- Aug 2022
-
www.theguardian.com www.theguardian.com
-
Ball, P. (2022, February 26). Will we get a single, variant-proof vaccine for Covid? The Observer. https://www.theguardian.com/society/2022/feb/26/will-we-get-a-single-variant-proof-vaccine-for-covid
-
-
www.biorxiv.org www.biorxiv.org
-
Iketani, S., Liu, L., Guo, Y., Liu, L., Huang, Y., Wang, M., Luo, Y., Yu, J., Yin, M. T., Sobieszczyk, M. E., Huang, Y., Wang, H. H., Sheng, Z., & Ho, D. D. (2022). Antibody Evasion Properties of SARS-CoV-2 Omicron Sublineages (p. 2022.02.07.479306). bioRxiv. https://doi.org/10.1101/2022.02.07.479306
-
-
-
Varmus, H. (2021, August 31). Covid has revealed the need for genomic sequencing around the world. Financial Times. https://www.ft.com/content/342fd3c3-5a22-49a0-9cef-135f2ccd8700
-
-
plus.tagesspiegel.de plus.tagesspiegel.de
-
Karberg, S., & Friebe, R. (2022, January 18). Virologe Drosten im Interview: „Wie lange geht diese Quälerei noch weiter?“. https://plus.tagesspiegel.de/wissen/virologe-drosten-im-interview-wie-lange-geht-diese-qualerei-noch-weiter-361636.html
-
-
www.nature.com www.nature.com
-
Meng, B., Abdullahi, A., Ferreira, I. A. T. M., Goonawardane, N., Saito, A., Kimura, I., Yamasoba, D., Gerber, P. P., Fatihi, S., Rathore, S., Zepeda, S. K., Papa, G., Kemp, S. A., Ikeda, T., Toyoda, M., Tan, T. S., Kuramochi, J., Mitsunaga, S., Ueno, T., … Gupta, R. K. (2022). Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature, 1–1. https://doi.org/10.1038/s41586-022-04474-x
-
-
twitter.com twitter.com
-
ReconfigBehSci. (2021, December 12). RT @ryan_landay: > A new diverse genome has appeared within the B.1.1.529 lineage that has all of the shared mutations of B.1.1.529, some o… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1470066521615605766
-
-
twitter.com twitter.com
-
ReconfigBehSci on Twitter: “RT @chrischirp: As well as Tom’s new one (B.1.1.529), C.1.2 seems to be spreading in S Africa—C.1.2 was the one with lots of worrying mut…” / Twitter. (n.d.). Retrieved December 23, 2021, from https://twitter.com/SciBeh/status/1463597407082532864
-
-
www.washingtonpost.com www.washingtonpost.com
-
Perspective | Even the best-case scenario with omicron will still be bad. (n.d.). Washington Post. Retrieved December 23, 2021, from https://www.washingtonpost.com/outlook/2021/12/21/omicron-mild-cases-numbers/
-
- May 2022
-
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
-
DICER1 syndrome is a rare genetic condition predisposing to hereditary cancer and caused by variants in the DICER1
GeneName: DICER1 PMCID: PMC7859642 HGNCID: Unavailable Inheritance Pattern: Autosomal dominant. Disease Entity: Familial pleuropulmonary blastoma (PPB), cervix embryonal rhabdomyosarcoma, multinodular goiter, nasal chondromesenchymal hemartoma, Ciliary body medulloepithelioma, Sertoli-Leydig Cell Tumor (SLCT), differentiated thyroid carcinoma, pituitary blastoma, pineoblastoma, cystic nephroma, Wilm's tumor and sarcomas of different sites including, amongst others, the uterine cervix, kidney and brain. Mutation: Germline Zygosity: Heterozygose Variant: No ClinVarID present. Family Information: No family outline Case: No specified information of patients included. CasePresentingHPO's: n/a CasePrevious Testing: n/a gnomAD: n/a Mutation Type: nonsense, frameshift, or splice affected.
Tags
- Multinodular goiter
- Mutation type: Frameshift
- Inheritance Pattern: Autosomal dominant
- Cervix embryonal rhabdomyosarcoma
- Mutation type: Nonsense
- Zygosity: Heterozygous
- Differentiated thyroid carcinoma
- Familial pleuropulmonary blastoma (PPB)
- PMCID: PMC7859642
- Sertoli-Letdig Cell Tumor(SLCT)
- Gene: DICER1
- Mutation: Germline
- Ciliary body medulloepitheliomma
- Wilm's tumor
- Nasal chondromesenchymal hemartoma
Annotators
URL
-
-
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
-
Pathogenic germline variants in DICER1 underlie an autosomal dominant, pleiotropic tumor-predisposition disorder.
gene name: DICER 1 PMID (PubMed ID): 33570641 HGNCID: n/a Inheritance Pattern: autosomal dominant Disease Entity: benign and malignant tumor mutation Mutation: somatic Zygosity: heterozygous Variant: n/a Family Information: n/a Case: people of all sexes, ages, ethnicities and races participated CasePresentingHPOs: individuals with DICER1-associated tumors or pathogenic germline DICER1 variants were recruited to participate CasePreviousTesting: n/a gnomAD: n/a
-
-
watermark.silverchair.com watermark.silverchair.com
-
DICER1 syndrome is an autosomal-dominant,pleiotropic, tumor-predisposition disorder arisingfrom pathogenic germline variants in DICER1, whichencodes an endoribonuclease integral to processingmicroRNAs
DICER1 is the gene name. PubMed ID, HGCNCID, and Variant: I can't find Inheritance Pattern: autosomal-dominant The disease entity: DICER1 syndrome The type of mutation: germline. Zygosity: not known. Family Information: a family was used, DICER1 carriers, and non DICER1 variant used, some of the family members had tumors from DICER1 Case Information: mean age is 34, the range of age is 18.6 to 43 years, male, and female used, ethnicity can't find Case Presenting HPO: cancer testing, chemotherapy, radiotherapy gnomeAD: 9.2,8.3.2 Mutation type: Pleiotropic, loss of function, missense
-
-
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
-
Embryonal rhabdomyosarcoma (ERMS) of the uterus has recently been shown to frequently harbor DICER1 mutations.
HGNCID:
Tags
- Family Information: not identified
- Mutation: 5428 G>C
- Mutation: c.4267G>T
- Mutation: c.5428G>T
- Mutation: c.4420A>G
- case wt: m&f 0.5-19
- Inheritance Pattern: Non- inheritance(DNA methylation)
- Mutation: c.5125G > A
- Mutation: c.3580delA
- case mut: f 28-67
- PMID (PubMed ID): 33846547
- Disease Entity: Embryonal rhabdomyosarcoma (ERMS)
- Zygosity: Some Cases displayed homozygosity
- Mutation: c5113G>A
- Variant: Clinvar ID not identified
- pathogenicity: only 2 of 17 patients died from disease
- GeneName: DICER1
- Mutation: c.5438 A> C
Annotators
URL
-
-
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
-
GeneName: DICER1 syndrome (pleuropulmonary blastoma familial tumor susceptibility syndrome), PMID (PubMed ID): 29762508, HGNCID: 17098, Inheritance pattern: autosomal-dominant disease, Disease entity: Plueropulomary Blastoma, Mutation: Somatic, Zygosity: heterozygous, Variant: multiple variants, Family information: NA, Case: young children, CasePresentingHPO: N/A, CasePreviousTesting: N/A, Gnomade #: N/A , Mutation type: deletion
-
- Apr 2022
-
twitter.com twitter.com
-
ReconfigBehSci on Twitter: “RT @COGUK_ME: The @CovidGenomicsUK Mutation Explorer https://t.co/x2zsrhKj8Y is now tracking the combinations of spike substitutions known…” / Twitter. (n.d.). Retrieved April 29, 2022, from https://twitter.com/SciBeh/status/1462782003787542529
-
-
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
-
DICER1 syndrome is a rare genetic condition predisposing to hereditary cancer and caused by variants in the DICER1 gene.
Gene Name: DICER1 PMID:33552988 HGNCID: Unavailable Inheritance Pattern:Autosomal Dominant Disease Entity: familial pleuropulmonary blastoma (PPB),cystic nephroma, ovarian Sertoli-Leydig cell tumor (SLCT), multinodular goiter, cervix embryonal rhabdomyosarcoma, Wilms’ tumor, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, differentiated thyroid carcinoma, pituitary blastoma, pineoblastoma, and sarcomas of different sites. Mutation: Nonsense, Frameshift<br /> Zygosity: Heterosygosity Variant:No ClinVar ID present Family Information:no diseases mentioned in family Case: no specified case in this article gnomAD: n/a Mutation type: Nonsense. frameshift
Tags
- sarcomas
- familial pleuropulmonary blastoma
- Mutation: Nonsense
- SLCT
- cystic nephroma
- ciliary body medulloepithelioma
- ovarian Sertoli-Leydig cell tumor
- PPB
- cervix embryonal rhabdomyosarcoma
- Inheritance Pattern: Autosomal Dominant
- pineoblastoma
- pituitary blastoma
- PMID:33552988
- differentiated thyroid carcinoma
- multinodular goiter
- Gene: DICER1
- Wilms’ tumor
- Mutation: Frameshift
- Zygosity: Heterosygosity
- nasal chondromesenchymal hamartoma
Annotators
URL
-
-
twitter.com twitter.com
-
Ravi K Gupta [@ravgup33_ravi]. (2021, November 24). This one is worrying and I’ve not said that since delta. Please get vaccinated and boosted and mask up in public as the mutations in this virus likely result in high level escape from neutralising antibodies [Tweet]. Twitter. https://twitter.com/ravgup33_ravi/status/1463626745651806208
-
-
twitter.com twitter.com
-
Prof. Christina Pagel 🇺🇦 [@chrischirp]. (2021, November 24). As well as Tom’s new one (B.1.1.529), C.1.2 seems to be spreading in S Africa—C.1.2 was the one with lots of worrying mutations first reported in August... Plus cases in S Africa suddenly increasing again in the middle of their summer. Https://t.co/fCqfOMcO83 [Tweet]. Twitter. https://twitter.com/chrischirp/status/1463504890530086917
-
-
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
-
The DICER1 syndrome is an autosomal dominant tumor‐predisposi-tion disorder associated with pleuropulmonary blastoma, a rare pediatric lung cancer
GeneName:DICER1 PMID (PubMed ID): PMCID: PMC6418698 PMID: 30672147 HGNCID: NOT LISTED<br /> Inheritance Pattern: Autosomal Dominant Disease Entity: Cancer; benign and malignant tumors including pleuropulmonary blastoma, cystic nephroma, Sertoli-Leydig cell tumors, multinodular goiter, Thryoid cancer, rhabdomyosarcoma, and pineoblastoma. Mutation: Somatic missense variation Mutation type: missense Zygosity: None stated Variant: unregistered…. Family Information: Characterize germline variants in familial early-onset clorectal cancer patients; The observation of germline DICER1 variation with uterine corpus endometrial carcinoma merits additional investigation. CasePresentingHPOs: uterine and rectal cancers in germline mutation
-
-
www.who.int www.who.int
-
Update on Omicron. (n.d.). Retrieved April 22, 2022, from https://www.who.int/news/item/28-11-2021-update-on-omicron
-
-
twitter.com twitter.com
-
Dr Emma Hodcroft [@firefoxx66]. (2021, November 26). We now have B.1.1.529 sequences (designed at @nextstrain clade 21K) up in our Africa build. You can check them out below. These are from South Africa & Botswana—You can see the high number of mutations. CoVariants focal build & updates will come ASAP. https://t.co/fqBldneF5U [Tweet]. Twitter. https://twitter.com/firefoxx66/status/1464145615571623938
-
-
twitter.com twitter.com
-
Nathan Grubaugh [@NathanGrubaugh]. (2021, September 24). Hi @Newsweek 👋. I understand that #variant news has been slow recently with the near-complete dominance of Delta, but do you really need to go and make things up? Lineage R.1 is not a concern. Let me briefly explain why. (1/4) https://t.co/OD46PsXZEu [Tweet]. Twitter. https://twitter.com/NathanGrubaugh/status/1441522760832933888
-
-
twitter.com twitter.com
-
ReconfigBehSci. (2022, January 28). RT @chrischirp: BA.2 & BA.1.1 (Omicron variants) are growing in many countries. Quite what this means in terms of cases, hospitalisation… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1487066966363934720
-
-
www.nature.com www.nature.com
-
Tao, K., Tzou, P. L., Nouhin, J., Gupta, R. K., de Oliveira, T., Kosakovsky Pond, S. L., Fera, D., & Shafer, R. W. (2021). The biological and clinical significance of emerging SARS-CoV-2 variants. Nature Reviews Genetics, 1–17. https://doi.org/10.1038/s41576-021-00408-x
-
-
twitter.com twitter.com
-
nature. (2021, April 16). Coronavirus variants: Where do they come from? How do we spot them? What do they mean for COVID vaccines, and future of the pandemic? Https://t.co/NRbORu2hoF [Tweet]. @Nature. https://twitter.com/Nature/status/1383093697374474240
-
-
-
Callaway, E. (2021). Heavily mutated Omicron variant puts scientists on alert. Nature, 600(7887), 21–21. https://doi.org/10.1038/d41586-021-03552-w
-
-
twitter.com twitter.com
-
Trevor Bedford on Twitter. (n.d.). Twitter. Retrieved 1 April 2022, from https://twitter.com/trvrb/status/1447566558973231104
-
- Mar 2022
-
twitter.com twitter.com
-
ReconfigBehSci. (2022, February 21). RT @Mike_Honey_: Here’s a look at the frequency of BA.2 (Omicron) samples with an unusual mutation: ORF1a:M85del (NSP1:M85del). It was fir… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1497864547880902656
-
-
twitter.com twitter.com
-
Mia Malan. (2021, November 25). [Thread] What is the potential impact of the new B.1.1.529 #COVID19 variant? @rjlessells: 1. It’s relatively simple to detect some B.1.1.529 cases, as it’s possible to use PCR tests to do this in some cases 2. B.1.1.529 = has many mutations across different parts of the virus https://t.co/ytktqLzJUi [Tweet]. @miamalan. https://twitter.com/miamalan/status/1463846528578109444
-
- Feb 2022
-
twitter.com twitter.com
-
Meaghan Kall. (2022, February 17). BA.2 risk assessment New this week is upgrading Immune Evasion—Amber 🟨 from low to moderate that BA.2 is antigentically different to BA.1 Unsurprising given the mutation profile, with BA.2 slightly more immune evasive than BA.1 on neuts studies https://t.co/n6DWtiRaNH [Tweet]. @kallmemeg. https://twitter.com/kallmemeg/status/1494100170195312646
-
-
www.mercurynews.com www.mercurynews.com
-
Living with COVID-19: How the virus could turn into the common cold, or something far worse. (2022, January 9). The Mercury News. https://www.mercurynews.com/2022/01/09/living-with-covid-19-how-the-virus-could-turn-into-the-common-cold-or-something-far-worse
-
-
www.sciencedirect.com www.sciencedirect.com
-
Chatterjee, D., Tauzin, A., Marchitto, L., Gong, S. Y., Boutin, M., Bourassa, C., Beaudoin-Bussières, G., Bo, Y., Ding, S., Laumaea, A., Vézina, D., Perreault, J., Gokool, L., Morrisseau, C., Arlotto, P., Fournier, É., Guilbault, A., Delisle, B., Levade, I., … Finzi, A. (2022). SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-weeks interval between doses. Cell Reports, 0(0). https://doi.org/10.1016/j.celrep.2022.110429
-
-
theconversation.com theconversation.com
-
Willett, J. D. S. (n.d.). Omicron: Vaccines remain the best defence against this COVID-19 variant and others. The Conversation. Retrieved February 8, 2022, from http://theconversation.com/omicron-vaccines-remain-the-best-defence-against-this-covid-19-variant-and-others-174195
-
-
twitter.com twitter.com
-
Yaneer Bar-Yam on Twitter. (n.d.). Twitter. Retrieved February 7, 2022, from https://twitter.com/yaneerbaryam/status/1474091037861761026
-
-
twitter.com twitter.com
-
Trisha Greenhalgh. (2022, January 8). Apart from (e.g.): 1. Severe disease in clinically vulnerable (they are people too); 2. Long covid in many; 3. Strokes / heart attacks / kidney failure from micro-clots; 4. New-onset diabetes and MIS-C in children; 5. High potential for recombinant mutations. [Tweet]. @trishgreenhalgh. https://twitter.com/trishgreenhalgh/status/1479738523511136258
-
-
twitter.com twitter.com
-
Ulrich Elling. (2022, January 12). While #Omicron BA.1 leads the race, the little sister BA.2 is catching up in numbers. They are rather different with likely functional implications. BA.2 might be more immune evasive in RBD, less in NTD. And due to reduced mutation load in NTD maybe different fusion properties? Https://t.co/kEACjzQDs3 [Tweet]. @EllingUlrich. https://twitter.com/EllingUlrich/status/1481214901997682692
-
-
twitter.com twitter.com
-
Jonathan Li on Twitter: “There’s a lineage of Omicron that’s gained the R346K mutation (BA.1.1). This one could spell some trouble for the AZ mAb (tixagevimab/cilgavimab, Evusheld) that’s being used for pre-exposure prophylaxis. If you want to learn about tix/cil vs Omicron, read on 1/7” / Twitter. (n.d.). Retrieved February 6, 2022, from https://twitter.com/DrJLi/status/1487479972293853188
-
-
twitter.com twitter.com
-
Trevor Bedford. (2022, January 28). Omicron viruses can be divided into two major groups, referred to as PANGO lineages BA.1 and BA.2 or @nextstrain clades 21K and 21L. The vast majority of globally sequenced Omicron have been 21K (~630k) compared a small minority of 21L (~18k), but 21L is gaining ground. 1/15 [Tweet]. @trvrb. https://twitter.com/trvrb/status/1487105396879679488
-
-
twitter.com twitter.com
-
Prof. Christina Pagel. (2022, January 26). here is BA.2 growth in Denmark. Https://t.co/stake8vHvq [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1486300603735330816
-
- Jan 2022
-
www.nejm.org www.nejm.org
-
Pajon, R., Doria-Rose, N. A., Shen, X., Schmidt, S. D., O’Dell, S., McDanal, C., Feng, W., Tong, J., Eaton, A., Maglinao, M., Tang, H., Manning, K. E., Edara, V.-V., Lai, L., Ellis, M., Moore, K. M., Floyd, K., Foster, S. L., Posavad, C. M., … Montefiori, D. C. (2022). SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMc2119912
-
-
twitter.com twitter.com
-
Cornelius Roemer. (2021, December 22). @mccarthy_kr I took a look at all these NY sequences. I don’t think these point mutations S:681H are real. Why? Because they appear all over the Omicron diversity. Some sequences have S:346K, some S:701V, most miss S679K, a few have it. That’s the signature of contamination/co-infection. Https://t.co/DcJD4q44EM [Tweet]. @CorneliusRoemer. https://twitter.com/CorneliusRoemer/status/1473507369455923203
-
-
www.niid.go.jp www.niid.go.jp
-
Active epidemiological investigation on SARS-CoV-2 infection caused by Omicron variant (Pango lineage B.1.1.529) in Japan: Preliminary report on infectious period. (n.d.). Retrieved January 14, 2022, from https://www.niid.go.jp/niid/en/2019-ncov-e/10884-covid19-66-en.html
-
- Dec 2021
-
twitter.com twitter.com
-
Eric Topol. (2021, November 27). View of key mutations of Omicron’s 50, with 30 in the spike protein, 15 in its receptor binding domain https://ft.com/content/42c5ff3d-e676-4076-9b9f-7243a00cba5e http://covariants.org @EllingUlrich @_b_meyer https://t.co/onMoNFVLFJ [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1464452102382448643
-
-
www.medrxiv.org www.medrxiv.org
-
Wilhelm, A., Widera, M., Grikscheit, K., Toptan, T., Schenk, B., Pallas, C., Metzler, M., Kohmer, N., Hoehl, S., Helfritz, F. A., Wolf, T., Goetsch, U., & Ciesek, S. (2021). Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and monoclonal antibodies (p. 2021.12.07.21267432). https://doi.org/10.1101/2021.12.07.21267432
-
-
github.com github.com
-
Proposal to split B.1.1.529 to incorporate a newly characterised sibling lineage · Issue #361 · cov-lineages/pango-designation. (n.d.). GitHub. Retrieved 17 December 2021, from https://github.com/cov-lineages/pango-designation/issues/361
-
-
www.medrxiv.org www.medrxiv.org11779531
-
Garcia-Beltran, W. F., Denis, K. J. S., Hoelzemer, A., Lam, E. C., Nitido, A. D., Sheehan, M. L., Berrios, C., Ofoman, O., Chang, C. C., Hauser, B. M., Feldman, J., Gregory, D. J., Poznansky, M. C., Schmidt, A. G., Iafrate, A. J., Naranbhai, V., & Balazs, A. B. (2021). MRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant (p. 2021.12.14.21267755). https://doi.org/10.1101/2021.12.14.21267755
-
-
twitter.com twitter.com
-
Carl T. Bergstrom. (2021, November 26). I’d be careful not to overinterpret the following graph from @jburnmurdoch. Yes, the fraction of B.1.1.529 is increasing faster. But I think that is that is largely due to different denominators. Https://t.co/NDhSqJpLlw [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1464061037292883970
-
-
-
Mahase, E. (2021). Covid-19: Do vaccines work against omicron—and other questions answered. BMJ, 375, n3062. https://doi.org/10.1136/bmj.n3062
Tags
- antiviral
- severity
- PCR
- variant
- risk
- modeling
- booster
- mask wearing
- data
- COVID-19
- treatment
- South Africa
- hospitalization
- travel ban
- Africa
- UK
- antibody
- restrictions
- response
- lang:en
- research
- is:article
- mutation
- Omicron
- delta
- work from home
- detection
- vaccine
- reinfection
- epidemiology
- testing
- transmissibility
- EU
- infection rate
- domestic measures
- Europe
Annotators
URL
-
-
www.gavi.org www.gavi.org
-
What do we know about the new B.1.1.529 coronavirus variant and should we be worried? (n.d.). Retrieved 10 December 2021, from https://www.gavi.org/vaccineswork/what-we-know-about-new-b11529-coronavirus-variant-so-far
-
-
inews.co.uk inews.co.uk
-
Omicron cases may be far higher than currently confirmed, variant marker analysis reveals. (2021, December 8). Inews.Co.Uk. https://inews.co.uk/news/health/omicron-covid-cases-may-be-seven-times-higher-than-confirmed-1341156
-
-
www.bbc.co.uk www.bbc.co.uk
-
New Covid variant: How worried should we be? (2021, November 25). BBC News. https://www.bbc.com/news/health-59418127
-
-
www.theguardian.com www.theguardian.com
-
Devlin, H., & Kollewe, J. (2021, November 26). BioNTech says it could tweak Covid vaccine in 100 days if needed. The Guardian. https://www.theguardian.com/society/2021/nov/26/biontech-says-it-could-tweak-covid-vaccine-in-100-days-if-needed
Tags
- variant-specific booster
- Pfizer
- clinical trials
- lang:en
- BioNTech
- research
- mutation
- variant
- spike protein
- immunity
- Omicron
- escape variant
- booster
- effectiveness
- development
- vaccine
- is:news
- COVID-19
- science
- transmissibility
- protection
Annotators
URL
theguardian.com/society/2021/nov/26/biontech-says-it-could-tweak-covid-vaccine-in-100-days-if-needed -
-
-
Cotterill, J. (2021, November 26). South African anger over ‘rushed’ Covid travel restrictions. Financial Times. https://www.ft.com/content/6a177732-4faf-4ecb-adc1-667c22248e0f
-
-
www.abbott.com www.abbott.com
-
Evaluating Omicron and Other COVID Variants to Ensure Test Effectiveness. (n.d.). Abbott. Retrieved December 3, 2021, from https://www.abbott.com/corpnewsroom/diagnostics-testing/monitoring-covid-variants-to-ensure-test-effectiveness.html
-
-
www.statnews.com www.statnews.com
-
Cause for optimism on Omicron: Our immune systems aren’t blank slates. (2021, December 1). STAT. https://www.statnews.com/2021/12/01/a-reason-for-optimism-on-omicron-our-immune-systems-are-not-blank-slates/
Tags
- previous infection
- COVID-19
- immune response
- lang:en
- mutation
- protection
- variant
- Omicron
- immunity
- immunology
- vaccine efficacy
- vaccine
- is:news
Annotators
URL
-
-
twitter.com twitter.comTwitter1
-
Kristian G. Andersen on Twitter. (n.d.). Twitter. Retrieved 3 December 2021, from https://twitter.com/K_G_Andersen/status/1465822536629821442
-
-
news.sky.com news.sky.com
-
COVID-19: Most Omicron cases are “mild” and there’s no evidence to suggest vaccines may be less effective against the variant, says WHO official. (n.d.). Sky News. Retrieved December 2, 2021, from https://news.sky.com/story/covid-19-most-omicron-cases-are-mild-and-theres-no-evidence-to-suggest-vaccines-may-be-less-effective-against-the-variant-says-who-12483729
-
-
twitter.com twitter.com
-
nference. (2021, November 27). Here is how B.1.1.529 (#Omicron #B11529) compares to Alpha, Beta, Gamma, Delta variants. Omicron has highest novel Spike mutations including striking cluster on the “crown” suggesting significant selection pressure & antigenic distinction from prior strains (Credits: Nference) https://t.co/4oZQbjhbG8 [Tweet]. @_nference. https://twitter.com/_nference/status/1464404770098229250
-
- Nov 2021
-
www.npr.org www.npr.org
-
N, P, & R. (2021, November 27). Does omicron pose a risk to the vaccinated? Too early to tell, epidemiologist says. NPR. https://www.npr.org/2021/11/27/1059539509/too-early-to-tell-whether-omicron-poses-a-threat-to-vaccinated-epidemiologist-sa
-
-
tamil.oneindia.com tamil.oneindia.com
-
P681H, N679K, N501Y
B.1.1529 MUTATION OMICRON
-
-
twitter.com twitter.com
-
Meaghan Kall. (2021, November 26). B.1.1.529 in the UK • Designated a Variant Under Investigation (VUI) VUI-21NOV-01 • No cases in the UK 🇬🇧 to date • Enhanced case finding & rapid assessment is underway https://t.co/0DGvlgvdPR [Tweet]. @kallmemeg. https://twitter.com/kallmemeg/status/1464210457795907588
-
- Oct 2021
-
www.dailymail.co.uk www.dailymail.co.uk
-
UK’s daily Covid deaths hit SEVEN-MONTH high of 223 while cases jump 13% in a week to 43,738 | Daily Mail Online. (n.d.). Retrieved October 25, 2021, from https://www.dailymail.co.uk/news/article-10108203/UKs-daily-Covid-deaths-hit-SEVEN-MONTH-high-223-cases-jump-13-week-43-738.html
-
-
www.theguardian.com www.theguardian.com
-
Davis, N. (2021, October 19). Offshoot of Covid Delta variant on the rise in England. The Guardian. https://www.theguardian.com/world/2021/oct/19/fears-grow-in-england-over-rise-of-new-covid-delta-variant
-
-
www.biorxiv.org www.biorxiv.org
-
Rono, E. K. (2021). Covid-19 genomic analysis reveals clusters of emerging sublineages within the delta variant [Preprint]. Genomics. https://doi.org/10.1101/2021.10.08.463334
-
-
-
Mlcochova, P., Kemp, S. A., Dhar, M. S., Papa, G., Meng, B., Ferreira, I. A. T. M., Datir, R., Collier, D. A., Albecka, A., Singh, S., Pandey, R., Brown, J., Zhou, J., Goonawardane, N., Mishra, S., Whittaker, C., Mellan, T., Marwal, R., Datta, M., … Gupta, R. K. (2021). SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion. Nature, 1–6. https://doi.org/10.1038/s41586-021-03944-y
-
-
twitter.com twitter.com
-
Pablo Tsukayama on Twitter. (n.d.). Twitter. Retrieved 4 October 2021, from https://twitter.com/pablotsukayama/status/1435725621599027202
-
- Sep 2021
-
www.nytimes.com www.nytimes.com
-
Zimmer, C., Corum, J., & Wee, S.-L. (2020, June 10). Coronavirus Vaccine Tracker. The New York Times. https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html
-
-
twitter.com twitter.com
-
ReconfigBehSci. (2021, August 22). RT @chrischirp: Some good news from PHE’s Friday Delta tech briefing update: Two sublineages of Delta called AY.1 and AY.2 do not seem to b… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1430638002586329088
-
- Aug 2021
-
www.biorxiv.org www.biorxiv.org
-
Liu, Y., Arase, N., Kishikawa, J., Hirose, M., Li, S., Tada, A., Matsuoka, S., Arakawa, A., Akamatsu, K., Ono, C., Jin, H., Kishida, K., Nakai, W., Kohyama, M., Nakagawa, A., Yamagishi, Y., Nakagami, H., Kumanogoh, A., Matsuura, Y., … Arase, H. (2021). The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines (p. 2021.08.22.457114). https://doi.org/10.1101/2021.08.22.457114
-
-
www.thebulwark.com www.thebulwark.com
-
What Is “Natural Immunity”? And Why Should You Get the Vaccine Even if You Already Had COVID? - The Bulwark. (n.d.). Retrieved August 11, 2021, from https://www.thebulwark.com/what-is-natural-immunity-and-why-should-you-get-the-vaccine-even-if-you-already-had-covid/
-
- Jun 2021
-
www.bmj.com www.bmj.com
-
Darby, Alistair C., and Julian A. Hiscox. ‘Covid-19: Variants and Vaccination’. BMJ 372 (23 March 2021): n771. https://doi.org/10.1136/bmj.n771.
-
-
news.harvard.edu news.harvard.edu
-
Vaccines should end the pandemic, despite the variants, say experts – Harvard Gazette. (n.d.). Retrieved June 19, 2021, from https://news.harvard.edu/gazette/story/2021/02/vaccines-should-end-the-pandemic-despite-the-variants-say-experts/
-
-
twitter.com twitter.com
-
ReconfigBehSci. (2021, June 8). RT @TWenseleers: Across whole of England, 76% [74-78%] of all newly diagnosed infections now B.1.617.2. We see familiar pattern of combinat… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1402633076396552193
-
-
twitter.com twitter.com
-
ReconfigBehSci. (2021, June 5). RT @TWenseleers: Estimated growth rate advantage of B.1.617.2 vs B.1.1.7 is 8.3%/day [7.9-8.8%] 95% CLs and 4%/day [3-5%] for B.1.617.1 vs… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1402243029407178757
-
-
twitter.com twitter.com
-
ReconfigBehSci. (2021, June 14). RT @AdamJKucharski: Compare relationship between R and proportion of sequences consistent with the B.1.1.7 variant in autumn 2020 (below le… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1404604886117797888
-
-
www.cell.com www.cell.com
-
SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD and S2: Cell. (n.d.). Retrieved 18 June 2021, from https://www.cell.com/cell/fulltext/S0092-8674(21)00706-6
-
-
graphql-ruby.org graphql-ruby.org
-
It works, but a stronger solution is to treat errors as data.
-
In mutations, when errors happen, the other fields may return nil. So, if those other fields have null: false, but they return nil, the GraphQL will panic and remove the whole mutation from the response, including the errors!
-
-
-
graphql-ruby.org graphql-ruby.org
-
In general, top-level errors should only be used for exceptional circumstances when a developer should be made aware that the system had some kind of problem. For example, the GraphQL specification says that when a non-null field returns nil, an error should be added to the "errors" key. This kind of error is not recoverable by the client. Instead, something on the server should be fixed to handle this case. When you want to notify a client some kind of recoverable issue, consider making error messages part of the schema, for example, as in mutation errors.
-
-
www.theguardian.com www.theguardian.com
-
UK tightens borders and travel rules as variants spark new alarm | Coronavirus | The Guardian. (n.d.). Retrieved June 5, 2021, from https://www.theguardian.com/world/2021/jun/03/concern-over-delta-covid-variant-tightens-borders-of-uk
-
-
www.bmj.com www.bmj.com
-
Mahase, E. (2021). Covid-19: Government faces legal challenge over alleged suppression of school data. BMJ, 373, n1408. https://doi.org/10.1136/bmj.n1408
-
- May 2021
-
www.thelancet.com www.thelancet.com
-
Ramanathan, M., Ferguson, I. D., Miao, W., & Khavari, P. A. (2021). SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00262-0
-
-
twitter.com twitter.com
-
John Burn-Murdoch. (2021, May 7). NEW: time for a proper thread on B.1.617.2, the subtype of the Indian variant that has been moved to ‘variant of concern’ today by Public Health England. First, it’s clear case numbers from this lineage are growing faster than other imported variants have done in the UK. https://t.co/hUUzBvCsY1 [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1390666071724765185
-
-
www.nature.com www.nature.com
-
Mallapaty, S. (2021). How a worrisome coronavirus variant spread unnoticed. Nature. https://doi.org/10.1038/d41586-021-01285-4
-
-
twitter.com twitter.com
-
Eric Topol. (2021, May 1). Downgrading the concern on B.1.617, the poorly named ‘double mutant’—98% effectiveness of mRNA vaccine in an Israeli outbreak @CT_Bergstrom https://t.co/tGbuwPUmAL —Lab studies: Minimal immune evasion, expected full protection from vaccine @GuptaR_lab https://t.co/AIp24G0ROK https://t.co/AK20UWlDBD [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1388539223230140422
-
-
twitter.com twitter.com
-
ReconfigBehSci. (2021, May 1). RT @GuptaR_lab: Given the dire situation in India and questions regarding the new variant B.1.617, the so called ‘Double Mutant’ we are sha… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1388915829383720961
-
-
www.scientificamerican.com www.scientificamerican.com
-
Brazil’s Pandemic Is a “Biological Fukushima” That Threatens the Entire Planet—Scientific American. (n.d.). Retrieved May 12, 2021, from https://www.scientificamerican.com/article/brazils-pandemic-is-a-lsquo-biological-fukushima-rsquo-that-threatens-the-entire-planet/
-
-
www.theguardian.com www.theguardian.com
-
Davis, N. (2020, May 26). Research reveals gene role in both dementia and severe Covid-19. The Guardian. https://www.theguardian.com/world/2020/may/26/research-reveals-gene-role-in-both-dementia-and-severe-covid-19
-
-
virological.org virological.org
-
Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: Preliminary findings - SARS-CoV-2 coronavirus / nCoV-2019 Genomic Epidemiology. (2021, January 25). Virological. https://virological.org/t/genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-manaus-preliminary-findings/586/2
-