37 Matching Annotations
  1. Last 7 days
    1. the question is why are the mitochondria not doing their job why is the self not responding to insulin 00:05:34 that's the issue different tissues different reasons but the main one is the liver

      for - question - health - insulin resistance - why aren't mitochondria within cells not responding to insulin?

      question - health - insulin resistance - why aren't mitochondria within cells not responding to insulin? - The fat cells are being stored in the liver, resulting in - fatty liver disease - The liver stores the fat cells floating in blood (triglycerides) then recirculates it back to the cells. - The cells and liver are caught up in a vicious cycle of "hot potatos" with the fat cells.<br /> - (See Stanford explainer video above)

  2. Jan 2024
    1. "If we give it to aged mice, they rejuvenate. If we give it to young mice, they age slower. No other therapy right now can do this

      for - CAR T cells - anti aging - eliminate senescent cells in mice. - quote - anti aging - CAR T cells

      quote - (see below)

      • If we give it to aged mice, they rejuvenate.
      • If we give it to young mice, they age slower.
      • No other therapy right now can do this,
      • author: Amor Vegas
    2. for - CAR T cells - research - anti aging - adjacency - CAR T cells - Michael Levin - Cold Spring Harbor Lab - Corina Amor Vegas - senescent cells - fountain of youth

    1. here we have a string of spheres of different colors all right that would be indicative perhaps of some kind of contact i mean i'm just speculating now 00:14:40 this is pure hypothesis but my sense is that these are very much related to what we see inside the cells

      for - claim - painting of meditation experience - direct experience of cells of body

      claim - painting of meditation experience - direct experience of cells in body <br /> - This is an extraordinary claim and would imply we could actually experience our bodies at a microscopic level

  3. Oct 2023
    1. While it is capable of providing constant power, hydrogen fuel cells are also being considered for providing backup power to data centers. This is greatly appealing to data center operators as a more environment-friendly replacement for traditional diesel generators. This change would see the use of fast-start fuel cells, such as proton exchange membrane (PEM) fuel cells which could take the place of diesel generators.

      Proton exchange membranes are presumably the newer types of fuel cells, that are more flexible and need less heat, but are more pricey

    2. The key benefit and primary motivation for installing hydrogen fuel cells within a data center is to reduce carbon emissions. As stated, some fuel cells, such as SOFCs, can use natural gas. While it is less damaging to the environment than diesel, it still results in significant carbon emissions.

      Is this some of the missing context for the CCS next to datacentre patents from M$?

      If you can capture the CO2, and use the waste heat to separate the CO2 from the absorbing material, then it might improve the economics of the SOFC fuel cells, AND deal with the CO2 emissions problem.

    3. SOFCs and PEM fuel cells differ from one another in their construction, materials, and operation. In a high-level view, the primary differences are the electrolyte materials (where the hydrogen and oxygen react) and operating temperatures. SOFCs operate at high temperatures, requiring longer start-up times and as a result, only being suitable for continuous power supply. PEMs, by contrast, operate at lower temperatures and are capable of fast-start or continuous operation, but are a more expensive option.

      Oh wow, so there are two kinds of fuel cells, and the expensive one is the fast ramp up one

    1. From a mechanical perspective, designing a hydrogen storage system is significantly more complex than a diesel storage system. Hydrogen has more storage options available however, it presents higher risks than diesel such as greater flammability and explosivity, higher pressures, potential for low temperature, or chemical storage methods which are all hazardous. This therefore requires the mechanical design for such a system to comply with rigorous safety standards.

      Ok, so h2 unsurprisingly is wast more explodey, and hard to store safely and cheaply

  4. Jul 2023
    1. you can actually grow neuronal stem cells from corpses
    1. Translocation to a cell’s surface utilizes a signal peptide (for inner membrane translocation) and AIDAc as an outer membrane autotransporter pore
  5. Dec 2022
  6. Jul 2022
    1. Published in 2010, Rebecca Skloot’s book The Immortal Life of Henrietta Lacks, offers a three-fold story.  It is the story of the development of the first immortal human cell line (called HeLa) and the scientific advances facilitated thereby. It is also the story of the African American woman from whom the cell line came: Henrietta Lacks was the great-great granddaughter of slaves, who grew up in extreme poverty in Virginia in the 1920s and who died of an aggressive cervical cancer in 1951 in the ward for “colored people” at Johns Hopkins Hospital. Finally, it is the story of her family members, who had no idea about the existence, importance and the financial gains made from HeLa cells until Skloot began her research.   This book sparked more than just an HBO film by the same name starring Oprah Winfrey, it also sparked an attempt at broad policy change in the U.S. regarding consent procedures for human tissue research. Currently, the regulations on research with human subjects issued by the Department of Health and Human Services (HHS) mandate informed consent for the use of biospecimens in research when those specimens are taken specifically for the purpose of research. However, no informed consent for research use is required for tissue samples taken in the course of clinical practice. In 2015, HHS proposed a rule change to give patients much greater control over the use of their biospecimens in research. Yet this effort failed due to backlash from the scientific community.   In this paper, I shall address some of the major arguments against such regulatory changes. For instance, Chadwick & Berg stress a duty to participate in research for the benefit of others; Knoppers & Chadwick further criticize the emphasis on individualism and autonomy over the value of solidarity in contemporary research ethics and policy. My aim is to counter these arguments and to support the proposed regulatory changes in the U.S. regarding tissue research. I hope to highlight important contemporary lessons we have yet to fully appreciate from the case of Henrietta Lacks.

      Skloot sparks interest in HeLa cells.

  7. Mar 2022
    1. Eric Topol. (2022, February 28). A multimodal #AI study of ~54 million blood cells from Covid patients @YaleMedicine for predicting mortality risk highlights protective T cell role (not TH17), poor outcomes of granulocytes, monocytes, and has 83% accuracy https://nature.com/articles/s41587-021-01186-x @NatureBiotech @KrishnaswamyLab https://t.co/V32Kq0Q5ez [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1498373229097799680

  8. Jan 2022
  9. Oct 2021
    1. Granted, how a natural entity can have interiority, i.e., subjectivity, is a hard problem, but if the question of integration and unification is not identical to the “Hard Problem of Consciousness” (Chalmers 1995) it is also inseparable from it and surely a presupposition of the very possibility of interiority. Nor would even an understanding of how subjectivity could be resident to a single cell tell us how consciousness could become an integrated unity across many cells. If we assume consciousness is a physically based phenomenon, and that it draws upon the activity of various parts of the brain, let alone constituent cells, then we must face our deficits in understanding how the experience of a unified consciousness is realized at the level of an integration of some cells but not others albeit in the absence of evident, non-arbitrary, physical boundaries.

      This is a very salient point. The experience of consciousness of a (multicellular) human being is the experience of a biological superorganism. While normativity may apply to the both single and multi-cellular beings by extension, we cannot infer from that alone that our experience of consciousness has an analog at the cellular level.

  10. Mar 2021
  11. Feb 2021
    1. When T-Cells are activated they release cytokines (yes, that cytokine), which trigger additional T-Cells to be made, which then release even more cytokines. One type of T-cells that are created are called cytotoxic T-cells. Cytotoxic T-cells are the cells that are able to roam the body and mercy kill infected cells who are chemically calling out to be killed and ideally to stop the increased production of viruses like COVID-19.
  12. Dec 2020
  13. Aug 2020
  14. Jun 2020
  15. Feb 2020
  16. Aug 2019
    1. the maintenance of the pluripotent state of animal stem cells requires hypoxic conditions, whereas higher oxygen tension promotes cell differentiation
  17. Feb 2019
  18. Oct 2018
  19. biopub.hypothes.is biopub.hypothes.is
    1. Global protein acetylation

      See for example "Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions" by Chunaram Choudhary, Chanchal Kumar, Florian Gnad, Michael L. Nielsen, Michael Rehman, Tobias C. Walther, Jesper V. Olsen, Matthias Mann, Science, 14 Aug 2009, which demonstrates that "the regulatory scope of lysine acetylation is broad and comparable with that of other major posttranslational modifications".

    1. Passaged rBMSCs exhibited significantly greater proliferation rates at 1% O2 and 5% O2 than those at 18% O2 and the cells exposed to 1% O2 showed the highest proliferative potential, which was evidenced by the growth curves, colony-forming efficiencies, and CCK-8 absorbance values.
  20. Oct 2017
  21. Mar 2017
  22. Oct 2016
    1. Eventually cells stuck together to form creatures with many cells. Plants and animals came out of the sea onto land and became ever more complex and aware