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Gilbert, P. B., Montefiori, D. C., McDermott, A., Fong, Y., Benkeser, D. C., Deng, W., Zhou, H., Houchens, C. R., Martins, K., Jayashankar, L., Castellino, F., Flach, B., Lin, B. C., O’Connell, S., McDanal, C., Eaton, A., Sarzotti-Kelsoe, M., Lu, Y., Yu, C., … Teams, U. S. G. (USG)/CoVPN B. (2021). Immune Correlates Analysis of the mRNA-1273 COVID-19 Vaccine Efficacy Trial. MedRxiv, 2021.08.09.21261290. https://doi.org/10.1101/2021.08.09.21261290
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Gutman, R. (2021, October 28). Is Moderna Really Better Than Pfizer—Or Is It Just a Higher Dose? The Atlantic. https://www.theatlantic.com/health/archive/2021/10/pfizer-moderna-dose-which-vaccine-best/620501/
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Sadoff, J., Gars, M. L., Cardenas, V., Shukarev, G., Vaissiere, N., Heerwegh, D., Truyers, C., Groot, A. M. de, Scheper, G., Hendriks, J., Ruiz-Guinazu, J., Struyf, F., Hoof, J. V., Douoguih, M., & Schuitemaker, H. (2021). Durability of antibody responses elicited by a single dose of Ad26.COV2.S and substantial increase following late boosting (p. 2021.08.25.21262569). https://doi.org/10.1101/2021.08.25.21262569
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Zimmer, C. (2021, September 21). An extra J. & J. shot substantially boosts protection against Covid, the company reports. The New York Times. https://www.nytimes.com/2021/09/21/health/johnson-and-johnson-shot.html
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Collier, A. Y., Brown, C. M., Mcmahan, K., Yu, J., Liu, J., Jacob-Dolan, C., Chandrashekar, A., Tierney, D., Ansel, J. L., Rowe, M., Sellers, D., Ahmad, K., Aguayo, R., Anioke, T., Gardner, S., Siamatu, M., Rivera, L. B., Hacker, M. R., Madoff, L. C., & Barouch, D. H. (2021). Immune Responses in Fully Vaccinated Individuals Following Breakthrough Infection with the SARS-CoV-2 Delta Variant in Provincetown, Massachusetts (p. 2021.10.18.21265113). https://doi.org/10.1101/2021.10.18.21265113
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Dean, N. E. (2021, September 21). Hmm okay. J&J two dose results are a bit more complicated, with different results globally versus within the US. https://t.co/prFUorU8LE [Tweet]. @nataliexdean. https://twitter.com/nataliexdean/status/1440318770665324560
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ReconfigBehSci. (2021, December 12). RT @EricTopol: If you think Prior Covid protects against Omicron (B.1.1.529), think again https://medrxiv.org/content/10.1101/2021.12.08.21267491v1 and "Neutralizing antibo… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1470434736304803845
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Payne, R. P., Longet, S., Austin, J. A., Skelly, D. T., Dejnirattisai, W., Adele, S., Meardon, N., Faustini, S., Al-Taei, S., Moore, S. C., Tipton, T., Hering, L. M., Angyal, A., Brown, R., Nicols, A. R., Gillson, N., Dobson, S. L., Amini, A., Supasa, P., … Zawia, A. A. T. (2021). Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine. Cell, 184(23), 5699-5714.e11. https://doi.org/10.1016/j.cell.2021.10.011
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Ravi K Gupta [@ravgup33_ravi]. (2021, November 24). This one is worrying and I’ve not said that since delta. Please get vaccinated and boosted and mask up in public as the mutations in this virus likely result in high level escape from neutralising antibodies [Tweet]. Twitter. https://twitter.com/ravgup33_ravi/status/1463626745651806208
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Tao, K., Tzou, P. L., Nouhin, J., Gupta, R. K., de Oliveira, T., Kosakovsky Pond, S. L., Fera, D., & Shafer, R. W. (2021). The biological and clinical significance of emerging SARS-CoV-2 variants. Nature Reviews Genetics, 1–17. https://doi.org/10.1038/s41576-021-00408-x
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Lauren Pelley. (2022, February 24). BREAKING: Made-in-Canada #COVID19 vaccine from Medicago approved by Health Canada today. Shot dubbed ‘Covifenz,’ and uses virus-like particles. Background on the high efficacy against infection seen during Phase 3 clinical trials: Https://t.co/5clkYzatVK [Tweet]. @LaurenPelley. https://twitter.com/LaurenPelley/status/1496859590402654208
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ReconfigBehSci on Twitter: ‘surprising how the logic of argument around C19 has not updated to the fact that reinfection is a big thing, as are new variants. Delay = a round of infection you never got...’ / Twitter. (n.d.). Retrieved 13 February 2022, from https://twitter.com/SciBeh/status/1483716840316706824
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Gentles, L. E., Kehoe, L., Crawford, K. H. D., Lacombe, K., Dickerson, J., Wolf, C., Yuan, J., Schuler, S., Watson, J. T., Nyanseor, S., Briggs-Hagen, M., Saydah, S., Midgley, C. M., Pringle, K., Chu, H., Bloom, J. D., & Englund, J. A. (2022). Dynamics of infection-elicited SARS-CoV-2 antibodies in children over time (p. 2022.01.14.22269235). medRxiv. https://doi.org/10.1101/2022.01.14.22269235
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Wernike, K., Boettcher, J., Amelung, S., Albrecht, K., Gaertner, T., Donat, K., & Beer, M. (2022). Serological screening suggests single SARS-CoV-2 spillover events to cattle (p. 2022.01.17.476608). https://doi.org/10.1101/2022.01.17.476608
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Glenn Beck has Covid again after refusing vaccine: ‘It’s going into my lungs.’ (2022, January 13). The Independent. https://www.independent.co.uk/news/world/americas/us-politics/glenn-beck-covid-ivermectin-mark-levin-b1992427.html
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Reuters. (2021, December 20). Moderna says booster produces strong antibody response to Omicron. The Guardian. https://www.theguardian.com/world/2021/dec/20/moderna-booster-strong-antibody-response-omicron-covid-vaccine-variant
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Garcia-Beltran, W. F., Denis, K. J. S., Hoelzemer, A., Lam, E. C., Nitido, A. D., Sheehan, M. L., Berrios, C., Ofoman, O., Chang, C. C., Hauser, B. M., Feldman, J., Gregory, D. J., Poznansky, M. C., Schmidt, A. G., Iafrate, A. J., Naranbhai, V., & Balazs, A. B. (2021). MRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant (p. 2021.12.14.21267755). https://doi.org/10.1101/2021.12.14.21267755
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ReconfigBehSci. (2021, December 12). RT @florian_krammer: New preprint led by Kaori Sano in collaboration with @VivianaSimonLab https://medrxiv.org/content/10.1101/2021.12.06.21267352v1. Convalescent individual… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1469936301466079233
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Roessler, A., Riepler, L., Bante, D., Laer, D. von, & Kimpel, J. (2021). SARS-CoV-2 B.1.1.529 variant (Omicron) evades neutralization by sera from vaccinated and convalescent individuals (p. 2021.12.08.21267491). https://doi.org/10.1101/2021.12.08.21267491
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Mahase, E. (2021). Covid-19: Antibody boost after third dose varies greatly by vaccine, study finds. BMJ, 375, n3011. https://doi.org/10.1136/bmj.n3011
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www.irishtimes.com www.irishtimes.com
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GSK-Vir antibody-based Covid-19 treatment works against Omicron variant. (n.d.). The Irish Times. Retrieved December 2, 2021, from https://www.irishtimes.com/business/health-pharma/gsk-vir-antibody-based-covid-19-treatment-works-against-omicron-variant-1.4744831
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- Nov 2021
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www.nature.com www.nature.com
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Mallapaty, S. (2021). The coronavirus is rife in common US deer. Nature. https://doi.org/10.1038/d41586-021-02110-8
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ReconfigBehSci. (2021, November 1). 2/2 from the paper ‘We speculate that the extraordinarily high antibody titers observed in vaccinated individuals who develop breakthrough infections may lead to subsequent long-term protection in those individuals.’ [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1455104597454954497
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- Oct 2021
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www.bmj.com www.bmj.com
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Mahase, E. (2021). Covid-19: Just a third of blood cancer patients had antibodies against delta variant after two vaccine doses, study finds. BMJ, 375, n2623. https://doi.org/10.1136/bmj.n2623
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John Roberts on Twitter. (n.d.). Twitter. Retrieved 31 October 2021, from https://twitter.com/john_actuary/status/1453289464441233422
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www.nature.com www.nature.com
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Andreano, E., Paciello, I., Piccini, G., Manganaro, N., Pileri, P., Hyseni, I., Leonardi, M., Pantano, E., Abbiento, V., Benincasa, L., Giglioli, G., De Santi, C., Fabbiani, M., Rancan, I., Tumbarello, M., Montagnani, F., Sala, C., Montomoli, E., & Rappuoli, R. (2021). Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants. Nature, 1–7. https://doi.org/10.1038/s41586-021-04117-7
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Prof. Akiko Iwasaki. (2021, September 23). Thankfully, we have not seen any evidence of antibody-dependent enhancement of infection or disease by any COVID vaccines to date. Vaccine are not making infections worse, and are very effective in preventing disease. [Tweet]. @VirusesImmunity. https://twitter.com/VirusesImmunity/status/1441074260534075392
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China’s ‘zero Covid’ vs Singapore’s ‘living with it’: Rapid low-cost testing could mean we don’t need to choose | South China Morning Post. (n.d.). Retrieved October 15, 2021, from https://www.scmp.com/comment/opinion/article/3152167/chinas-zero-covid-vs-singapores-living-it-rapid-low-cost-testing
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Mahase, E. (2021). Covid-19: Antibody levels fall after second Pfizer dose, but protection against severe disease remains, studies indicate. BMJ, 375, n2481. https://doi.org/10.1136/bmj.n2481
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Should the Unvaccinated Get Priority for Monoclonal Antibodies? (2021, October 8). https://www.medpagetoday.com/infectiousdisease/covid19/94937
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Mateus, J., Dan, J. M., Zhang, Z., Rydyznski Moderbacher, C., Lammers, M., Goodwin, B., Sette, A., Crotty, S., & Weiskopf, D. (n.d.). Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells. Science, 0(0), eabj9853. https://doi.org/10.1126/science.abj9853
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Full Fact. ‘What Do We Know about the Covid-19 Vaccines Crossing the Placenta?’, 16:58:51+00:00. https://fullfact.org/pregnant-then-screwed/vaccines-crossing-placenta/.
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Emary, K. R. W., Golubchik, T., Aley, P. K., Ariani, C. V., Angus, B., Bibi, S., Blane, B., Bonsall, D., Cicconi, P., Charlton, S., Clutterbuck, E. A., Collins, A. M., Cox, T., Darton, T. C., Dold, C., Douglas, A. D., Duncan, C. J. A., Ewer, K. J., Flaxman, A. L., … Pollard, A. J. (2021). Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(21)00628-0
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Yahoo Finance. (2021, September 21). “The J&J results exceed expectations,” Yale Radiology and Public Health Professor @thehowie says about the COVID-19 vaccine. “They continue to point out that the J&J vaccine is highly effective even as a one dose vaccine.” https://t.co/AOsxo9IwKT [Tweet]. @YahooFinance. https://twitter.com/YahooFinance/status/1440356401826590727
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- Sep 2021
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www.theguardian.com www.theguardian.com
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Geddes, L. (2021, September 28). Covid can infect cells in pancreas that make insulin, research shows. The Guardian. https://www.theguardian.com/society/2021/sep/29/covid-can-infect-cells-in-pancreas-that-make-insulin-research-shows
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Dupuy, B. (2021, August 6). COVID-19 vaccines offer benefits even to those previously infected. AP NEWS. https://apnews.com/article/fact-checking-130053228518
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Klein, Alice. “Cheap Covid-19 Antibody Test Shows If You Have Immunity in 5 Minutes.” New Scientist. Accessed September 20, 2021. https://www.newscientist.com/article/2290120-cheap-covid-19-antibody-test-shows-if-you-have-immunity-in-5-minutes/.
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Wilson, C. (2021, September 9). Blood test could reveal who is most likely to get severe covid-19. New Scientist. https://www.newscientist.com/article/2289718-blood-test-could-reveal-who-is-most-likely-to-get-severe-covid-19/
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www.science.org www.science.org
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Israelow, B., Mao, T., Klein, J., Song, E., Menasche, B., Omer, S. B., & Iwasaki, A. (2021). Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2. Science Immunology. https://doi.org/10.1126/sciimmunol.abl4509
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John Burn-Murdoch. (2021, August 23). NEW: in the last couple of weeks there have a lot of new studies out assessing vaccine efficacy, many of which have touched on the question of waning immunity. Unsurprisingly, these have prompted a lot of questions. Time for a thread to summarise what we do and don’t know: [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1429878189011111936
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- Aug 2021
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www.biorxiv.org www.biorxiv.org
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Liu, Y., Arase, N., Kishikawa, J., Hirose, M., Li, S., Tada, A., Matsuoka, S., Arakawa, A., Akamatsu, K., Ono, C., Jin, H., Kishida, K., Nakai, W., Kohyama, M., Nakagawa, A., Yamagishi, Y., Nakagami, H., Kumanogoh, A., Matsuura, Y., … Arase, H. (2021). The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines (p. 2021.08.22.457114). https://doi.org/10.1101/2021.08.22.457114
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Madhi, S. A., Koen, A. L., Izu, A., Fairlie, L., Cutland, C. L., Baillie, V., Padayachee, S. D., Dheda, K., Barnabas, S. L., Bhorat, Q. E., Briner, C., Aley, P. K., Bhikha, S., Hermanus, T., Horne, E., Jose, A., Kgagudi, P., Lambe, T., Masenya, M., … Kwatra, G. (2021). Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in people living with and without HIV in South Africa: An interim analysis of a randomised, double-blind, placebo-controlled, phase 1B/2A trial. The Lancet HIV, 0(0). https://doi.org/10.1016/S2352-3018(21)00157-0
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We shouldn’t be giving Covid boosters while millions wait for a first dose | Andrew Pollard and Seth Berkley | The Guardian. (n.d.). Retrieved August 17, 2021, from https://www.theguardian.com/commentisfree/2021/aug/13/covid-boosters-dose-vaccine
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Hillus, David, Tatjana Schwarz, Pinkus Tober-Lau, Hana Hastor, Charlotte Thibeault, Stefanie Kasper, Elisa T. Helbig, et al. “Safety, Reactogenicity, and Immunogenicity of Homologous and Heterologous Prime-Boost Immunisation with ChAdOx1-NCoV19 and BNT162b2: A Prospective Cohort Study,” June 2, 2021. https://doi.org/10.1101/2021.05.19.21257334.
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Prof. Devi Sridhar. “Rest of the World Watching Closely: ‘In Scotland, Estimated That 92.5% of Adults Would Have Tested Positive for Antibodies against SARS-CoV-2 on a Blood Test in the Week Beginning 12 July 2021’- Is This Enough to Dampen Transmission & Protect under 12s from Infection? Under 18s?” Tweet. @devisridhar (blog), August 4, 2021. https://twitter.com/devisridhar/status/1422852550957617157.
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Greinacher, A., Thiele, T., Warkentin, T. E., Weisser, K., Kyrle, P. A., & Eichinger, S. (2021). Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. New England Journal of Medicine, 384(22), 2092–2101. https://doi.org/10.1056/NEJMoa2104840
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Shrotri, M., Navaratnam, A. M. D., Nguyen, V., Byrne, T., Geismar, C., Fragaszy, E., Beale, S., Fong, W. L. E., Patel, P., Kovar, J., Hayward, A. C., & Aldridge, R. W. (2021). Spike-antibody waning after second dose of BNT162b2 or ChAdOx1. The Lancet, 398(10298), 385–387. https://doi.org/10.1016/S0140-6736(21)01642-1
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papers.ssrn.com papers.ssrn.com
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Shen, X., Tang, H., McDanal, C., Wagh, K., Fischer, W. M., Theiler, J., Yoon, H., Li, D., Haynes, B. F., Saunders, K. O., Gnanakaran, S., Hengartner, N. W., Pajon, R., Smith, G., Dubovsky, F., Glenn, G. M., Korber, B. T., & Montefiori, D. C. (2021). SARS-CoV-2 Variant B.1.1.7 is Susceptible to Neutralizing Antibodies Elicited by Ancestral Spike Vaccines (SSRN Scholarly Paper ID 3777473). Social Science Research Network. https://papers.ssrn.com/abstract=3777473
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Mandavilli, A. (2020, June 18). You May Have Antibodies After Coronavirus Infection. But Not for Long. The New York Times. https://www.nytimes.com/2020/06/18/health/coronavirus-antibodies.html
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www.reuters.com www.reuters.com
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Ahlander, J. & Pollard, N. (2020, May 20). Swedish antibody study shows long road to immunity as COVID-19 toll mounts. Reuters. https://www.reuters.com/article/us-health-coronavirus-sweden-strategy-idUSKBN22W2YC
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twitter.com twitter.com
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Devi Sridhar on Twitter: “Early serology results based on antibody testing: 5% for UK, 17% for London. From Matt Hancock, Health Secretary in today’s briefing. In line with what other countries have reported on their seroprevalence.” / Twitter. (n.d.). Twitter. Retrieved May 31, 2020, from https://twitter.com/devisridhar/status/1263507332224475136
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Goodman, J. D., & Rothfeld, M. (2020, April 23). 1 in 5 New Yorkers May Have Had Covid-19, Antibody Tests Suggest. The New York Times. https://www.nytimes.com/2020/04/23/nyregion/coronavirus-antibodies-test-ny.html
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Vespignani, A., Tian, H., Dye, C. et al. Modelling COVID-19. Nat Rev Phys (2020). https://doi.org/10.1038/s42254-020-0178-4
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dash.harvard.edu dash.harvard.edu
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Larremore, Daniel B., Kate M. Bubar, and Yonatan H. Grad. Implications of test characteristics and population seroprevalence on ‘immune passport’ strategies (May 2020).https://dash.harvard.edu/handle/1/42664007
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Wang, C., Li, W., Drabek, D. et al. A human monoclonal antibody blocking SARS-CoV-2 infection. Nat Commun 11, 2251 (2020). https://doi.org/10.1038/s41467-020-16256-y
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Kaplan, E. H., & Forman, H. P. (2020). Logistics of Aggressive Community Screening for Coronavirus 2019. JAMA Health Forum, 1(5), e200565–e200565. https://doi.org/10.1001/jamahealthforum.2020.0565
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doi.org doi.org
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Gray, N., Calleja, D., Wimbush, A., Miralles-Dolz, E., Gray, A., De-Angelis, M., Derrer-Merk, E., Oparaji, B. U., Stepanov, V., Clearkin, L., & Ferson, S. (2020). “No test is better than a bad test”: Impact of diagnostic uncertainty in mass testing on the spread of Covid-19 [Preprint]. Epidemiology. https://doi.org/10.1101/2020.04.16.20067884
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Mullard, A. (2020). Flooded by the torrent: The COVID-19 drug pipeline. The Lancet, 395(10232), 1245–1246. https://doi.org/10.1016/S0140-6736(20)30894-1
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- Mar 2020
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antibodystructure.org antibodystructure.org
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antibody modeling
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- Sep 2015
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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It was transferred to Boehringer-Mannheim as Clone 12H11, resold to Roche and finally bought by Chemicon, and it is now sold as MAB3026.
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