in ¶90-96 he provides some advice about selection and discrimination of reading sources and materials for indexing as a means of cutting down on the information overload problem

Some of his factors include: - relying on experience in a field/area to narrow down - limiting one's scope of activity - staying away from reference books (dictionaries, encyclopedias - discriminate in favor of the specific versus the general - don't admit duplicative literature (unless one is working syntopically—though he doesn't admit this caveat), and prefer the most authoritative sources - prefer authoritative authors, when given, but make space for new writers who may be more careful in their writing and argumentation - discriminate by style and composition and in particular stay away from pernicious advertising-related material (today he might advocate away from listicles, content farms, etc.)

Only personal experience in your note taking practice will guide you on what is most valuable for excerpting. After time you will come to know and understand what is worth spending your time on and what isn't. You will not learn this from others experience, only your own, and this is why we call it practice.

A great admission to make upfront in such a massive endeavor which one hopes to shape the future.

What does this mean for ars excerpendi writ large? Particularly when it may apply to hundreds of thousands?

Studies have shown that humans are highly selective about whom they choose to imitate. Children up to age seven show a propensity to imitate their parents over strangers and after that they primarily imitate people who have shown themselves to be knowledgeable and competent within an area of expertise.

This has applications to teaching with respect to math shaming. A teacher who says that math is personally hard for them is likely to be signaling to students that what they're teaching is not based on experience and expertise and thus demotivating the student from following and imitating their example.

Neeley, L. (2020, March 31). How to Talk About the Coronavirus. The Atlantic. https://www.theatlantic.com/ideas/archive/2020/03/how-talk-about-coronavirus/609118/

Luban, J., Sattler, R., Mühlberger, E., Graci, J. D., Cao, L., Weetall, M., Trotta, C., Colacino, J. M., Bavari, S., Strambio-De-Castillia, C., Suder, E. L., Wang, Y., Soloveva, V., Cintron-Lue, K., Naryshkin, N. A., Pykett, M., Welch, E. M., O’Keefe, K., Kong, R., … Peltz, S. (2020). The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines. BioRxiv, 2020.08.05.238394. https://doi.org/10.1101/2020.08.05.238394

the compound and kinase are incubated together for at least 2 hours. And 2 hours is enough for covalent adduct to form. if compound can form covalent adduct with FGFR1, why FGFR1 inhibition IC50 is so poor?