Have to look this up, but this might be dependent on culture and historical moment -- how important is the verbalization of writing (and often scripture). Thinking here of Plato's time when reading aloud was seen as the easier one to understand in contrast to repetition from memory. Or the Romans and early Christianity where silent reading was not as common.

Study: Functional study

Model: HEK293 cell lines

Variant: VWF NM_000552.5: c.7664C>G, p.(Pro2555Arg), described as GOF mutation

rare missense variant, MAF = 0.00007

RefSNP_ID:rs915754316

Not reported in ClinVar

Cells lines were transfected and expressed one of the following: wtVWF, p.Pro2555Arg, both variants, or a negative control variant p.Asp2509Glu

Main result:

p.Pro2555Arg is the first VWF GOF variant that increases platelet aggregate size (AS), which is shear-dependent and independent of fibrinogen (fb). May provide a novel risk factor for thromboembolic disease.

Additional results:

Variant does not affect the binding affinity of the C4 domain for BPIIb/IIIa

VWF stem region mutations can enhance VWF's prothrombotic properties

C4 domain of VWF may be a novel antithrombotic drug target.

for - definition - emptiness - interdependent origination - dependent arising - definition - interdependent origination - Francesca Fremantle

definition - interdependent origination - According to this law (of interdependent origination), - nothing has - independent, - permanent, or - absolute - existence. - Everything is - part of a limitless web of interconnections and - undergoes a continual process of transformation. - Every appearance arises from - complex causes and - conditions, - and in turn combines with others to produce countless effects. - By interrupting the causal chain at certain key points, - the course of existence can be altered and - effects prevented by eliminating their causes.

comment - This definition of interdependent origination is very closely related to that of - emptiness (shunyata) and - https://hyp.is/nyBf5CFTEe-wpwveR5kjtg/www.dalailama.com/news/2014/teaching-about-emptiness-and-dependent-arising-at-likir-ladakh - dependent arising - relationship between - dependent arising and - emptiness - from his Holiness, the Dalai Lama - https://hyp.is/nyBf5CFTEe-wpwveR5kjtg/www.dalailama.com/news/2014/teaching-about-emptiness-and-dependent-arising-at-likir-ladakh

adjacency - between - emptiness - dependent arising - interdependent origination - Indyweb/Indranet - adjacency relationship - The Indyweb/Indranet is epistemologically designed to reflect this trilogy of intertwingled Buddhist ideas: - emptiness - interdependent origination - dependent arising - within the sphere of human thinking - The Indyweb/Indranet is designed as people-centered, - which means that individual human beings are the locus which their entire world of ideation - evolving moment by moment - can be captured to detect the evolutionary flow of ideation - The Deep Humanity praxis employs the term - "human INTERbeCOMing" to shift the frame of a person - from a noun / object - to a verb / evolutionary process - Ideas are intrinsically dependently arising - from other causes and conditions - which are the source ideas that inspired the new ones - The Indyweb/Indranet's people-centered provenance feature assures that - any idea generated by a person is ASSOCIATED to that person - and tracks the exact time of the occurrence of that idea - The other half of the Indyweb/Indranet is that it is INTERPERSONAL - allowing all people, - with their people-centered nexus of evolutionary ideas to - SHARE them with OTHER people - Hence, from looking at a record of our evolutionary history of ideas - we can see that we are psychologically fundamentally following interdependent origination - Ideas are in constant flux, giving rise to new ideas - in a continuous process of transformation

for - adjacency - emptiness - dependent arising - Je Tsongkhapa

adjacency - between - emptiness - dependent arising - Je Tsongkhapa - adjacency relationship - (quote - see below) - His Holiness then announced his intention to give a transmission of Je Tsongkhapa’s text, - ‘In Praise of Dependent Arising’ - which emphasizes the importance of both - emptiness and - dependent arising. - He suggested that it would be good to recite the Heart Sutra followed by this text daily. - He said that - emptiness and - dependent arising - are complementary. - If - dependent arising makes you think of emptiness and - emptiness makes you think of dependent arising - at the same time, - you have a proper understanding of emptiness.

for - adjacency - emptiness - dependent arising

Dependent variables depend upon independent variables (whereas independent variables are independent).

• for: collaborative commons - technological dependence

• comment

  • since the collaborative commons emerged from the internet, it is obviously dependent on and made possible by ICT technologies

"demands context" :)

!- Shabti Deva : dependant origination quoted

Yogachara explains how we mistakenly construct dependently originating reality as independently and intrinsically existing, and how we take the mediated, constructed reality for the immediate reality.

SARS-CoV-2 variants of concern and variants under investigation. (2021). 45.

Theory: The external context of one's physical surroundings (pen, paper, textures, sounds, smells, etc.) combined with the internal context, the learner's psychological state, mood, etc., comprises a potentially closed system where each part props up the other for the best learning outcomes.

Do neurodiversity effects help/hinder this process? What if people are missing one or more of these bits of contextualization? What does the literature look like in this space? Research?

Liu, C., Yang, Y., Chen, B., Cui, T., Shang, F., & Li, R. (2022). Revealing spatio-temporal interaction patterns behind complex cities. ArXiv:2201.02117 [Physics]. http://arxiv.org/abs/2201.02117

Ingale, M., & Shekatkar, S. M. (2020). Resource dependency and survivability in complex networks. Physical Review E, 102(6), 062304. https://doi.org/10.1103/PhysRevE.102.062304

Landry, N. (2021). The effect of time-dependent infectiousness on epidemic dynamics. ArXiv:2106.10384 [Physics, q-Bio]. http://arxiv.org/abs/2106.10384

I'm not sure what he meant by:

fully detached from the activerecord I didn't think it was tied to ActiveRecord.

But I definitely agree with:

code is a bit hacky and complex to modify

Seems like these helper functions could be just as easily used in ActiveRecord models. Therefore, they should be in a separate gem, or at least module, that can be used in both these objects and ActiveRecord objects.

Understanding types of variables

pre-incubation time is 30 min

Van Mieghem, P., & Wang, F. (2020). Time dependence of susceptible-infected-susceptible epidemics on networks with nodal self-infections. Physical Review E, 101(5), 052310. https://doi.org/10.1103/PhysRevE.101.052310

Ting, C., Palminteri, S., Lebreton, M., & Engelmann, J. B. (2020, March 25). The elusive effects of incidental anxiety on reinforcement-learning. https://doi.org/10.31234/osf.io/7d4tc MLA

This perspective of looking at individuals in categories is the foundation of statistics--two variables that are mutually exclusive and the goal is to see if they relate in any way. SNA is very different--all variables are related and dependent. That is why SNA is descriptive--can't do predictive without mutually exclusive variables.