53 Matching Annotations
  1. Feb 2022
  2. Dec 2021
    1. Usually it is more fruitful to look for formulations of problems that relate heterogeneous things with each other.

      A great quote, but this is likely a nebulous statement to those with out the experience of practice. Definitely worth expanding on this idea to give it more detail.

  3. Jul 2021
    1. Collier, D. A., Ferreira, I. A. T. M., Kotagiri, P., Datir, R., Lim, E., Touizer, E., Meng, B., Abdullahi, A., Elmer, A., Kingston, N., Graves, B., Gresley, E. L., Caputo, D., Bergamaschi, L., Smith, K. G. C., Bradley, J. R., Ceron-Gutierrez, L., Cortes-Acevedo, P., Barcenas-Morales, G., … Gupta, R. K. (2021). Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2. Nature, 1–9. https://doi.org/10.1038/s41586-021-03739-1

  4. Oct 2020
  5. Sep 2020
    1. Hennessy, E. A., Acabchuk, R., Arnold, P. A., Dunn, A. G., Foo, Y. Z., Johnson, B. T., Geange, S. R., Haddaway, N. R., Nakagawa, S., Mapanga, W., Mengersen, K., Page, M. J., Sánchez-Tójar, A., Welch, V., & McGuinness, L. A. (2020). Ensuring Prevention Science Research is Synthesis-Ready for Immediate and Lasting Scientific Impact [Preprint]. MetaArXiv. https://doi.org/10.31222/osf.io/ptg9j

  6. Aug 2020
    1. Mateus, J., Grifoni, A., Tarke, A., Sidney, J., Ramirez, S. I., Dan, J. M., Burger, Z. C., Rawlings, S. A., Smith, D. M., Phillips, E., Mallal, S., Lammers, M., Rubiro, P., Quiambao, L., Sutherland, A., Yu, E. D., Antunes, R. da S., Greenbaum, J., Frazier, A., … Weiskopf, D. (2020). Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. https://doi.org/10.1126/science.abd3871

  7. Jul 2020
  8. Jun 2020
  9. May 2020
  10. Dec 2019
    1. A single transformant may have a mutation at a low level that will eventually sweep through the population

      How does transforming a pure plasmid (miniprep) produce a mixed population?

      • Is a single colony on the transformation plate not really clonal due to evolution occurring in growth from the single founder cell?
      • And also the outgrowth steo prior to plating is introducing additional variation that differentiates different colonies
      • Hence adding these two statements together, picking 3 colonies from a plate streaked from a glycerol stock (derived from a clonal population) has lower variability than 3 colonies picked from a fresh transformation?

      Does this make any suggestion of using one or the other method for generating independent biological replicates?

  11. Sep 2019
  12. Aug 2019
    1. Here, we show how three phenomena—Simpson’s paradox, context-dependence, and nonlinear averaging—can lead to erroneous conclusions about population parameters and species interactions when samples contain heterogeneous mixtures of populations or communities.
    2. These issues can be overcome by measuring and accounting for spatial heterogeneity at very small scales
  13. May 2019