trimethoprim-sulfamethoxazole (two double-strength tablets orally twice daily for 7–10 days) should be considered when there is concern that the pathogen is MRSA (see Tables 35–5 and 35–6). Vancomycin, 15 mg/kg intravenously every 12 hours, is used for patients with signs of a systemic inflammatory response.

      cephalexin, dicloxacillin, penicillin VK, amoxicillin/clavulanate, or clindamycin (for penicillin-allergic patients). [1-2] These beta-lactam antibiotics provide excellent coverage against streptococci and methicillin-susceptible S. aureus (MSSA

    1. Urgent treatment for neoplasm consists of (1) cautious use of intravenous diuretics and (2) mediastinal irradiation, starting within 24 hours, with a treatment plan designed to give a high daily dose of radiation but a short total course of therapy to rapidly shrink the local tumor. Intensive radiation therapy combined with chemotherapy will palliate the process in up to 90% of patients. In patients with a subacute presentation, radiation therapy alone usually suffices. Chemotherapy is added if lymphoma or small-cell carcinoma is diagnosed

      endovascular stenting emerging as first-line therapy for rapid symptom relief, while definitive treatment targets the underlying cause

      Glucocorticoids (dexamethasone 4 mg every 6 hours) are commonly prescribed but lack robust supporting data; they may be more beneficial in lymphoma or thymoma and as prophylaxis against radiation-induced edema. [2-4] Importantly, SVC syndrome is no longer considered a medical emergency except in rare cases with life-threatening cerebral edema, laryngeal edema, or altered mental status. When thrombosis is present, catheter-directed thrombolysis or aspiration thrombectomy should be performed within 2-5 days of symptom onset before thrombus organization occurs. [3] The role of long-term anticoagulation after stenting remains unclear, though it is standard when significant thrombosis is present The American College of Chest Physicians recommends obtaining histologic diagnosis before treatment in suspected lung cancer cases, as stenting does not interfere with tissue diagnosis. [2] For small cell lung cancer (SCLC), chemotherapy alone is recommended as first-line treatment given rapid response rates. [2] For non-small cell lung cancer (NSCLC), radiation therapy and/or stent insertion are recommended, with response rates of 59% for chemotherapy and 63% for radiation therapy. [2] Patients with chemotherapy- or radiation-refractory disease should receive vascular stents For device-related thrombosis (catheters, pacemakers), catheter removal should be considered in conjunction with anticoagulation. [4] Endovascular therapy is first-line for device-related obstruction, while surgical bypass may be preferred for mediastinal fibrosis. [7] Both approaches show good mid-term patency, though secondary interventions are common (approximately 27-28%

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    1. Treatment of superficial vein reflux (see Varicose Veins, above) has been shown to decrease the recurrence rate of venous ulcers. Where there is substantial obstruction of the femoral or popliteal deep venous system, superficial varicosities supply the venous return and should not be removed.

      Failure of venous insufficiency ulcerations to heal is most often due to inconsistent use of first-line treatment methods. Ongoing control of edema is essential to prevent recurrent ulceration; the use of compression stockings following ulcer healing is critical, with recurrence rates 2–20 times higher if compression stockings are not used

      Duplex ultrasound evaluation should assess blood flow direction, venous reflux, and venous obstruction, and include examination of the deep venous system, great saphenous vein (GSV), small saphenous vein (SSV) and its thigh extension (Giacomini vein), accessory saphenous veins, and perforating veins. Venography is recommended primarily in patients with post-thrombotic disease, especially when intervention is planned, as it provides greater anatomic detail than duplex ultrasonograph The examination also identifies patterns of disease that have treatment implications. Axial reflux is defined as uninterrupted retrograde flow from groin to calf and can occur in either superficial or deep systems. [4] Junctional reflux is limited to the saphenofemoral or saphenopopliteal junction, while segmental reflux occurs in a portion of a truncal vein. [4] Understanding whether reflux originates from superficial junctions versus deep venous incompetence fundamentally changes treatment planning, as superficial disease is amenable to ablation while deep disease typically requires conservative management Management of secondary varicose veins from post-thrombotic syndrome (PTS) is fundamentally different and more challenging. Compression therapy, lifestyle modifications, and symptom management form the cornerstone of PTS treatment. [4-8] Elastic compression stockings (20-30 mm Hg), leg elevation, weight loss, and exercise constitute the primary therapeutic approach Endovascular interventions for PTS—including percutaneous transluminal venoplasty and stenting—are reserved for select patients with significant iliofemoral obstruction who have failed conservative management. [7] These procedures require careful patient selection and standardized criteria. The role of superficial venous ablation in PTS patients with concomitant superficial reflux remains controversial and should be approached cautiously, as the underlying deep venous pathology may limit benefit

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  2. Mar 2026
  3. Feb 2025
  4. Nov 2024
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  6. Jun 2024
  7. May 2023
  8. Jan 2023
  9. Nov 2022
    1. Because the official images are intended to be learning tools for those new to Docker as well as the base images for advanced users to build their production releases, we review each proposed Dockerfile to ensure that it meets a minimum standard for quality and maintainability. While some of that standard is hard to define (due to subjectivity), as much as possible is defined here, while also adhering to the "Best Practices" where appropriate.
  10. Apr 2022
  11. Sep 2021
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  13. Jul 2021
  14. Jun 2021
    1. https://github.com/rycus86/githooks is a really option for managing hooks It is... safe (it uses an opt-in model, where it will ask for confirmation whether new or changed scripts should be run or not (or disabled)) configurable handles a lot of the details for you lets you keep your hooks nicely organized. For example:
    1. Or if you're looking for a core extension that adds this to the Array class, I'd recommend the facets gem (require 'facets/array/average'). Then you can just do array.average. And, from looking at the source, it turns out they do the exact same thing as the instance_eval approach above. The only difference is that it's implemented as a method—which of course already has self pointing to itself—instead of a block): def average; return nil if empty?; reduce(:+) / length.to_f; end Main advantage of this is that it's even more concise/readable and it handles the empty? case.
  15. May 2021
    1. I've been using (and recently, contributing slightly to) Git for well over a decade. I don't have any single thing I'd specifically recommend at this point, but if you're looking for a decent book on Git, the Pro Git book has a bunch of plus-es: it's on line and kept up to date, it's free, and it's correct (unlike far too many online tutorials). There is also Think Like (a) Git, which covers most of what's missing from Pro Git.
  16. Apr 2021
  17. Mar 2021
  18. Feb 2021
    1. While Trailblazer offers you abstraction layers for all aspects of Ruby On Rails, it does not missionize you. Wherever you want, you may fall back to the "Rails Way" with fat models, monolithic controllers, global helpers, etc. This is not a bad thing, but allows you to step-wise introduce Trailblazer's encapsulation in your app without having to rewrite it.
    1. @adisos if reform-rails will not match, I suggest to use: https://github.com/orgsync/active_interaction I've switched to it after reform-rails as it was not fully detached from the activerecord, code is a bit hacky and complex to modify, and in overall reform not so flexible as active_interaction. It has multiple params as well: https://github.com/orgsync/active_interaction/blob/master/spec/active_interaction/modules/input_processor_spec.rb#L41

      I'm not sure what he meant by:

      fully detached from the activerecord I didn't think it was tied to ActiveRecord.

      But I definitely agree with:

      code is a bit hacky and complex to modify

    1. References Garrison, D. Randy, Terry Anderson, and Walter Archer. “Critical inquiry in a text-based environment: Computer conferencing in higher education.” The internet and higher education 2, no. 2-3 (1999): 87-105. Orlov, George, Douglas McKee, James Berry, Austin Boyle, Thomas DiCiccio, Tyler Ransom, Alex Rees-Jones, and Jörg Stoye. “Learning During the COVID-19 Pandemic: It Is Not Who You Teach, but How You Teach.” NBER Working Paper 28022 (2020). Rienties, Bart, and Bethany Alden Rivers. “Measuring and understanding learner emotions: Evidence and prospects.” Learning Analytics Review 1, no. 1 (2014): 1-27.

      yay more reading references

  19. Jan 2021
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  28. Jan 2020
    1. you will find better treatise for all individual topics covered; for example:- What we understand about the brain is essentially covered by Tim Urban in his article "Neuralink and the Brain's Magical Future" in, I might add, more entertaining manner. Alternatively, for a much more in-depth look, look at the book "Principles of Neural Design"- The short time Oliveira spends on superintelligence is better covered by Bostrom in his book "Superintelligence", which Oliveira references- What an algorithm is and what can be computed is better covered by "What algorithms want"- The "common sense" aspect of AI is better covered by "Common Sense, the Turing Test and the Quest for Real AI"- On the title promise, how science is "redefining humanity", the Digital Mind is relatively light on, aside from broadly listing topics that we need to think about like ownership and rights. For a (much) further-taken discussion on this, look at Yuval Noah Harari's Homo Deus, for example.
  29. Dec 2019
  30. Nov 2019