Karyotype
Below is a complete explanation of “Karyotype” with English + Chinese plus appropriate images that clearly show what a karyotype looks like.
🧬 Karyotype(核型)
📸 Images of Karyotypes
1. Human Karyotype (46 chromosomes, 23 pairs)
2. Labeled karyotype showing chromosome pairs
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3. Process of making a karyotype
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🇬🇧 English Explanation
What is a karyotype?
A karyotype is an organized photograph of all the chromosomes in a cell, arranged in matching pairs from largest to smallest. It shows:
- the number of chromosomes
- their sizes
- their shapes
- the position of the centromeres
- whether they appear in homologous pairs
- the sex chromosomes (XX or XY)
A karyotype is often used to check for genetic abnormalities.
How chromosomes are arranged in a karyotype
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Chromosomes are photographed during metaphase, when they are condensed and visible.
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They are cut out (digitally) and arranged by:
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Pair (homologous chromosomes)
- Size (largest first)
- Centromere position
-
Banding pattern
-
The final chart shows 23 pairs in humans:
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22 pairs of autosomes
- 1 pair of sex chromosomes (XX or XY)
What a karyotype is used for
Doctors and scientists use karyotypes to detect:
1. Chromosome number abnormalities
- Down syndrome (Trisomy 21) – an extra chromosome 21
- Turner syndrome (XO) – missing one X chromosome
- Klinefelter syndrome (XXY) – extra X in males
2. Structural abnormalities
- deletions
- duplications
- translocations
- inversions
3. Determining biological sex
- XX → typically female
- XY → typically male
🇨🇳 中文解释(Chinese Explanation)
什么是核型(karyotype)?
核型 是把细胞中所有染色体 拍照并按固定顺序排列 所得到的图像。 它可以展示:
- 染色体的 数量
- 染色体的 大小
- 形状和带纹模式
- 着丝点的位置
- 同源染色体是否成对
- 性染色体 XX 或 XY
核型常用于检测 遗传疾病或染色体异常。
染色体如何在核型中排列?
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染色体在 中期(metaphase) 最清晰,因此在该阶段拍照。
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然后按以下顺序排列:
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同源染色体成对
- 按 从大到小 排列
- 根据 着丝点位置
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根据 染色带纹(banding patterns)
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人类共有 23 对染色体:
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22 对常染色体(autosomes)
- 1 对性染色体(XX 或 XY)
核型用于哪些检测?
1. 染色体数目异常
- 唐氏综合征(21 三体) – 多了一条 21 号染色体
- 特纳综合征(XO) – 缺少一条 X 染色体
- 克氏综合征(XXY) – 男性多一条 X
2. 染色体结构异常
- 缺失(deletion)
- 重复(duplication)
- 转位(translocation)
- 倒位(inversion)
3. 判断生物学性别
- XX → 通常为女性
- XY → 通常为男性
🧩 Want More?
I can also provide:
- A comparison chart: karyotype vs genotype
- A step-by-step diagram of how a karyotype is made
- A worksheet-style labeled karyotype practice (English + Chinese)
- Explanation of Down syndrome karyotype (Trisomy 21) with pictures
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