restricted European expansion into North America, including Russia in Alaska.

The age cohort projected to make the earliest transition to majority-minority is the one that includes workers age 25 to 34. These are today’s 18- to 27-year-olds and for them, the projected transition year is 2021.

Toute décision d'orientation post-3e non conforme à la demande de la famille doit obligatoirement être motivée. Le chef d'établissement est tenu de mettre en avant des éléments objectifs sur lesquels repose sa décision. "Les motivations comportent des éléments objectifs ayant fondé les décisions, en termes de connaissances, de capacités et d'intérêts (Article D331-34 - Code de l'éducation)."

The phrase "Rule 34" was coined from an August 13, 2003 webcomic captioned, "Rule #34 There is porn of it. No exceptions." The comic was drawn by TangoStari (Peter Morley-Souter) to depict his shock at seeing Calvin and Hobbes parody porn.[1][2]

With the exception of the blues, the rhythm changes progression is probably the mostimportant chord progression in jazz. The term “rhythm changes” refers to a 32-bar AABAform based on the harmonic structure of “I Got Rhythm” by George and Ira Gershwin.The song appeared in the Aarons and Freedley production Girl Crazy (1930) andoriginally featured a 34-bar AABA form with a two-bar extension in the last A section.The two-bar extension was eventually cut and the chord changes of the last A sectionreplicated those from the second A. A newly composed line based on the rhythm changesprogression is known as a contrafact. The enormous popularity of rhythm changes hasbeen well documented by an ever-increasing number of composed contrafacts andrecordings

Archival Resource Keys (ARKs) serve as persistent identifiers, or stable, trusted references for information objects. Among other things, they aim to be web addresses (URLs) that don’t return 404 Page Not Found errors.

nach § 122 Abs. 1

Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected

SUPPLEMENTARY DATA

To this end, 44 missense variants found in breast cancer patients were identified in the ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar) and/or selected by literature curation based on their frequency of description or amino acid substitution position in the protein (Supplemental Table S1).

While 3 VUS (p.W912G, p.L961P, and p.G1043D) had a dramatic impact on the percentage of cells showing RAD51 foci, 2 VUS (p.G937R and p.L947S) displayed a more minor effect.

Source Data

Source Data

Source Data

We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.

Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

we selected 73 previously unstudied variants: 63 suspected Brugada syndrome variants and 10 suspected benign variants

Supplemental material

Supplemental material

We analysed a total of 82 blood samples derived from 77 individuals (online supplemental table 3). These 77 individuals corresponded either to new index cases suspected to harbour a pathogenic TP53 variant or to relatives of index cases harbouring TP53 variants.

In order to protect local interests, and to prevent sectional jealousies, it was found requisite that the three great divisions into which British North America is separated, should be represented in the Upper House on the principle of equality. There are three great sections, having different interests, in this proposed Confederation.

To the Upper House is to be confided the protection of sectional interests ; therefore is it that the three great divisions are there equally represented, for the purpose of defending such interests against the combinations of majorities in the Assembly.

But the very essence of our compact is that the union shall be federal and not legislative. Our Lower Canada friends have agreed to give us representation by population in the Lower House, on the express condition that they shall have equality in the Upper House. On no other condition could we have advanced a step ; and, for my part, I am quite willing they should have it. In maintaining the existing sectional boundaries and handing over the control of local matters to local bodies, we recognize, to a certain extent, a diversity of interests ; and it was quite natural that the protection for those interests, by equality in the Upper Chamber, should be demanded by the less numerous provinces.

Gentlemen, if the principle is good in one case, it is good in another ; let us make the Speaker elective. No, no, they said, that will not do ; that is republicanism.

The Speaker of the Legislative Council is also to be appointed by the Crown, this is another step backwards, and a little piece of patronage for the Government. We have heard in a speech lately delivered in Prince Edward Island or New Brunswick, I forget which, of the allurements offered to the delegates while here in the shape of prospective appointments as judges of the Court of Appeal, Speaker of the Legislative Council, and local governors