On ne réinvente aucune roue
On peut mentionner ça vite fait, mais cette section va en annexe
On ne réinvente aucune roue
On peut mentionner ça vite fait, mais cette section va en annexe
n votants / m inscrits
Inscrit ici est utilisé pour dire ce que votant veut dire ailleurs...
pour qu’on ne puisse pas reconstruire l’ordre soumis par le précédent à partir de la position initiale.
C'est aussi pour éviter le biais cognitif qui tend à préférer le premier choix
, il ne voit aucun
" il ne doit voir aucun"
localStorage scopée à l’URL du doc
Readback.
sync est assurée par le serveur automergesync via WebSocket Automerge.
Readback
mesocosms
Definition of mesocosm: an experimental tool—a small-scale, enclosed, and controlled, outdoor or indoor system that models a natural ecosystem
benthic
definition of benthic: the lowest ecological zone in a body of water, including the seafloor, sediment surface, and sub-surface layers
Principio precautorio.
Respecto de este principio, es importante prepararse para situaciones futuras, ya que en cualquier momento pueden ocurrir.
Principio de progresividad
Este principio se me hace sumamente interesante, ya que como lo hemos venido viendo a lo largo del curso, las normas deben actualizarse conforme pasa el tiempo y se deben adaptar a las necesidades de la sociedad
Sockets Direct Protocol (SDP): Supports socket communication over RDMA-enabled networks.
SDP improves data transfer speed by enabling direct memory access communication. This reduces latency and increases performance. It is beneficial for high-speed and large-scale data operations.
Remote Procedure Call Protocol (RPCP): Allows a program to execute procedures in another address space (client-server interaction).
RPCP enables communication between programs across different systems. This allows efficient client-server interaction. It improves system flexibility and distributed computing capabilities.
AppleTalk Data Stream Protocol (ADSP): Developed by Apple for LAN communication with self-configuration support.
ADSP simplifies communication in local networks by enabling automatic configuration. This reduces manual setup and potential errors. It improves ease of use and efficiency in network communication.
Password Authentication Protocol (PAP): Provides password-based user authentication in PPP connections.
PAP ensures that only authorized users can access network resources. It verifies identity using simple password authentication. This adds a basic level of security to communication sessions.
Point-to-Point Tunnelling Protocol (PPTP): Enables Virtual Private Networks (VPNs) over TCP/IP.
PPTP allows secure communication over public networks by creating VPN tunnels. This protects sensitive data from unauthorized access. It improves privacy and security in data transmission.
Real-time Transport Control Protocol (RTCP): Provides QoS feedback for RTP-based multimedia sessions.
RTCP enhances multimedia communication by monitoring quality of service parameters. This feedback helps systems adjust transmission for better performance. It ensures smoother and more reliable audio/video sessions.
Ensures data integrity by reducing duplication or message loss.
Reducing duplication and message loss helps maintain accurate and consistent data transfer. This ensures that the received data matches what was sent. It improves the reliability and correctness of communication.
Inserts synchronization checkpoints for recovery from failures.
Synchronization checkpoints allow communication to resume from a specific point after interruption. This minimizes data loss and avoids restarting the entire process. It enhances reliability in data transmission.
Manages token-based dialogue control to avoid collisions.
Token-based control ensures that only one device transmits data at a time. This reduces the chances of data collision and confusion during communication. It improves overall efficiency and clarity in data exchange.
Resynchronization & Recovery: Recovers from failures using synchronization points.Session Termination: Gracefully ends communication after all data is exchanged.
Proper session termination ensures that all data is successfully transmitted before closing the connection. It prevents incomplete transfers and data loss. This leads to a clean and reliable end to communication.
Activity & Dialog Management: Controls turns, prevents collisions, and avoids duplication.
Dialogue management ensures that only one device communicates at a time when required. This prevents data collisions and duplication issues. It improves clarity and efficiency in communication.
xchange data in an organized manner and properly close the session when communication is complete.
Checkpoints help maintain proper sequence and structure of data during transmission. They allow systems to resume communication from a specific point after failure. This reduces data loss and improves reliability.
The Session Layer ensures that two communicating devices can establish a meaningful dialogue, exchange data in an organized manner and properly close the session when communication is complete.
Session establishment ensures both devices agree on communication rules before data transfer begins. This reduces the chances of errors or mismatched configurations. It improves the efficiency and security of communication.
It handles dialogue control, deciding whose turn it is to send or receive data.
The concept of dialogue control implies that orderly communication between devices is necessary to prevent data collisions and confusion. By determining which device can send or receive data at a given time, the Session Layer ensures structured and efficient interaction. This suggests that without such control, simultaneous transmissions could lead to errors or data overlap. It can be hypothesized that dialogue control improves communication efficiency, particularly in systems where multiple interactions occur concurrently. Furthermore, this mechanism is crucial in half-duplex or structured communication systems where strict turn-taking is required. Overall, dialogue control enhances clarity, reduces transmission conflicts, and ensures smooth data exchange between devices.
t provides mechanisms for session setup, management and termination.It ensures that communication remains synchronized and reliable, even during long or complex data transfers.
The emphasis on synchronization and reliability indicates that the Session Layer plays a critical role in maintaining consistency during extended communication processes. In long or complex data transfers, interruptions or delays are more likely, and without proper synchronization, data integrity could be compromised. This suggests that the Session Layer helps divide communication into manageable checkpoints, allowing systems to resume efficiently in case of failure. It can be hypothesized that systems with strong session synchronization mechanisms experience fewer data inconsistencies and improved performance. Additionally, this function becomes especially important in applications such as video streaming or large file transfers, where continuous and stable communication is essential. Therefore, synchronization contributes directly to enhancing user experience and system dependability.
The Session Layer is the 5th layer of the OSI model that establishes, manages, synchronizes, and terminates communication sessions between applications on different devices.Operates at Layer 5 (Session Layer) of the OSI modelManages session setup, maintenance, and terminationControls dialogue (who sends/receives and when)Provides synchronization and recovery mechanismsMany of its functions are integrated into Transport or Application layers in modern TCP/IP networks
The inclusion of synchronization and recovery mechanisms in the Session Layer suggests that reliable communication between applications depends not only on data transmission but also on the ability to handle interruptions effectively. If a session is disrupted due to network failure or system issues, these mechanisms allow communication to resume from a known checkpoint rather than restarting entirely. This likely improves efficiency and reduces data loss in long-running interactions. It can be hypothesized that systems utilizing Session Layer synchronization are more robust in unstable network environments compared to those that rely solely on lower-layer protocols. Furthermore, even though modern TCP/IP models integrate these functions into other layers, the conceptual importance of session recovery remains critical for maintaining seamless user experiences.
The quantified subject
teste
Figure 1. Culture as an Iceberg
This is a great visual representation and I love the iceberg analogy being used here because it's true, there's so much more to culture than what meets the eye. Generations of ideas, behaviors, attitudes all work to form associations with these examples and how they are regarded and put into practice by a certain group of people.
There isn’t just one definition of culture… because it is not an easy task to define culture.
I'm glad this sentence was included. It's very true, culture is a very fluid and expansive thing that embodies a lot of different aspects of people, places, and practices and I think it would be doing a disservice to contain it to a set few examples.
One of the most beautiful things about culture is that it impacts and is viewed by everyone differently.
I appreciate this definition, I have seen a couple differing definitions of culture across my life and I have recently wondered if there was a "best" definition in this class. I suppose it will always be an ever changing and growing definition that will differ across different places and ideals. I think its cool.
Do you feel like you were able to soak it all in? Perhaps you’ll need to reflect on what you’ve read a bit. After all, as you’ve learned, reflecting is a crucial part of the learning process.
This was a great demonstration to me of how repetition helps me to learn. Being introduced to a concept, having some material to help expand upon it, and then being able to revisit it in summary and see it's application is one of the most effective ways I am able to commit something to memory and sustain the knowledge of it. I'm glad this last part of the chapter was added in because it gave me a chance to reflect on this.
Having fun with others while learning
This is such an underrated aspect of education. Being able to have fun, be inspired, and make positive connections with your experience makes a huge difference, even just from a scientific standpoint. Dopamine and serotonin are proven to help increase attention and improve memory retention. It's no wonder people tend to excel in classes, subjects, and environments they genuinely enjoy. It brings fulfillment to our bodies, literally.
Learning strategies can be used deliberately as part of the metacognitive process,
I feel like any learning strategy you decide works best for you should be implemented into anything you learn. It would greatly help you retain and use information if you are learning how you learn best.
Keeping our task specific keeps our end result of the goal clear and focused.
Having a specific goal is a much better approach when learning is so important because it gives purpose. I find it easy to overload my own brain and have trouble absorbing information when I'm not clear about the why and how to begin with. This advice is very helpful and makes me more mindful about not overwhelming myself with so many things. It's better to set clear, attainable, and direct goals that will continue to encourage me.
SMART goals have us consider what exactly we want to achieve in the end and how we will achieve it. Even after we set the goal, we continue to reflect on our final result and the measures we are taking
I feel like this way of thinking combines the pros from reflective and strategic as well as expanding upon them. this is a good way to think not just about learning but anything you want to achieve.
Metacognition is not a linear process; It is a cycle that repeats itself. There isn’t a ceiling that qualifies the “absolute best” study habits or metacognitive abilities. Metacognition gives us the opportunity to constantly improve
I really appreciate this quote being included because it's incredibly true. Metacognition is very much a process of continuous growth. Realizing that it's much more of a cycle than one linear process is very important in being able to apply this knowledge in different areas of study. In language learning specifically, it helps to evaluate where we're at, where we want to go, and have self awareness in our own process.
n this stage, we will apply the strategies while considering our strengths and weaknesses, as well as monitor our progress. What is going well?
I feel like noticing what is and inst going well has the opportunity to course correct. like this chapter said its not really a linear progress and often I find i dont have the chance to reflect until ive tried and erred a few times to get the thing finally right.
Ableism. December 2023. Page Version ID: 1188412565. URL: https://en.wikipedia.org/w/index.php?title=Ableism&oldid=1188412565
This article on ableism explains that it's a form of discrimination and social prejudice against people with disabilities. It highlights how ableism operates through stereotypes, assumptions, and society that limit opportunities and shape how disabled people are perceived and treated. It also shows that ableism exists at multiple levels, including individual attitudes, cultural beliefs, and institutional systems like education and healthcare. It's inherently embedded in society and affects many aspects of life for people with disabilities.
Color blindness. December 2023. Page Version ID: 1188749829. URL: https://en.wikipedia.org/w/index.php?title=Color_blindness&oldid=1188749829 (visited on 2023-12-07).
This source grabs my attention simply because of how common it is in society, especially amongst men. I feel like the general idea of color blindness is so interestingly perceived but also having it holds back from many careers in life. This disability most commonly defines men.
t
LAPLACE TIME DELAY
$$\mathcal{L}{f(t - a)u(t - a)} = e^{-as} F(s)$$
time delay
Time Delay Example:
After energizing relay, it takes time before power reaching other end.
Essentially, delay from signal sent to signal received to output motion carried out.
.
Transfer Function is in polynomial form, traditionally to see poles in the CE, denominator.
When it isn't given in polynomial form, it becomes hard to find poles.
In this way of managing disabilities, the burden is put on the designers to make sure the environment works for everyone, though disabled people might need to go out of their way to access features of the environment.
This part of the reading stood out to me, the contrast between putting the burden on individuals as well as the designers was interesting. The section on coping strategies made me realize how often people are forced to quietly adapt themselves to systems that were never designed with them in mind like students sitting in front of the classroom without knowing why they struggle to see. That idea felt frustrating because it just normalizes the expectations that individuals should adjust rather than questioning. I personally think the shift toward universal design and ability based design is more ethical and sustainable. It reminds me of discussions in UX design where we talk about designing for edge cases and benefitting for everyone as a whole. I feel that companies should just treat accessibility as a core requirement instead of an extra feature implemented.
Em automação industrial, as funções de uma plantadevem ser formalizadas como algoritmos.
theses
image testing
Boa parte dos esforços de automação envolvemexatamente a abstração de princípios derivados de práticasprodutivas (heurística
teste
So nice
One very effective metacognitive strategy is being able to identify realistic, doable goals for yourself,
Is this suggesting a heirarchy in these thinking strategies or are strategic and reflective both tied at better than aware and tacit. I feel like there are pros and cons to each for the "top 2", like strategic could be better for learning in a classroom and reflective could be better for implicit learning.
See Vose (2008), Risk Analysis for a textbook treatment of correlated sampling in cost models, and Morgan & Henrion (1990), Uncertainty for foundational discussion of dependent uncertainties.
Make this a tool tip
copula-based correlation
Use less bold text. Italics are generally preferred
uptime
Up time as a share I assume
improve
Validate correct and improve
CLINICAL FEATURES
La mayoría de pacientes presentan alteraciones renales dentro de 6 a 36 meses después del diagnóstico y se manifiesta como un uroanálisis con proteínas y sedimento (hematuria, piuria, cilindros celulares). LA ELEVACIÓN DE LA CREATININA SÉRICA NO SIEMPRE ESTÁ PRESENTE, POR ESO ES IMPORTANTE SIEMPRE PEDIR UN UROANÁLISIS. En raras ocasiones, se puede presentar NL silente en donde hay anormalidades observadas en el riñón sin embargo no hay ninguna manifestación clínica presente.
PATHOGENESIS
La nefritis lúpica es la forma clásica de glomerulonefritis por inmunocomplejos, principalmente compuestos por anti-dsDNA o anti-DNA. Estos complejos se depositan en el mesangio y espacio subendotelial, activando el complemento y la quimiotaxis que atrae neutrófilos los cuales producen NETs. Se ha visto que pacientes con LES y NL tienen menor capacidad para degradar los NETs. También puede haber depósito en el espacio subepitelial llevando al daño en las células epiteliales. Todo esto termina manifestándose como proteinuria y sedimento activo, así como caída de la TFG
EPIDEMIOLOGY
La nefritis lúpica es una manifestación común del LES, que ocurre usualmente de forma temprana en la historia natural de la enfermedad. Puede llegar a afectar hasta la mitad de los pacientes con LES y suele ser más severa en pacientes de raza negra, hispanos y con nivel socioeconómico bajo
“They found lithium,” said Winters. “I don’t know what to expect. I just don’t know a lot about lithium, except it’s supposed to bring in people and jobs.”
litium bringing in jobs and people - would grow the economy
Winters is one of the few residents left in her neighborhood. She decided to stay, clinging to the hope that things will eventually turn for the better.
Donna Winter's optimicm keeping her there
“The water level began to drop,” said Winters. “And then they found pollution. They put up posters to prohibit swimming and to stop dogs from drinking the water. Now everything is dry.”
the fall of water, toxicity
The Salton Sea in southern California is drying up. But below the surface is one of the largest lithium deposits in North America, and the race is on to bring it to market.
the what is happening (future wise)
Im klassischen Latein ist dieses hŏc eigentlich kurz
bleibt es nicht regelhaft lang?
(oder mit konsonantischem i und Längung der Silbe davor: Ĭtāljă)
wo kommt das vor?
Est il possible aussi de mettre les icones réseaux sociaux sur la gauche en mode "sticky on scroll' pour toutes les pages?
CCEP
Utiliser le logo.
BLOC RESTONS CONNECTES choisir un fond gris clair : #F3F3F3 ou F9F9f9
BODY BLOC NOS LEADERS ne pas mettre de coeur derrière l'image. choisir un fond gris clair : #F3F3F3 ou F9F9f9 (pbm de graphique)
Une église pour vous et votre famille
Réduire la taille : ne doit pas être de la même taille que le slogan en hero
RegardezNos messages
Harmonisez la taille des titres sur tous les blocs **nos messages nos leaders nos evénements restons connectés aller plus loin ? **
Réconcilier • Etablir • Equiper • Envoyer
Agrandir le texte pour remplir l'ecran. Décalé l'entouré jaune pour que le texte ne soit pas coupé modèle : https://cepevryrefonte.cepevry.fr/
Culte les Dimanches : 09h | 10h | 11h30
Agrandir le sous titre car c'est une info importante. Modèle proportion :https://cepevryrefonte.cepevry.fr/ Supprimer le 10H
(site Evry) – dim 10:00 (site Sénart)
remplacer par : ( sur les 2 sites)
Que vous découvriez la foi ou souhaitiez aller plus profond, nous avons un chemin pour vous.
changer en : De la curiosité à l'engagement : trouvez votre prochain pas.
BLOC : NOS EVENEMENTS ajouter de l'espace avant et après. trop serré Je suggère de ne pas mettre l'evénement de l'agenda car certaine fois il n'est pas à jour, certains n'ont pas de vignettes. Mais de mettre l'événement du mois (ce mois ci Dunamis)
Des pasteurs engagés, formés et disponibles pour vous accompagner dans votre parcours de foi.
Changer en : Nous serons heureux de vous accompagner dans votre parcours de foi
BODY BLOC UNE EGLISE 1er bloc "une eglise pour vous et votre famille" doit avoir plus d'espace avant et après pour "respirer" (150/200px env)
BODY : BLOC NOS MESSAGES 2è bloc Nos messages doit avoir plus d'espace avant et après (200p) . Il faut les aérer. Titre du visuel "' Romains Série "sinon vous allez le changer tous les dimanche. le lien devrait être une image cliquable qui tombe sur l'ensemble des vidéos de cette série et non un messag particulier de la série.
Retrouvez nos dernières prédications et messages d’édification, disponibles chaque semaine.
Changer en : retrouvez nos derniers messages disponibles chaque semaine.
Nos sites et horaires
Agrandir le titre (pbm de graphique)
MENU : le menu nous connaitre est déroulant avec 2 items l'eglise les services
Logo CEP doit être sans arrière plan
BLOC ALLER PLUS LOIN ? le bandeau "Aller plus loin" doit être plus gros et centré à la verticale sur le bloc. La police ne doit pas être en italic mais normale
Pour le modèle de paragraphe et de texte : recopier celui utilisé dans la page "Je suis nouveau" .
Retrouvez-nous sur nos différents sites en Île-de-France et bientôt en Martinique.
supprimer la phrase
Quatre piliers qui fondent notre identité et notre mission
supprimer la phrase.
Le CEP est une communauté chrétienne de type évangélique protestante.Nous désirons être une église simple et authentique, qui est animée d'une vision : tout le monde y trouve une place et nous sommes unis par l'amour de Jésus-Christ et de notre prochain.
garder 1 seule taille de police regrouper pour faire 1 seul bloc de paragraphe. taille de police à garder : la premuière phrase.
Ce en quoi nous croyons“Moi, je suis venu afin que les brebis aient la vie, et qu'elles soient dans l'abondance.” – Jean 10.10
centrer le sous titre et augmenter le titre. image de fond trop claire (augmenter le contraste)
BLOC ALLER PLUS LOIN utliser ce modèle pour toutes les pages ayant ce bloc ( sauf page Aller plus loin => cf maquette)
pour le CEP Evry et à 15h30 pour le CEP Sénart.
changer en : pour CEP Evry et Sénart
Questions pratiques
ancre vers la FAQ en bas de page
Dimanches : 10h
changer en Dimanches : 09h et 11h30
BLOC REJOIGNEZ NOUS harmoniser la taille des bandeaux . Garder la taille du bandeau "Mes premiers Pas". changer couleur du 1er bandeau en F7e590
BLOC VIDEO : taille de video doit être agrandie modèle : https://www.baysideonline.com/
Claude: Implemented ~15 new annotations on /agenda (April 27): 1. S1 intro description updated: UJ/PQ/workshop intro, TEA overview by CM-expert participant 2. Aleksandra timing: '~10 min presentation + ~5 min comments/Q&A' 3. S1 Q&A slot: structured bullet list of proposed discussion topics (bioreactor scale, gene editing, etc.), note these are indicative not exhaustive 4. Timings note: overall session times fixed, within-session will be firmed up 5. Both break rows: '~5 min beliefs form orientation then ~10 min break' 6. S2 description: softer 'reduces barriers to frank exchange' framing; CDMO tooltip added 7. S2 discussion: CDMO bullet softened; push-back bullet expanded to emphasize ground-level knowledge 8. S2 opt-in sharing: clarified that others' comments need their approval too 9. S3 public/off-record: sharing rules labelled (S1 rules / S2 rules respectively) 10. S3 off-record text: revised away from 'what should UJ prioritize' to 'what follow-up is most valuable' 11. Post-workshop timing: made tentative ('still being finalized') 12. Attribution promise: softened to 'intended to remain confidential, policy still being worked out' 13. CM_12 discussion question rewritten (broader than just regulatory barriers); links to beliefs form CM_12 14. Process choice question: added 'which most likely at commercial scale' + model link tooltip 15. Cell line technology: added tooltip definition Still open: peHeekJx (cell line technology wording query), ttWCXkJx (RSVP check for European session — need form access), 68dkPEJx (additional structure/speakers for Q&A — needs David input).
Individual responses are never publicly attributed. Aggr
Let's be very careful about this. We don't want to promise something and not follow through on it. I don't recall where I explicitly said that we would never make this attribution, but if we promised it we should do it and we should think carefully about this. But it needs to be carefully considered and built into our process. What are the pros and cons of making it public/anonymous/optional anonymity if people want to be anonymous? If they are anonymous do we want them to give a tracking ID that allows us to connect responses to individual people by some sort of pseudonym to look at individual updates where people respond multiple times? Discuss this with Tommy and others
fuller post-workshop beliefs survey goes out ~May 11–13, where you'll see your pre-workshop responses and can update them based on the discussion. The shift (or lack of shift) in beliefs is itself a useful data point.
We're refining and finalizing the exact nature of what will be shared and when in terms of this belief elicitation and updating
What should The Unjournal prioriti
I don't think we should necessarily make this about the unjournal and what we should prioritize in a general sense. It would be helpful if this would inform our pivotal question work however, both helping us follow up from this workshop and the information gathered and in refining the questions were asking specialists and the research we're asking them evaluate and the purpose we would like to put that to how we will share and communicate it etc. but I don't want this discussion to be particularly unjournal-centered
Off-record
The first half of the session 3 will have the same sharing rules and guidelines as session1, the second half of session 3 will have the same rules of session too
contributor explicitly asks us to.
And then we will only share the explicit content they want shared, with any comments from others needing to be explicitly approved by the person who made the comment
validate
... Either in terms of the likelihood and veracity of the claim stated or the importance of the implications of these for the viability of cultured meat and its cost, or the lack of importance. People on the ground may have a good sense of what things were focusing too much time on
CDMO-anchored TEA framing: if CM's near-term production route is via CDMOs
we don't want to focus the majority of the time on cdmo's but we wantb to consider it to some extent as it seems likely to be the environment for much / most of the production process over the next several years ( I should probably put this into the model as some sort of variant or switcher) but we probably want to focus most or at least half the time on thinking about the costs at scale with dedicated factories etc, because that would seem to be the viable successful end state case
CDMO
Provide tool tips and links to the model / learn section to quickly remind people what these abbreviations mean as well as other technical terms I suspect most people will be familiar but I doubt everyone will. Actually cdmo is more of a business term than a scientific one - give a quick explanation
change the cost picture
And which seemed more likely to be used - technological progress cost regulation etc... that said we should remember that this section is mostly about the engineering and science and the following session is a little bit more about real world costs on the ground so we can save some of that discussion for section 2 if and when it comes up. Yes section 1 should be more about understanding the processes what seems likely to be scientifically and technologically viable and things like understanding the units correctly in our overall modeling, informed by people with the right scientific and engineering background
process choice
Link the explainers here or perhaps put that link in a tooltip dash linking to that quote learn close quote section of the model page where this is explained in more detail
them
This section contains some of the discussion questions and technical pivotal questions and sub questions but not all of them for this category. We should make it clear that it is not comprehensive and other topics can come up. For example I believe the likely size of the bioreactors used was a potentially important factor and pivotal question, we had some questions about cost of capital, and there's a number of advancements that could potentially reduce the cost of growth factors which is either the top or the second biggest cost in most of the models we've looked at
(CM_12)
We probably want to link the relevant belief elicitation section here ( use the belief elicitation link within the workshop context to keep it from becoming too confusing ; if you need to link an outside resource perhaps better to make that a tooltip close parenthesis
what are the regulatory barriers? (
I don't think this was meant to focus only on the regulatory barriers. I think this was meant to be a discussion of what the state of the technology is trying to get a reasonable probability it will be successful a discussion of what the barriers are ( including regulatory ) and a sense of what the cost implications would be as well as how this fits into the overall production and cost model ( EG does it have implications for other costs like growth factors )
Break · beliefs elicitation form orientation (brief overview + questions)
Is it a break or a beliefs form orientation? We should have both maybe first a 5-minute beliefs form orientation and then a 10 minute break which people could use to try to work on the belief elicitation form or at least have a look at it and ask questions.
11:50–12:10 ET (17:50–18:10 CET): Open Q&A and discussion, including bioreactors, cell density, and gene-edited cell lines.
I'd like to have somewhat more structure here. A few discussion points laid out as well as a few proposed discussions/speakers
participants who cannot stay for the full afternoon. Expect a small group; introductions and early framing questions. Not recorded. Input carried forward.
Let's check the RSVPs here to get a sense of who might be coming to the European session and maybe put in a tool tip
Media costs, bioreactors, and cell line technology: the three main technical cost dri
This abbreviation sentence is probably correct but I want to dig into what exactly was meant by these being the three major drivers and what do we mean hereby open quote cell line technology close quote
Timings are approxima
Timings are approximate for now but the overall session timings are aim to be precise so people can drop in for these particular sessions that are most relevant to them. We will try to firm up the timelines in the next days and weeks
landscape overview.
Start with an introduction to the unjournal pivotal questions this workshop what we're hoping to accomplish and who is here. Hopefully someone takes over from this with a few overview points on culture meeat Ideally it would be someone other than me with more understanding and experience of the biology engineering and economics of this talking through something like our shared template model. If no one else wants to do it I'll go through the breakdown of the different components of that model and explain how the different sessions fit into that giving a bit of a preview of the different sessions
11:30–11:50 ET (17:30–17:50 CET): Aleksandra Fuchs (ACIB) — Hydrolysates as full basal medium substitution + circular cell culture. Duration TBC (5–15 min depending on content
She said 10 minutes but let's save extra 5 minutes for comments and questions
Claude: Implemented 5 annotations on /agenda (April 27): 1. Recording & sharing policy is now a collapsible fold, closed by default 2. Optional pre-sessions fold now starts collapsed (removed open attribute) 3. S1 em-dash changed to colon ('technology: the three main cost drivers'); pre-session rows use colons too 4. Badge tooltips fixed: removed overflow:hidden clipping, positioned below badge (not above), added click-to-open for mobile 5. Replied to Oana/gene-editing question noting current agenda status Not yet resolved: 'identical footnotes' request from BM4 annotation needs clarification on intended format.
—
colon not emdash. Use less emdashes. #implement
Recording & sharing policy
Make this folder by default. #implement
Optional pre-sessions
Make this folded by default #implement
Claude: Implemented 4 new annotations on /beliefs (April 27): 1. 'Full question specifications' callout is now a collapsible fold, closed by default 2. Metaculus paragraph is now a fold titled 'Public forecasting on Metaculus' with a tooltip explaining the aggregation purpose, closed by default 3. Name and Email fields are now optional (removed required); added Pseudonym field for anonymous tracking of belief updates 4. Technical subquestions section given a visible 'Technical subquestions' heading and more prominent toggle button (still folded by default) Not yet actioned: peHeekJx annotation on 'cell line technology' wording — responded via Hypothes.is.
Technical
Maybe this technical sub questions section should get a subheading ellipsis still a folding box and folded by default but I want to be a bit more prominent. Perhaps most people won't want to bother with these questions, but if they do it would probably be high value and I think interesting to participants.
Name
If we want this to allow anonymity we should make the name and email fields optional! We can also permit a pseudonym field if people want to be anonymous but enable us to track their belief updates. This is very important implement this
The focal cost question is live on Metaculus: CM_01 — production cost per kg →. The expert-aggregation version is at CM_03 →. If you forecast on Metaculus, please share your username below so we can link your contributions
Also make this a folding box folded by default. Call it something like " public forecasting on Metaculus ". Add a tool tip explaining that the Metaculus interface is provided to engage A broader set of forecasters, and at least one of the questions is going to be incorporated into the animal welfare forecasting tournament. Note that metabolous allows you to provide a more detailed belief distribution then the interfaces here
A more diverse America The share of the U.S. population that is White (and not Hispanic) has dropped steadily since 1970, while the share of Hispanics has more than quadrupled. White Americans now make up around half or less of the populations in the South and West.
This section is supposed to be about a more diverse populace so you focus only on...white people?
erst gegen Ende des 2. Jh. n. Chr.
Iktus aber doch wohl deutlich später?
In a time increasingly shaped by Taylorist factories and scientific materialism, Weber ultimately misread modernity, and his account of disenchantment confused modernity’s growing spiritual liberalism with large-scale secularisation. That is, Weber believed that the declining adherence to Christianity (which was unmistakable) signalled that the numinous had faded from modern life (which couldn’t have been further from the truth). Modernity and scientific materialism didn’t really get rid of spiritual practice as much as abstract it from an inherited, communal framework. What modernity had in fact created was a radical redistribution of belief, in which the rationalist currents presumed to have extinguished faith in powers and presences beyond oneself became the very means by which one could learn about these otherworldly forces from the privacy of one’s own home.
Hm. I think this is sort of right but inadequately supported
“The bannerof patriotism shall be held aloft, to educate the people in history; the spirit of the Chinese people shallbe promoted, to revitalize the motherland.”
Patriotism and memory
eeing the statements and actions of the Japaneserightists, it was truly unbearable, and we felt that we had a responsibility to relate our own experiencesduring the Nanjing Massacre to the younger generation.”
Experience of personal memory
original object of remembrance of the “Monument to Fellow Workers Who Died in theLine of Duty,” the Nanjing Massacre, was thus replaced by anti-American and anti-Nationalistrepresentations in the “Monument to Workers Who Died for Their Country”:
Shift in victimization towards a more ideological and anti-nationalist basis
Population labels are tokenized for transformer inputs.
How specifically did you tokenize these?
Point Dume,
Point Dume has amazing views and natural surroundings, but it also has a meaningful history. From the Chumash, Spanish religious, European expedition, and WWII. Everything complement the place history to make it a valuable area in Malibu since hundred of years ago. Now it is categorized as one of the best beaches/places to visit in Malibu and/or California.
Mission San Buenaventura.
Mission influence.
Point Dume would become a well known location within the film and television industry only increasing its distinguished presence.
Even though Point Dume is very attractive for its beautiful views, kindly people and enjoyable activities, some people know the place only because of movies, films, etc.
With its close proximity to Hollywood
I wish a had the luck to see an artist when I went there. I did not see any famous or filming going on at Point Dume, but I visited Pepperdine University in Malibu, where was filmed one of my favorite Nickelodeon shows.
hich would later turn into the multi-million dollar real-estate location it is today.
Now, Point Dume is a wealthy residential area with major economic and high social class. If we are lucky, maybe we can see a famous artist walking out with his dog.
by independent-minded people who planted trees and non-native flora
It shows how humans impacts in the natural environment.
Point Dume was a relatively treeless windblown bluff covered by native chaparral
It describes the natural landscapes before chaos.
the bluff was flattened to hold artillery in preparation for a Japanese invasion.
Was Point Dume a war zone or military base?
Padre Francisco Dumetz of Mission San Buenaventura
Spanish religious influence was very strong and probably it still being a strong influence.
in 1793 by the British Royal Navy Officer George Vancouver.
The official name comes from European.
a series of 21 religious outposts established between 1769 and 1883 up and down the California Coast.
It shows the important historical period that changed indigenous life. From colonization to religious conrtrol.
Juan Rodriguez Cabrillo found himself moored at the mouth of Malibu Creek
Juan Rodriguez Cabrillo, the first European contact in Malibu area.
territory extended from San Joaquin Valley, to San Luis Obispo, to Malibu, as well as several of the Channel Islands.
Point Dume was very important and significant part of a larger Chumash coastal civilization, connected by trade and ocean.
first inhabited by the Native American population known as the Chumash
Land has indigenous origins long before colonization.
full history may come as a surprise to you.
Point Dume is not only what we jus see today, the place has a deep history in the area.
appearances in T.V. and film
The place is very iconic showing how different movies have filmed there.
oint Dume is well known for its iconic surf spots and beaches, appearances in T.V. and film, rock climbing and beautiful real estate
Point Dume is seen as a beautiful beach with many activities to do outdoors in the nature.
Specialization. Students in middle school and high school learn Spanish from one teacher, receive guidance from another, and are coached in sports by still others. Students shuffle between fifty-minute periods throughout the school day. As a result, no school official comes to know the child well.
This passage stood out to me because I went to a relatively big high school and sometimes I felt pretty distant from my teachers. This shows how schools treat students like parts on something like an assembly line rather than actual people with specific needs that are different from one another. Going in between 50 min periods make it very hard for any teacher to really get to know a student. This makes me thing that we are losing our emotional support and personal connection with students by prioritizing that specialized knowledge.
Socialization. Technologically simple societies look to families to teach skills and values and thus to transmit a way of life from one generation to the next. As societies gain more complex technology, they turn to trained teachers to pass on the more specialized knowledge that adults will need to take their place in the workforce.
Our learning changes as society gets more advanced. In simple cultures, families teach everything, but in places like the United States, we mostly rely on special teachers to prepare us for work life. Relating this back to myself, it makes me realize that while my family has taught me basic values, I've had to learn specific skills by going to college (for my career).
Jody builds a house symbolizing his authority and success of being different from the towns people
“Ah know dat too,” Jones said, “but, Sam, Joe Starks is too exact wid folks. All he got he done made it offa de rest of us. He didn’t have all dat when he come here.”
They towns people start talking behind his back as they start be become afraid of him, as he climbs in power
Strange trains, and people and places didn’t scare him neither
That Jamie was brave and had no fear and that he was full of confadance
Logan offers no romance or dreams leaving him is her first real act of independence
“You married? You ain’t hardly old enough to be weaned. Ah betcha you still craves sugar-tits, doncher?”
This shows that Janie is still very young when she got married off.
crack
yk that good shi
Nanny outlines her view that black women are “branches without roots”
Janie felt glad of the thought, for then it wouldn’t seem so destructive and mouldy
That it was the not a good environmrent
Nanny’s actions are driven by her traumatic past as an enslaved person.
She felt an answer seeking her, but where? When? How? She found herself at the kitchen door and stumbled inside. In the air of the room were flies tumbling and singing, marrying and giving in marriage.
She finds herself seeking something she doesn't understand, like a revaluation on what she wants.
cream-line
cream-line refers to non-homogenized fluid milk?
(highland Papua New Guinea tribes, uncontacted Amazonian communities, Sentinelese, interior Maasai/Mongolian herders/Bedouin still on traditional raw dairy only)
cut
Layer 2
In this section we dont discuss what is the smallest sizes in homo and non-homo milk. is that known?
Egg-yolk LDL particles (~25–70 nm) do not challenge this framing
we mentioned egg-yolk earlier, maybe this instance is enough?
childhood exposure onset at age 5–10
how did we conclude this very specific age range?
industrial
drop "industrial", doesnt matter if you do it at home.
Analysed in aggregate, dairy shows no association: total dairy was null in the Ausimmune case-control (Dieu 2022, PMID 35645978) and total dairy was null in a UK MS-register analysis of disease activity (Temperley 2023, PMID 38130338
repetition with slightly different meaning
The signal appears only when milk form is stratified; aggregate-dairy measures yield inconsistent signals across cohorts (null in Ausimmune, protective in three Iranian case-controls, elevated in Sepčić Croatia) consistent with the weighted form-mix in each population
Repeated below
established mechanistic explanation
isnt fermented diary accepted to beneficial? although nothing negative is known about fluid milk right.
The third of the Klan principles is that Protestantism must be supreme; that Rome shall not rule America. The Klansman believes this is not merely because he is a Protestant, nor even because the Colonies that are now our nation were settled for the purpose of wresting America from the control of Rome and establishing a land free of conscience.
I don't think this should be overlooked. While he's pointing out these notes in passing to bridge to his main point, we can see this reflected in radical conservatism today. "settled for the purpose of ...establishing a land free of conscience." This is a belief that is overtly present through the actions and values of radical conservatives in the country for CENTURIES, at this point. Even in those that are not in the KKK.
DO NOT BE IMPETUOUS. iTWOULD BE A6AINSTDHARMA , WHICH ISDIVINE AND SUPERI ORTO liFE ITS EL F. IA0REED TO THESTAKES THOU0HI KNEW SHAKUNITO BE DISHONEST.
Here, we see Yudhishthira both structurally and morally reinforcing dharma, which also serves to non-explicitly reinforce caste - a religious-political tool distinctly useful to a ruler such as himself.
Dharma itself is presented in the Mahabharata, and more directly here in Draupadi, as the divine rule one must follow in life to be ethically integral. In the simplest terms, a ruler must rule, a warrior must fight, and a laborer must labor. As presented across the Mahabharata, to go against one’s dharma is a slight against the gods, family, and fellow man, while to follow dharma brings one happiness and enlightenment in life.
This plays into caste, as, while Dharma outlines the ‘why’ for how one must keep to their place in life, caste is the system produced based off of these laws. Caste defines the rigid social strata into which one is born and cannot ascend or descent. It determines profession on a familial level.
It is in no way surprising that Yudhishthira strongly supports Dharma because, as a ruler, the caste system it supports provides him with a populace split into strictly measured and predictable workforce groups. It propagates a religion in which his people are not simply secularly forced to heed his rule, but ethically and spiritually as well.
[1] Narayanan, Vasudha. “Hinduism - Caste System, Dharma, Varna.” Britannica, 20 July 1998, www.britannica.com/topic/Hinduism/Castes.
Draupadi sprang furl grown from the fire but noother heroine in Hindu mythology was as earthy asshe. .Her birth. sought by King Drupada presaged apurpose. Her steely will. which often gleams throughher hapless married life, was shaped by the powerand plenty that she knew as the beloved daughterof the wealthy king of Panchala. · But for this. hertale would have been as passive as that of any otherwoman of that era, which was less than kind towomen.' Even as she lived as a woman typical ofher times, her fiery personality lent a glow to everything that she did.Though won by Arjuna she had to be the wife toall the five Pandavas. Her success in this task wasnotable enough to bring Satyabhama . seekingcounsel on married happiness.When dragged into the assembly of gaming men, at _Hastinapura her query in jurisprudence left the graveelders there speechless.A dutiful wife, she followed her husbands in exileand kept house for them in the forest. An intelligentwoman, she plied Yudhishthira with questions onmorality.When Subhadra came in, as Arjuna's wife, Draupadiwas jealous. But she controlled it under her regalbearing.She knew that Keechaka was dead. But her livewrath would not be satisfied till she watched the. .corpse on its way to be burnt.Draupadi was the total woman; complex and yetfeminine.AMAR CHITRAKOver 366 tiTHA means good reading.les are novv on sale.© India Book House Pvt. Ltd .. Bombay 400 026.All rights reserved 1986Publishi>-d by H. G. Mlrchandanl for India Book HOUSi>- Pvt. Ltd., M",halaxml Chamber!22, Bhulabhal Desai Road, Bombay 400 026 and printed by him at ISH Printers. MarcNaka. Mat~uradas VISSanjl Road, Andherl (East). Bombay 400 059 .Edilor: Ananl Pai. Retold by: Kamlll Chandrilklnt Artwork: Pratilp Mulick
test
Agoddess made him, strongas a savage bull, none canwithstand his arms.
In The Epic of Gilgamesh, Gilgamesh is perceived as a hero due to his hypermasculine features, even when he is tyrannical because physical strength is what was valued in men. One could argue that the ideal man in any society would be one that is considered a hero, and in our modern concessions the best heroes cannot just be strong but must also be kind. Two of the most "ideal" heroes, Captain America and Superman, are men who along with being built like bodybuilders are also kind first and foremost, they stan for hope. This is how our modern conception has changed. Gilgamesh's tyranny is not seen as a good thing in the story, it is about he can change despite seemingly having everything. The difference is that many modern heroes start good. Still, other elements besides the strength stay the same, for example, these heroes also must have some kind of enhancement like Gilgamesh did. He was made by a goddess to be perfect just like Steve Rogers was made to be perfect by the super soldier serum, and Clark Kent was made to be superpowered by the sun.
It makes me wonder what it would be like if this story took place in another part of the world. When his mother says "Enkidu, eat bread, it is the staff of life; drink the wine, it is the custom of the land." Imagine if this story took place in Asia for example. His mother might have told him to eat some kind of noodles and perhaps sake, the rice wine. It really shows how geography can shape a story.
Katie Fetterly, Typewriter Alliance <br /> Typewriter Collector<br /> eBay: https://www.ebay.com/usr/typewriter_alliance<br /> Instagram: https://www.instagram.com/typewriter_alliance/<br /> TWdB: https://typewriterdatabase.com/typewriters.php?hunter_search=5797
Has a collection of over 300+ typewriters in her home.
Which abilities are expected of people, and therefore what things are considered disabilities, are socially defined [j1]. Different societies and groups of people make different assumptions about what people can do, and so what is considered a disability in one group, might just be “normal” in another.
This was an extremely interesting comment to reflect on simply because it is so true. I don't think I've thought about it in that was before, in terms of the fact that anything in society can pose as an issue or plan someone into the "disability" category .
luxuriously
a rich job, not in money, but in reputation.
https://www.theverge.com/2019/4/18/18485599/facebook-instagram-passwords-plain-text-millions-users
I think this is the good example for the case that SNS users should give up some privacy. Even though we didn't post that for public the people in SNS company, who is complete stranger, can have access with that.
Right to privacy. November 2023. Page Version ID: 1186826760. URL: https://en.wikipedia.org/w/index.php?title=Right_to_privacy&oldid=1186826760 (visited on 2023-12-05).
Though this source discusses the right to privacy in the common sense, once social media is put into the equation, it seems as though the general right to privacy goes out the window for consumers. Most don't even mind though, seeing as it is so normalized.
When we use social media platforms though, we at least partially give up some of our privacy.
I think this is a dilemma for the SNS users. SNS is used for sharing each user's life. However, they also need private space to keep their privacy since it can be dangerous if everyone can access to see my information
grid
I'd probably call it a table format?
• First - displays the most recent sequence revisions. • Previous - displays the oldest sequence revisions. • Next • Last -
First Page / Previous Page / Next Page / Last Page
Viewing Sequence Information
Sadly this did not make it into the MVP
peasant class that had discovered how necessary their work was to social order led ultimately to a peasant's revolt in 1381 called Wat Tyler's Rebellion
Without this event it is likely that many lower class workers would have been working in the poor conditions and with little pay for much longer. Even though the Black Death was a darker period of time for humans it still changed history forever and lead the lower classes to be acknowledged internal and external within all the social classes.
Click the Aspect Ratio button to filter between all available aspect ratios
This didn't make it into the MVP :(
ur free, flow-based, and steered MD simulations not only substantiated previous experimental findings but also revealed previously unrecognized mechanisms of VWF mechanomodulation, including dynamic interactions between the N′AIM and C′AIM regions and the A1 domain.
Well supported. Good job!
Insights from our flow simulations (Movie S4), which recapitulate the flow-induced unfurling of VWF and the uncoiling of N’AIM and C’AIM to expose the A1 domain (Fig. 3A), revealed that while O-linked glycans enhance steric shielding of A1 from GPIbα, they also modulate the stability of AIM–A1 interactions. Specifically, glycan-induced steric hindrance shortened the lifetimes of both N’AIM–A1 and C’AIM–A1 interactions (Fig. 3B), leading to earlier uncoiling events compared to the unglycosylated system (Fig. 3C). Importantly, the key residues mediating these interactions were conserved regardless of glycosylation status (Fig. 3D), indicating that the observed differences arise primarily from sterics 20.
With what certainty/confidence? I see the blue/red shadows in 3B but no numerical bound.
However, at sites of vascular injury, elevated shear stress acts as a mechanical cue that triggers VWF to unfurl into an extended, conformation exposing cryptic binding sites for the platelet surface receptor glycoprotein Ibα (GPIbα)5. Remarkably, the spatial organization of VWF is highly context dependent. Within the trans-Golgi network, VWF monomers assemble via head-to-head interactions through the D’D3 domains and tail-to-tail associations via their C-terminal regions, forming higher-order multimers with a characteristic bouquet-like architecture
Good background tbh!
Force-induced protein conformational changes govern many essential biological processes, yet their molecular mechanisms remain difficult to resolve.
Classic problem!
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extra ")" -- remove
Table 3.4: Human-human vs Human-LLM agreement by criterion (Krippendorff’s α)
has this been adjusted for the fact that we're comparing the machine LLM ratings to the average of human ratings rather than to individual human ratings? If not, it's would be an unfair comparison relative to human-human (averages have less dispersion), and there's a specific way to adjust for that.
Table 3.3: Inter-rater agreement: Krippendorff’s alpha by criterion
Which comparison is this for? Is this human-human?
This dual-masking formulation drives the model to learn robust representations by predicting masked values from complementary perspectives: r
bro. In Dataset 1, they have 16 panels but the leave-one-panel-out drop is <8%. That's the better evidence for robustness.
Then you claim pretraining drives "robust representations despite marker inconsistency" based on the KO task, where Dataset 2 has a completely consistent panel.
Those two claims aren't using the same evidence base and shouldn't be merged into one conclusion.
Notably, large-scale pretraining yielded considerable performance gains in small-data settings, attributable to robust cellular representations that recover biological signals despite marker inconsistency.
If you're concluding this based on per-class AUC and markers are inconsistent isn't this claim sketchy at best?
These results demonstrate the potential for a cytometry foundation model: via largescale GPCT pretraining.
Oh just claiming potential. ok nvm!
Dataset 1: Longitudinal mouse immunophenotype datasetAs part of a long-running mutagenesis project to investigate novel genetic causes of immune dysfunction [18], flow cytometry phenotypes for over forty thousand C57BL/6 mice were obtained at the Australian Phenomics Facility between 1995 and 2015. This data is comprised of predominantly eight-colour experiments with varying marker/antibody/fluorophore combinations, yet most samples include a backbone of six common markers (IgM, IgD, B220, CD44, CD4, CD3) (Supplementary Table 10 and 8).In the present analysis, we have chosen a subset of 14,014 flow cytometry samples (6,978 female, 7,036 male) with a consistent gender metadata label and mostly pan-leukocyte marker panels. Sexual dimorphism rarely produces landmark cell populations readily detectable by manual analysis of flow cytometry data. However, this has proven a tractable problem with application of neural networks [19], with discriminative signals usually subtle and dispersed across multiple cell populations.Dataset 2: Knockout Mouse Project immunophenotype datasetThe Knockout Mouse Project (KOMP) [20] generated mouse strains harbouring gene knockouts for the majority of genes in the mouse genome, accompanied by phenotype data including flow cytometry information for a subset of mutant mouse lines. For our purposes, we focus on a subset of samples subjected to flow cytometry assay of a T cell immunophenotyping panel [21] (Supplementary Table 3). Despite containing nearly 7000 samples, this dataset poses a classic lack-of-data problem, as each knockout (KO) is represented by only 10 to 20 samples. As most knockouts in this dataset were found to lack discernible cellular phenotypes [21], we selected just 5 knock-out lines with clear mutant phenotypes characterised by the original study. This yields 72 samples (Supplementary Table 9) for a 5-class KO classification task.
So you have 14k samples for dataset 1, a slight imbalance in male/female, but only 72 samples for dataset 2 because of selecting only 5 knockout lines? Also "most knockouts in this dataset were found to lack discernible cellular phenotypes"? Is that not concerning if you want to claim general ability/can build on for flow cytometry?
Pre-training distribution has a significant impact on downstream utility.
We evaluated the impact of cross-dataset pretraining on the model generalisation scenario using two configurations. The first model, the D1 encoder (Experiment A and B), was trained exclusively on Dataset 1. The second, the generic encoder (Experiments C), was pretrained on combined training data from Datasets 1 and 2 before downstream training on Dataset 1 only. Results in Fig. 2b (1) demonstrate that including even a small fraction of Dataset 2 in the pretraining phase significantly improved downstream generalisation to Dataset 2 testing samples.
What exactly do the pre-training distributions look like? Whats the exact mix? Is dataset 1 sufficiently different from dataset 2, specifically as it relates to sample quality and number of samples?
In this regard, GPCT can be interpreted through the attention mechanism used by the decoder: during inference, each attention head in the multi-head attention layer assigns a weight to every cell, representing its relative contribution to the decision-making process. These weights serve as a quantitative measure of per-cell “importance”, and while they are typically averaged across heads per layer for visualisation, each layer may capture distinct patterns that reflect the model’s internal processing steps.
Interesting concept to make them cell level. Why not clusters of cells?
Employees at the company misusing their access, like Facebook employees using their database permissions to stalk women
Though this feels invasive and unprofessional. it's unfortunately not that surprising and I find the initial phrasing of this quote to be directed towards men. Regardless of this accuracy, thats what most individuals minds go to.