1,160 Matching Annotations
  1. Oct 2025
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    Comparison of Infinium MethylationEPIC v2.0 to v1.0 for human population epigenetics: considerations for addressing EPIC version differences in DNA methylation-based tools
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    biorxiv.org/lookup/doi/10.1101/2024.07.02.600461
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    Genome-scale prediction of gene ontology from mass fingerprints reveals new metabolic gene functions
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    biorxiv.org/lookup/doi/10.1101/2024.11.27.625594
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    Hepatitis E Virus-induced antiviral response by plasmacytoid dendritic cells is modulated by the ORF2 protein
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    biorxiv.org/lookup/doi/10.1101/2024.04.12.589258
  5. Sep 2025
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    Differential cell survival outcomes in response to diverseamino acid stress
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    biorxiv.org/lookup/doi/10.1101/2025.04.01.646536
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    Co-occurrence of essential gene dispensability and bypass suppressor mutations across species
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    biorxiv.org/lookup/doi/10.1101/2022.11.11.516117
  8. Aug 2025
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    Gut microbiome remains stable following COVID-19 vaccination in healthy and immuno-compromised individuals
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    biorxiv.org/lookup/doi/10.1101/2023.08.23.554506
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    Chondrodysplasia-inducing COL2A1 p.Gly1170Ser causes an ER storage defect without associated unfolded protein response in a human cartilage model
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    biorxiv.org/lookup/doi/10.1101/2023.10.19.562780
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    Computing hematopoiesis plasticity in response to genetic mutations and environmental stimulations
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    biorxiv.org/lookup/doi/10.1101/2024.08.02.606315
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    The nucleocytoplasmic translocation of HINT1 regulates the maturation of cell density
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    biorxiv.org/lookup/doi/10.1101/2025.01.13.632869
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    In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals
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    biorxiv.org/lookup/doi/10.1101/2024.12.06.627170
  14. Jul 2025
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    Multiple domains of scaffold Tudor protein play non-redundant roles in Drosophila germline
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    biorxiv.org/lookup/doi/10.1101/2025.03.13.643173
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    PSME3 Regulates Migration and Differentiation of Myoblasts
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    biorxiv.org/content/10.1101/2025.01.08.632048v1
  17. Jun 2025
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    Wound closure after brain injury relies on force generation by microglia in zebrafish
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    biorxiv.org/lookup/doi/10.1101/2024.06.04.597300
  19. May 2025
  20. www.biorxiv.org www.biorxiv.org
    AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation
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    biorxiv.org/content/10.1101/2024.11.01.621527v1
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    Lipid-driven SRC self-association modulates its transformation capacity
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    biorxiv.org/content/10.1101/2024.11.12.623151v1
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    STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs
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    biorxiv.org/content/10.1101/2024.12.20.629685v1
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    Optogenetic control of pheromone gradients reveals functional limits of mating behavior in budding yeast
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    biorxiv.org/content/10.1101/2024.02.06.578657v2
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    DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance
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    biorxiv.org/content/10.1101/2025.02.17.638677v1
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    Shared requirement for MYC upstream super-enhancer in tissue regeneration and cancer
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    biorxiv.org/content/10.1101/2022.11.04.515076v2
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    Predicting cell cycle stage from 3D single-cell nuclear-stained images
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    biorxiv.org/content/10.1101/2024.08.30.610553v2
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    Matrix-driven jamming dynamics mediates transition of ovarian cancer spheroids to stable morphologies
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    biorxiv.org/content/10.1101/2022.02.09.479678v3
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    Molecular mechanism of bacteriophage tail contraction- structure of an S-layer-penetrating bacteriophage
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    biorxiv.org/content/10.1101/2023.08.04.551987v1
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    Divergent Plasmodium protein kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
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    biorxiv.org/content/10.1101/2024.09.22.613647v1
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    The late onset Alzheimer’s disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis
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    biorxiv.org/content/10.1101/2024.09.13.612888v1
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    Diversification of Dentate Gyrus Granule Cell Subtypes is Regulated by Neuregulin1 Nuclear Back Signaling.
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    biorxiv.org/content/10.1101/2024.10.15.618334v1
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    Variety in the USP deubiquitinase catalytic mechanism
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    biorxiv.org/content/10.1101/2023.07.24.550302v2
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    Mechanical forces and ligand-binding modulate Pseudomonas aeruginosa PilY1 mechanosensitive protein
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    biorxiv.org/content/10.1101/2023.08.03.551776v3
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    MDC1 mediates Pellino recruitment to sites of DNA double-strand breaks
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    biorxiv.org/content/10.1101/2024.07.20.604390v1
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    Novel determinants of NOTCH1 trafficking and signaling in breast epithelial cells
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    biorxiv.org/content/10.1101/2023.03.05.531156v2
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    DICE: Fast and Accurate Distance-Based Reconstruction of Single-Cell Copy Number Phylogenies
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    biorxiv.org/content/10.1101/2024.06.03.597037v1
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    Canonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate
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    biorxiv.org/content/10.1101/2024.08.07.606990v1
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    Mitochondrial Signatures Shape Phenotype Switching and Apoptosis in Response to PLK1 and RSK Inhibitors in Melanoma
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    biorxiv.org/content/10.1101/2024.06.14.599035v1
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    Transcription Factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress
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    biorxiv.org/content/10.1101/2023.05.30.542913v1
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    Loss-of-function cancer-associated mutations in the EIF4G2 non-canonical translation initiation factor
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    biorxiv.org/content/10.1101/2023.08.22.554280v2
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    Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal Parvalbumin interneurons
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    biorxiv.org/content/10.1101/2024.06.17.599289v2
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    FAM172A controls the nuclear import and alternative splicing function of AGO2
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    biorxiv.org/content/10.1101/2022.03.04.482948v2
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    Specific vulnerability of long telomeres to undergo end fusions revealed by mutational analysis of Rap1
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    biorxiv.org/content/10.1101/2021.12.16.472883v1
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    STAT1 is required to establish but not maintain IFNγ-induced transcriptional memory
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    biorxiv.org/content/10.1101/2022.09.17.508285v1
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    RNA sensing via LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency
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    biorxiv.org/content/10.1101/2021.10.27.465188v1
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    LTK and ALK regulate neuronal polarity and cortical migration by modulating IGF1R activity
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    biorxiv.org/content/10.1101/2023.01.29.526107v1
  47. Dec 2024
  48. www.biorxiv.org www.biorxiv.org
    N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs
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    biorxiv.org/content/10.1101/2023.06.20.545713v4
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    4G cloning: rapid gene assembly for expression of multisubunit protein complexes in diverse hosts
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    biorxiv.org/content/10.1101/2024.06.17.599261v1
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    Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor-tumor connections
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    biorxiv.org/content/10.1101/2024.03.26.586725v1
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    Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in mice
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    biorxiv.org/content/10.1101/2024.04.09.588709v1
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    A complete digital karyotype of the B-cell leukemia REH cell line resolved by long-read sequencing
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    biorxiv.org/content/10.1101/2023.03.08.531483v1
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    Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice
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    biorxiv.org/content/10.1101/2023.03.14.532682v2
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    Transcriptional regulators ensuring specific gene expression and decision making at high TGFβ doses
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    biorxiv.org/content/10.1101/2024.04.23.590740v1
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    Structural basis for inhibition of mycobacterial ATP synthase by squaramides and second generation diarylquinolines
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    biorxiv.org/content/10.1101/2023.02.03.527018v1
  56. Nov 2024
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    Mass spectrometry-based proteomic exploration of diverse murine macrophage cellular models
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    biorxiv.org/content/10.1101/2024.04.09.588684v1
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    Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein
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    biorxiv.org/content/10.1101/2024.06.10.598172v2
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    An auto-release mechanism for HMCES-DNA-protein crosslinks
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    biorxiv.org/content/10.1101/2022.12.18.520715v1
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    Nutritional status and fecundity are synchronised by muscular exopheresis
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    biorxiv.org/content/10.1101/2020.06.17.157230v2
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    Cell–cell adhesion drives patterning in stratified epithelia
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    biorxiv.org/content/10.1101/2023.11.24.567740v1
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    Deregulation of multiple mechanisms shapes the onset of LAMA2-congenital muscular dystrophy
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    biorxiv.org/content/10.1101/2024.01.20.576409v1
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    CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation
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    biorxiv.org/content/10.1101/2024.05.29.596395v1
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    The hGID GID4 E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration
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    biorxiv.org/content/10.1101/2023.07.20.549906v1
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    Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish
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    biorxiv.org/content/10.1101/2024.03.17.585386v1
  66. Oct 2024
  67. www.biorxiv.org www.biorxiv.org
    TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44
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    biorxiv.org/content/10.1101/2024.06.12.598629v1
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    Metabolic resistance of Abeta3pE-42, epitope of the anti-Alzheimer therapeutic antibody, donanemab.
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    biorxiv.org/content/10.1101/2024.01.30.578111v1
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    Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis
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    biorxiv.org/content/10.1101/2024.03.18.585508v1
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    Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1b
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    biorxiv.org/content/10.1101/2023.10.19.563039v1
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    FAM111A regulates replication origin activation and cell fitness
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    biorxiv.org/content/10.1101/2020.04.22.055574v1
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    Regulation of proteostasis by sleep through autophagy in Drosophila models of Alzheimer's Disease
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    biorxiv.org/content/10.1101/2024.07.01.601554v1
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    Differential Modulation of Polycomb-Associated Histone Marks by cBAF, pBAF, and gBAF Complexes
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    biorxiv.org/content/10.1101/2023.09.23.557848v2
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    A Novel Role for CSA in the Regulation of Nuclear Envelope Integrity: Uncovering a Non-Canonical Function
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    biorxiv.org/content/10.1101/2023.12.14.571633v1
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    Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism
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    biorxiv.org/content/10.1101/2023.08.22.554238v1
  76. Sep 2024
  77. www.biorxiv.org www.biorxiv.org
    Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons
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    biorxiv.org/lookup/doi/10.1101/2023.10.02.560439
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    The mitotic surveillance pathway requires PLK1-dependent 53BP1 displacement from kinetochores
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    biorxiv.org/lookup/doi/10.1101/2023.03.27.534346
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    Proteomic analysis reveals microvesicles containing NAMPT as mediators of radiation resistance in glioma
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    biorxiv.org/lookup/doi/10.1101/2022.03.23.485479
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    De-tensioning of collagen fibers optimizes endometrial receptivity and improves the rate of embryo implantation
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    biorxiv.org/lookup/doi/10.1101/2022.01.18.476712
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    A highly scalable approach to topic modelling in single-cell data by approximate pseudobulk projection
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    biorxiv.org/lookup/doi/10.1101/2024.02.21.581497
  82. Aug 2024
  83. www.biorxiv.org www.biorxiv.org
    Passive diffusion accounts for the majority of intracellular vesicle transport
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    biorxiv.org/content/10.1101/2023.05.10.540182v1
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    Multi-modal adaptor-clathrin contacts drive coated vesicleassembly
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    biorxiv.org/content/10.1101/2021.05.22.445240v1
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    RedRibbon: A new rank-rank hypergeometric overlap pipeline to compare gene and transcript expression signatures
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    biorxiv.org/content/10.1101/2022.08.31.505818v1
  86. Jul 2024
  87. www.biorxiv.org www.biorxiv.org
    Global Huntingtin Knockout in Adult Mice Leads to Fatal Neurodegeneration that Spares the Pancreas
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    biorxiv.org/content/10.1101/2024.01.11.575238v1
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    Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis
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    biorxiv.org/content/10.1101/2023.11.24.568591v2
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    A large-scale cancer-specific protein-DNA interaction network
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    biorxiv.org/content/10.1101/2024.01.24.577099v1
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    Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain
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    biorxiv.org/content/10.1101/2023.12.21.572875v2
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    Exploring the molecular composition of the multipass translocon in its native membrane environment
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    biorxiv.org/content/10.1101/2023.11.28.569136v1
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    Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activity
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    biorxiv.org/content/10.1101/2023.12.18.572154v1
  93. Jun 2024
  94. www.biorxiv.org www.biorxiv.org
    Translation inhibition efficacy does not determine the Plasmodium berghei liver stage antiplasmodial efficacy of protein synthesis inhibitors
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    biorxiv.org/content/10.1101/2023.12.07.570699v1
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    The type of DNA damage response after Decitabine treatment depends on the level of DNMT activity
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    biorxiv.org/content/10.1101/2023.09.02.556017v2
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    Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
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    biorxiv.org/content/10.1101/2022.06.14.495968v1
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    Trim66 paternal deficiency causes intrauterine overgrowth
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    biorxiv.org/content/10.1101/2024.02.12.579976v1
  98. www.biorxiv.org www.biorxiv.org
    The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts
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    biorxiv.org/content/10.1101/2022.08.08.503265v1
  99. May 2024
  100. www.biorxiv.org www.biorxiv.org
    DNA binding site II is required for RAD51 recombinogenic activity in Arabidopsis thaliana
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    biorxiv.org/content/10.1101/2024.03.07.583932v1
  101. www.biorxiv.org www.biorxiv.org
    Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
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  128. Feb 2024
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    TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA
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    Comprehensive comparison of female germ cell development in vitro and in vivo identifies epigenetic gene regulation crucial for oocyte development and embryonic competence
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    Enhanced Airway Epithelial Response to SARS-CoV-2 Infection in Children is Critically Tuned by the Cross-Talk Between Immune and Epithelial Cells
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    Revisiting degron motifs in human AURKA required for its targeting by APC/C-FZR1
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  191. Oct 2023
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    High Resolution Kinetic Characterization and Dynamic Mathematical Modeling of the RIG-I Signaling Pathway and the Antiviral Responses
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    EMBRYO-UTERINE INTERACTION COORDINATES MOUSE EMBRYOGENESIS DURING IMPLANTATION
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    M-CSF induces a coordinated myeloid and NK cell differentiation program protecting against CMV after hematopoietic cell transplantation
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  197. www.biorxiv.org www.biorxiv.org
    Neuroprotective effects of hepatoma-derived growth factor in models of Huntington's disease
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    biorxiv.org/content/10.1101/2023.02.23.529222v1
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    biorxiv.org/content/10.1101/2023.05.28.541924v1
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    A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance
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    biorxiv.org/content/10.1101/2023.02.26.530079v2
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    biorxiv.org/content/10.1101/2022.08.17.504229v1
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    biorxiv.org/content/10.1101/2021.10.11.463714v2
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    PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.
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    biorxiv.org/content/10.1101/2022.11.29.518198v1
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    biorxiv.org/content/10.1101/2023.01.10.523468v2
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    biorxiv.org/content/10.1101/2022.04.16.488523v2
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    Predictability of the community-function landscape in wine yeast ecosystems
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    biorxiv.org/content/10.1101/2022.12.15.520418v1
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    Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
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    biorxiv.org/content/10.1101/2022.12.27.521482v1
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    A Sterol-PI(4)P exchanger controls the Tel1/ATM axis of the DNA Damage Response
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    biorxiv.org/content/10.1101/2022.07.13.499867v1
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    Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generation
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    biorxiv.org/content/10.1101/2022.10.13.512034v1
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    Identification of a novel enhancer essential for Satb1 expression in TH2 cells and activated ILC2s.
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    biorxiv.org/content/10.1101/2023.01.03.522551v1
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    biorxiv.org/content/10.1101/2022.10.05.511040v1
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    MAP4K3 inhibits Sirtuin-1 to repress LKB1-AMPK to promote amino acid dependent activation of mTORC1
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    biorxiv.org/content/10.1101/2021.11.08.467702v2
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    Origin and segregation of the human germline
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    biorxiv.org/content/10.1101/2022.07.06.498671v1
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    Distant sequence regions of JBP1 contribute to J-DNA binding
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    IKBKB reduces huntingtin aggregation by phosphorylating Serine 13 via a non-canonical IKK pathway
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    biorxiv.org/content/10.1101/2022.12.05.519070v1
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    Germinal Centers Convergent Evolution and B cell Recirculation in Human Lymph Nodes
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    biorxiv.org/content/10.1101/2022.11.09.463832v9
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    Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis
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    Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
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    Robust dimethyl-based multiplex-DIA workflow doubles single-cell proteome depth via a reference channel
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  221. Aug 2023
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    A metabolic map of the DNA damage response identifies PRDX1 in nuclear ROS scavenging and aspartate synthesis
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    NLRP3 controls ATM activation in response to DNA damage.
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    biorxiv.org/content/10.1101/2020.05.12.087015v1