684 Matching Annotations
  1. Jun 2021
    1. Parry, H. M., Tut, G., Faustini, S., Stephens, C., Saunders, P., Bentley, C., Hilyard, K., Brown, K., Amirthalingam, G., Charlton, S., Leung, S., Chiplin, E., Coombes, N. S., Bewley, K. R., Penn, E. J., Rowe, C., Otter, A., Watts, R., D’Arcangelo, S., … Moss, P. (2021). BNT162b2 Vaccination in People Over 80 Years of Age Induces Strong Humoral Immune Responses with Cross Neutralisation of P.1 Brazilian Variant. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3816840

  2. May 2021
  3. Apr 2021
  4. Mar 2021
  5. Feb 2021
    1. When T-Cells are activated they release cytokines (yes, that cytokine), which trigger additional T-Cells to be made, which then release even more cytokines. One type of T-cells that are created are called cytotoxic T-cells. Cytotoxic T-cells are the cells that are able to roam the body and mercy kill infected cells who are chemically calling out to be killed and ideally to stop the increased production of viruses like COVID-19.
  6. Jan 2021
  7. Dec 2020
  8. www.investopedia.com www.investopedia.com
  9. Oct 2020
  10. Sep 2020
    1. Le Bert, N., Tan, A. T., Kunasegaran, K., Tham, C. Y. L., Hafezi, M., Chia, A., Chng, M. H. Y., Lin, M., Tan, N., Linster, M., Chia, W. N., Chen, M. I.-C., Wang, L.-F., Ooi, E. E., Kalimuddin, S., Tambyah, P. A., Low, J. G.-H., Tan, Y.-J., & Bertoletti, A. (2020). SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature, 584(7821), 457–462. https://doi.org/10.1038/s41586-020-2550-z

  11. Aug 2020
    1. Mateus, J., Grifoni, A., Tarke, A., Sidney, J., Ramirez, S. I., Dan, J. M., Burger, Z. C., Rawlings, S. A., Smith, D. M., Phillips, E., Mallal, S., Lammers, M., Rubiro, P., Quiambao, L., Sutherland, A., Yu, E. D., Antunes, R. da S., Greenbaum, J., Frazier, A., … Weiskopf, D. (2020). Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. https://doi.org/10.1126/science.abd3871

    1. Ferretti, A. P., Kula, T., Wang, Y., Nguyen, D. M., Weinheimer, A., Dunlap, G. S., Xu, Q., Nabilsi, N., Perullo, C. R., Cristofaro, A. W., Whitton, H. J., Virbasius, A., Olivier, K. J., Baiamonte, L. B., Alistar, A. T., Whitman, E. D., Bertino, S. A., Chattopadhyay, S., & MacBeath, G. (2020). COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2. MedRxiv, 2020.07.24.20161653. https://doi.org/10.1101/2020.07.24.20161653

  12. Jun 2020
  13. May 2020
    1. Grifoni, A., Weiskopf, D., Ramirez, S. I., Mateus, J., Dan, J. M., Moderbacher, C. R., Rawlings, S. A., Sutherland, A., Premkumar, L., Jadi, R. S., Marrama, D., de Silva, A. M., Frazier, A., Carlin, A., Greenbaum, J. A., Peters, B., Krammer, F., Smith, D. M., Crotty, S., & Sette, A. (2020). Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals. Cell, S0092867420306103. https://doi.org/10.1016/j.cell.2020.05.015

  14. Apr 2020
  15. Oct 2019
    1. Let's make the example even easier. function convertDate<T extends string | undefined>(isoDate?: string): T { return undefined } 'undefined' is assignable to the constraint of type 'T' Means: What you return in the function (undefined), matches the constraints of your generic type parameter T (extends string | undefined). , but 'T' could be instantiated with a different subtype of constraint 'string | undefined'. Means: TypeScript does not consider that as safe. What if you defined your function like this at compile time: // expects string return type according to generics // but you return undefined in function body const res = convertDate<string>("2019-08-16T16:48:33Z") Then according to your signature, you expect the return type to be string. But at runtime that is not the case! This discrepancy that T can be instantiated with a different subtype (here string) than you return in the function (undefined) is expressed with the TypeScript error.
    1. Based on examples given in https://github.com/Microsoft/TypeScript/issues/29049

      Specific link: http://www.typescriptlang.org/play/#code/LAKAZgrgdgxgLgSwPZQARigRgDwBVUCmAHnAVACYDOqlcATglAOYB8AFEQFyq4CU3+AN6hUqOgTgQ6aAEQALAgBtFSVAHckdReQCEM1AHoDAQ2q4A3KAC+oOAE8ADgVQBleseaoAvKnkIZoDAotDT0jEzcbnQeTN6+cv6BwUiKBAB0KkxsGJhstAzMvLygoJCwiCjoUABMeIQkZFSoABK4ALIAMgCiqQC2ZHDsSABGAFYC-DyowiCi4pLSqFAEai3tHQAiCMaZPQT9UHBsRaimPJYgNiCl0PDIaBgAzHXEpBTUw0gpBB5DYwJxMA7SgEXjTaw3cr3KoAFheDXeqE+31+bBG4x4kyEIkMBnmUjQ6Jx+MWQMUIIhIHsTh4dAgBFwjmcPno9IuQSgIWRilwdIIAj5jJpLL57OSqQySCyGBhbG5vPpRRKIDIEF6qC64NmolQAA0ADSoACahoAWtYgA

      and: http://www.typescriptlang.org/play/#code/LAKAZgrgdgxgLgSwPZQARigRgDwBVUCmAHnAVACYDOqlcATglAOYB8AFEQFyq4CU3+AN6hUqOgTgQ6aAEQALAgBtFSVAHckdReQCEM1AHoDAQ2q4A3KAC+oOAE8ADgVQBleseaoAvKnnH9AD6+csbKSDKgMCi0NO7M3G50Hkzewf6R0UiKBAB0KkxsGJhstEnMvLygoJCwiCjoUABMeIQkZFSoABK4ALIAMgCi2QC2ZHDsSABGAFYC-DyowiCi4pLSqFAEal29fQAiCKFITEMEo1BwbBWopjyWIDYg1dDwyGgYAMwtxKQU1JNILIEDwTGYCVJgUKUAi8RbWZ61N4NAAs3zaf1QAKBILYU1mPHmQhEhgMqykaDxxLJ60himh8JA9icPDoEAIuEczh89DZ9yiUBiWMUuFZBAEoo5zO5or5mWyeWOhSgyLYQpFbIqVRAZAgw1QAzhy1EqAAGgAaVAATQtAC1rEA

    1. In the body of the function you have no control over the instantiation by the calling context, so we have to treat things of type T as opaque boxes and say you can't assign to it. A common mistake or misunderstanding was to constraint a type parameter and then assign to its constraint, for example: function f<T extends boolean>(x: T) { x = true; } f<false>(false); This is still incorrect because the constraint only restricts the upper bound, it does not tell you how precise T may really be.
  16. Feb 2019
    1. he names of simple ideas tlie least doubtful. c8. Fr

      So, Locke is trying to establish somewhat of a hierarchy of language based in clarity. Names of simple substances are closest to the Truth of the substance. "Philosophical" words are furthest from Truth because what the concepts/things they represent are most difficult to nail down. I wonder, then, if we can translate this to exploring the human--do we have a hierarchy of understanding? Or a hierarchy of Truest representation?

    2. certain and undoubted

      "Certain and undoubted" brings to mind the classical sense of logos, where it's meaning isn't logic or reasoning (as we tend to think of it now) but is more about the commonly accepted truth. It's a truth that people believe--but that doesn't make it correct. Locke undoubtedly is not intending this meaning but is instead calling for an objective Truth.

    1. Among athousand different opinions which different menmay entenain of the same subject, there is one,and but one, that is just and true;

      Aaaand there we have it, the rejection of relativism that was also in Locke. "Come, John! There is one Truth and we must seek it out!"

  17. Jan 2019
    1. prove

      Interesting that there's this call for "proof," some form of evidence, something tangible that we can point to. Such a desire feels very objective, as though there's some Truth this proof will point to. What would such proofs be?

  18. Sep 2018
  19. Aug 2018
    1. Contributions to the practice and theory of teaching and learning literature, including publications in peer-reviewed and professional journals, conference publications, book chapters, textbooks and open education repositories/resources.

      P&T language supporting Open activities

  20. Nov 2017
    1. Toxoplasmosis is caused by the obligate intracellular parasite, Toxoplasma gondii. Its life cycle consists of 3 forms, including an oocyst, a tissue cyst, and an active (proliferative) form.

      See also: CDC- Toxoplasmosis

      Toxoplasmosis

      Source of Infection in humans:

      1. Eating under cooked meat of animals harboring tissue cysts
      2. Consuming food or water contaminated with cat feces or by contaminated environmental samples (such as fecal-contaminated soil or changing the litter box of a pet cat)
      3. Blood transfusion or organ transplantation
      4. Transplacentally from mother to fetus

      Sources of T. gondi infection

      Life cycle of T. gondi

  21. Oct 2017
  22. May 2017
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  25. Oct 2016
  26. Sep 2016
  27. Jul 2016
  28. Jun 2016
  29. Mar 2016
  30. Oct 2015
  31. Jul 2015
    1. Could or would each of the 2.1 million registered users of Airbnb come up with about $120 per year to complete the buy-out of a $2.5 billion dollar company in 10 years? Maybe. The number of users is growing rapidly, which would reduce the buy-in cost for each user. And I, for one, would probably encourage everyone I know to buy in, if Airbnb took the revolutionary step of converting to a cooperative.