19 Matching Annotations
  1. May 2024
  2. Apr 2024
    1. This is not a discrete project but an ongoing process and should always be competing for focus in strategic decision making.

      Absolutely agreed. One limitation of the Iron Triangle concept is that it often seems to be used to make decisions based on a snapshot in time (i.e. which two are we choosing now), when some choices have longer half-lives than others.

  3. Feb 2024
  4. Jan 2024
    1. I wash and dry my pan immediately after each use, but it’s what happens next that matters: I heat it gently over a low flame and add a bit of ghee. Then, I grab my dedicated “cast iron cloth” and rub the oil into the bottom and sides of the pan. I wait until the pan feels warm, but the ghee isn’t shimmering and snapping. Then I simply turn off the heat and let the pan cool naturally. This small step keeps it glossy and well-seasoned.
  5. Oct 2023
    1. "Iron Eyes" Cody (1904–1999)[79][80] – Born as Espera Oscar de Corti, and came to be known as "The Crying Indian". An Italian-American actor most well known for his appearance in a 1970's anti-littering commercial. Cody pretended to be from various tribes and denied his Italian heritage for the rest of his life.
  6. May 2023
    1. iron-bearing transferrin interacts with its receptor
      1. Iron is transported in the blood by the iron-transferrin complex.
      2. The complex interacts with specific transferrin receptors on the surface of cells that express transferrin receptors, such as developing erythroblast cells.
      3. The iron-bearing transferrin is internalized via clathrin-coated pits and transported to an acidic endosome.
      4. Iron is released from the transferrin at the low pH of the endosome.
      5. Iron is made available for heme synthesis.
      6. The transferrin-receptor complex is recycled to the surface of the cell.
      7. The bulk of the transferrin is released back into circulation, and the transferrin receptor re-anchors into the cell membrane.
      8. Iron in excess of the amount needed for hemoglobin synthesis binds to a storage protein, apoferritin, forming ferritin.
      9. Senescent red cells are recognized by the cells of the reticuloendothelial system and undergo phagocytosis.
      10. Hemoglobin is broken down, and the iron is shuttled back to the surface of the RE cell.
      11. Iron is presented to circulating transferrin via the iron export channel, ferroportin.
      12. Iron is then available for reutilization for hemoglobin synthesis
  7. Mar 2023
    1. Hatti at War

      Iron at this time was meteoric in origin and incredibly valuable, so it wouldn't have been used until after the collapse of the Hittite Empire when iron smelting began its rise; bronze weapons would have been more common as a result.

  8. Jan 2023
    1. during Iron Age I, in the 12th–11thcenturies BCE, Ekron, which is located very near the Sorek Valley, was thedominant Philistine center, and the biblical tradition accordingly places thenarrative concerning the Philistines in that valley.
    2. duringIron Age IIA, the 10th–9th centuries BCE, Gath in the Elah Valley becamethe dominant Philistine center and the biblical tradition recounting theborder disputes between the Philistines and the Israelites accordingly shiftsfrom the Sorek Valley to the Elah Valley.
    3. Traditions connected to the Elah Valley are preserved in the books ofSamuel and Chronicles, which relate to Iron Age IIA.
  9. Nov 2021
    1. And it's this process, the gravitational dance of 100,000 galaxies swirling together, 00:05:25 which drive the process of galaxies colliding, which drive massive star formation, which drive the process of creating the iron that courses through each one of our veins with every heartbeat.

      For a deeper explanation outside of the TED Talk format, it would be enlightening to unpack a bit of the science behind how astronomers come to these conclusions.

  10. Oct 2021
  11. May 2020
    1. indicating that delftibactin is most likely a siderophore that serves at least two purposes for this organism.

      What is the second purpose (regarding interactions with iron)?



  12. Feb 2020
    1. A commodity, such as iron, corn, or a diamond, is therefore, so far as it is a material thing, a use value, something useful

      What commodities are thought to be useful for or not is irrelevant to Marx at this very early stage of his analysis, even from a moral point of view. Diamonds satisfy a need in some societies at specific times and places the same as corn or iron.

  13. Sep 2018
    1. As student numbers have increased, teaching has regressed for a variety of reasons to a greater focus on information transmission and less focus on questioning, exploration of ideas, presentation of alternative viewpoints, and the development of critical or original thinking. Yet these are the very skills needed by students in a knowledge-based society.

      Related to Vijay Kumar's iron triangle. You can't increase the number of students without sacrificing quality or increasing costs.

  14. Feb 2018
    1. Let the abysmal brute roar and the police and Mercenaries slay.

      "Abysmal brute" is a term of elitism, as is the expectation that they should die for the vision of the revolutionists. Is the relationship any different than he one between Jackson and the mill?



  15. Feb 2017