21 Matching Annotations
  1. Aug 2024
  2. Jul 2024
  3. May 2024
  4. Apr 2024
  5. Feb 2024
  6. Jan 2024
    1. I wash and dry my pan immediately after each use, but it’s what happens next that matters: I heat it gently over a low flame and add a bit of ghee. Then, I grab my dedicated “cast iron cloth” and rub the oil into the bottom and sides of the pan. I wait until the pan feels warm, but the ghee isn’t shimmering and snapping. Then I simply turn off the heat and let the pan cool naturally. This small step keeps it glossy and well-seasoned.
  7. Oct 2023
  8. May 2023
    1. iron-bearing transferrin interacts with its receptor
      1. Iron is transported in the blood by the iron-transferrin complex.
      2. The complex interacts with specific transferrin receptors on the surface of cells that express transferrin receptors, such as developing erythroblast cells.
      3. The iron-bearing transferrin is internalized via clathrin-coated pits and transported to an acidic endosome.
      4. Iron is released from the transferrin at the low pH of the endosome.
      5. Iron is made available for heme synthesis.
      6. The transferrin-receptor complex is recycled to the surface of the cell.
      7. The bulk of the transferrin is released back into circulation, and the transferrin receptor re-anchors into the cell membrane.
      8. Iron in excess of the amount needed for hemoglobin synthesis binds to a storage protein, apoferritin, forming ferritin.
      9. Senescent red cells are recognized by the cells of the reticuloendothelial system and undergo phagocytosis.
      10. Hemoglobin is broken down, and the iron is shuttled back to the surface of the RE cell.
      11. Iron is presented to circulating transferrin via the iron export channel, ferroportin.
      12. Iron is then available for reutilization for hemoglobin synthesis
  9. Mar 2023
  10. Jan 2023
  11. Nov 2021
    1. And it's this process, the gravitational dance of 100,000 galaxies swirling together, 00:05:25 which drive the process of galaxies colliding, which drive massive star formation, which drive the process of creating the iron that courses through each one of our veins with every heartbeat.

      For a deeper explanation outside of the TED Talk format, it would be enlightening to unpack a bit of the science behind how astronomers come to these conclusions.

  12. Oct 2021
  13. May 2020

    Tags

    Annotators

  14. Feb 2020
  15. Sep 2018
    1. As student numbers have increased, teaching has regressed for a variety of reasons to a greater focus on information transmission and less focus on questioning, exploration of ideas, presentation of alternative viewpoints, and the development of critical or original thinking. Yet these are the very skills needed by students in a knowledge-based society.

      Related to Vijay Kumar's iron triangle. You can't increase the number of students without sacrificing quality or increasing costs.

  16. Feb 2018
    1. Let the abysmal brute roar and the police and Mercenaries slay.

      "Abysmal brute" is a term of elitism, as is the expectation that they should die for the vision of the revolutionists. Is the relationship any different than he one between Jackson and the mill?

    Tags

    Annotators

  17. Feb 2017