Ensure that the product image updates accurately and consistently when users select a product variation by:Using a centralized, reliable image source tied to each variant.Dynamically updating the product image based on the selected variant.Providing graceful fallbacks when a variant-specific image is not available.
Ensure accurate Shopify variant image loading on selection with proven methods. Enhance user experience, reduce bounce rate & improve product display.
The objective is to provide an enhanced product viewing experience by:Displaying a dedicated image gallery or slider for each product variation.Dynamically loading and rendering the correct set of images when the user selects a variation (e.g., color, material).Organizing images per variant to reflect the actual look and feel of the selected option.
Explore whether to use sliders or static views for Shopify variant image galleries. Learn which layout offers better UX and performance for your store.
Dynamically updating product images based on the selected variant (e.g., color or size).Mapping and displaying the correct image associated with the currently selected variant.Avoiding mismatched visuals that can confuse users and increase return rates.
Learn how to change product image on variant select Shopify using JavaScript and theme customizations for better UX.
Disease: Von-willebrand Disease (Type 2A)
Patient: 50 yo female
Variant: VWF NM_000552.5 c:4232_4249del p.(Val411_Ile416del), Exon 28, heterozygous variant
According to this paper, ACMG-AMP guidelines for interpreting this variant resulted in classification of likely pathogenic
Phenotypes: increased bruising, fatigue, recurrent sinusitis, menorrhagia, neutropenia, anaemia. Reduction in high-molecular-weight multimers
Family: segregation analysis showed two affected family members had the variant and two unaffected family members did not have variant.
Note: Patient also has diagnosed Acute Myeloid Leukaemia (AML) NM_000546.6(TP53):c704A>G p.(Asn235Ser), listed as VUS and found by NGS
Disease: Von-willebrand Disorder (2N)
Patient: 32 yo, male
Variant: VWF NM_000552.5 c:2527C>T, p.(Arg760Cys), exon 17, noted to be dominant effect
Note: Proband also has an Arg91Gln mutation in exon 20 of VWF too.
Phenotypes: Mild bleeding history, epistaxis, bleeding gums, bleeding after tooth extraction. 11 years old had severe hemorrhage following tonsillectomy. Previous diagnosis of hemophilia A.
Family: father has history of epistaxis but never eamined prior to study. Father has the Arg760Cys mutation at heterozygous level. Mother is asymptomatic and classified as hemophilia A carrier following hemophilia A diagnosis in son. Mother also has the Arg91Gln mutation in exon 20 at heterozygous level.
Molecular Phenotypes: mild decrease in plasma FVIII and VWF levels, normal platelet VWF content, decreased FVIII binding capacity of VWF. Causes retention of pro-VWF(suggest defects in the maturation process of VWF). Abnormal VWF and platelet GPIb interaction(documented by impaired or absent RIPA and decreased VWF:RCo).
Disease: Von-willebrand Disorder Type 2B, Noncanonical
Patient: 55 YO, Italian male
Note: these heterozygous variants are in cis mutations
Variant1: VWF NM_000552.5 c.2771G>A p.(R924Q), in exon 21, D'D3 domain affected
Variant2: VWF NM_000552.5 c.6532G>T p.(A2178S), in exon 37, D4 domain affected
Phenotypes: Mucosal and cutaneous bleeding, low VWF antigent and VWF activity, mild thrombocytopenia, increased ristocetin-induced platelet aggregation, deficiency in high-molecular-weight multimers. Epistaxis, repeated GI bleeding, easy bruising, ISTH BAT score of 7.
Note: Proband initially diagnosed with VWD type 1 in 2010 but later re-diagnosed as VWD-Type 2.
Family: No reported family history of bleeding, parents unable to be included in family work-up as they were deceased by time of study. Paternity test was performed for family, parental link established. Patient's daughter does not present the same mutation noted in proband but has heterozygous polymorphic variant inherited from mother which is: VWF NM_000552.5 c.3379C>T p.(P1127S), in exon 25. Daughter did not show menorrhagia or hemorrhagic disorder except for large hematoma on the thigh after trauma of moderate intensity.
Molecular workup: Paternity test, Sanger-sequencing to validate genetic variants, multimer analysis with electrophoresis, platelet aggregation analysis with Ristocetin, electron micrographs to observe conformation differences.
Prediction workup: Structural analysis with I-TASSER modeling program to identify perturbed structure. A2178S is predicted as tolerated in all in-silico systems used.
Database Information: Effect of the R924Q mutation is noted in literature database but has contradicting reports of effects altering VWF levels. Some studies do report it as a polymorphic variant
Variant is present in dbSNP database (rs33978901). MAF in European population 0.01< MAF< 0.02
Effect of A2178S variant is present in dbSNP database (rs34230288), MAF = 0.02 in European population.
Disease: Myopathic Ehlers-Danlos Syndrome (mEDS)
Patient(s): 47 yo male, japanese descent
Variant: COL12A1 NM_004370.6: c.395-1G>A (Homozygous variant, at splice acceptor site in exon 6, causes in-frame skipping)(located in the genomic region encoding the first von Willebrand factor A domain)
Family: consanguineous parents with no related features of mEDS, healthy older brother
Phenotypes (Childhood): hypotonia, weak spontaneous movements, scoliosis, torticollis, soft plams, undescended testes, motor developmental delay, slender build, triangular face, short palpebral fissures, small nose, small mouth, large ears, bilateral knee dislocations, short stature.
Phenotypes (Adulthood): short stature, high palate, hypermobile small joints, deformed cervical spine, brachycephaly, bilateral long deformed 5th finger, severe scoliosis post surgical fixation, asymmetric pelvis
Classification: sequencing panel found the variant and it was confirmed through sanger sequencing.
According to ClinGenSVI recommendation: PVS1_Strong
Applicable criteria:
1) the one at a GT-AG 1,2 splice site
2) the one exerting exon skipping or use of a crypic splice site that preserved the reading frame.
3) the one at a truncated/altered region critical to protein function; was classified as PM3_Supporting (homozygous)
Variant not registered in gnomAD (PM2_Supporting)
Partial defect of first vWA in collagen XII judged as PS3
Disease: Von Willebrand Disease (VWD)
Patient(s): Found in 2 families
Variant: VWF NM_000552.5: c.2311A>G, p.(M771V Homozygous variant in exon 18 (VWF D' domain; 8 residues down from proteolytic VWFpp furin cleavage site)
Family: In family 1 there are 4 homozygous patients (2 male and 2 female), and one heterozygous patient (1 female). The affected females are denoted as person 1 and person 4 and the affected males are person 2 and person 3. There are three WT family members (1 female and 2 male), grandparents of these members are of unknown genotype including a daughter of an affected female and a WT male. Note here that in the family a p.R2663P variant has co-segregated with the above-mentioned variant but is not suspected to be the pathogenic driver of resulting bleeding tendency.
In family 2 the parents of the homozygous affected male are of unknown genotype. The affected male is denoted as person 7.
Phenotypes: Person 1- nose bleed, skin bleed, GI bleeding, oral cavity bleeds, Menorrhagia, muscle bleeding, and joint bleeding. Receives on-demand treatment for bleeding.
Person 2-Nose bleed, skin bleed, bleeding from small wounds, oral cavity bleeds, bleeding after tooth extraction, joint bleeding. Received prophylactic treatment, reduced to on-demand treatment after a few years.
Person 3-Nose bleed, skin bleed, oral cavity bleeds, bleeding after tooth extraction, muscle bleeding. Receives on-demand treatment for bleeding phenotype.
Person 4- Nose bleed, bleeding from small wounds, oral cavity bleed, bleeding after tooth extraction, joint bleeding. Received prophylactic treatment that was increased after her menarche.
Person 7- Nose bleed, oral cavity bleeds, bleeding after surgery or trauma, joint bleeding. Previously on prophylaxis, now managing bleeding with on-demand treatment.
Note that both the p.R2663P co-segregated variant and p.M771V variant are reported in NCBI dbSNP database but functional effect not yet established.
NGS confirmed the genotype of all study participants.
Disease: Von-willebrand Disorder Type 3
Patient: 26 yo, female
Variant: VWF NM_000552.5 c:997+118 T>G g.(6073501 A>C), homozygous, intronic
Phenotypes: No detectable VWF in plasma, early onset bleeding complications, epistaxis, easy bruising, bleeding following injury, menorrhagia, iron-deficient anemia
Note: underwent prophylaxis replacement therapy, on-demand antihemorrhagic treatments, oral contraceptives, and replacement therapy.
Family: not mentioned
Predictions:
VEP SpliceAI tool predicted variant likely deleterious (delta score 0.95)
Used Polyphen-2 and SIFT which determined pathogenic likelihood.
Neural Network Splicing, Alternative Splice Site Predictor, plug-in MaxEnt(For 5' donor site) of Human Splicing Finder all concur this variant can create a new donor splice site in intron 8. Contains premature stop codon and susceptible to NMD.
Functional work:
qRT-PCR performed to identify levels of VWF in IP-derived endothelial cells.
histochemical immunostaining for IP-derived endothelial cells confirm no VWF production, only a residual amount present. Suggests leaky mutation.
performed RNA sequencing to assess co-regulated gene networks
Disease: Platelet-type Von-willebrand Disorder (PT-VWD)
Patient: 17 yo, male, adopted
Variant: GP1BA NM_000173.7: c:580C>T p.(P.Leu194Phe), Heterozygous, gain-of-function
Phenotypes: moderate bleeding phenotype, ISTH-BAT bleeding score of 3, recurrent epistaxis, easy bruising, mild thrombocytopenia
Family: Adopted, no other family history mentioned, segregation studies not performed.
Genetic analysis performed: found variant in GP1BA, results obtained by sanger sequencing.
Variant present in gnomAD(rs368111193): low allele frequency, contradictory classifications
Variant is not present in ClinVar, LOVD, or HGMD databases
According to this paper, ACMG guidelines classified this variant as a VUS.
This paper entered it into Clinvar (var ID 1693270)
Disease: Von Willebrand Disease (VWD) Type 2A
Patient: 31 yo, Female
Variant1: VWF NC_000012.12: c.875-5T>Gdel, p.(Ser292_Glu333delinsLys) Causes complete exon 8 skipping
Variant2: VWF NM_000552.5: c.813C>G, p.(Tyr271*)
Phenotypes: History of bleeding (epistaxis, uncontrollable by conventional hemostatic treatment), Easy bruising, gum bleeding, excessive menstrual bleeding, mild decrease in plasma VWF:Ag, severe impairment in VWF function, VWF:Ab/VWF:Ag ratio decreased, VWF:CB/VWF:Ag ratio decreased, FVIII:C lvs slighly below normal range
Family: Son had bleeding diathesis and spontaneous epistaxis (less severe than proband), normal parents
In silico data available: SpliceAI delta score of 0.51 for loss of splice acceptor caused by variant 1
Alamut showed small to moderate effects of the variant on normal splicing of VWF
NetGene2 showed weak strength of 3' splice sites in exon 8
SpliceAid2 showed TIA-1 and TIAL 1, which bind to U-rich motifs and facilitate 5' splice site recognition where destroyed in the mutated sequence
Disease: Von-Willebrand Disorder
Patient 2 Variant(s):
VWF NM_000552.5: c.4135C>T p.(Arg1379Cys) Exon 28 VWF NM_000552.5: c.4130C>T p.(Ala1377Val) Exon 28 VWF NM_000552.5: c.3797C>T p.(Pro1266Leu) Exon 28 VWF NM_000552.5: c.3835G>A p.(Val1279Ile) Exon 28
Note: Pro1266Leu and Val1279Ile are in trans with Ala1377Val and Arg1379Cys
Note2: MAF of Ala1377Val is present in Exome Variant Server (<0.01) and 1000 Genomes database (<0.02), designated as rare variant, typically found in indiv with African ethnicity
Family: Relatives molecular analysis showed Arg1379 and Ala1377Val variants mentioned above were in cis
Patient 2 Phenotype: Mild bleeding symptom Nearly normal VWF:Ag value, reduced VWF:RCo value slight loss of HMWM with smear decreased/slightly decreased proteolysis Slightly reduced RIPA VWFpp/VWF:Ag ratio shows increased VWF clearance VWF platelet levels reduced reduced rBpIba binding in VWF plasma VWF:GPIbM values slightly increased
Note: Treated with desmopressin in case of minor surgeries or delivery
Note 2: Slightly decreased RIPA may be explained by presence of 2B New York Variant (Pro1266Leu) that mitigates RIPA assay in 2M phenotype.
In silico analysis available:
I-Mutant 3.0 states decrease in A1 domain stability for both mutations (Ala1377Val = -0.91, Arg1379Cys = -1.36)
PYMOL predicts Ala1377Val does not alter formation of hydrogen bonds with Arg1374 residue and water. Predicts substitution of ARG 1379 with a cysteine results in the loss of hydrogen bonds with Lys1407 and Lys1408, predicted change in secondary structure of A1 domain
Ala1377Val was previously reported in 3 other patients Publications:
Millar CM, Riddel AF, Mellors G, Yee TT. The spectrum of VWD type 2 phenotypes associated with A1 domain mutations posters. J Thromb Haemost 2009; 7: 531–2.
Logsdon BA, Dai JY, Auer PL et al. A variational Bayes discrete mixture test for rare variant association. Genet Epidemiol 2014; 38: 21–30.
Final note: Authors suggest patients' 2M phenotype is due to the presence of Ala1377Val and Arg1379Cys together to create synergistic effect. Though difficult to discern with this specific patient having two other variants in addition to the two mentioned above.
In at least one other published version the first two items on this list are not peacock fans and Japanese screens but “ormolu garden gates, handleless cups”. The Oxford Book of Victorian Ghost Stories, ed. Michael Cox and R.A. Gilbert
Ormolu is the gilding technique of applying finely ground, high-carat gold–mercury amalgam to an object of bronze, and for objects finished in this way. The mercury is driven off in a kiln leaving behind a gold coating. The French refer to this technique as "bronze doré"; in English, it is known as "gilt bronze". https://en.wikipedia.org/wiki/Ormolu?wprov=sfti1
peacock fans, Japanese screens,
In at least one other published version the first two items on this list are not peacock fans and Japanese screens but “ormolu garden gates, handleless cups”. The Oxford Book of Victorian Ghost Stories, ed. Michael Cox and R.A. Gilbert
Ormolu is the gilding technique of applying finely ground, high-carat gold–mercury amalgam to an object of bronze, and for objects finished in this way. The mercury is driven off in a kiln leaving behind a gold coating. The French refer to this technique as "bronze doré"; in English, it is known as "gilt bronze". https://en.wikipedia.org/wiki/Ormolu?wprov=sfti1
Karim, S. S. A., & Karim, Q. A. (2021). Omicron SARS-CoV-2 variant: A new chapter in the COVID-19 pandemic. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(21)02758-6
Lucas, C., Vogels, C. B. F., Yildirim, I., Rothman, J. E., Lu, P., Monteiro, V., Gelhausen, J. R., Campbell, M., Silva, J., Tabachikova, A., Peña-Hernandez, M. A., Muenker, M. C., Breban, M. I., Fauver, J. R., Mohanty, S., Huang, J., Shaw, A. C., Ko, A. I., Omer, S. B., … Iwasaki, A. (2021). Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity. Nature, 1–9. https://doi.org/10.1038/s41586-021-04085-y
Pisani, J. (2021, July 9). Amazon to end testing for COVID-19 at warehouses this month. King5.Com. https://www.king5.com/article/news/health/coronavirus/amazon-to-stop-covid-testing/507-63caa9ee-3a30-49af-b2cd-1851637f1807
Kustin, T., Harel, N., Finkel, U., Perchik, S., Harari, S., Tahor, M., Caspi, I., Levy, R., Leschinsky, M., Dror, S. K., Bergerzon, G., Gadban, H., Gadban, F., Eliassian, E., Shimron, O., Saleh, L., Ben-Zvi, H., Amichay, D., Ben-Dor, A., … Stern, A. (2021). Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2 mRNA vaccinated individuals. MedRxiv, 2021.04.06.21254882. https://doi.org/10.1101/2021.04.06.21254882
Pearson, C. (2021, September 27). New Study Finds A Huge Perk Of Getting Vaccinated After Having COVID-19. HuffPost UK. https://www.huffpost.com/entry/study-covid-vaccine_l_6151dbbde4b098483a792e18
Willsher, K. (2021, October 11). French study of over 22m people finds vaccines cut severe Covid risk by 90%. The Guardian. https://www.theguardian.com/world/2021/oct/11/french-study-vaccines-cut-covid-deaths
Dolgin, E. (2021). Omicron is supercharging the COVID vaccine booster debate. Nature. https://doi.org/10.1038/d41586-021-03592-2
Johnson, S. (2021, June 7). Spat at, abused, attacked: Healthcare staff face rising violence during Covid. The Guardian. http://www.theguardian.com/global-development/2021/jun/07/spat-at-abused-attacked-healthcare-staff-face-rising-violence-during-covid
Chrisafis, A. (2021, July 12). France mandates Covid health pass for restaurants and cafés. The Guardian. http://www.theguardian.com/world/2021/jul/12/france-mandates-covid-health-pass-for-restaurants-and-cafes
American Academy of Pediatrics urges FDA to approve COVID vaccines for children under 12. (2021, September 13). PBS NewsHour. https://www.pbs.org/newshour/show/american-academy-of-pediatrics-urges-fda-to-approve-covid-vaccines-for-children-under-12
Monto, A. S. (2021). The Future of SARS-CoV-2 Vaccination—Lessons from Influenza. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMp2113403
Varmus, H. (2021, August 31). Covid has revealed the need for genomic sequencing around the world. Financial Times. https://www.ft.com/content/342fd3c3-5a22-49a0-9cef-135f2ccd8700
Davis, N. (2021, October 18). Valneva Covid vaccine could be as effective as Oxford jab, study suggests. The Guardian. https://www.theguardian.com/society/2021/oct/18/valneva-covid-vaccine-could-be-as-effective-as-oxford-jab-study-suggests
Lauring, A. S., Tenforde, M. W., Chappell, J. D., Gaglani, M., Ginde, A. A., McNeal, T., Ghamande, S., Douin, D. J., Talbot, H. K., Casey, J. D., Mohr, N. M., Zepeski, A., Shapiro, N. I., Gibbs, K. W., Files, D. C., Hager, D. N., Shehu, A., Prekker, M. E., Erickson, H. L., … Self, W. H. (2022). Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: Prospective observational study. BMJ, 376, e069761. https://doi.org/10.1136/bmj-2021-069761
Torjesen, I. (2021). Covid-19: Omicron may be more transmissible than other variants and partly resistant to existing vaccines, scientists fear. BMJ, 375, n2943. https://doi.org/10.1136/bmj.n2943
Krause, P. R., Fleming, T. R., Peto, R., Longini, I. M., Figueroa, J. P., Sterne, J. A. C., Cravioto, A., Rees, H., Higgins, J. P. T., Boutron, I., Pan, H., Gruber, M. F., Arora, N., Kazi, F., Gaspar, R., Swaminathan, S., Ryan, M. J., & Henao-Restrepo, A.-M. (2021). Considerations in boosting COVID-19 vaccine immune responses. The Lancet, 4. https://doi.org/10.1016/S0140-6736(21)02046-8
Sandra Ciesek. (2021, December 8). Unsere ersten Daten zur Neutralisation von Omicron versus Delta sind fertig: 2x Biontech, 2x Moderna, 1xAZ/1x Biontech nach 6 Monaten 0% Neutralisation bei Omicron, auch 3x Biontech 3 Monate nach Booster nur 25% NT versus 95% bei Delta. Bis zu 37fache Reduktion Delta vs. Omicron https://t.co/w0gHww26sg [Tweet]. @CiesekSandra. https://twitter.com/CiesekSandra/status/1468465347519041539
Lipsitch, M., Krammer, F., Regev-Yochay, G., Lustig, Y., & Balicer, R. D. (2021). SARS-CoV-2 breakthrough infections in vaccinated individuals: Measurement, causes and impact. Nature Reviews Immunology, 1–9. https://doi.org/10.1038/s41577-021-00662-4
Collier, A. Y., Brown, C. M., Mcmahan, K., Yu, J., Liu, J., Jacob-Dolan, C., Chandrashekar, A., Tierney, D., Ansel, J. L., Rowe, M., Sellers, D., Ahmad, K., Aguayo, R., Anioke, T., Gardner, S., Siamatu, M., Rivera, L. B., Hacker, M. R., Madoff, L. C., & Barouch, D. H. (2021). Immune Responses in Fully Vaccinated Individuals Following Breakthrough Infection with the SARS-CoV-2 Delta Variant in Provincetown, Massachusetts (p. 2021.10.18.21265113). https://doi.org/10.1101/2021.10.18.21265113
Wise, J. (2021). Winter is coming—But will the gloomiest forecasts come to pass? BMJ, 374, n2357. https://doi.org/10.1136/bmj.n2357
Smith, L., Potts, H., Amlôt, R., Fear, N. T., Michie, S., & Rubin, J. (2022). How has the emergence of the Omicron SARS-CoV-2 variant of concern influenced worry, perceived risk, and behaviour in the UK? A series of cross-sectional surveys. OSF Preprints. https://doi.org/10.31219/osf.io/rpcu2
Karberg, S., & Friebe, R. (2022, January 18). Virologe Drosten im Interview: „Wie lange geht diese Quälerei noch weiter?“. https://plus.tagesspiegel.de/wissen/virologe-drosten-im-interview-wie-lange-geht-diese-qualerei-noch-weiter-361636.html
Meng, B., Abdullahi, A., Ferreira, I. A. T. M., Goonawardane, N., Saito, A., Kimura, I., Yamasoba, D., Gerber, P. P., Fatihi, S., Rathore, S., Zepeda, S. K., Papa, G., Kemp, S. A., Ikeda, T., Toyoda, M., Tan, T. S., Kuramochi, J., Mitsunaga, S., Ueno, T., … Gupta, R. K. (2022). Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature, 1–1. https://doi.org/10.1038/s41586-022-04474-x
Hamblin, J. (2021, December 9). Perspective | Omicron won’t keep us from ending the pandemic. We’re doing that ourselves. Washington Post. https://www.washingtonpost.com/outlook/2021/12/09/omicron-coronavirus-individual-threat/
Page, M. L. (2021, March 17). UK variant looks set to cause a surge in global coronavirus cases. New Scientist. https://www.newscientist.com/article/mg24933263-900-uk-variant-looks-set-to-cause-a-surge-in-global-coronavirus-cases/
SARS-CoV-2 variants of concern and variants under investigation. (2021). 45.
Vöhringer, H. S., Sanderson, T., Sinnott, M., De Maio, N., Nguyen, T., Goater, R., Schwach, F., Harrison, I., Hellewell, J., Ariani, C. V., Gonçalves, S., Jackson, D. K., Johnston, I., Jung, A. W., Saint, C., Sillitoe, J., Suciu, M., Goldman, N., Panovska-Griffiths, J., … Gerstung, M. (2021). Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 1–11. https://doi.org/10.1038/s41586-021-04069-y
Harris, J. E. (2021). COVID-19 Incidence and Hospitalization During the Delta Surge Were Inversely Related to Vaccination Coverage Among the Most Populous U.S. Counties (p. 2021.08.17.21262195). medRxiv. https://doi.org/10.1101/2021.08.17.21262195
Le Page, M. (2021, November 22). What we know so far about AY.4.2 and other new coronavirus variants. New Scientist. https://institutions.newscientist.com/article/2298363-what-we-know-so-far-about-ay-4-2-and-other-new-coronavirus-variants/?utm_campaign=echobox&utm_medium=social&utm_source=Twitter
ReconfigBehSci. (2021, December 14). RT @thehowie: "...The vaccine provided 70 percent protection in fully vaccinated individuals against severe complications that would requir… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1470749072160133128
How are new Covid cases impacting sport? (n.d.). BBC Sport. Retrieved December 23, 2021, from https://www.bbc.com/sport/59682938
ReconfigBehSci. (2021, December 14). RT @thehowie: BREAKING South Africa: 82% increase in cases, week over week. 34.9% positive rate. Record 7-day average. Not near platea… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1470814593610047490
Dr Nisreen Alwan 🌻. (2021, December 23). We’re in unchartered territory. Https://t.co/O1GGcXpMll [Tweet]. @Dr2NisreenAlwan. https://twitter.com/Dr2NisreenAlwan/status/1474051397570248716
Kai Kupferschmidt. (2021, December 10). “the severity profile of Omicron cases must be interpreted along with an understanding of its capacity to re-infect (and infect the vaccinated)“ This is what I have been trying to explain the last few days. As usual @nataliexdean does it better (and in color)! [Tweet]. @kakape. https://twitter.com/kakape/status/1469270407995867139
Yaniv Erlich. (2021, December 8). Updated table of Omicron neuts studies with @Pfizer results (which did the worst job in terms of reporting raw data). Strong discrepancy between studies with live vs pseudo. Https://t.co/InQuWMAm4l [Tweet]. @erlichya. https://twitter.com/erlichya/status/1468580675007795204
ReconfigBehSci. (2021, December 12). RT @ryan_landay: > A new diverse genome has appeared within the B.1.1.529 lineage that has all of the shared mutations of B.1.1.529, some o… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1470066521615605766
ReconfigBehSci. (2021, December 9). RT @RachelLavin: As Omicron reality dawns, consider investing in better masks: "....Tight-fitting FFP2 masks provide 75 times better pro… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1474030898551087113
Campbell, D., Sabbagh, D., & Devlin, H. (2022, January 7). Military deployed at London hospitals due to Omicron staff shortages. The Guardian. https://www.theguardian.com/world/2022/jan/07/military-deployed-at-london-hospitals-due-to-omicron-staff-shortages
ReconfigBehSci. (2021, November 26). RT @mvankerkhove: Following the meeting of the @WHO TAG-VE today, WHO classifies B.1.1.529 as a variant of concern named Omicron. We call… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1464302372100976650
ReconfigBehSci. (2021, December 12). RT @EricTopol: If you think Prior Covid protects against Omicron (B.1.1.529), think again https://medrxiv.org/content/10.1101/2021.12.08.21267491v1 and "Neutralizing antibo… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1470434736304803845
ReconfigBehSci. (2021, November 26). vaccine equity has been a disaster, but I do wonder whether the exclusive focus on donations does the US/EU comparison justice. The EU allowed the export of huge numbers of EU produced doses at a time when the US did not (and EU itself was struggling to meet demand). [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1464255575416520749
ReconfigBehSci on Twitter: “RT @BNODesk: BREAKING: U.S. reports 716,714 new coronavirus cases, setting world record for cases in one day” / Twitter. (n.d.). Retrieved January 7, 2022, from https://twitter.com/SciBeh/status/1478987541332348933
Karan, A. (2022). We cannot afford to repeat these four pandemic mistakes. BMJ, 376, o631. https://doi.org/10.1136/bmj.o631
ReconfigBehSci. (2021, December 23). Risk of hospital stay 40% lower with Omicron than Delta, UK data suggests https://t.co/VupN8hY4qq [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1473916654421643266
ReconfigBehSci. (2021, November 26). maybe this is a good moment to remind people that makers of mRNA vaccines have been extensively prepping for the possibility of new variants. Biontech/Pfizer have given a timeline of 100 days to the delivery of a retooled version of their vaccine [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1464225264523747359
Kissane, E. (2021, December 23). We’re About to Lose Track of the Pandemic. The Atlantic. https://www.theatlantic.com/ideas/archive/2021/12/were-about-to-lose-track-of-the-pandemic/621097/
ReconfigBehSci. (2021, December 11). RT @MackayIM: Booster access brought forward to slow spread of Omicron COVID-19 variant https://t.co/PukbPydylw [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1469633384511119364
Eric Topol. (2022, January 2). As the world turns.....vertical the Omicron signature (|) @OurWorldInData https://t.co/LOBiaiBapD [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1477433315896430592
ReconfigBehSci. (2021, December 13). RT @DrEricDing: 11) Omicron is doubling every 1.6 days in UK 🇬🇧 according to @DrWilliamKu’s figure. That’s way faster growth than in South… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1470451594378502154
Prof. Christina Pagel. (2021, December 23). UKHSA surveillance report shows reinfections rising sharply as Omicron takes hold https://t.co/UGArY4sbOA [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1474041921249189896
Thomas, T., & Duncan, P. (2021, December 23). If Omicron is the dominant variant in UK, why is the number of confirmed cases so low? The Guardian. https://www.theguardian.com/world/2021/dec/23/if-omicron-is-the-dominant-variant-in-uk-why-is-the-number-of-confirmed-cases-so-low
ReconfigBehSci. (2021, December 13). Important update on the now withdrawn @BallouxFrancois tweet identifying hopeful turning of the corner in SA omicron data [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1470311016114364420
ReconfigBehSci. (2021, December 11). RT @DrEricDing: DOUBLING % in one day: The spike of probable #Omicron variant in Scotland🏴 has critically surged—Now at 13.3%, up fro… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1469596523222781954
ReconfigBehSci. (2021, December 8). RT @kallmemeg: NEW: @UKHSA Mini Omicron Update Omicron VOC-21NOV-01 (B.1.1.529) update on cases, S gene target failure and risk assessment… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1468673329494216726
John Burn-Murdoch. (2021, November 25). Five quick tweets on the new variant B.1.1.529 Caveat first: Data here is very preliminary, so everything could change. Nonetheless, better safe than sorry. 1) Based on the data we have, this variant is out-competing others far faster than Beta and even Delta did 🚩🚩 https://t.co/R2Ac4e4N6s [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1463956686075580421
CNN, I. K. (n.d.). Vaccine inequity and hesitancy made the Omicron variant more likely, scientists say. CNN. Retrieved December 23, 2021, from https://www.cnn.com/2021/11/28/world/omicron-coronavirus-variant-vaccine-inequity-intl-cmd/index.html
ReconfigBehSci. (2021, December 22). RT @chrischirp: Positivity rising steeply too—There are definitely many more people we aren’t catching https://t.co/4xDPwYQtrx [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1473695678610214927
ReconfigBehSci on Twitter: “RT @chrischirp: As well as Tom’s new one (B.1.1.529), C.1.2 seems to be spreading in S Africa—C.1.2 was the one with lots of worrying mut…” / Twitter. (n.d.). Retrieved December 23, 2021, from https://twitter.com/SciBeh/status/1463597407082532864
ReconfigBehSci. (2021, December 16). RT @MadsAlbertsen85: #Omicron update from Denmark. Omicron cases on the 12th of December adjusted up to 20.5% (+2%). Omicron is now having… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1471516083819462670
ReconfigBehSci. (2021, December 11). RT @thehowie: BREAKING: Hospitalizations South Africa Hospitalizations⬆️67% week over week. Gauteng Province⬆️66%. GP⬆️1.6% from yesterd… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1469685234149072897
ReconfigBehSci. (2021, December 9). a rather worrying development- a (local) newspaper “fact checking” the new German health minister simply by interviewing a virologist who happens to have a different view. There’s simply no established “fact” as to the severity of omicron in children at this point in time [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1469037817481334786
Trevor Bedford. (2021, December 11). We find that logistic growth of Omicron sequence fraction looks similar between the UK, the US and Germany with roughly 1% of sequenced cases in all three countries being Omicron on Dec 1. 3/10 https://t.co/De0t2xreU9 [Tweet]. @trvrb. https://twitter.com/trvrb/status/1469784757261127685
Gollub, R. L. (2022). Brain changes after COVID revealed by imaging. Nature. https://doi.org/10.1038/d41586-022-00503-x
ReconfigBehSci. (2021, December 17). RT @EricTopol: No evidence that Omicron is less severe, new @imperialcollege study reports https://ft.com/content/020534b3-5a54-4517-9fd1-167a5db50786 https://t.co/5YYzJ6tVtc [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1472156681098469380
ReconfigBehSci. (2021, November 26). RT @HZiauddeen: 🧵 COVID-19 & B.1.1.529: A chance for govt & others to change their mind and their approach? While we are still gathering d… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1464200877888184324
ReconfigBehSci. (2021, December 22). RT @chrishendel: We need increased targeted measures now to slow the spread of #Omicron by @DrSarahHal via @bmj_latest https://t.co/3Tx… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1473987200509521925
Perspective | Even the best-case scenario with omicron will still be bad. (n.d.). Washington Post. Retrieved December 23, 2021, from https://www.washingtonpost.com/outlook/2021/12/21/omicron-mild-cases-numbers/
Covid: Dutch go into Christmas lockdown over Omicron wave. (2021, December 18). BBC News. https://www.bbc.com/news/world-europe-59713503
Nature Portfolio. (2021, October 15). A study in @NatureMedicine indicates that the effectiveness of the Pfizer/BioNTech and Oxford-AstraZeneca vaccines against SARS-CoV-2 infections with symptoms or high viral burden is reduced with the Delta variant compared to the Alpha variant. Https://go.nature.com/3vecpoj https://t.co/XQdnMYguFz [Tweet]. @NaturePortfolio. https://twitter.com/NaturePortfolio/status/1449145321188216836
Prof. Shane Crotty. (2021, October 19). 1/ The regular vaccines give great booster responses against Delta and other variants This was first shown by Moderna, with “original recipe” vaccine booster, compare to Beta booster. Https://nature.com/articles/s41591-021-01527-y https://t.co/g7YDwGIURP [Tweet]. @profshanecrotty. https://twitter.com/profshanecrotty/status/1450489709050744833
ReconfigBehSci [@SciBeh]. (2021, November 26). RT @mvankerkhove: I thank researchers from 🇿🇦 and 🇧🇼 for sharing information with @WHO & the world about B.1.1.529 variant that has been re… [Tweet]. Twitter. https://twitter.com/SciBeh/status/1464196599773642779
ReconfigBehSci. (2021, December 20). RT @thehowie: South Africa Deaths (7 day average) are near double levels of a few weeks ago. They will go up further. They are only 7.5%… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1472991477672419334
Yale researchers develop RNA-based therapy that clears SARS-CoV-2 from mice. (n.d.). EurekAlert! Retrieved January 9, 2022, from https://www.eurekalert.org/news-releases/934454
whole-genome sequencing (WGS) provides the highest possible subtyping resolution improving the surveillance, outbreak investigation, source attribution, and microbial population studies
DICER1 syndrome is an autosomal-dominant, pleiotropic, tumor-predisposition disorder arising from pathogenic germline variants in DICER1, which encodes an endoribonuclease integral to processing microRNAs (1).
Gene Name: DICER1 PMCID: PMC5443331 PMID: 28323992 HGNCID: not found Inheritance Pattern: autosomal dominant Disease Entity: thyroid cancer and familial multinodular doiter Mutation: germline loss-of-function mutation Zygosity: not provided Variant: c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.3726C>A; p.Tyr1242a, c.3675C>G; p.Tyr1225a, c.3675C>G; p.Tyr1225a Family Information: 145 individuals with a DICER1 germline mutation and 135 controls from 48 families Case: family members used; both males and females used and no significant differences seen among sex; ages range from 20-40 with carriers being significantly younger than controls; no significant differences seen among ethnicity but participants located from the US, UK, and Great Britain CasePresentingHPOs: thyroid cancer or MNG diagnosis common to those with a DICER! mutation but with no chemotherapy or radiation treatment yet CasePreviousTesting: tested levels of thyroid-stimulating hormone, thyroxine, thyroxine-binding globulin, and serum albumin; thyroid palpation; thyroid ultrasound; Sanger or next-generation sequencing assays gnomAD: n/a Mutation Type: missense
Pathogenic germline variants in DICER1 underlie an autosomal dominant, pleiotropic tumor-predisposition disorder.
gene name: DICER 1 PMID (PubMed ID): 33570641 HGNCID: n/a Inheritance Pattern: autosomal dominant Disease Entity: benign and malignant tumor mutation Mutation: somatic Zygosity: heterozygous Variant: n/a Family Information: n/a Case: people of all sexes, ages, ethnicities and races participated CasePresentingHPOs: individuals with DICER1-associated tumors or pathogenic germline DICER1 variants were recruited to participate CasePreviousTesting: n/a gnomAD: n/a
Embryonal rhabdomyosarcoma (ERMS) of the uterus has recently been shown to frequently harbor DICER1 mutations.
HGNCID:
Covid-19: Efficacité vaccinale. (2021, October 11). EPI-PHARE. https://www.epi-phare.fr/rapports-detudes-et-publications/impact-vaccination-covid-octobre-2021/
Times, T. N. Y. (2020, March 3). Coronavirus in the U.S.: Latest Map and Case Count. The New York Times. https://www.nytimes.com/interactive/2021/us/covid-cases.html
Schlosser, F. (2021, November 29). Omicron—Import Risk. Covid-19 Mobility Project. https://www.covid-19-mobility.org/reports/importrisk_omicron/
Kai Kupferschmidt. (2021, December 1). @DirkBrockmann But these kinds of models do help put into context what it means when certain countries do or do not find the the variant. You can find a full explanation and a break-down of import risk in Europe by airport (and the people who did the work) here: Https://covid-19-mobility.org/reports/importrisk_omicron/ https://t.co/JXsYdmTnNP [Tweet]. @kakape. https://twitter.com/kakape/status/1466109304423993348
Kai Kupferschmidt. (2021, December 1). @DirkBrockmann That percentage number tells you “how likely an infected passenger from South Africa or Botswana travels to each country and exits the airport there”. So: “0.9% in Germany means that out of 1000 such individuals, 9 are expected to have Germany as their final destination.” [Tweet]. @kakape. https://twitter.com/kakape/status/1466107478807097354
🇺🇦 Meaghan Kall. (2022, January 27). NEW: 🏴 Vaccine effectiveness (symptomatic infection) data for BA.2 {Omicron’s more infectious sister} NO difference in VE between Omicron (BA.1) and BA.2 Possibly even higher VE for BA.2 but estimates overlap See full thread 🧵 from @freja_kirsebom https://t.co/bJ7uCn2cGV [Tweet]. @kallmemeg. https://twitter.com/kallmemeg/status/1486821549458001927
Tom Wenseleers. (2022, January 23). @HarrySpoelstra @trvrb @CorneliusRoemer @JosetteSchoenma BA.2 has a growth rate advantage over BA.1 of ca 0.11/day. That’s quite sizeable. If it would have the same short generation time as BA.1 of 2.2 days it would imply a ca.1.3x higher transmissibility, due to higher contagiousness or immune escape. Https://t.co/X8TcWJ4pXQ [Tweet]. @TWenseleers. https://twitter.com/TWenseleers/status/1485375883066101763
Shalin Naik [@shalinhnaik]. (2021, October 14). 📢The first episode of the @thejabgab http://thejabgab.com is LIVE!! 🎙 Join me and the fabulous comedians @nazeem_hussain and @calbo as they chat about the Delta variant, vaccines …. And cows? With experts @DrKGregorevic and @BedouiSammy! Search your fav platform or... Https://t.co/bo4HiRfqF6 [Tweet]. Twitter. https://twitter.com/shalinhnaik/status/1448510610837159939
Shalin Naik. (2021, October 14). 📢The first episode of the @thejabgab http://thejabgab.com is LIVE!! 🎙 Join me and the fabulous comedians @nazeem_hussain and @calbo as they chat about the Delta variant, vaccines …. And cows? With experts @DrKGregorevic and @BedouiSammy! Search your fav platform or... Https://t.co/bo4HiRfqF6 [Tweet]. @shalinhnaik. https://twitter.com/shalinhnaik/status/1448510610837159939
ReconfigBehSci [@SciBeh]. (2021, November 1). RT @HJWesteneng: Growth advantage and extrapolation of AY.4.2 based on Sanger Institute data in the UK (multilevel multinomial model). Base… [Tweet]. Twitter. https://twitter.com/SciBeh/status/1455467011509731332
Dr Dominic Pimenta [@DrDomPimenta]. (2021, December 15). An illustration of communicating risk with “less severe” variants: [Thread] Assume Omicron is 4x more transmissible than Delta. [1] Assume Omicron leads to 1/3 less admissions than Delta. [Figure below] Assume 1 in 100 cases of Delta are admitted to hospital. Https://t.co/XtnVwoOrUo [Tweet]. Twitter. https://twitter.com/DrDomPimenta/status/1471094002808242177
The DICER1 syndrome is an autosomal dominant tumor‐predisposi-tion disorder associated with pleuropulmonary blastoma, a rare pediatric lung cancer
GeneName:DICER1 PMID (PubMed ID): PMCID: PMC6418698 PMID: 30672147 HGNCID: NOT LISTED<br /> Inheritance Pattern: Autosomal Dominant Disease Entity: Cancer; benign and malignant tumors including pleuropulmonary blastoma, cystic nephroma, Sertoli-Leydig cell tumors, multinodular goiter, Thryoid cancer, rhabdomyosarcoma, and pineoblastoma. Mutation: Somatic missense variation Mutation type: missense Zygosity: None stated Variant: unregistered…. Family Information: Characterize germline variants in familial early-onset clorectal cancer patients; The observation of germline DICER1 variation with uterine corpus endometrial carcinoma merits additional investigation. CasePresentingHPOs: uterine and rectal cancers in germline mutation
DICER1 syndrome is a rare genetic disorder that predisposes individuals to multiple cancer types.
GeneName = DICER1 PMID = 29762508 HGNCID = Can't find Inheritance pattern = Autosomal dominant Disease entity = cancer, multinodular goiter, pleuropulmonary blastoma, cystic nephroma, ovarian Sertoli-Leydig cell tumor Mutation = germline OR somatic Zygosity = causes loss of heterozygosity Variant = unregistered Family = those with the mutation almost always passed it on
ReconfigBehSci [@SciBeh]. (2021, November 26). RT @timcolbourn: @kallmemeg so no cases of B.1.1.529 cases in UK as of Mon 22nd Nov? Do you know when the S-gene drop out PCR results for… [Tweet]. Twitter. https://twitter.com/SciBeh/status/1464320681315905542
Pfizer and BioNTech Provide Update on Omicron Variant | Pfizer. (n.d.). Retrieved April 22, 2022, from https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-provide-update-omicron-variant
ReconfigBehSci [@SciBeh]. ‘RT @vikkypaedia: B.1.1.529 Seems to Have Gone from 0.1% to 50% in Just a Couple of Weeks, When It Took Delta Several Months to Achieve That…’. Tweet. Twitter, 26 November 2021. https://twitter.com/SciBeh/status/1464194450406752282.
ReconfigBehSci [@SciBeh]. ‘RT @Tuliodna: Busy Day on B.1.1.529 - a Variant of Great Concern - The World Should Provide Support to South Africa and Africa and Not Dis…’. Tweet. Twitter, 25 November 2021. https://twitter.com/SciBeh/status/1464130377178619904.
ReconfigBehSci [@SciBeh]. (2021, November 26). RT @macroliter: 👋Hi Journalists! Are you interested in covering the new B.1.1.529 #B11529 variant🦠? Here’s a link to a TABLE with the name… [Tweet]. Twitter. https://twitter.com/SciBeh/status/1464195246175272984
ReconfigBehSci [@SciBeh]. ‘RT @AdamJKucharski: Not a Thread, but Key Point: 6/6 Https://T.Co/LpCs46qSk6’. Tweet. Twitter, 25 November 2021. https://twitter.com/SciBeh/status/1464133953493815296.
The Guardian. ‘We Can Prevail over Omicron. We Just Need to Use the Tools We Have’, 1 December 2021, sec. Opinion. https://www.theguardian.com/commentisfree/2021/dec/01/we-can-prevail-over-omicron-use-tools-we-have.
Pérez-Then, E., Lucas, C., Monteiro, V. S., Miric, M., Brache, V., Cochon, L., Vogels, C. B. F., Cruz, E. D. la, Jorge, A., Santos, M. D. los, Leon, P., Breban, M. I., Billig, K., Yildirim, I., Pearson, C., Downing, R., Gagnon, E., Muyombwe, A., Razeq, J., … Iwasaki, A. (2021). Immunogenicity of heterologous BNT162b2 booster in fully vaccinated individuals with CoronaVac against SARS-CoV-2 variants Delta and Omicron: The Dominican Republic Experience (p. 2021.12.27.21268459). medRxiv. https://doi.org/10.1101/2021.12.27.21268459
Nathan Grubaugh [@NathanGrubaugh]. (2021, September 24). Hi @Newsweek 👋. I understand that #variant news has been slow recently with the near-complete dominance of Delta, but do you really need to go and make things up? Lineage R.1 is not a concern. Let me briefly explain why. (1/4) https://t.co/OD46PsXZEu [Tweet]. Twitter. https://twitter.com/NathanGrubaugh/status/1441522760832933888
Levine-Tiefenbrun, M., Yelin, I., Alapi, H., Katz, R., Herzel, E., Kuint, J., Chodick, G., Gazit, S., Patalon, T., & Kishony, R. (2021). Viral loads of Delta-variant SARS-CoV-2 breakthrough infections after vaccination and booster with BNT162b2. Nature Medicine, 1–3. https://doi.org/10.1038/s41591-021-01575-4
Morris, J. (2021, August 17). Israeli data: How can efficacy vs. severe disease be strong when 60% of hospitalized are vaccinated? Covid Data Science. https://www.covid-datascience.com/post/israeli-data-how-can-efficacy-vs-severe-disease-be-strong-when-60-of-hospitalized-are-vaccinated
Scott, national medical reporter S., & Thorne, the S. R. T. L. (2021, July 5). The Delta COVID variant is spreading overseas. Here’s why experts say it’s “absolutely essential” to protect children. ABC News. https://www.abc.net.au/news/2021-07-06/children-need-covid-protection-vaccines-experts-say/100269228
Sanderson, K. (2021). COVID vaccines protect against Delta, but their effectiveness wanes. Nature. https://doi.org/10.1038/d41586-021-02261-8
Carl T. Bergstrom. (2021, August 18). 1. There has been lots of talk about recent data from Israel that seem to suggest a decline in vaccine efficacy against severe disease due to Delta, waning protection, or both. This may have even been a motivation for Biden’s announcement that the US would be adopting boosters. [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1427767356600688646
Tao, K., Tzou, P. L., Nouhin, J., Gupta, R. K., de Oliveira, T., Kosakovsky Pond, S. L., Fera, D., & Shafer, R. W. (2021). The biological and clinical significance of emerging SARS-CoV-2 variants. Nature Reviews Genetics, 1–17. https://doi.org/10.1038/s41576-021-00408-x
Eric Topol. (2021, June 9). Despite increasing incentives, the US vaccination campaign is really struggling. Notably, the top 5 states are approaching 60% total population fully vaccinated which should provide strong protection vs the delta variant. A different story for the bottom 5 states @OurWorldInData https://t.co/boqk3Khhuc [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1402413221667954690
Adam Kucharski. (2021, March 11). New summary report on SARS-CoV-2 variants of concern and variants of interest in the UK: https://t.co/hJFljrN22E via @fact_covid https://t.co/43EYkfYzJO [Tweet]. @AdamJKucharski. https://twitter.com/AdamJKucharski/status/1370036245557051401
Carlos del Rio. (2021, April 7). U.K. variant now dominant form of COVID in US @CDCDirector As predicted B.1.1.7 is now the predominant SARS-CoV-2 strain in the US. Let’s remember it is much more transmissible and likely also more severe. Vaccines do cover it. @ajc https://t.co/Wc4oaYkxqR [Tweet]. @CarlosdelRio7. https://twitter.com/CarlosdelRio7/status/1379816377356333057
Hilda Bastian, PhD. (2021, February 6). Unofficial unnamed AstraZeneca insider says they are doing the interim analysis for the US trial of the Oxford vaccine. AstraZeneca spokesperson says 4-6 weeks till data release. Https://t.co/VUHgbHN02d One is wrong? Or they’ll release only when have FDA minimum follow-up? Https://t.co/LgjfX8AIti [Tweet]. @hildabast. https://twitter.com/hildabast/status/1357862227106095105
Alessandro Vespignani. (2021, April 14). “Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil”—P.1 may be 1.7–2.4-fold more transmissible—Previous (non-P.1) infection provides 54–79% of the protection against infection with P.1 that it provides against non-P.1 lineages https://t.co/aUpL4YOFYo https://t.co/YniaLb9YiF [Tweet]. @alexvespi. https://twitter.com/alexvespi/status/1382370044374511621
Joshua Weitz. (2021, April 7). The same approaches that work against SARS-CoV-2 work against variants like B.1.1.7: Mask Avoid indoor gatherings Socialize outdoors And, reinforces the need to continue to scale-up vaccine administration to all 16+. [Tweet]. @joshuasweitz. https://twitter.com/joshuasweitz/status/1379820197696180233
nature. (2021, April 16). Coronavirus variants: Where do they come from? How do we spot them? What do they mean for COVID vaccines, and future of the pandemic? Https://t.co/NRbORu2hoF [Tweet]. @Nature. https://twitter.com/Nature/status/1383093697374474240
Prof. Christina Pagel. (2021, December 29). Omicron was dominant everywhere in England by Christmas https://t.co/x58pJi7VcD [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1476161382852796419
Pan-Hammarström lab. (2022, January 7). Our new study: Heterogeneous vaccination strategy with inactivated vaccine + mRNA booster elicits strong B and T cell response against the WT and VOC including Omicron @VirusesImmunity https://t.co/aBiN9anMBL [Tweet]. @panhammarstrom. https://twitter.com/panhammarstrom/status/1479449892410044419
(20) Prof. Christina Pagel on Twitter: “THREAD (a bit delayed) on UK & covid: TLDR: flattish cases overall are masking differences between nations, regions & age groups. And we’re still out of whack with Europe. 1/20” / Twitter. (n.d.). Retrieved October 4, 2021, from https://twitter.com/chrischirp/status/1443261013911085056
Anthony J Leonardi, PhD, MS. (2022, January 23). Calling all GBD fans, your continued reinfection loyalty card. Nice one, @PeteUK7 https://t.co/AEMpdI5sr9 [Tweet]. @fitterhappierAJ. https://twitter.com/fitterhappierAJ/status/1485260239557509128
ReconfigBehSci. (2021, March 8). RT @rozeggo: New study on mortality of B.1.1.7 using health records from England. We found the variant of concern (VOC) was 1.67x more like… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1369567353722310657
ReconfigBehSci. (2021, May 7). RT @kallmemeg: The @PHE_uk Variant Technical Briefing 10 now published Confirms B.1.617.2 upgraded to a VOC due to transmissibility conce… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1391209724285050883
ReconfigBehSci. (2021, February 9). RT @ChristoPhraser: Our paper on evaluating the first three months of the NHS COVID-19 app is out now as a pre-print. A 🧵 1/n https://t.co/… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1359132102927798275
ReconfigBehSci on Twitter: ‘RT @AJWhisky: Missed this yesterday, but excellent once again from John. Largely reassuring on B.1.617.2 as things stand https://t.co/GtgJ…’ / Twitter. (n.d.). Retrieved 21 May 2021, from https://twitter.com/SciBeh/status/1391201750758031362
Prof. Christina Pagel. (2021, May 3). THREAD: Update on B.1.617 (‘India’) variant in England using latest data from the Sanger institute. This data excludes sequenced cases from travellers & surge testing so ‘should be an approximately random sample of positive tests in the community’ TLDR: warning signs! 1/10 https://t.co/0UzhM8GNIA [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1389273187586875396
ReconfigBehSci on Twitter: ‘RT @dgurdasani1: The bigger picture is sadly that we’re seeing rapid spread of B.1.617.2 among school age children in many parts of England…’ / Twitter. (n.d.). Retrieved 16 August 2021, from https://twitter.com/SciBeh/status/1396887312059944962
(1) ReconfigBehSci on Twitter: ‘RT @ScottGottliebMD: The U.K. is experiencing a growing surge of COVID infections with a new variant that appears more pathogenic, and that…’ / Twitter. (n.d.). Retrieved 21 June 2021, from https://twitter.com/SciBeh/status/1402048528189300737
BU Epi COVID Response Corps. (2021, February 17). We’ve seen so many vaccine questions, we did two videos! Here’s part 1 of our vaccine FAQ: https://t.co/gYASlhiwmm [Tweet]. @EpiCOVIDCorps. https://twitter.com/EpiCOVIDCorps/status/1362099096102854657
Denise Dewald, MD 🗽. (2021, August 12). Here are some modeling predictions for the delta variant from COVSIM (group at North Carolina State): PLEASE CHECK THIS OUT - RESOURCES TO SHARE WITH YOUR SCHOOL DISTRICT School-level COVID-19 Modeling Results for North Carolina for #DeltaVariant https://t.co/zU5hB9bKlY [Tweet]. @denise_dewald. https://twitter.com/denise_dewald/status/1425626289399009288
Prof. Shane Crotty. (2021, October 15). And here https://t.co/aDPrQ17AUD [Tweet]. @profshanecrotty. https://twitter.com/profshanecrotty/status/1449030846711681025
Prof. Christina Pagel. (2021, May 23). LONG THREAD on B.1.617.2 & latest PHE data covering: 1) latest tech report on B.1.617.2 (aka ‘India’ variant) 2) vaccine efficacy against B.1.617.2 3) consequences for roadmap 4) avoidability... Or not. [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1396574267349872644
Marc Lipsitch. (2021, July 20). At the risk of boiling down too much and certainly losing some detail, one way to summarize this wonderful thread is that when we think about vaccine effectiveness, we should think of 4 key variables: 1 which vaccine, 2 age of the person, 3 how long after vax, 4 vs what outcome. [Tweet]. @mlipsitch. https://twitter.com/mlipsitch/status/1417595538632060931
Prof. Christina Pagel 🇺🇦. (2021, November 25). THREAD on the new variant B.1.1.529 summarising what is known from the excellent South African Ministry of Health meeting earlier today TLDR: So much uncertain but what is known is extremely worrying & (in my opinion) we should revise red list immediately. This is why: 1/16 [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1463885539619311616
BNO/Medriva Newsroom [@medriva]. (2021, November 26). South Africa’s health minister says, based on a small sample of Omicron cases, the majority of hospital patients are unvaccinated: ‘It indicates that the vaccines are providing protection’ [Tweet]. Twitter. https://twitter.com/medriva/status/1464327805836083201
3 big questions about the Biden administration’s COVID response in 2022. (2021, December 30). PBS NewsHour. https://www.pbs.org/newshour/health/3-big-questions-about-the-biden-administrations-covid-response-in-2022
Abu-Raddad, L. J., Chemaitelly, H., Ayoub, H. H., AlMukdad, S., Tang, P., Hasan, M. R., Coyle, P., Yassine, H. M., Al-Khatib, H. A., Smatti, M. K., Al-Kanaani, Z., Al-Kuwari, E., Jeremijenko, A., Kaleeckal, A. H., Latif, A. N., Shaik, R. M., Abdul-Rahim, H. F., Nasrallah, G. K., Al-Kuwari, M. G., … Bertollini, R. (2022). Effectiveness of BNT162b2 and mRNA-1273 COVID-19 boosters against SARS-CoV-2 Omicron (B.1.1.529) infection in Qatar (p. 2022.01.18.22269452). medRxiv. https://doi.org/10.1101/2022.01.18.22269452
Prof. Shane Crotty. (2021, December 8). 3 studies today on antibodies & Omicron. 🔵 There may be a large drop in neutralization of Omicron 🔵 Antibodies stop Omicron well in hybrid immunity (infected+vax) 🔵 Sotrovimab is active versus Omicron Take home: Get vaccinated. Get boosted. Immune system is clever. 🧵 1/n [Tweet]. @profshanecrotty. https://twitter.com/profshanecrotty/status/1468390479280574472
Sample, I., & Walker, P. (2021, December 7). Scientists find ‘stealth’ version of Omicron that may be harder to track. The Guardian. https://www.theguardian.com/world/2021/dec/07/scientists-find-stealth-version-of-omicron-not-identifiable-with-pcr-test-covid-variant
Coronavirus (COVID-19) Infection Survey, UK: 29 October 2021, Office for National Statistics
Callaway, E. (2021). Heavily mutated Omicron variant puts scientists on alert. Nature, 600(7887), 21–21. https://doi.org/10.1038/d41586-021-03552-w
Trevor Bedford on Twitter. (n.d.). Twitter. Retrieved 1 April 2022, from https://twitter.com/trvrb/status/1447566558973231104
ReconfigBehSci. (2022, February 27). RT @theosanderson: BA.1 and BA.2 prevalence by region from ONS Community Infection survey https://t.co/BkBFpP9O48 [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1498205787948294145
Mia Malan. (2021, November 25). [Thread] What is the potential impact of the new B.1.1.529 #COVID19 variant? @rjlessells: 1. It’s relatively simple to detect some B.1.1.529 cases, as it’s possible to use PCR tests to do this in some cases 2. B.1.1.529 = has many mutations across different parts of the virus https://t.co/ytktqLzJUi [Tweet]. @miamalan. https://twitter.com/miamalan/status/1463846528578109444
Coronavirus variant fear sparks Africa travel curbs. (2021, November 26). BBC News. https://www.bbc.com/news/uk-59424269
ReconfigBehSci. (2022, January 1). RT @wanderer_jasnah: Quick glance at B.1.640.2 before anyone asks me about it: It’s basically B.1.1.7 w/a large Spike NTD deletion. I see… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1478289563776962563
ReconfigBehSci on Twitter: ‘it seems just yesterday that Twitter was ablaze with “nobody has died of omicron”’ / Twitter. (n.d.). Retrieved 29 March 2022, from https://twitter.com/SciBeh/status/1478483795863089154
ReconfigBehSci. (2022, January 5). RT @thehowie: "...Rapid antigen tests may not be as fit-for-purpose in routine workplace screening to prevent asymptomatic spread of Omicro… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1478796550004486151
Israel said delaying rollout of 4th COVID shots amid signs Omicron less severe | The Times of Israel. (n.d.). Retrieved 29 March 2022, from https://www.timesofisrael.com/israel-said-to-delay-rollout-of-4th-covid-shots-amid-signs-omicron-less-severe/amp/
Jens von Bergmann. (2021, December 14). Every time a new variant with a selective advantage is making the rounds, but especially this time. Https://t.co/fDEq54nHCl [Tweet]. @vb_jens. https://twitter.com/vb_jens/status/1470604121640030214
ReconfigBehSci. (2021, December 5). RT @AnnaAlbecka: I guess Omicron is not going anywhere with already >5% of sequences in Belgium and Netherlands #Omicron https://t.co/b2Xs7… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1467821013941510145
name. (n.d.). På trods af historisk høje smittetal følger indlæggelserne ikke med. Retrieved 28 March 2022, from https://www.ssi.dk/aktuelt/nyheder/2022/paa-trods-af-hoeje-smittetal-foelger-indlaeggelserne-ikke-med
Myths about COVID-19 vaccination. (n.d.). HackMD. Retrieved March 23, 2022, from https://hackmd.io/@scibehC19vax/misinfo_myths
Altmann, D. M., & Boyton, R. J. (2022). COVID-19 vaccination: The road ahead. Science, 375(6585), 1127–1132. https://doi.org/10.1126/science.abn1755
ReconfigBehSci on Twitter: ‘RT @amymaxmen: Link to the meeting: Https://t.co/3UH1R8fblN’ / Twitter. (n.d.). Retrieved 22 March 2022, from https://twitter.com/SciBeh/status/1486268859741052930
Corbevax: All About India’s First Protein Sub-Unit Covid Vaccine to be Given to 12-14 Age Group From Today. (2022, March 16). News18. https://www.news18.com/news/india/corbevax-all-about-indias-first-protein-sub-unit-covid-vaccine-to-be-given-to-12-14-age-group-from-today-4874345.html
Bacharach, J., Schreiber, M., Schreiber, M., Schreiber, M., Schreiber, M., Adler-Bell, S., Adler-Bell, S., Beacock, I., Beacock, I., Rosenfeld, S., Rosenfeld, S., Subramanian, S., & Subramanian, S. (2022, March 15). Why Is David Leonhardt So Happy? The New Republic. https://newrepublic.com/article/165729/david-leonhardt-happy-review-new-york-times-morning-newsletter
Mar 03, M. V. B. | N. W. | C. N. | & 2022. (n.d.). Third vaccine dose boosts Omicron protection, with some waning. CIDRAP. Retrieved 7 March 2022, from https://www.cidrap.umn.edu/news-perspective/2022/03/third-vaccine-dose-boosts-omicron-protection-some-waning
BA.2 sub-lineage has even higher propensity to spread among people and has the ability to infect people who have been fully vaccinated and/or previously infected by escaping from neutralising antibodies induced by vaccination or infection.
Marc Stegger. (2022, February 22). New preprint on #COVID19 is out: “Occurrence and significance of Omicron BA.1 infection followed by BA.2 reinfection”. Using the national surveillance system in Denmark, we show that reinfections with #SARSCoV2 VOC #Omicron BA.2 can occur after recent BA.1 infection #SSI_dk https://t.co/Cm0n8vga4P [Tweet]. @MarcStegger. https://twitter.com/MarcStegger/status/1496099303143653379
Kok, K.-H., Wong, S.-C., Chan, W.-M., Lei, W., Chu, A. W.-H., Ip, J. D., Lee, L.-K., Wong, I. T.-F., Lo, H. W.-H., Cheng, V. C.-C., Ho, A. Y.-M., Lam, B. H.-S., Tse, H., Lung, D., Ng, K. H.-L., Au, A. K.-W., Siu, G. K.-H., & Yuen, K.-Y. (2022). Cocirculation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong. Emerging Microbes & Infections, 1–39. https://doi.org/10.1080/22221751.2022.2040922
Stegger, M., Edslev, S. M., Sieber, R. N., Ingham, A. C., Ng, K. L., Tang, M.-H. E., Alexandersen, S., Fonager, J., Legarth, R., Utko, M., Wilkowski, B., Gunalan, V., Bennedbæk, M., Byberg-Grauholm, J., Møller, C. H., Christiansen, L. E., Svarrer, C. W., Ellegaard, K., Baig, S., … Rasmussen, M. (2022). Occurrence and significance of Omicron BA.1 infection followed by BA.2 reinfection (p. 2022.02.19.22271112). medRxiv. https://doi.org/10.1101/2022.02.19.22271112
Tseng, H. F., Ackerson, B. K., Luo, Y., Sy, L. S., Talarico, C. A., Tian, Y., Bruxvoort, K. J., Tubert, J. E., Florea, A., Ku, J. H., Lee, G. S., Choi, S. K., Takhar, H. S., Aragones, M., & Qian, L. (2022). Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants. Nature Medicine, 1–1. https://doi.org/10.1038/s41591-022-01753-y
Cornelius Roemer. (2022, February 12). Fantastic work by @UKHSA comparing serial intervals of BA.1, BA.2 and Delta as published in the most recent technical briefing. BA.2 seems to have even shorter serial interval than BA.1 This could help explain different relative growth rates of BA.2 vs BA.1 in different countries https://t.co/Gch94Ew8CX [Tweet]. @CorneliusRoemer. https://twitter.com/CorneliusRoemer/status/1492434232664375304
Altarawneh, H. N., Chemaitelly, H., Hasan, M. R., Ayoub, H. H., Qassim, S., AlMukdad, S., Coyle, P., Yassine, H. M., Al-Khatib, H. A., Benslimane, F. M., Al-Kanaani, Z., Al-Kuwari, E., Jeremijenko, A., Kaleeckal, A. H., Latif, A. N., Shaik, R. M., Abdul-Rahim, H. F., Nasrallah, G. K., Al-Kuwari, M. G., … Abu-Raddad, L. J. (2022). Protection against the Omicron Variant from Previous SARS-CoV-2 Infection. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMc2200133
Dr. Peter Hotez: Omicron is like a fast-moving freight train. (n.d.). MSN. Retrieved February 20, 2022, from https://www.msn.com/en-us/news/us/dr-peter-hotez-omicron-is-like-a-fast-moving-freight-train/vi-AARPfVG
Mckeever, A. (n.d.). COVID-19 variants will keep coming until everyone can access vaccines. Retrieved February 20, 2022, from https://www.nationalgeographic.com/science/article/covid-19-variants-will-keep-coming-until-everyone-can-access-vaccines
Eric Feigl-Ding. (2022, January 13). WATCH📺—Despite 97.5% of all adults in England🏴 with antibodies to #COVID19 (via vax/infection)–hospitalizations still surging. Why? Because variants like #Omicron are adapting. Need multivalent vax, plus ➡️N95 & ventilation are agnostic to variants—Key! Https://t.co/gDNRJIWojX [Tweet]. @DrEricDing. https://twitter.com/DrEricDing/status/1481732793482813443
Ali Ellebedy. (2021, December 30). We need those who are adept at #SciComm to explain that “Omicron” is sufficiently different from the original strain that was used to make the vaccine. Therefore, the definition of “fully vaccinated” will have to be updated, but that does not mean that the vaccines have failed. [Tweet]. @TheBcellArtist. https://twitter.com/TheBcellArtist/status/1476649138691444740
Living with COVID-19: How the virus could turn into the common cold, or something far worse. (2022, January 9). The Mercury News. https://www.mercurynews.com/2022/01/09/living-with-covid-19-how-the-virus-could-turn-into-the-common-cold-or-something-far-worse
Academics: Viral Evolution Scenarios, 10 February 2022. (n.d.). GOV.UK. Retrieved February 14, 2022, from https://www.gov.uk/government/publications/academics-viral-evolution-scenarios-10-february-2022
Fionna O’Leary, 🕯🇪🇺. (2022, January 18). All that herd immunity …. Covid 3 times. Balloux https://t.co/OfwRvgakK9 [Tweet]. @fascinatorfun. https://twitter.com/fascinatorfun/status/1483260151620644864
ReconfigBehSci on Twitter: ‘RT @HelenBranswell: The latest “Nowcast” from @CDCgov suggests Omicron has pretty much swept the table. Https://t.co/BAwPhsyPwW https://t.…’ / Twitter. (n.d.). Retrieved 13 February 2022, from https://twitter.com/SciBeh/status/1483495777376903175
ReconfigBehSci on Twitter: ‘surprising how the logic of argument around C19 has not updated to the fact that reinfection is a big thing, as are new variants. Delay = a round of infection you never got...’ / Twitter. (n.d.). Retrieved 13 February 2022, from https://twitter.com/SciBeh/status/1483716840316706824
Anthony J Leonardi, PhD, MS. (2022, January 22). Wow. This is concerning. H/t @ForesightWisdom it is learning to become more chronic. Https://t.co/XwFR4D0kiy [Tweet]. @fitterhappierAJ. https://twitter.com/fitterhappierAJ/status/1484996537889476610
World Health Organization (WHO) on Twitter. (n.d.). Twitter. Retrieved 13 February 2022, from https://twitter.com/WHO/status/1485554889900142599
Grubaugh, N. D., Hodcroft, E. B., Fauver, J. R., Phelan, A. L., & Cevik, M. (2021). Public health actions to control new SARS-CoV-2 variants. Cell, 184(5), 1127–1132. https://doi.org/10.1016/j.cell.2021.01.044
American Medical Association (AMA). (2021, December 6). Peter Hotez, MD, PhD, on the omicron variant and Delta winter surge | COVID-19 Update for Dec. 6, 20. https://www.youtube.com/watch?v=WnfpC1_N2Mg
Pak, C. (2022, February 8). Endemic Fatalism and Why It Won’t Resolve COVID-19. Medical Humanities. https://blogs.bmj.com/medical-humanities/?p=3280
Tulio de Oliveira. (2022, February 9). As expected, Omicron BA.2 takes over in South Africa, close to 100% of the new genomes. What does it mean? Https://t.co/SAb9mGYSjN [Tweet]. @Tuliodna. https://twitter.com/Tuliodna/status/1491483399265075202
Wong, S.-C., Au, A. K.-W., Chen, H., Yuen, L. L.-H., Li, X., Lung, D. C., Chu, A. W.-H., Ip, J. D., Chan, W.-M., Tsoi, H.-W., To, K. K.-W., Yuen, K.-Y., & Cheng, V. C.-C. (2022). Transmission of Omicron (B.1.1.529) - SARS-CoV-2 Variant of Concern in a designated quarantine hotel for travelers: A challenge of elimination strategy of COVID-19. The Lancet Regional Health – Western Pacific, 18. https://doi.org/10.1016/j.lanwpc.2021.100360
PaedsHaemDoc. (2022, January 9). Had the misfortune (via @fatemperor) to come across Dr Paul Alexander -apparently credentialed yet in single blog post demonstrates perfectly either a disconnect from rational thought or deliberate misinformation spreading of the #masspsychosis of the anti-Vax crew let’s examine https://t.co/Ctd49cb1qK [Tweet]. @dr_barrett. https://twitter.com/dr_barrett/status/1479986071832248322
Jorge A. Caballero, MD (jorgecaballero.eth). (2022, January 10). 🧵/ I just spoke with two journalists about data that shows how the U.S. healthcare system is collapsing before our eyes. The million dollar question during both interviews was, “What else could we be doing right now?” The answer: Flatten the hospitalization curve. Now. [Tweet]. @DataDrivenMD. https://twitter.com/DataDrivenMD/status/1480607009867132928
Yaneer Bar-Yam on Twitter. (n.d.). Twitter. Retrieved February 7, 2022, from https://twitter.com/yaneerbaryam/status/1474091037861761026
Ulrich Elling. (2022, January 12). While #Omicron BA.1 leads the race, the little sister BA.2 is catching up in numbers. They are rather different with likely functional implications. BA.2 might be more immune evasive in RBD, less in NTD. And due to reduced mutation load in NTD maybe different fusion properties? Https://t.co/kEACjzQDs3 [Tweet]. @EllingUlrich. https://twitter.com/EllingUlrich/status/1481214901997682692
Mike Honey 💉💉💉. (2022, January 27). Here’s the latest variant picture for Australia. BA.1 (Omicron) is still very dominant. The new sub-lineage BA.1.1 (with the Spike R346K mutation) is significant, but not growing rapidly. Https://t.co/LsOCkUQhai [Tweet]. @Mike_Honey_. https://twitter.com/Mike_Honey_/status/1486654152939765766
Barnes, O., & Alabi, L. O. (2022, January 27). UK coronavirus cases tick up 10%, symptom tracker app shows. Financial Times. https://www.ft.com/content/f9833324-7986-48c4-a96c-153049ed9b5a
Jonathan Li on Twitter: “There’s a lineage of Omicron that’s gained the R346K mutation (BA.1.1). This one could spell some trouble for the AZ mAb (tixagevimab/cilgavimab, Evusheld) that’s being used for pre-exposure prophylaxis. If you want to learn about tix/cil vs Omicron, read on 1/7” / Twitter. (n.d.). Retrieved February 6, 2022, from https://twitter.com/DrJLi/status/1487479972293853188