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  1. Last 7 days
    1. Watts, Charles J. The Cost of Production. Muskegon, MI: The Shaw-Walker Company, 1902. http://archive.org/details/costproduction01wattgoog.

      Short book on managing manufacturing costs. Not too much of an advertisement for Shaw-Walker manufactured goods (files, file management, filing cabinets, etc.). Only 64 pages are the primary content and the balance (about half) are advertisements.

      Given the publication date of 1902, this would have preceded the publication of System Magazine which began in 1903. This may have then been a prototype version of an early business magazine, but with a single author, no real editorial, and only one article.

      Presumably it may also have served the marketing interests of Shaw-Walker as a marketing piece as well.


      Tangentially, I'm a bit intrigued by the "Mr. Morse" mentioned on page 109 who is being touted as an in-house consultant for Shaw-Walker.... Is this the same Frank Morse who broke off to form the Browne-Morse Co.? (very likely)

      see: see also: https://hypothes.is/a/Sp8s4sprEe24jitvkjkxzA for a snippet on Frank Morse.

    1. Webflow is a cloud-based platform that enables you to create responsive websites without writing code. With Webflow, you can quickly and easily create a fully functional website in just minutes! In this article, we’ll look at the step-by-step process for How to Build a website with Webflow, plus an overview of the cost involved.

  2. Mar 2023
    1. My translation of Niklas Luhmann (1997): Die Gesellschaft der Gesellschaft, Frankfurt/M: Suhrkamp. S.11: “Bei meiner Aufnahme in die 1969 gegründete Fakultät für Soziologie der Universität Bielefeld fand ich mich konfrontiert mit der Aufforderung, Forschungsprojekte zu benennen, an denen ich arbeite. Mein Projekt lautete: Theorie der Gesellschaft; Laufzeit: 30 Jahre; Kosten: keine.”

      As I began to work at the 1969 founded faculty of sociology of the University of Bielefeld, I was confronted with the request to name research projects I work on. My project was: a theory of society; Duration: 30 years; Costs: none.(1)

  3. Jan 2023
    1. civilizations have risen and Fallen based on their ability to manage their 00:08:45 scarce Water Resources we are no different

      !- water boundary : technological assistance -low cost ocean water purification

  4. Dec 2022
    1. In 1988, when polio was endemic in 125 countries, the annual assembly of national health ministers, meeting in Geneva, declared their intent to eradicate polio by 2000. That target was missed, but a $3 billion campaign had it contained in six countries by early 2003.
    1. The polio-vaccine conspiracy theory has had direct consequences: Sixteen countries where polio had been eradicated have in recent months reported outbreaks of the disease – twelve in Africa (Benin, Botswana, Burkina Faso, Cameroon, Central African Republic, Chad, Ethiopia, Ghana, Guinea, Mali, Sudan, and Togo) and four in Asia (India, Indonesia, Saudi Arabia, and Yemen). Yemen has had the largest polio outbreak, with more than 83 cases since April. The WHO calls this "a major epidemic."
    1. f you started in January 2022 the numbers in Brackets if you started January 2023 so look how much difference one year makes particularly under the 1.5 budget it's 00:25:55 just enormous you realize how rapidly each year we choose to fail how much that changes the following year and I think that's a really key message here that because we've left it so late every day of failure makes makes 00:26:09 tomorrow much much harder whichever way you look at this whether it's 1.5 or 2 degrees Centigrade whether it's Sweden the UK the US Australia Japan whatever this is profound 00:26:22 an immediate change in our system in so many respects in way above what governments are ever prepared to talk about and I say I don't particularly like these conclusions but that's what's what comes out of the arithmetic

      !- difference in annual emissions reduction required in just one year is enormous - comparing the actual, required emissions of a climate progressive country (Sweden) - emissions reduction just one year later (in brackets) is enormous

    1. Basic facelift (redecoration)£2,000£3,000£2,500 Basic refurbishment - (incl. new kitchen, painting, new flooring, joinery work, modifying bathroom)£15,000£18,000£16,500 Full refurbishment (incl.all of the above, plus new bathroom, new boiler and radiators, structural work, new electrics, re-plastering)£33,000£48,000£40,500

      Refurb cost

    1. With Mailgun, you'll need to upgrade to a dedicated IP or "managed email service" and pay extra for "better deliverability." At Postmark, great deliverability isn't an up-charge. It's simply included, and we share live delivery data so you can judge for yourself.
  5. Nov 2022
    1. How Much Does it Cost to Hire App Developers in 2023?

      One of the most significant factors in determining the cost of hiring an app developer is the expected output. So want to know the cost of Hire App Cost Developers? In this, Blog we have explained the how much does it Cost to Hire an App Developers.https://bit.ly/3AKLsfP

    1. How Startups Can Reduce Mobile App Development Cost? In today’s business climate, developing a high-quality mobile app can be expensive. Fortunately, there are some things you can do to reduce the cost of developing the app. Here, we have some of the trendy ways how to reduce app development costs. https://bit.ly/3B4CURp

  6. Oct 2022
    1. In the interest of reducing warranty claims (which are much more expensive than that incremental manufacturing cost) carmakers are sizing the whole unit to reliably accommodate the worst case draw (driver turns everything on at the same time, at idle).
    1. After the first week of the campaign, we realized what are the main problematic pillars and fixed them right away. Nevertheless, even with these improvements and strong support from the Gamefound team, we’re not even close to achieving the backer numbers with which we could safely promise to create a game of the quality we think it deserves.
    2. First and foremost, we need to acknowledge that even though the funding goal has been met–it does not meet the realistic costs of the project. Bluntly speaking, we did not have the confidence to showcase the real goal of ~1.5 million euros (which would be around 10k backers) in a crowdfunding world where “Funded in XY minutes!” is a regular highlight.

      new tag: pressure to understate the real cost/estimate

    1. When people ask me about my life’s ambitions, I often joke that my goal is to become independently wealthy so that I can afford to get some work done. Mainly that’s about being able to do things without having to explain them first, so that the finished product can be the explanation. I think this will be a major labor saving improvement.
    2. Alas, many things really must be experienced to be understood. We didn’t have much of an experience to deliver to them though — after all, the whole point of all this evangelizing was to get people to give us money to pay for developing the software in the first place!
    1. iOS App Development Cost – A Complete Guide for 2023 Looking for best iOS app development company and want to know the iOS app development cost? In this blog, you will get a complete guidance regarding the iOS app development cost. And overview of what factors impact the cost of developing an iOS app.https://bit.ly/3T8MtFV

    1. How to Hire Offshore Laravel Developers | A Comprehensive Guide

      Offshore Laravel Web App Development can be a great option for businesses of all sizes. The demand for hiring a dedicated Laravel developer is increasing because this framework is used to create both top-notch and complex enterprise-level apps. Check out for more: https://bit.ly/3TjrM9M

  7. Sep 2022
    1. One common use case for rbspy is profiling slow unit test runs -- instead of spending a bunch of time adding instrumentation, you can run rbspy record ruby my-test.rb and instantly get profiling information about what's going on.
    1. However, as an interpreted language, Ruby is slow compared to compiled languages. The general solution adopted by Rubyists was to throw more hardware at the problem. “Hardware is cheaper than salaried engineers,” went the common maxim.
  8. Aug 2022
    1. API Development & Integration Guide for 2022, we all must have heard about But the questions that How is API important for developers and our mobile apps? So in this blog we will help you get all the knowledge about APIs. Read more about: https://bit.ly/3wzeuNC

  9. Jul 2022
    1. We don’t expect National Defence or health care to promote growth: we just accept that territorial integrity and a healthy populace are good things.

      Been making that point about health (especially since, like education, it's a provincial jurisdiction). It's easy to think of perverse incentives if a profit motive dominates education and health. Physicians would want people to remain sick and teachers would prefer it if learners required more assistance.

      Hadn't thought enough about the DND part. Sure gives me pause, given the amounts involved. Or the fact that there's a whole lot of profit made in that domain.

      So, businesspeople are quick to talk about "cost centres". Some of them realize that those matter a whole lot.

    1. Development and designing of the application goes hand in hand. Hence, it is vital to know about the budget for mobile app development. In this article, we will learn about how much does it Cost to Design a Mobile App – native or custom.

  10. May 2022
    1. In 2022, the focus is exploring and envisioning the hyper-response and embarking on this mission. It will involve engaging and energizing people, analysis, planning, and some early actions. The “E” in PLAN E stands for “Earth,” “everyone,” “everything,” and “everywhere.”

      The global, open access Tipping Point Festival can be launched as a zero marginal cost festival (ZMCF) or a netfest for bottom-up, rapid whole system change to synchronize the ordinary citizens of the globe to deal with the hyperthreat.

    2. It orientates around making the threat visible and knowable, to an extent that this inspires automatic configuration and realignment across human tribes

      This can be done through a decentralized, zero marginal cost hyperthreat education campaign relying on crowdsourcing via the internet. Since the threat level has become salient to a sufficient scale, these aware actors can be crowdsourced for a scalable education campaign.

    3. the current global military buildup could represent a situation whereby many nations are entering, unconsciously or perhaps because there seems to be no other option, into a new type of mutually assured destruction (MAD) scenario, or even the Homo sapiens death spiral.

      It sucks enormous material and energy resources whose purpose is to destroy built environments, human lives, nonhuman lives and the built environment .... not very climate friendly! Military spending only sucks up valuable resources required to fight the climate change hyperthreat.

    1. The argument used to propose its use is to avoid the construction of multiple volatile objects. This supposed advantage is not real in virtual machines with efficient garbage collection mechanisms.

      Consider a Sufficiently Smart Compiler/Runtime where a multiply-instanced class has the exact same runtime characteristics as code that has been hand-"tuned" to use a singleton.

  11. Apr 2022
    1. If you are also thinking of developing an app, you need to know how much it costs to develop a full-fledged app. In this article, we are going to answer all the questions related to the App Development Cost in 2022.

    1. “An NFT marketplace is abbreviated as a digital token. It is specifically designed to be used as proof of a digital certificate of the proprietary rights for things like tweets, physical or virtual assets, codes, videos and much more. For example, the very first tweet of Jack Dorsey (best known as being the co-founder of Twitter) was sold as an NFT for $2.9m.”
    1. David Fisman. (2021, December 15). HEPA air cleaners in hospital...lets compare cost to ECMO. ECMO course in the US costs around $93,000 CDN; US cost:charge ratio is around 0.2, so let’s say that’s $20,000 CDN. That’s the cost of 50 high end hepa air cleaners! Or you could do 250 CR boxes at around $80 a pop. [Tweet]. @DFisman. https://twitter.com/DFisman/status/1471259305961828355

    1. Michael Bang Petersen. (2021, March 17). This is worsened as costs of #covid19 are not mentally similar to costs of side effects, even if the latter are less risky. People prefer controllable risks to uncontrollabe risks, even if less lethal (https://t.co/kSIcObWYmT). That is why you fear flying but not driving. [2/2] [Tweet]. @M_B_Petersen. https://twitter.com/M_B_Petersen/status/1372103708218159109

  12. Mar 2022
    1. If you are planning to start with an e-commerce business then building an e-commerce mobile app is a must. But before connecting with an app development company one should get some basic understanding of which factors would be affecting the cost of creating an app. Here we discussed all the details about which factors you have to consider in eCommerce App Development Cost.

  13. Feb 2022
    1. For Nvidia, the speed of the 3080 package makes for a solid sales pitch: This cloud PC is probably faster than your home system, so cloud gaming is worth it. Cloud gaming will always present a latency tradeoff, but that latency is easier to accept if you're getting otherwise-unattainable graphics quality along with it.

      Smart strategy by Nvidia.

  14. Jan 2022
  15. Dec 2021
    1. How to Create a Micro-Job Marketplace Like Fiverr: Features, Cost, TimelineTimurTech JournalistMarketplaceProduct GuideHomeBlogEntrepreneurshipHow to Create a Micro-Job Marketplace Like Fiverr: Features, Cost, TimelinePublishedNov 19, 2021UpdatedNov 19, 202120 min readIt’s no secret that the COVID-19 pandemic has led many people to reconsider their jobs. Now, freelance as an alternative career path steadily becomes a reality. 50.9% of the U.S. workforce will be freelancing by 2027, a Statista survey shows. Businesses like Fiverr and fellow gig-focused companies rode the wave. To be more precise, they adopted a model allowing the hire of independent contractors without any legwork. How do such tools set the new trend in powering freelancers? In this article, we share proven methods geared towards freelance website growth. Moreover, you will get a glimpse of how to create a micro-job marketplace like Fiverr of your own.

      It’s no secret that the COVID-19 pandemic has led many people to reconsider their jobs. Now, freelance as an alternative career path steadily becomes a reality. 50.9% of the U.S. workforce will be freelancing by 2027, a Statista survey shows.

      Businesses like Fiverr and fellow gig-focused companies rode the wave. To be more precise, they adopted a model allowing the hire of independent contractors without any legwork. How do such tools set the new trend in powering freelancers?

      In this article, we share proven methods geared towards freelance website growth. Moreover, you will get a glimpse of how to create a micro-job marketplace like Fiverr of your own.

  16. Nov 2021
    1. after building a mobile app, you need to maintain the app. Inadequate app maintenance can be a reason behind your app failure. Though the cost to maintain an app draws some extra money, it is worth it.
  17. Oct 2021
    1. Leading SaaS Trends for 2021 You Shouldn’t MissDmitryChief Executive OfficerSaaSTrendsHomeBlogTechnologyLeading SaaS Trends for 2021 You Shouldn’t MissDec 1, 202012 min readNowadays, different kinds of businesses are extensively moving to the cloud. O’Reilly reports that 88% of the respondent companies had used cloud services before lockdown and expect their further growth by Q2 2021. Therefore, SaaS application development looks also like a profitable venture today. Yet, to stay afloat in the cloud arena, you need to arm your offering with precise technology and fresh tools. In other words, you need to keep your eye on the future of SaaS. To help you deploy the promptest cloud solutions, in this post, I collected the top SaaS trends for 2021.

      SaaS application development looks also like a profitable venture today. Yet, to stay afloat in the cloud arena, you need to arm your offering with precise technology and fresh tools. In other words, you need to keep your eye on the future of SaaS.

      To help you deploy the promptest cloud solutions, in this post, I collected the top SaaS trends for 2021.

  18. Sep 2021
    1. Top 8 SaaS Pricing Models: Ultimate Guide for 2021Alina NechvolodE-Commerce & SaaS StrategistSaaSHomeBlogEntrepreneurshipTop 8 SaaS Pricing Models: Ultimate Guide for 2021Oct 28, 202016 min readThere’s hardly a thing that impacts your software-as-a-service product revenue more than SaaS pricing models. Still, for many companies choosing the right monetization strategy is no easy feat. To shed some light on this matter, we have prepared a detailed guide on the most popular SaaS pricing strategies. You will find out the pros and cons of each option and learn how to adopt them properly from well-known SaaS companies. Finally, we will discuss the required steps to take when choosing between different SaaS business models.

      There’s hardly a thing that impacts your software-as-a-service product revenue more than SaaS pricing models. Still, for many companies choosing the right monetization strategy is no easy feat.

      To shed some light on this matter, we have prepared a detailed guide on the most popular SaaS pricing strategies. You will find out the pros and cons of each option and learn how to adopt them properly from well-known SaaS companies.

      Finally, we will discuss the required steps to take when choosing between different SaaS business models.

    1. Know what is the affordable cost of Mobile Application Installation in India

      They finished obviously various years back and are ceaselessly worked by the proprietor of the Mobile Application Installation Cost India working framework, for example, the Apple Application Store, Google Play, Windows Telephone Store, and BlackBerry Application World. A few applications are free, while others should be gotten. Routinely, they are downloaded from the stage to an objective gadget, yet a piece of the time can be downloaded to PCs or work stations. Some pre-introduced applications can be cleared by a standard uninstall Mobile Application Installation Cost India measure, thus leaving all around more extra space for required ones. Where the thing doesn't permit, a few contraptions can be related with taking out the undesired applications. Applications that are not preinstalled are generally open through scattering stages called application stores. Furthermore close to correspondingly in like way likewise also similarly as with other programming, the Mobile Application Installation Cost India influence in number and mix of applications made introduction a test, which as such affected the course of action of a wide degree of study, suggestion, and term sources, including web journals, magazines, and submitted online application revelation affiliations. Mobile applications were from the most prompt early phase offered for general piece of room and data recovery, including email, plan, contacts, the confirmation exchange and climate data. Regardless, open interest and the Mobile Application Installation Cost India straightforwardness of power contraptions undertaken into different groupings, for example, those supervised by work zone application programming packs. At Brandezza study revealed that during the past quarter, more mobile endorsers utilized applications than investigated the Mobile Application Installation Cost India web on their contraptions: half versus 49 uninhibitedly. Specialists found that usage of mobile applications unequivocally interfaces with client setting and relies on the client's area and time. Mobile applications are driving forward through a dependably growing work inside supportive affiliations and when arranged and made totally can yield explicit focal focus interests. With different mobile applications open at application stores and the Mobile Application Installation Cost India improved hindrances of PDAs, individuals are downloading more applications to their contraptions. Use of mobile applications has gotten undeniably focal across mobile telephone clients.

      Mobile Application Installation Cost India

  19. Aug 2021
    1. Now consider we want to handle numbers in our known value set: const KNOWN_VALUES = Object.freeze(['a', 'b', 'c', 1, 2, 3]) function isKnownValue(input?: string | number) { return typeof(input) === 'string' && KNOWN_VALUES.includes(input) } Uh oh! This TypeScript compiles without errors, but it's not correct. Where as our original "naive" approach would have worked just fine. Why is that? Where is the breakdown here? It's because TypeScript's type system got in the way of the developer's initial intent. It caused us to change our code from what we intended to what it allowed. It was never the developer's intention to check that input was a string and a known value; the developer simply wanted to check whether input was a known value - but wasn't permitted to do so.
    1. How to Build a SaaS Startup in 10 Smart StepsAlina NechvolodE-Commerce & SaaS StrategistSaaSStartupHomeBlogEntrepreneurshipHow to Build a SaaS Startup in 10 Smart StepsJul 30, 202018 min readSaaS solutions are noted for their flexibility. This quality serves as a key reason why 37% of businesses switch to cloud-based systems. Given their growing popularity, the idea of launching a company offering SaaS products seems very lucrative. So, how to build a SaaS startup? In this article, we will answer this question, and guide you through the main stages of starting a SaaS business. You will learn to make market research and write a lean plan. Also, we will discuss the most suitable pricing models and effective marketing strategies. Finally, you will know how to track the progress of your startup.

      SaaS solutions are noted for their flexibility. This quality serves as a key reason why 37% of businesses switch to cloud-based systems. Given their growing popularity, the idea of launching a company offering SaaS products seems very lucrative.

      So, how to build a SaaS startup? In this article, we will answer this question, and guide you through the main stages of starting a SaaS business.

      You will learn to make market research and write a lean plan. Also, we will discuss the most suitable pricing models and effective marketing strategies.

      Finally, you will know how to track the progress of your startup.

    1. How to Calculate the Cost to Build a SaaS App in 2021Dmitry ChekalinChief Executive OfficerAlina NechvolodE-Commerce & SaaS StrategistSaaSHomeBlogEntrepreneurshipHow to Calculate the Cost to Build a SaaS App in 2021Jan 6, 202114 min readHow much will it cost to build a SaaS app? If you decided to follow the latest trends and invest in SaaS development, this question is relevant more than ever. This blog post is written to help you clear up this matter. Here, we will cover in detail the main factors that define the final cost of building a SaaS product. They include the project scope and timeline, API integration, and the required functionality. Also, you will learn how the total cost of a completed software-as-a-service product changes depending on the chosen SaaS development service provider.

      How much will it cost to build a SaaS app? If you decided to follow the latest trends and invest in SaaS development, this question is relevant more than ever.

      This blog post is written to help you clear up this matter. Here, we will cover in detail the main factors that define the final cost of building a SaaS product. They include the project scope and timeline, API integration, and the required functionality.

      Also, you will learn how the total cost of a completed software-as-a-service product changes depending on the chosen SaaS development service provider.

  20. Jul 2021
    1. Leah McElrath 🏳️‍🌈. (2021, July 12). One reason the right-wing outrage machine is focused on attacking Biden’s plan for door-to door outreach isn’t because they actually fear confiscation of guns or Bibles. It’s because they don’t want poor people to have access to life-saving vaccinations. Https://t.co/GnZMmlBfqK [Tweet]. @leahmcelrath. https://twitter.com/leahmcelrath/status/1414660179061264388

    1. reduce the production time

      Promotes economies of scale- cost advantage due to the scale of operation. As the cost per unit of output decreasing it causes the scale to increase.

    1. The Fishing Points app converts your mobile phone into a fishing tool. The versatility is the key thing that makes this app shine out among other fishing apps. So let’s explore deeper into the review of the Fishing Points app.
    1. Sarah Kliff on Twitter: “Coronavirus vaccines are free—But 9 percent of Americans say they’re not getting one because they are worried about cost. I see this a lot in my reporting: Patients who don’t seek care because they’re become so accustomed to surprise bills that follow. Https://t.co/gu6oDnlvhB” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/sarahkliff/status/1395032095819542528?s=20

  21. Jun 2021
    1. n the past, many organizations connected remote branches and retail locations to the central data center through a hub and spoke WAN model that relied on individual MPLS connections. As a result, all data, workflows, and transactions, including access to cloud services or the internet, required traffic to be backhauled to the data center for processing and redistribution. Compared to an SD-WAN solution, this is extremely cost-inefficient. SD-WAN reduces costs by providing optimized, multi-point connectivity using distributed, private data traffic exchange and control points to give your users secure, local access to the services they need – whether from the network or the cloud – while securing direct access to cloud and internet resources.
    1. "While it takes time to make these changes now, it's a one-time engineering cost that will have lasting impacts, both internally and externally," Sorenson said in an email. "We're in this for the long game, and we know inclusive language is just as much about how we code and what we build as it is about person-to-person interactions."
    1. I'm not sure why MSFT decided to change these codes in the first place. While it might have been a noble goal to follow the IETF standard (though I'm not really familiar with this), the old codes were already out there, and most developers don't benefit by the new codes, nor care about what these codes are called (a code is a code). Just the opposite occurs in fact, since now everyone including MSFT itself has to deal with two codes that represent the same language (and the resulting problems). My own program needs to be fixed to handle this (after a customer contacted me with an issue), others have cited problems on the web (and far more probably haven't publicised theirs), and MSFT itself had to deal with this in their own code. This includes adding both codes to .NET even though they're actually the same language (in 4.0 they distinguished between the two by adding the name "legacy" to the full language name of the older codes), adding special documentation to highlight this situation in MSDN, making "zh-Hans" the parent culture of "zh-CHS" (not sure if it was always this way but it's a highly questionable relationship), and even adding special automated code to newly created "add-in" projects in Visual Studio 2008 (only to later remove this code in Visual Studio 2010, without explanation and therefore causing confusion for developers - long story). In any case, this is not your doing of course, but I don't see how anyone benefits from this change in practice. Only those developers who really care about following the IETF standard would be impacted, and that number is likely very low. For all others, the new codes are just an expensive headache. Again, not blaming you of cours
    2. I feel the pain. It is a normal thing that standards do evolve over time, though, and our software needs to cope with it.
    3. I'm not sure why MSFT decided to change these codes in the first place. While it might have been a noble goal to follow the IETF standard (though I'm not really familiar with this), the old codes were already out there, and most developers don't benefit by the new codes, nor care about what these codes are called (a code is a code).
  22. May 2021
    1. Andre, F., Booy, R., Bock, H., Clemens, J., Datta, S., John, T., Lee, B., Lolekha, S., Peltola, H., Ruff, T., Santosham, M., & Schmitt, H. (2008). Vaccination greatly reduces disease, disability, death and inequity worldwide. Bulletin of the World Health Organization, 86(2), 140–146. https://doi.org/10.2471/BLT.07.040089

  23. Apr 2021
  24. Mar 2021
    1. much software requires continuous changes to meet new requirements and correct bugs, and re-engineering software each time a change is made is rarely practical.
  25. Feb 2021
    1. A freemium model is sometimes used to build a consumer base when the marginal cost of producing extra units is low.
    1. Economists call this a "network effect": the more people there are on Twitter, the more reason there is to be on Twitter and the harder it is to leave. But technologists have another name for this: "lock in." The more you pour into Twitter, the more it costs you to leave. Economists have a name for that cost: the "switching cost."
  26. Jan 2021
    1. What’s the use of ie. snap libreoffice if it can’t access documents on a samba server in my workplace ? Should I really re-organize years of storage and work in my office for being able to use snap ? A too high price to pay, for the moment.
  27. Nov 2020
    1. IS186-mediated integration of the plasmid into the chromosome or deletion of these accessory genes from an evolved plasmid that remained capable of self-replication conferred greater fitness benefits than SP formation

      Can we say this is because of the combined fitness benefit

      • by avoiding maintenance of a plasmid and
        • lower expression of proteins?

      Especially considering that there is expression of the accessory genes (ex: GFP in fig.2e)-> so the protein level fitness burden still exists, albeit at a lower extent.

      How much of this burden is attributed to keeping a plasmid around?, maybe this could be tested with a low copy pSC101 type plasmid or by deleting all the accessory genes and repeating the evolution experiment to specifically look for the integrants this time

  28. Oct 2020
    1. With Flutter, the quality of app development is such that although being a Hybrid framework, the feel is of a native app. Flutter is the brainchild of Google. Companies want to build the best app for the most number of people that they can reach. Flutter fulfills the exact requirements for the developers as well as the business owners.

      There are several factors to consider in the app development like the benefits of Flutter-based app development, the cost to make a Flutter app, etc. The best mobile app designs and development process goes hand in hand with Flutter.

    1. Handling all these requests costs us considerably: servers, bandwidth and human time spent analyzing traffic patterns and devising methods to limit or block excessive new request patterns. We would much rather use these assets elsewhere, for example improving the software and services needed by W3C and the Web Community.
  29. www.youtube.com