485 Matching Annotations
  1. Jun 2023
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    Structure-based design and characterization of Parkin activating mutations
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    biorxiv.org/content/10.1101/2022.02.22.481412v1
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    Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins
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    biorxiv.org/content/10.1101/2022.10.27.514032v1
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    Upf3a is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells
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    biorxiv.org/content/10.1101/2022.07.04.495064v2
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    Structural insights into ubiquitin chain cleavage by Legionella ovarian tumor deubiquitinases
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    biorxiv.org/content/10.1101/2023.01.02.522462v1
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    The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells
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    biorxiv.org/content/10.1101/2022.08.19.504520v1
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    Missense variant interaction scanning reveals a critical role of the FERM-F3 domain for tumor suppressor protein NF2 conformation and function
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    biorxiv.org/content/10.1101/2022.12.11.519953v2
  8. May 2023
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    BAZ2A-RNA mediated association with TOP2A and KDM1A represses gene expression in prostate cancer
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    biorxiv.org/content/10.1101/2021.07.15.452487v2
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    Recursive splicing discovery using lariats in total RNA sequencing
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    biorxiv.org/content/10.1101/2022.12.22.521701v1
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    Exploratory Meta-Analysis of Hypoxic Transcriptomes Using a Precise Transcript Reference Sequence Set
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    biorxiv.org/content/10.1101/2022.05.01.489280v2
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    VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome
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    biorxiv.org/content/10.1101/2022.03.16.484566v1
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    Telescoping bimodal latent Dirichlet allocation to identify expression QTLs across tissues
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    biorxiv.org/content/10.1101/2021.10.27.466156v2
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    RAS and PP2A activities converge on epigenetic gene regulation
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    biorxiv.org/content/10.1101/2022.05.11.491459v1
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    Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
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    biorxiv.org/content/10.1101/2022.05.09.491247v1
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    Gapless provides combined scaffolding, gap filling and assembly correction with long reads
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    biorxiv.org/content/10.1101/2022.03.08.483466v2
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    Z-Flipon Variants reveal the many roles of Z-DNA and Z-RNA in health and disease
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    biorxiv.org/lookup/doi/10.1101/2023.01.12.523822
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    The value of genotype-specific reference for transcriptome analyses
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    biorxiv.org/content/10.1101/2021.09.14.460213v1
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    Genome-wide CRISPRi screening reveals regulators of Alzheimee's tau pathology shared between exosomal and vesicle-free tau seeds.
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    biorxiv.org/content/10.1101/2022.04.26.489622v1
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    Small non-coding vault RNA1-2 modulate expression of cell membrane proteins through nascent RNA silencing
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    biorxiv.org/content/10.1101/2022.08.12.503724v2
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    LuminoCell: a versatile and affordable luminometer platform for monitoring in-cell luciferase-based reporters
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    biorxiv.org/content/10.1101/2022.01.28.478134v1
  22. Apr 2023
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    Efficient knock-in method enabling lineage tracing in zebrafish
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    biorxiv.org/content/10.1101/2022.07.15.500272v1
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    The TUDOR domain of SMN is an H3K79me1 histone mark reader
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    biorxiv.org/content/10.1101/2022.10.06.511070v1
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    Preference of CAMSAP3 for microtubules with expanded lattice contributes to stabilization of the minus end
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    biorxiv.org/content/10.1101/2022.08.21.504720v2
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    Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells
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    biorxiv.org/content/10.1101/2022.08.15.503960v1
  27. Mar 2023
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    Peroxisomes contribute to intracellular calcium dynamics
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    biorxiv.org/content/10.1101/2020.09.02.279174v1
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    An extended DNA-free intranuclear compartment organizes centrosomal microtubules in Plasmodium falciparum
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    biorxiv.org/content/10.1101/2021.03.12.435157v2
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    Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16
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    biorxiv.org/content/10.1101/2021.11.30.470499v1
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    The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation, epithelial repair, and tumor growth
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    biorxiv.org/content/10.1101/2022.04.11.487842v1
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    Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition
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    biorxiv.org/content/10.1101/2021.10.03.462949v4
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    Lack of peroxisomal catalase affects heat shock response in C. elegans
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    biorxiv.org/content/10.1101/2021.07.13.452156v1
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    Lineage Tracing Reveals Fate Bias and Transcriptional Memory in Human B cells
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    biorxiv.org/content/10.1101/2022.07.14.499766v2
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    Critical roles of ICOS in controlling Foxp3-expressing T follicular cell subsets during early-stage germinal center reactions
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    biorxiv.org/content/10.1101/2021.09.14.460384v2
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    The human MRS2 magnesium binding domain is a regulatory feedback switch for channel activity.
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    biorxiv.org/content/10.1101/2022.09.27.509701v1
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    Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases
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    biorxiv.org/content/10.1101/2022.02.18.481032v1
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    Segregation of pathways leading to pexophagy
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    biorxiv.org/content/10.1101/2022.11.08.515582v1
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    New algorithms for accurate and efficient de-novo genome assembly from long DNA sequencing reads
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    biorxiv.org/content/10.1101/2022.08.30.505891v1
  40. Feb 2023
  41. www.biorxiv.org www.biorxiv.org
    Adenylyl cyclase 9 is auto-stimulated by its isoform-specific carboxyl terminal domain and equipped with paradigm-switching mechanisms.
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    biorxiv.org/content/10.1101/2022.06.05.494885v3
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    Lung macrophages utilize cathepsin K-dependent phagosomal machinery to degrade intracellular collagen
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    biorxiv.org/content/10.1101/2022.05.16.492085v1
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    SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology
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    biorxiv.org/content/10.1101/2022.07.26.501499v1
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    The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex
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    biorxiv.org/content/10.1101/2021.09.20.461067v1
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    Human RNA Nm-MTase FTSJ1: new tRNA targets and role in the regulation of brain-specific genes.
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    biorxiv.org/content/10.1101/2021.02.06.430044v4
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    A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
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    biorxiv.org/content/10.1101/2022.09.08.507072v1
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    Epigenetic signals that direct cell type specific interferon beta response in mouse cells
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    biorxiv.org/content/10.1101/2022.02.26.481127v1
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    Convergent evolution and horizontal gene transfer in Arctic Ocean microalgae
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    biorxiv.org/content/10.1101/2021.07.31.454568v1
  49. Jan 2023
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    Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing
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    biorxiv.org/content/10.1101/2022.06.02.494495v2
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    Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2
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    biorxiv.org/content/10.1101/2022.08.31.506132v1
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    SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.
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    biorxiv.org/content/10.1101/2022.02.13.480288v1
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    Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely specified among human cells
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    biorxiv.org/content/10.1101/2022.09.07.506974v1
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    Identifying novel regulators of placental development using time series transcriptomic data and network analyses
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    biorxiv.org/content/10.1101/2022.05.17.492330v1
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    De novo discovery of traits co-occurring with chronic obstructive pulmonary disease
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    biorxiv.org/content/10.1101/2022.07.20.500731v1
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    An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation
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    biorxiv.org/content/10.1101/2022.07.01.498448v1
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    Comparative analysis of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing
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    biorxiv.org/content/10.1101/2022.03.04.483068v3
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    A synergistic activation of RARb and RARg nuclear receptors restores cell-types specialization during stem cells differentiation by hijacking RARa-controlled program
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    biorxiv.org/content/10.1101/2022.05.31.494116v2
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    Nuclear envelope reshaping around the vacuole determines the morphology of the ribosomal DNA
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    biorxiv.org/content/10.1101/2021.06.23.449658v1
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    Porcine intestinal innate lymphoid cells and lymphocyte spatial context revealed through single-cell RNA sequencing
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    biorxiv.org/content/10.1101/2022.01.09.475571v1
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    Sibling rivalry among the ZBTB transcription factor family: homo vs. heterodimers
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    biorxiv.org/content/10.1101/2021.12.17.472994v2
  62. Dec 2022
  63. www.biorxiv.org www.biorxiv.org
    Stage-specific gene and transcript dynamics in human male germ cells
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    biorxiv.org/content/10.1101/2022.03.22.485121v1
  64. earthcommission.org earthcommission.org
    New Earth Commission Working Group to Focus on the Challenges of Cross-Scale Translation - Earth Commission
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    earthcommission.org/news/earth-commission-news/new-earth-commission-working-group-to-focus-on-the-challenges-of-cross-scale-translation/
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    Cdh5-lineage independent origin of dermal lymphatic vessels revealed by temporally restricted lineage tracing
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    biorxiv.org/content/10.1101/2022.06.08.495310v1
  66. www.biorxiv.org www.biorxiv.org
    Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces
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    biorxiv.org/content/10.1101/2022.05.14.491942v1
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    Genome-wide Profiling of Histone Modifications in Plasmodium falciparum using CUT&RUN.
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    biorxiv.org/content/10.1101/2022.08.01.502378v2
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    Systematic analysis of ADP-ribose detection reagents and optimisation of sample preparation to detect ADP-ribosylation in vitro and in cells
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    biorxiv.org/content/10.1101/2022.02.22.481411v1
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    Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes
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    biorxiv.org/content/10.1101/2022.08.12.503771v2
  70. Nov 2022
  71. www.biorxiv.org www.biorxiv.org
    Actin binding domain of Rng2 strongly inhibits actin movement on myosin II HMM through structural changes of actin filaments
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    biorxiv.org/content/10.1101/2020.04.14.041046v4
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    Miro GTPase domains regulate assembly of the mitochondrial motor-adaptor complex
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    biorxiv.org/content/10.1101/2022.05.13.491728v1
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    Improving the computation efficiency of polygenic risk score modeling: Faster in Julia
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    biorxiv.org/content/10.1101/2021.12.27.474263v1
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    Structure of mammalian V-ATPase with the TLDc domain protein mEAK7 bound
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    biorxiv.org/content/10.1101/2021.11.03.466369v2
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    Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish
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    biorxiv.org/content/10.1101/2021.12.22.473872v1
  76. Oct 2022
  77. www.biorxiv.org www.biorxiv.org
    https://biorxiv.org/cgi/content/10.1101/2022.03.06.483172
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    biorxiv.org/content/10.1101/2022.03.06.483172v1
  78. www.biorxiv.org www.biorxiv.org
    Replication-associated inversions are the dominant form of bacterial chromosome structural variation
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    biorxiv.org/content/10.1101/2022.02.15.480581v1
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    Contribution of the Golgi apparatus in morphogenesis of a virus induced cytopathic vacuolar system
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    biorxiv.org/content/10.1101/2022.03.14.484265v1
  80. www.biorxiv.org www.biorxiv.org
    Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain
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    biorxiv.org/content/10.1101/2022.04.21.489014v1
  81. www.biorxiv.org www.biorxiv.org
    Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions
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    biorxiv.org/content/10.1101/2022.04.03.486870v1
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    Synthetic evolution of herbicide resistance using a T7 RNAP-based random DNA base editor
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    biorxiv.org/content/10.1101/2021.11.30.470689v1
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    Evaluation of CA repeat arrays as targets for MeCP2 function in the brain
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    biorxiv.org/content/10.1101/2022.04.26.489598v2
  84. Sep 2022
  85. www.biorxiv.org www.biorxiv.org
    Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein level changes
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    biorxiv.org/content/10.1101/2022.02.24.481857v1
  86. www.biorxiv.org www.biorxiv.org
    Human gene function publications that describe wrongly identified nucleotide sequence reagents are unacceptably frequent within the genetics literature
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    biorxiv.org/content/10.1101/2021.07.29.453321v1
  87. Aug 2022
  88. www.biorxiv.org www.biorxiv.org
    Decreasing pdzd8-mediated mitochondrial-ER contacts in neurons improves fitness by increasing mitophagy
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    biorxiv.org/content/10.1101/2020.11.14.382861v1
  89. www.biorxiv.org www.biorxiv.org
    Islet Gene View - a tool to facilitate islet research
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    biorxiv.org/content/10.1101/435743v3
  90. www.biorxiv.org www.biorxiv.org
    Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis
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    biorxiv.org/content/10.1101/2022.05.02.490246v1
  91. www.biorxiv.org www.biorxiv.org
    CFTR modulator response measurements in subjects with cystic fibrosis using 2D differentiated nasal epithelia converted into spheroids
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    biorxiv.org/content/10.1101/2021.07.20.453105v2
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    A minimal hepatocyte growth factor mimic acting as a powerful agonist of the MET receptor tyrosine kinase for regeneration of epithelial tissues and organs.
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    biorxiv.org/content/10.1101/2020.07.20.212654v3
  93. www.biorxiv.org www.biorxiv.org
    Drosophila insulator proteins exhibit in-vivo liquid-liquid phase separation properties
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    biorxiv.org/content/10.1101/2022.05.27.493687v1
  94. www.biorxiv.org www.biorxiv.org
    ScRNA-seq Expression of APOC2 and IFI27 Identifies Four Families of Alveolar Macrophage Superclusters in Cystic Fibrosis and Healthy BALF
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    biorxiv.org/content/10.1101/2022.01.30.478325v3
  95. www.biorxiv.org www.biorxiv.org
    ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
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    biorxiv.org/content/10.1101/2021.12.22.473898v2
  96. Jul 2022
  97. www.biorxiv.org www.biorxiv.org
    LncRNA RUS shapes the gene expression program towards neurogenesis
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    biorxiv.org/content/10.1101/2022.02.17.480853v1
  98. Jun 2022
  99. www.civicsoftechnology.org www.civicsoftechnology.org
    Whose interests do teaching machines serve? — Civics of Technology
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    civicsoftechnology.org/blog/whose-interests-do-teaching-machines-serve
  100. www.biorxiv.org www.biorxiv.org
    Negative curvature-promoting lipids instruct nuclear ingression of low autophagic potential vacuoles
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  174. Jun 2021
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      G7 support for pharma monopolies is putting millions of lives at risk | Amnesty International. (n.d.). Retrieved June 12, 2021, from https://www.amnesty.org/en/latest/news/2021/06/g7-support-for-pharma-monopolies-putting-millions-of-lives-at-risk/

      is:webpage lang:en COVID-19 G7 G7 Leaders' Summit People's Vaccine Alliance vaccine government UK patent waiving resources campaign vaccine inequity inequity health inequality public health vaccine technology vaccine production funding COVAX pharmaceutical corporation supply finance intellectual property
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  176. May 2021
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  180. Apr 2021
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  191. Feb 2021
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    Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F
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    biorxiv.org/content/10.1101/2020.06.02.130047v1
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    Overlapping oriC and centromere-like functions in secondary genome replicons determine their maintenance independent of chromosome I in Deinococcus radiodurans
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    The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity
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    A double role of the Gal80 N-terminus in activation of transcription by Gal4p
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  207. Oct 2020
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    Predicting gene regulatory networks from cell atlases
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    A meiosis-specific AAA+ assembly reveals repurposing of ORC during budding yeast gametogenesis
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    multicrispr: fast gRNA designer enables prime editing and parallel targeting of thousands of targets
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    Profiles of circulating histidine-rich glycoprotein associate with age and risk of all-cause mortality
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    Peptide-based quorum sensing systems in Paenibacillus polymyxa
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    A time resolved interaction analysis of Bem1 reconstructs the flow of Cdc42 during polar growth
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    An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella
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    Attenuation of cGAS/STING Activity During Mitosis
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    biorxiv.org/content/10.1101/2019.12.19.883090v2
  217. Jul 2020
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    An unexpected contribution of lincRNA splicing to enhancer function.
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    Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells
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    Lipid-associated PML domains regulate CCTα, Lipin1 and lipid homeostasis
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    Mitochondrial fusion defects caused by CMT2A disease-associated variants of Mfn2
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    Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis
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    A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus
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    Evaluation of colorectal cancer subtypes and cell lines using deep learning
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    Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling
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  226. Jun 2020
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    Plant-microbe co-evolution: allicin resistance in a Pseudomonas fluorescens strain (PfAR-1) isolated from garlic
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    Ubiquitin and SUMO conjugation as biomarkers of Acute Myeloid Leukemias response to chemotherapies
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    Dynamic changes in the regulatory T cell heterogeneity and function by murine IL-2 mutein
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    BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression
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    biorxiv.org/content/10.1101/2019.12.13.876268v2