2,291 Matching Annotations
  1. Aug 2020
    1. their structure formed by interrelated dimeric polypeptide chains

      TGF beta forms dimer to bind with TGF beta receptor. Homodimers are reported for beta 1 and 2; does heterodimer exists?

    1. This value is about 10 times higher than thevalue reported in literature for this system

      Kd determination by STD may not be accurate with the method mentioned in this paper

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    1. You cannot imagine what it would be like to be dead, because death is an absence of existence.

      What is existence?

    1. ask important questions, s

      Here's another question:

      Why does the open education movement seem unable to break through their margins to take on the man?

    1. regardless of your field of study, honing your writing, reading, and critical-thinking skills will give you a more solid foundation for success, both academically and professionally.

      Can you think of some of the concrete ways that sharpening your writing abilities will help you as you advance in your education and/or profession?

    1. Chapter 2Variables, expressions andstatements2.1 V

      how to assign value to a variable?

    2. Think Python

      what is python?

    1. wereobtainedbycollecting128scans

      number of scans can be accumulated?

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    1. Then when giving answers I'm even less certain. For example I see occasional how-to questions which (IMO) are ridiculously complex in bash, awk, sed, etc. but trivial in python, (<10 lines, no non-standard libraries). On such questions I wait and see if other answers are forthcoming. But if they get no answers, I'm not sure if I should give my 10 lines of python or not.
    2. There is an observable widespread tendency to give an awk answer to almost everything, but that should not be inferred as a rule to be followed, and if there's (say) a Python answer that involves less programming then surely that is quite on point as an answer for a readership of users.
    3. "When an OP rejects your edit, please do not edit it back in!" Correspondingly, when a user repeatedly does try to edit, understand that something in your framing isn't working right, and you should reconsider it.
  2. Jul 2020
    1. narrowpassageway

      How to define is a passageway is narrow or not?

    2. diffusion-limitedon-rate(kon109M1s1)

      this should be the maximum kon, right?

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    1. As shown in Appendix B, for the specific case of AMP, we could have reducedthe computational cost grossly by one order of magnitude

      100 us is enough?

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    1. QUIC 功能
      • ZERO-RTT 如何实现的?
      • TCP 如何重传?
      • TCP 基于 IP&PORT, UDP呢?
      • 加密?how?
    1. This isn’t an accident. OpenOffice’s sidebar code was copied and incorporated into LibreOffice. The Apache OpenOffice project uses the Apache License, while the LibreOffice uses a dual LGPLv3 / MPL license. The practical result is LibreOffice can take OpenOffice’s code and incorporate it into LibreOffice — the licenses are compatible. On the other hand, LibreOffice has some features — like font embedding — that don’t appear in OpenOffice. This is because the two different licenses only allow a one-way transfer of code. LibreOffice can incorporate OpenOffice’s code, but OpenOffice can’t incorporate LibreOffice’s code. This is the result of the different licenses the projects chose.

      What part of LGPLv3 / MPL prevents LibreOffice code from being incorporated back into OpenOffice's Apache Licensed code??

    1. Take a look at the slogans of some of the popular companies.

      Hmm, are these taglines or slogans? According to https://yourbusiness.azcentral.com/slogan-vs-tagline-12643.html:

      A tagline should represent your business, while a slogan represents a single product or is part of an advertising campaign

      it seems that these are more taglines than slogans.

    1. The rela-tively large-sized AR NTDs, however, wrap around the LBDs,blocking the access of SRC-3 to the LBD. Consequently,SRC-3 is solely recruited by the AR NTD, and p300 recruitmentis stabilized by contacting two AR NTDs

      AR NTD wrap around its LBD. Does AR NTD mimic the function of some NR co-activator? These conclusion is only true when AR agonist R1881 is added, check figure 4

    2. in the presence of 1mM R1881

      does AR NTD interact with SRC-3 without R1881?

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    1. The keys will be copied to the heap for the process calling get/0, but the values will not.

      What does this mean?

    1. Low-MODe (LMOD) optimization methods

      Could this be used to LMW?

    2. LMOD

      could I use this for conformational search

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    1. How to deal with solute concentration in MD simulation?

    2. Solvent-balance method of computing binding enthalpies.

      the total potential energy of each system is used ?

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    1. In the Set class we already called this - and difference, which it is ok but not really accurate because of the previous explanation, but probably not worthwhile to change it.

      Is this saying that the name difference is inaccurate?

      Why is it inaccurate? You even called it the "theoretic difference" above.

      Is that because "relative complement" would be better? Or because the full phrase "theoretic difference" [https://en.wiktionary.org/wiki/set-theoretic_difference] is required in order for it to be accurate rather than just "difference"?

    2. inaccurate

      How is the use of - for sets inaccurate?

    1. (Henry 2004, 243), et l’autre à un livre d’Anne Henry

      il est étrange de citer à la suite deux fois Henry

    2. (Körper) des sciences et du corps-sujet (Leib)

      est-ce qu'il ne faudrait pas inclure les déterminant dans les traductions ?

    3. , le philosophe

      cette expression un peu générale l'est peut-être trop

    4. demande à

      nous demande de ?

    1. Flash dont l’activité est déclenchée

      C'est une drôle de comparaison dans la mesure ou le Flash est aujourd'hui obsolète et que les contenus dans ce format sont irrécupérable faute d'avoir les clefs de déchiffrement. Est-ce le même cas pour Proust ?

    2. son regard laborieux en coup de sonde

      je ne suis pas sûre de bien comprendre l'expression

    3. prisonnière

      il me semble que dans les chapitres précédents, le terme était avec une majuscule

    1. La prisonnière.

      majuscule ?

    2. tant soit peu réussie

      je ne suis pas sûre de ce que cette précision apporte.

    3. œuvre littérature

      littéraire ?

    4. steadicam

      en italique ?

    5. filmées au m

      quel est le référent ici ?

    6. selon l’expression de Wittgenstein.

      est ce qu'il existe une référence précise ?

    7. l’-être-présent-au-corps. 

      faut-il conserver le tiret entre l'apostrophe et être ?

    8.  Qu’on imagine à présent la pulpe d’un fruit dont nous apprécions la saveur.

      est-ce une référence à un extrait plus précis ?

    9. Nouvelle Vague

      à vérifier mais il me semble que dans le premier chapitre, Nouvelle Vague est écrit sans majuscule à vague.

    10. ant, le point marquant la transgression d’un silence initial.

      devient le point marquant ? On ne sait pas si cette portion se réfère au corps ou au moment.

    11. À la vérité, cette opposition nous éloigne de la dimension opaque du langage qui se trouve au cœur de l’écriture de Proust.

      peut-être expliciter ici, ce que tu comptes en faire, si le traiter pourquoi, sinon pourquoi également.

    12. considère semble

      semble le considérer ?

    13. textuellement :

      je ne comprends pas bien l'usage de cet adverbe ici

    14. Mais il nous faut maintenant revenir au problème de l’expression qui marque l’éternel commencement, l’univers en perpétuelle création.

      Je ne suis pas sûre de saisir l'idée ici

    1. So why isn't there an easy way to remove an element from such an array in a way that respects both the order and number (count) of each element? Why do all methods for removing elements from an array assume that you always want to remove all matching elements from the receiver, with no option to do otherwise?
    1. JavaScript functions are themselves objects — like everything else in JavaScript — and you can add or change properties on them

      how can we add or change properties on a function?

      edit: see below section (Custom objects)

    1. , Francisco J

      pas de point à J ?

    2.  Quantique »

      tu ne mets pas "Article "..."" ?

    3. chercheur.e.s

      il ne me semble que l'écriture inclusive soit présentes partout...

    4. , c’est à l’écrivain qu’il revient de restituer la complexité de l’expérience intérieure.

      je ne suis pas sûre de la rhétorique de cette phrase

    5. (Francisco J 1996, 71).↩

      J. ?

    6.  (Francisco J 1996, 113

      J. ?

    7. Partant du phénomène physique du comportement des vagues qui présentent différents modèles de diffraction – par exemple les formes qui apparaissent lorsque nous jetons une pierre dans un volume aqueux – et qui résultent de la réaction des vagues en rencontrant un obstacle (2007, 28)

      c'est une phrase nominale ?

    8. décèdera des suites d’un accident à cheval

      C'est une hypothèse totalement parce que je ne connais pas bien le passage (si passage il y a) de l'accident de cheval, mais est-ce qu'il y aurait peut-être une piste ou un élément d'analyse à trouver dans cet objet du cheval (objet sexuel chez Freud) qui est à la fois un ancien corps "technique" de voyager ?

    9. Corps en mouvement : Le cas Saint-Loup

      je me demande pourquoi tu édites certaine parties comme des listes (ici certainement avec un *) plutôt que de mettre un titre de niveau 4

    10. nser »[No

      espace manquand, enlever le point dans les crochets, mais surtout pourquoi le souligner ?

    11. l’illustre le rendez-vous manqué avec Gilberte

      donner la référence ?

    12. Ces expériences lancinantes sont

      à quoi cela se réfère ? si c'est à la citation de la note, mieux vaut intégrer la citation en retrait dans le texte

    13. [corporelle]

      pourquoi des crochets ?

    14. « it is after all, the story of a ‘nervous Narrator’ who struggles against negative hereditary factors in his family (personified in the semi-invalid aunt Léonie), and who suffers from a chronic lack of drive that makes him prefer salon time to productive time alone 

      Il me semblait que dans les chapitres précédents les citations en anglais été traduites

    15. dimension originaire de silence

      je ne suis pas sûre de bien comprendre ici le rapport au silence

    16.  The disruption and constriction of one’s habitual world thus correlates with a new relation to one’s body. In pain, the body or a certain part of the body emerges as an alien presence » (Leder 1990, 76).

      peut-être proposer une traduction en note ?

    17.  L’espace intercorporel qui se fait jour existe en deçà des paramètres usuels qui nous permettent de saisir l’expérience humaine (langage, lois sociales), elle en efface les signifiants.

      je ne ne comprends pas bien la succession des sujets ici

    18. Autrement dit, si cette technique n’avait pas existé, le narrateur n’aurait pas pu exprimer la même chose

      Peut-être est-ce juste une question d'expression, parce que je saisis bien l'idée du paragraphe, mais cette phrase résonne à la lecture selon l'adage "avec des si, on mettrait Paris en bouteille"

    19. Si la voix inépuisable qui résonne à travers la Recherche s’adresse directement au lectorat, on peut être sensible à ce qu’elle recèle

      La construction "si...., alors ..." implique souvent une contradiction sousentendue, ici je ne la vois pas. Peut-être choisir une construction plus causale ?

  3. Jun 2020
    1. In this case, we notice that comment.post and post should belong to the same database object. But, is Rails smart enough to know that the comment should be removed from both of the associations? Or are comment.post and post different representations of the same database row?
    1. 1,103-membered F2X-Universal Library

      what compounds are contained in the library?

    2. ry presentation of the libraries al-lows CFS campaigns to be carried out with or without the co-solvent DMSO present.

      what does "dry presentation" mean?

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    1. great importance should be placed on accurately characterizing the solubility of a fragment library

      for X-ray screening, solubility must be good enough. what is the cutoff?

    2. use ligand-observed NMR

      Does "ligand observed NMR" equal to "ligand 1D-NMR"

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    1. but subsequent trials failed to show any acti

      cellular activity is not promising

    1. essais.

      majuscule ?

    2. Vocabulaire de.

      ?

    3. Cité d’après « L’œuvre d’art à l’époque de sa reproduction mécanisée », in Zeitschrift für Sozialforschung 5, 1936, p. 43 Benjamin (2010).↩

      je ne comprends pas très bien le lien entre la note et le texte

    4. (Cité d’après Benjamin 2010, 123)

      pourquoi le "cité d'après" ?

    5. laborieuses Proust

      virgule + pourquoi laborieuse ?

    6. espace médian entre un rire et le voile du regard.

      c'est à peu prè la même construction poétie ue plus haut, y-a-t-il un passage en particulier qui l'encourage ?

    7. l’information centrale est bien « la vague éclaboussante » qui s’est imprimée à la manière d’un pli dans la conscience d’Elstir

      je ne suis pas sûre de bien saisi l'idée dans le deuxième temps de cette phrase.

    8. Le toucher. Odorat et ouïe.

      pourquoi séparer les sens par un point ?

    9. n tant qu’étoffe indivise qui entre-tisse, en même temps que notre corps, les choses, les animaux, les autres

      j'ai de la difficulté à comprendre la structure de cet insert, une erreur quelque part ?

    10. qui est au monde.

      la formulation me semble un peu compliquée à comprendre, je m'interroge surtout sur le "qui"

    1. With this second scheme, the DBMS stores the physical addressof versions in the index entries. This approach is only applicablefor append-only storage, since the DBMS stores the versions in thesame table and therefore all of the indexes can point to them. Whenupdating any tuple in a table, the DBMS inserts the newly createdversion into all the secondary indexes. In this manner, the DBMScan search for a tuple from a secondary index without comparingthe secondary key with all of the indexed versions. Several MVCCDBMSs, including MemSQL and Hekaton, employ this scheme

      Physical Pointers: 只对Append-only storage有用

      问题:“since the DBMS stores the versions in the same table and therefore all of the indexes can point to the”这句话怎么理解

      Likewise, using physical pointers is better for read-intensive workloads because an index entry points to the exact version. But it is slower for update operations because this scheme requires theDBMS to insert an entry into every secondary index for each new version, which makes update operations slower

    2. multi-versioning does notbring any benefits to phantom prevention

      How to prevent Phantom in MVCC?

    3. Thebasic idea of MVCC is that the DBMS maintains multiple physicalversions of each logical object in the database to allow operations onthe same object to proceed in parallel.

      How to make sure different physical copies are in sync?

    4. when there are a large numberof threads running in parallel, the synchronization overhead canoutweigh the benefits of multi-versioning

      如何保证延展性

    1. Annotating in Sections

      What exactly do they mean by annotating? Is it note taking, or a conversation?

    1. de matière physico-chimiques

      si c'est bien les connexions qui sont physico-chimiques je placerai ce terme avant "de matière"

    2. Entfremdung en allemand

      pourquoi cette précision ?

    3. résulte l’impuissance

      résulte de ?

    4. dépayement

      dépaysement ?

    5. Ce n’est là qu’une des dénominations de couleur mythique que nous trouvons

      Je ne comprends pas le lien entre le texte et la note.

    6. un fond d’altérité sous-tendant le commerce d’un étant avec le monde

      Je trouve cette formule un peu trop complexe, on a du mal à voir ce que tu veux dire ... sous-entendu une relation avec autrui ?

    7. Dans la dichotomie qui s’établit entre l’aplatissement et la fragmentation de l’expérience (l’appréhension cinématographique du voyage en automobile) d’une part, et son intensification (« quand notre imagination nous portait du lieu où nous vivions jusqu’au cœur d’un lieu désiré »).

      est-ce volontairement ici une phrase nominale ?

    8. à la du Côté de chez Swann

      il manque un élément je crois + j'ajouterai une virgule après Swann

    9. incarnée

      je ne suis pas sûre du sens ici : corporelle ? ou tout simplement reçue ?

    10. simple:

      espace + peut être que simple est condescendant ?

    11. Prous),

      Proust ?

    12. sa lecture du monde

      le référent n'est pas clair : la lecture du stéréoscope ? la représentation alors plutôt ?

    13. (dé)limitent.

      Pourquoi cette précision avec parenthèse ?

    14. Or pourquoi recourir à l’image du stéréoscope pour expliquer la profondeur de l’image perçue?

      peut-être faut-il mieux exprimer l'apparente incohérence dans l'association : image intime / dispositif extérieur ?

    15. clarté de cette description

      clarté dans quel sens ?

    16. On peut alors se demander pour quelle raison Proust recourt à la vision artificielle du stéréoscope.

      est ce qu'il y a un fait étonnant à ce qu'il le fasse ?

    17. dont affectent

      dont ils ?

    18. Des premières p

      Dans les ? ou Dès ?

    19. est racontée

      le référent n'est pas clair ici, est-ce bien le récit ?

    20. à la croisée de la vie intérieure et des désordres situés au-delà des limites corporelles

      c'est une belle formule mais peut-être un peu trop forte dans le style, peut-être l'alléger un peu pour que l'idée soit plus évidente à la lecture ?

    21. caractère stérile

      pourquoi stérile ?

    22. s qu’elles éme

      problème de référent ici : ils émergent ?

    23. Pour rassurante qu’elle paraisse,

      rassurante parce que calculable ?

    24. Lalande, Poirier, et Philosophie

      le troisième auteur s'appelle vraiment Philosophie ?

    25. sont

      dont ?

    26. e, ;

      C'est peut-être ici une retranscription juste mais je m'étonne de la succession des deux ponctuations virgule et point virgule

    1. UT-34 induced the regression of enzalutamide-resistant tumors at doses when the AR is degraded

      What dose?

    2. T-34 caused the degradation of the full-length AR, but not the tau-5-deleted AR

      tau-5 locates between AF-1 and DBD, deletion of this region may cause significant protein structure change, such change may result in different AR degradation profile which is irrelavant with UT-34

    1. It would be better if you asked a new question. In the worst case scenario, it would be marked as a duplicate (which still means you would probably get some sort of resolution).
    1. chloroform extracts of ten marine sponges werescreened for their antimicrobial activit

      chloroform extracts were directly used without further separation for antimicrobial activity test. How to separate the active indigrient then?

    2. more than5000 different compounds have been isolated fromabout 500 species of sponges

      will this reference provide a list of extracts of marine sponges

    3. Since then well over 14,000 dif-ferent natural products from marine organismshave been described

      will this reference provide a list of extracts of marine sponges

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    1. A 2 fold molar excess of peptide was added to the protein prior to crystallization (RGAFQNLFQSV).

      why such a peptide is added for AR crystal structure?

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    1. tunnel splitting

      What exactly is tunnel splitting? The essay mentions this various times without clearly explaining what it is, and whenever I search it up online multiple things are said about it.

      From what I could understand, quantum spin tunnel splitting makes it so that the magnetization of a system can "switch between states with opposite magnetization that are separated by an energy barrier much larger than thermal energy". But what exactly happens during tunnel splitting? And why are there different ones mentioned in the article? [magnetization tunneling, zero-field tunnel splitting, ground-state tunnel splitting]

      I also understand that this phenomenon "defies classical physics" because of magnetization switching. How is that possible?

  4. May 2020
    1. Related concepts in other fields are: In natural language, the coordinating conjunction "and". In programming languages, the short-circuit and control structure. In set theory, intersection. In predicate logic, universal quantification.

      Strictly speaking, are these examples of dualities (https://en.wikipedia.org/wiki/Duality_(mathematics))? Or can I only, at strongest, say they are analogous (a looser coonection)?

    1. ssh-add <(echo "$PRIVATE_KEY")

      Does this have any advantage over simply saving that key to a key file under ~/.ssh?

      Like they do on https://stackoverflow.com/a/61944004/47185:

      mv "$DEPLOY_KEY_PRIVATE" ~/.ssh/id_rsa
      
    1. 1. Disabling concrete extension update. That's what I wanted! You can do this by editing the extensions manifest json-file on Windows: C:\Users\<USERNAME>\AppData\Local\Google\Chrome\User Data\Default\Extensions\<EXTENSION-ID>\<VERSION>\manifest.json (find out the extensions ID by enabling developer mode in the extension settings page) on Ubuntu for Chromium: ${HOME}/.config/chromium/Default/Preferences In this file set "update_url" property to something invalid like "https://localhost" for example. For now according to given url updating of that extension is simply impossible.
    1. If you update your pages and push to github, people revisiting the pages who have already got cached copies will not get the new pages without actually cleaning their browser cache. How can a script running in a page determine that it is stale and force an update?
    1. Mojofication, Onion Souping, and the Network Service.

      What is Mojofication?

      What is Onion Souping?

    1. The consent provided by the user is saved in some cookies within the host page’s domain. By verifying the presence or the absence of these cookies you can determine whether the user has given their consent or not.

      But how do you check if they've given consent to a specific category??

    1. Protein:lipid~3:1

      this ratio is contrary to the quote 1:10 Lipitor get through the membrane through OATP1B1?

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    1. Make it clear that signing up is optional. Consent must be “freely given”; you may not coerce users into joining your mailing list or make it appear as if joining the list is mandatory. For this reason, you must make it clear that signing up is optional. This is especially relevant in cases where you offer free white-papers (or e-books) for download. While the user’s email address is required for the delivery of the service, signing up for your newsletter is not. In such a case, you must not make it appear as if signing-up to the newsletter list mandatory and must make it clear that it is optional.

      Question (answer below)

      Are they saying that it's not allowed to make signing up for a mailing list a precondition/requirement for anything? This was surprising to me.

      So if you have a newsletter sign-up page that sends a digital bonus gift (like an e-book) to new subscribers, are required to completely change/repurpose your "newsletter sign-up page" into a "download e-book page" (that has an optional checkbox to also sign up for the newsletter, if you want)? That seems dumb to me, since it requires completely reversing the purpose of the page — which was, in my mind, primarily about signing up for the newsletter, with a bonus (an essentially optional one) thrown in for those who do so. Are you required to either repurpose it like that or remove the free bonus offer that would be sent to new subscribers?

      The irony of this is that it requires websites that have a newsletter sign-up page like that to change it into a "newsletter sign-up page" where the newsletter sign-up part is optional. Which make you look kind of stupid, making a page that claims to be one thing but doesn't necessarily do what it says it's for.

      Does this mean, in effect, that you may not lawfully provide any sort of incentive or reward for signing up for something (like a mailing list)? As long as it's very clear that some action is required before delivery of some thing, I don't see why this sort of thing should not be permitted? Would this fall under contract law? And as such, wouldn't such a contract be allowed and valid? Are mailing lists a special class of [service] that has special requirements like this? Or is it part of a broader category to which this requirement applies more generally?

      Why is requiring the user to provide an email address before they can download a digital reward allowed but not requiring signing up to a mailing list? Why isn't it required that even the email address be optional to provide? (To answer my own question, probably because it's allowed to allow a user to request a specific thing to be sent via email, and an email address is required in order to fulfill that request. But...) It seems that the website could just provide a direct link to download it via HTTP/FTP/etc. as an option for users that chose not to provide an email address. (But should they be required to provide that option anytime they / just because they provide the option to have the same thing delivered via email?)

      Answer

      Looks like my question was answered below:

      Explicit Form (where the purpose of the sign-up mechanism is unequivocal). So for example, in a scenario where your site has a pop-up window that invites users to sign up to your newsletter using a clear phrase such as: “Subscribe to our newsletter for access to discount vouchers and product updates!“, the affirmative action that the user performs by typing in their email address would be considered valid consent.

      So the case I described, where it is made very clear that the incentive that is offered is conditional on subscribing, is listed as an exception to the general rule. That's good; it should be allowed.

    1. Ideally you should really test these parameters (by comparing to ab initio calculations for example) to ensure they are reasonable

      How to compare?

    2. C, N, O, S, P, H, F, Cl, Br and I

      GAFF only supports 10 elements?

    1. Regular Expression Functions There are three regular-expression functions that operate on strings: matches() tests if a regular expression matches a string. replace() uses regular expressions to replace portions of a string. tokenize() returns a sequence of strings formed by breaking a supplied input string at any separator that matches a given regular expression. Example:   

      Test question: how many are there regular-expression functions in XSLT?

    2. What’s the difference between xsl:value-of, xsl:copy-of, and xsl:sequence? xsl:value-of always creates a text node. xsl:copy-of always creates a copy. xsl:sequence returns the nodes selected, subject possibly to atomization. Sequences can be extended with xsl:sequence.

      What’s the difference between xsl:value-of, xsl:copy-of, and xsl:sequence?

    3. <xsl:variable name="date" select="xs:date('2003-11-20')"/>

      How to declare the date in the variable in XSLT 2?

    4. Types XSLT 2.0 allows you to declare: The type of variables. The return type of templates. The type of sequences (constructed with xsl:sequence) The return type of (user-declared) functions. Both the type and required type of parameters.

      What are the types that one can declare in XSLT 2?

    1.  <xsl:sequence select="1 to 16"/>

      How to create a sequence with range.

    2. <xsl:for-each select="1 to 32">  <!-- Do something useful here --></xsl:for-each>

      How to create a loop in XSLT?

    3. The new as attribute defines the data type of the variable, and the asterisk (xs:integer*) means that the sequence contains zero or more integers

      How is the @as attribute? Which values can it have?

    4. One of the major new concepts in XPath 2.0 and XSLT 2.0 is that everything is a sequence.

      What is one of the major concepts in XPath 2.0 and XSLT 2.0?

    1. relax ligand-receptor complexeswithout causing major alterations of their originalgeometry, or to perform a torsional scan on a selecteddihedral while relaxing the rest of the molecule.

      such functions are like Schrodinger MacroModel, how to implement them?

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    1. MONN contains a pairwise interaction prediction module, which can capture the non-covalent interactions between atoms of a compound and residues of a protein with extra supervision from the labels extracted from available high-quality 3D compound-protein complex structures

      does that mean MONN can predict binding site

  5. Apr 2020
    1. A company runs a memory-intensive analytics application using on-demand Amazon EC2 C5 compute optimized instance. The application is used continuously and application demand doubles during working hours. The application currently scales based on CPU usage. When scaling in occurs, a lifecycle hook is used because the instance requires 4 minutes to clean the application state before terminating.Because users reported poor performance during working hours, scheduled scaling actions were implemented so additional instances would be added during working hours. The Solutions Architect has been asked to reduce the cost of the application.Which solution is MOST cost-effective?

      should be A here, cause C5 is 40% cheaper than R5

    1. Is UFF a all atom force field?

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    1. Mixed the plate thoroughly and incubated for one hour at room temperature. Then 5 μL development solution was added to each well and the plate was incubated for 1h at room temperature;

      the compound and kinase are incubated together for at least 2 hours. And 2 hours is enough for covalent adduct to form. if compound can form covalent adduct with FGFR1, why FGFR1 inhibition IC50 is so poor?

    1. Structure-Based Design

      which structure they used?

    2. 6NTS

      PDB code, but it is not available in PDB website yet

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    1. What is a Function Expression?A JavaScript function can also be defined using an expression.A function expression can be stored in a variable:var x = function (a, b) {return a * b};After a function expression has been stored in a variable, the variable can be used as a function. Functions stored in variables do not need function names. They are always invoked (called) using the variable name.

      Test question: What is function expression?

    1. Writing an async function is quite simple. You just need to add the async keyword prior to function:

      Test question: What is the syntax of async function?

    1. Using objects as keys is one of most notable and important Map features.

      Test question: What is one of the most notable and important Map features?

    2. Map is a collection of keyed data items, just like an Object. But the main difference is that Map allows keys of any type.

      Test question: What is the difference between Map and Object in JavaScript?

  6. javascript.info javascript.info
    1. he basic syntax is: let promise = fetch(url, [options])

      Test question: What s the basic syntax of fetch(); ?

    1. Webpack is a most have to compile a complete JavaScript project.

      Test question: how do you pack the web extension?

    2. linter

      Test question: What is a linter?

      Answer (Wikipedia): lint, or a linter, is a tool that analyzes source code to flag programming errors, bugs, stylistic errors, and suspicious constructs.[1] The term originates from a Unix utility that examined C language source code.[2]

    3. This tool accepts both a configuration file and line parameters.

      Test question: How can you configure web-ext?

    1. A poised fragment library enables rapid syntheticexpansion yielding thefirst reported inhibitors ofPHIP(2), an atypical bromodomain

      what is the library? compound in the library can be expanded quickly by synthesis why they designed it this way? they did not find convincing hits from solution screen. They use crystallography as primary screening tech what assay they used for the screening? AlphaScreen competition assay as function assay

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    1. Most pages aren’t very dynamic, and therefore won’t have any orphans. In these cases, the orphans tab will not appear.

      Question: What about to use archive.org when the page is dramatically changed?

    1. document.addEventListener(event, function, useCapture)

      Test question: What is the syntax of element.addEventListener() ?