- Aug 2022
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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SARS-CoV-2 variants of concern and variants under investigation. (2021). 45.
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twitter.com twitter.com
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ReconfigBehSci. (2021, December 22). RT @chrischirp: Positivity rising steeply too—There are definitely many more people we aren’t catching https://t.co/4xDPwYQtrx [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1473695678610214927
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twitter.com twitter.com
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ReconfigBehSci. (2021, November 26). RT @PeterHotez: …this info is more relevant than immune escape. For instance the B.1.351 from ZA last year never really took off. So transm… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1464240155070447632
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- Feb 2022
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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Academics: Viral Evolution Scenarios, 10 February 2022. (n.d.). GOV.UK. Retrieved February 14, 2022, from https://www.gov.uk/government/publications/academics-viral-evolution-scenarios-10-february-2022
Tags
- severity
- immune escape
- COVID-19
- infection
- waning immunity
- vaccine efficacy
- variant
- is:report
- prediction
- UK
- lang:en
- viral evolution
- vaccine
- antiviral drug resistance
- therapeutic
- vaccination
- immunity
- scenario
- antigenic escape
- surveillance
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Annotators
URL
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www.youtube.com www.youtube.com
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American Medical Association (AMA). (2021, December 6). Peter Hotez, MD, PhD, on the omicron variant and Delta winter surge | COVID-19 Update for Dec. 6, 20. https://www.youtube.com/watch?v=WnfpC1_N2Mg
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- Jan 2022
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www.imperial.ac.uk www.imperial.ac.uk
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Omicron largely evades immunity from past infection or two vaccine doses | Imperial News | Imperial College London. (n.d.). Imperial News. Retrieved January 12, 2022, from https://www.imperial.ac.uk/news/232698/omicron-largely-evades-immunity-from-past/
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www.medrxiv.org www.medrxiv.org
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Tseng, H. F., Ackerson, B. K., Luo, Y., Sy, L. S., Talarico, C., Tian, Y., Bruxvoort, K., Tupert, J. E., Florea, A., Ku, J. H., Lee, G. S., Choi, S. K., Takhar, H. S., Aragones, M., & Qian, L. (2022). Effectiveness of mRNA-1273 against SARS-CoV-2 omicron and delta variants (p. 2022.01.07.22268919). https://doi.org/10.1101/2022.01.07.22268919
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www.nature.com www.nature.com
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Carreño, J. M., Alshammary, H., Tcheou, J., Singh, G., Raskin, A., Kawabata, H., Sominsky, L., Clark, J., Adelsberg, D. C., Bielak, D., Gonzalez-Reiche, A. S., Dambrauskas, N., Vigdorovich, V., Group, P. S., Srivastava, K., Sather, D. N., Sordillo, E. M., Bajic, G., van Bakel, H., … Krammer, F. (2021). Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron. Nature. https://doi.org/10.1038/d41586-021-03846-z
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- Dec 2021
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twitter.com twitter.comTwitter1
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Kristian G. Andersen on Twitter. (n.d.). Twitter. Retrieved 3 December 2021, from https://twitter.com/K_G_Andersen/status/1465822536629821442
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- Nov 2021
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jamanetwork.com jamanetwork.com
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It remains unclear whether the reduction in the neutralization sensitivity of the N501Y.V2 strain to vaccine-induced antibodies is enough to seriously reduce vaccine efficacy. First, mRNA vaccines also induce virus-specific helper T cells and cytotoxic T cells, both of which might be involved in protection against challenge. Also, the mRNA vaccines, in particular, induce such a strong NAb response that there could be enough “spare capacity” to deal with reductions in the sensitivity of the variant to NAbs. In other words, N501Y.V2 (and the related virus from Brazil) may be less sensitive to NAbs, but not to an extent that will cause widespread vaccine failure.
Variants that show reduced sensitivity to NAbs don't necessarily mean mRNA vaccine failure
New variants may emerge that show reduced sensitivity to NAbs.
This may not result in vaccine failure because:
- The mRNA vaccines induce such a strong NAb response, there will be enough spare capacity to deal with the virus.
- The mRNA vaccines also induce other virus specific protection such as helper T cells and cytotoxic T cells, which may not be affected by the reduction in NAb sensitivity.
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