17 Matching Annotations
  1. Nov 2023
    1. in a normal person this is what their sympathetic nervous 00:06:45 system activity looks like and people with sleep apnea who are having these difficulties at night this is what their sympathetic nervous system looks like during the day when they're actually not having apnea it's because it's ramped up 00:06:57 and this is a problem that causes their blood pressure to not be able to relax
      • for: sleep apnea - sympathetic nervous system - comparison
    1. once we get under stress we hit what they call the sympathetic nervous system the sympathetic nervous system causes a a a stoppage 00:27:18 to the to the digestive system in other words you know with this pure sympathetic is what we call the rest and digest so when you're relaxed you digest food better okay when you're when you're in the skin tense 00:27:31 so what happens is when you get tense the digestive system doesn't function correctly so now you got food in there you need you need you need that acid you need the enzymes to work correctly but nothing's working so you got food 00:27:44 sitting in there that's not getting digested all right so what does it do it's got to go somewhere
      • for: stress - affects digestion - sympathetic nervous system
  2. Jun 2023
    1. The 4 (behavioral) keypoints for great physical and mental as well as cognitive health:

      One) (2:00-4:05) View sunlight early in the day. The light needs to reach the eyes--increasing alertness, mood, and focus, through certain receptors. Also increases sleep quality at night, according to Huberman. Ideally five to ten minutes on a clear day, and ten to twenty minutes on an overcast day. No sunglasses, and certainly not through windows and windshields. If no sun is out yet, use artificial bright light. Do this daily.

      Two) (4:05-6:10) Do physical exercise each and every day. Doesn't have to be super intense. Huberman recommends zone two cardiovascular exercise. Walking very fast, running, cycling, rowing, swimming are examples. He says to get at least between 150 and 200 minutes of this exercise per week. Some resistance training as well for longevity and wellbeing, increases metabolism as well. Do this at least every other day, according to Huberman. Huberman alternates each day between cardiovascular exercise and resistance training.

      Three) (6:20-9:10) People should have access to a rapid de-stress protocol or tools. This should be able to do quickly and instantly, without friction. You can just do one breath for destress. ( Deep long breath through nose, one quick breath in nose to completely fill the longs, and then breathe out through mouth long.)

      Four) (9:12-14:00) To have a deliberate rewiring nervous system protocol to use. A thing that can be done is NSDR (Non-Sleep Deep Rest protocol), this is specifically to increase energy.

      Ideally the NSDR should be done after each learning session as well to imitate deep sleep (REM) and therefore accelerate neuroplasticity and thus rewire the nervous system; increasing the strength of connections between neurons and therefore increase retention significantly.

      NSDR is also a process of autonomity and control, it allows one to find that they are in control of their body and brain. It makes one realize that external factors don't necessarily have influence. According to Huberman, NSDR even replenishes dopamine when it is depleted, making it also suitable for increasing motivation.

  3. Oct 2021
    1. Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J. U. G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C., … Schwaninger, M. (2021). The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nature Neuroscience, 1–12. https://doi.org/10.1038/s41593-021-00926-1

  4. Sep 2021
    1. I think Marshall McLuhan knew it all. I really do. Not exactly what it would look like, but his view and Postman’s view that we are creating a digital global nervous system is a way they put it, it was exactly right. A nervous system, it was such the exact right metaphor. And he didn’t — it’s not that they saw it exactly, but I really love those mid-century media critics because they saw something happening clearer than we see it now. And it is a nervous system. I’m a huge Marshall McLuhan stan.

      We are creating physical infrastructure to scale, enhance, and amplify human capabilities to extend our reach beyond the constraints of time and space.

  5. Jun 2021
    1. The PDMs of this model show promise in revealing the important dynamic characteristics of the underlying physiological mechanisms and allow the formulation of specific quantitative hypotheses about the role of the sympathetic and parasympathetic activity (corresponding to specific PDMs) in cerebral perfusion and autoregulation. Consistent with the widely held view regarding the temporal characteristics of autonomic control of the cardiovascular system, it is posited that the HR PDMs with a resonant spectral peak around 0.2 Hz may be associated with parasympathetic activity, whereas the PDMs with a resonant spectral peak around 0.12 Hz may be associated with sympathetic activity
  6. Feb 2021
  7. Jan 2021
  8. Jul 2020
  9. Aug 2018
    1. CONCLUSIONS: These findings suggest that higher standing BP is a biomarker that helps identify persons with combat PTSD who are likely to benefit from prazosin. These results also are consistent with α1AR activation contributing to PTSD pathophysiology in a subgroup of patients.

      This is precisely the results I would expect. However, I completely disagree with their interpretation.

      People with high blood pressure (BP) can tolerate a reduction in BP without instigating compensatory mechanisms. People with normal or low BP would invoke compensation by the sympathetic nervous system in response to alpha blockade. This would counteract the depressant effects of adrenergic antagonism. Indeed, adrenaline and noradrenaline elevate in response to standing, which I find to be an obvious prediction. Thus, the lack of benefit from prazosin in these subjects may be mediated by an increase in adrenergic receptor activation other than the apha1-adrenoreceptor; in particular, the beta-adrenergic receptors are likely at fault. Propranolol, a beta-blocker, is used for PTSD, so this mechanism seems well substantiated.

      The study apparently found benefit for patients with BP over 110 (with more benefit for higher BP). Thus, I would conclude that systolic pressure below 110 induce compensation.

  10. Oct 2016