GroupID: 35

DiseaseAssertion: assumed VHL

GroupSize: 10

GroupNumberMales: N/A

GroupNumberFemales: N/A

GroupEthnicity: N/A

GroupAgeRange: N/A

GroupInfo: 10 of the 573 patients discussed in this paper were found to have the following mutation belonging to 2 families altogether.

GroupPresentingHPOs: HP:0006880; HP:0009711; HP:0005584; HP:0002666 (cerebellar hemangioblastoma, retinal capillary hemangioma; renal cell carcinoma; pheochromocytoma)

GroupHPOFreeText: 8 patients had retinal angiomas diagnosed at a mean age of 27Y, 4 had cerebellar hemangioblastomas diagnosed at a mean age of 31Y, 1 member had RCC diagnosed at 50Y, and one has pheochromocytoma diagnosed at 27Y.

GroupNotHPOs: N/A

GroupNotHPOFreeText: N/A

GroupPreviousTesting: N/A

PreviouslyPublished: N/A

SupplementalData: Supplementary Table S1.

Variant: p.R177* (c.529A>T)

CaseProblemVariantFreeText: N/A

LegacyVariant: N/A

ClinVarID: 625258 https://www.ncbi.nlm.nih.gov/clinvar/variation/625258/

CAID: N/A

gnomAD: N/A

VariantEvidence: N/A

MutationType: stop_gained

CivicName: R177* (c.529A>T)

MultipleGeneVariants: N/A

GroupID: 33

DiseaseAssertion: assumed VHL

GroupSize: 3

GroupNumberMales: N/A

GroupNumberFemales: N/A

GroupEthnicity: N/A

GroupAgeRange: N/A

GroupInfo: 3 of the 573 patients discussed in this paper were found to have the following mutation belonging to 2 families altogether. 

GroupPresentingHPOs: HP:0006880; HP:0005584; HP:0009711 (cerebellar hemangioblastoma; renal cell carcinoma; retinal capillary hemangioma)

GroupHPOFreeText: 1 patient had retinal angiomas diagnosed at age 18Y, 3 had cerebellar hemangioblastomas diagnosed at mean age of 18Y, and 1 had RCC diagnosed at 50Y

GroupNotHPOs: HP:0002666 (pheochromocytoma)

GroupNotHPOFreeText: N/A

GroupPreviousTesting: N/A

PreviouslyPublished: N/A

SupplementalData: Supplementary Table S1.

Variant: p.R176Gfs*26 (c.526delA) 

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 625257 https://www.ncbi.nlm.nih.gov/clinvar/variation/625257/

CAID: N/A

gnomAD: N/A

VariantEvidence: N/A

MutationType: minus_1_frameshift_variant

CivicName: R176fs (c.526del) 

MultipleGeneVariants: N/A

PatientID: III-16 (proband)

KindredID: 1

Case: M, 52Y0M, Iranian

DiseaseAssertion: VHL

FamilyInfo: Familial history was positive for BL-PCC in his son and his daughters, and for retinal hemangioblastoma and bilateral pheochromocytoma in his siblings. A total of 43 members of the kindred, 24 males and 19 females, aged 2-77 years were reached for evaluation. It is stated in the paper that all affected subjects (13) were positive for the same mutation (c.500G>A). Additionally, gene sequencing revealed that 4 asymptomatic members of the kindred also harbored the pathogenic mutation.

CasePresentingHPOs: HP:0002666; HP:0006880 (Pheochromocytoma; cerebellar hemangioblastoma)

CaseHPOFreeText: Patient had bilateral pheochromocytoma diagnosed at 30Y which had been operated on surgically at 50Y. He was hospitalized at age 50Y also for headache, vertigo, and gait problems for the past 2 months. Brain MRI then showed a huge lobulated hyper-intense lesion measuring 48 by 38 by 28 mm in the right cerebellar hemisphere with significant projection into the fourth ventricle, consistent with hemangioblastoma of reticular pattern.

CaseNotHPOs: HP:0000077 (abnormality of the kidney)

CaseNotHPOFreeText: There was no case of kidney tumors among the kindred.

CasePreviousTesting: N/A

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.R167Q (c.500G>A)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 2216, https://www.ncbi.nlm.nih.gov/clinvar/variation/2216/

CAID: N/A

gnomAD: 0.000003977, https://gnomad.broadinstitute.org/variant/3-10191507-G-A

VariantEvidence: N/A

MutationType: missense_variant; transition

CivicName: R167Q (c.500G>A)

MultipleGeneVariants: N/A

PatientID: 3 (proband)

KindredID: 2

Case: F, 56Y0M, Ethnicity Unknown

DiseaseAssertion: assumed VHL

FamilyInfo: The same point mutation of VHL (c. 232A>T; p.Asn78Tyr) was identified in three family members including one sister, one brother and one nephew. Her sister was found with pancreatic NET and died of the hemorrhagic stroke at age of 40 years, and her brother and nephew refused for further examinations for VHL-related lesions. Her mother died of stroke at early of 50 years.

CasePresentingHPOs: HP:0030405, HP:0000107; HP:0005584 (pancreatic endocrine tumour, renal cyst, Renal cell carcinoma)

CaseHPOFreeText: at age 50, MRI scans revealed at least 3 lesions on her left kidney (recorded as bilateral RCC in August of 2011), and 3 lesions in her pancreas, which were stated to be pancreatic NETs.

CaseNotHPOs: HP:0006748, HP:0010797 (adrenal pheochromocytoma, cerebellar hemangioblastoma)

CaseNotHPOFreeText: MRI scan on brain was negative.

CasePreviousTesting: N/A

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.N78Y (c.232A>T)

LegacyVariant: N/A

ClinVar: 223167 https://www.ncbi.nlm.nih.gov/clinvar/variation/223167/

CAID: CA357056 http://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/allele?hgvsOrDescriptor=NM_000551.3%3Ac.232A%3ET

gnomAD: N/A

VariantEvidence: N/A

MutationType: missense_variant; transversion

CivicName: N78Y (c.232A>T)

MultipleGeneVariants: N/A

PatientID: II.1

KindredID: 3

Case: M, 50Y0M, Ethnicity Unknown

DiseaseAssertion: VHL

FamilyInfo: He inherited the p.Pro81Ser mutation from his healthy father (I.1) and the other mutation occured de novo. The patient had a son (III.1) who inherited his germline VHL large deletion, but not the VHL p. Pro81Ser variant. The son also had another VHL mutation which he inherited from his healthy mother (II.2). The son presented with retinal and cerebellar hemangioblastomas as well as pancreatic cysts. Refer to figure 1, pedigree C for family information.

CohortInfo: Patients were registrants from the European-American Pheochromocytoma-Paraganglioma and German von Hippel-Lindau Disease Registries.

CasePresentingHPOs: HP:0010797, HP:0001737 (hemangioblastoma, pancreatic cysts)

CaseHPOFreeText: Presented with hemangioblastoma at age 50.

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: RET/SDHB/SDHD/SDHC

PreviouslyPublished: May have been previously published in 11106358 and/or 7563486.

SupplementalData: Yes, File 1 for methods.

Variant: p.P81S(c.241C>T)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 2233 https://www.ncbi.nlm.nih.gov/clinvar/variation/2233/

CAID: N/A

gnomAD: 0.0002179 https://gnomad.broadinstitute.org/variant/3-10183772-C-T

VariantEvidence: The patient was hemizygous for this mutation.

MutationType: missense_variant;transition

CivicName: Exon 1-3 Deletion and P81S (c.241C>T)

MultipleGeneVariants: Germline, VHL, Exon 1-3 deletion

PatientID: Carrier 13 (mother to proband 7)

KindredID: 3

Case: F, 50Y0M, Chinese

DiseaseAssertion: VHL

FamilyInfo: Father, mother and sister (all relative to proband 7) had this variant. Both father and sister were asymptomatic. Proband and mother presented with unilateral PCC.

CasePresentingHPOs: HP:0002666 (Pheochromocytoma)

CaseHPOFreeText: Unilateral PCC diagnosed at 22Y and did not have any other clinical presentations. Stated as having VHL type IIC.

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: N/A

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.P138Afs*6 (c.410dup)

LegacyVariant: 623insTTTGTtG

CaseProblemVariantFreeText: N/A

ClinVarID: N/A

CAID: CA432421860, https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/allele?hgvsOrDescriptor=NM_000551.3%3Ac.410dup

gnomAD: N/A

VariantEvidence: The VHL NM_000551.3 reference sequence surrounding nucleotide 410 is a TTTGTG sequence, where the 4th T is at position 410, which converts to nucleotide 623 in the legacy reference sequence (AF010238.1). Therefore it is assumed that the authors reported their insertion variant in the legacy nomenclature and this was mapped to p.Pro138Alafs*6 (c.410dup) in NM_000551.3.

MutationType: insertion; plus_1_frameshift_variant

CivicName: P138fs (c.410dup)

MultipleGeneVariants: N/A

PatientID: 1

KindredID: 1

Case: M, 51Y0M, Arab

DiseaseAssertion: VHL

FamilyInfo: Patient 2 (the patient’s brother) presented with the same mutation and was diagnosed with VHL at age 45. The two brothers had very similar VHL clinical manifestations including cerebellar hemangioblastomas, renal cell carcinoma, and cysts in the pancreas. However, patient 1 had testicular and epididymal cysts, as well as lesions in the spine, which were absent in Patient 2. No other family history was noted. Immediate family members were recommended to genetically test for the relevant variant or monitor for VHL-related symptoms.

CasePresentingHPOs: HP:0005584; HP:0009713; HP:0006880; HP:0000107; HP:0001737; HP:0030424; HP:0033608; HP:0000541; HP:0012215 (renal cell carcinoma; spinal hemangioblastoma; cerebellar hemangioblastoma; renal cyst; pancreatic cysts; epididymal cyst; pulmonary nodule; retinal detachment; testicular microlithiasis)

CaseHPOFreeText: At 44Y, Patient 1 exhibited cerebellar and spinal hemangioblastomas, as well as retinal detachment. He also had renal cell carcinoma in both kidneys and multiple cysts in one kidney, testis, and pancreas. He also reported a history of headaches and vertigo, leading to a diagnosis of VHL disease type 1. At 49Y, multiple nodules were found in his lungs and a year later, a nodule in the testis and scrotal lithiasis were detected. At 51Y, renal cell carcinoma was identified in the left kidney and his left epididymis was enlarged. Patient continued to present with left testicular and scrotal lithiasis, right retinal detachment, and multiple nodules in both lungs. However, tMutation:Germlinehe lung phenotype was asymptomatic (see table 1).

CaseNotHPOs: HP:0001392; HP:0005264; HP:0001743 (abnormality of the liver; abnormality of the gallbladder; abnormality of the spleen)

CaseNotHPOFreeText: No lesions were observed in the liver, gallbladder, and spleen.

CasePreviousTesting: N/A

PreviouslyPublished: N/A

SupplementalData:  N/A

Variant: p.F76del (c.227_229del)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: N/A

CAID: CA357012, https://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/allele?hgvsOrDescriptor=NM_000551.3%3Ac.227_229delTCT

gnomAD: N/A

VariantEvidence: N/A

MutationType: inframe_deletion

CivicName: F76del (c.227_229del)

MultipleGeneVariants: N/Av

PatientID: 25

KindredID: 6012

Case: F, 50Y0M, Ethnicity Unknown

DiseaseAssertion: VHL

FamilyInfo: Another member of her family, (patient 26) presented with one radiologic pancreatic neuroendocrine tumor and had the same VHL gene mutation.

CasePresentingHPOs: HP:0030405 (pancreatic endocrine tumour)

CaseHPOFreeText: She presented with two radiologic pancreatic endocrine tumour.

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: N/A

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.A149S (c.445G>T)

LegacyVariant: p.A149S (c.658G>T)

CaseProblemVariantFreeText: N/A

ClinVar:127829 https://www.ncbi.nlm.nih.gov/clinvar/variation/127829/

CAID: CA020355 http://reg.clinicalgenome.org/redmine/projects/registry/genboree_registry/allele?hgvsOrDescriptor=NM_000551.3%3Ac.445G%3ET

gnomAD: N/A

VariantEvidence: N/A

MutationType: missense_variant;transversion

CivicName: A149S (c.445G>T)

MultipleGeneVariants: N/A

PatientID: 3

KindredID: 2 (group ID 5)

Case: M, 52Y0M, Chinese

DiseaseAssertion: assumed VHL

CohortInfo: Clinical characteristics of 258 patients from 80 unrelated Chinese families were reported in this study. Grouped by the 21 mutations found, 2 families with 21 members total were described, and phenotypic information was given for this group.

FamilyInfo: In family 2, 4 members were described in a 3 generation family. The patient’s father, sister, and niece were also present with the VHL mutation. See Fig 4 for family pedigree; Table 3 for details.

CasePresentingHPOs: HP:0010797; HP:0002666 (hemangioblastoma, pheochromocytoma)

CaseHPOFreeText: CNS hemangioblastoma and pheochromocytoma both presented at age of onset of 50Y

CaseNotHPOs: N/A

CaseNotHPOFreeText: N/A

CasePreviousTesting: N/A

PreviouslyPublished: N/A

SupplementalData: N/A

Variant: p.W88R (c.262T>C)

LegacyVariant: N/A

CaseProblemVariantFreeText: N/A

ClinVarID: 496053 https://www.ncbi.nlm.nih.gov/clinvar/variation/496053/

CAID: N/A

gnomAD: N/A

VariantEvidence: N/A

MutationType: missense_variant;transition

CivicName: W88R (c.262T>C)

MultipleGeneVariants: N/A

reply to James Grooms at https://typewriterdatabase.com/show.21794.typewriter

Notes on differentiating the Underwood SS/Rhythm Touch, SX-50, SX-100, and SX-150

How was it that you identified your model here as an SX-50? Are there ads/photos/manuals for an SX-50?

The SX-100 ads you show seem to have a similar 5 stripes of chrome on the side which is similar to the previous SS/Rhythm Touch Models, but this chrome detailing seems to be missing from your SX-50 as well as the SX-150 advertisement.

Your SX-50 exemplar and the SX-150 advertisements also seem to have/show vertical touch adjustment and ribbon selector switches while the SS/Rhythm Touch and the ad for the SX-100 have horizontal sliders for the touch adjustment and a vertical ribbon selector.

The main page of the database mentions an SX-50 and an SX-150 in July of 1953, but doesn't have a corresponding mention of an SX-100. It reads: "Oct. 1953: Model SX 150, SX 50 started (7500000)"

Polt's site has an explicit manual for the SX-150 which may help to differentiate on both form and functionality: https://site.xavier.edu/polt/typewriters/Underwood150.pdf though there are no corresponding manuals for a 50 or a 100.

This Tumbr identifies Sean Connery's machine in Finding Forrester as an SX-100: https://www.tumblr.com/typewriterspotting/16181699692/spotted-in-finding-forrester-2000-forrester-and <br /> Here's an extended clip from the film: https://www.youtube.com/watch?v=juko0sAndsA <br /> and some still photos of it from Robert Messenger's site: https://oztypewriter.blogspot.com/search?q=finding+forrester <br /> Given the appearance in the film, it might actually be an SS/Rhythm Touch, but it's difficult to distinguish this as well without a clear view of the front.

The database still seems to have empty landing pages for the:<br /> - SX-50: https://typewriterdatabase.com/Underwood.SX-50.4.bmys <br /> - SX-50 11\": https://typewriterdatabase.com/Underwood.SX-50+11%22.4.bmys - SX-100: https://typewriterdatabase.com/Underwood.SX-100.4.bmys <br /> - SX-150: https://typewriterdatabase.com/Underwood.SX-150.4.bmys <br /> Presumably they existed previously, but without clear delineations of features/changes over time and were concatenated into the SX page?

Additionally, I'm noticing that some of the SX exemplars at the bottom of the page at https://typewriterdatabase.com/Underwood.SX.4.bmys are really badged as Underwood Golden Touches!

【令人震惊】斯坦福 CooperBench 发现：当两个顶级 Coding Agent 协作时，性能下降近 50%！这彻底打破了「Agent 越多越好」的直觉。更令人不安的是，失败集中在「中等难度」任务的甜区——恰好是最应该从协作中受益的区间。这对 Multi-Agent 架构设计者是一个严峻的警示：规模化 Agent 系统的瓶颈不在算力，而在「社会智能」。

令人震惊的发现：同一道题，仅仅因为周围塞入了无关上下文，推理模型的思考链长度就缩短了最多 50%——而题目本身一字未改。这意味着我们以为在评估模型「解题能力」，实际上评估的是「在特定上下文包装下的解题能力」。所有在孤立问题上测得的推理 benchmark，都可能严重高估了模型在真实 Agent 场景中的实际推理深度。

via u/Koponewt at https://old.reddit.com/r/typewriters/comments/1qbwkp4/need_help_identifying_typewriters/

for - quote - holocene - should have at least 50 during the last ice age

for - stats - elites - top 10% - responsible for 50% of consumer spending

https://www.reddit.com/r/typewriters/comments/1mqcu0f/erika_typewriters_i_am_looking_to_potentially_get/<br /> via LeSwiss1886

for - stats - CDC - underaged American children who have been molested - 50 million / year - 5 % boys - 25% girls

for - carbon inequality - stats - carbon inequality - 2 days of our carbon budget - if everyone emitted transportation emissions of 50 richest billionaires - source - Oxfam - Carbon Inequality kills - 2024

for - stats - inequality - US - past 50 years - wealth redistribution - $80 trillion from bottom 90% - to top 1%

ES as a discipline studied for 50 years

for - meaning crisis - 50 episodes - John Vervaeke - meaning crisis - summary table of 50 episodes

meaning crisis - summary table of the title of 50 episodes - 1: Introduction - 2: Flow, Metaphor, and the Axial Revolution - 3: Continuous Cosmos and Modern World Grammar - 4: Socrates and the Quest for Wisdom - 5: Plato and the Cave - 6:Aristotle, Kant, and Evolution - 7: Aristotle's World View and Erich Fromm - 8: The Buddha and "Mindfulness" - 9: Insight - 10: Consciousness - 11: Higher States of Consciousness, Part 1 - 12: Higher States of Consciousness, Part 2 - 13: Buddhism and Parasitic Processing - 14: Epicurians, Cynics, and Stoics - 15: Marcel Aurelius and Jesus - 16:Christianity and Agape - 17:Gnosis and Existential Inertia - 18: Plotinus and Neoplatonism - 19: Augustine and Aquinas - 20: Death of the Universe - 21: Martin Luther and Descartes - 22: Descartes vs. Hobbes - 23: Romanticism - 24: Hegel - 25: The Clash - 26: Cognitive Science - 27:Problem Formulation - 28: Convergence to Relevance Realization - 29: Getting to the Depths of Relevance Realization - 30: Relevance Realization Meets Dynamical Systems Theory - 31: Embodied-Embedded RR as Dynamical-Developmental GI - 32: in the Brain, Insight, and Consciousness - 33: The Spirituality of RR: Wonder/Awe/Mystery/Sacredness - 34: Sacredness: Horror, Music, and the Symbol - 35: The Symbol, Sacredness, and the Sacred - 36: Religio/Perennial Problems/Reverse Eng. Enlightenment - 37: Reverse Engineering Enlightenment: Part 2 - 38: Agape and 4E Cognitive Science - 39: The Religion of No Religion - 40: Wisdom and Rationality? - 41: What is Rationality? - 42: Intelligence, Rationality, and Wisdom - 43: Wisdom and Virtue - 44: Theories of Wisdom - 45: The Nature of Wisdom - 46: Conclusion and the Prophets of the Meaning Crisis - 47: Heidegger - 48: Corbin and the Divine Double - 49: Corbin and Jung - 50: Tillich and Barfield

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يحافظ ع المكان الاصلي للعناصر المجاورة ويتحرك بالنسبة الى نفسه عند تعيين قيم الخصائص top وright وbottom وleft لعنصر تم تحديد موضعه باستخدام position: relative، يتم تعديل موضع العنصر بعيدًا عن موضعه الطبيعي . هذا يعني أن العنصر يتحرك بالنسبة إلى مكانه الأصلي، لكنه يظل يشغل نفس المساحة في التدفق العادي. ملحوظة: عند تحريك العنصر بهذه الطريقة، لن يتم تعديل المحتوى الآخر لملء الفراغ الذي تركه العنصر. بمعنى آخر، المساحة الأصلية التي كان يشغلها العنصر قبل تحريكه تظل محفوظة كما هي.

for - inequality - stats - global income thresholds for top 0.1% to bottom 50%

inequality - stats - global income thresholds for top 0.1% to bottom 50% - top 0.1% - $38,000,000 - next 0.9% below - $10,000,000 (rest of top 1%) - next 9% below - $ 1,800,000 (rest of top 10%) - next 40% below - $165,382 (rest of top 50%) - bottom 50% - $0

for - stats - carbon inequality - poorest 50% emit 12% - richest 10% emit 48% - Chancel, 2022

DOI: 10.1016/j.celrep.2024.115035

Resource: (ZFIN Cat# ZDB-GENO-100412-50,RRID:ZFIN_ZDB-GENO-100412-50)

Curator: @areedewitt04

SciCrunch record: RRID:ZFIN_ZDB-GENO-100412-50

What is this?

Könntest du bei diesem Thema in Zukunft eine kleine Infografik einblenden, welche Frequenzabweichung welche Konsequenzen hätte? So ähnlich wie du das bei den Wasserfiltern und der Partikelgröße machst.<br /> Das würde es deutlich einfacher machen, diese Zahlen einschätzen zu können. :-)

https://www.ingenieur.de/technik/fachbereiche/energie/neue-vde-anwenderregel-50-2-hz-problem-beheben/

Darauf fußt die neue VDE AR-N 4105 und fordert: Wechselrichter dürfen sich im Bereich von 51,5 Hz und 47,5 Hz nicht mehr automatisch vom Netz trennen. Bei 50,2 Hz werden nicht mehr schlagartig die PV-Wechselrichter abgeschaltet, sondern deren Leistung reduziert; die „Leistungskennlinie bei Überfrequenz“ endet mit dem Abschalten des Wechselrichters erst bei 51,5 Hz.

https://de.wikipedia.org/wiki/Unterfrequenz#Deutschland

http://www.alexmumm.de/pg50Hz_de.htm

https://www.s0-recorder.com/energie-monitoring/kundenprojekte/50-hz-netzfrequenz-messung/

27.11.2024 21:00 UTC - circa 49,88 Hz

... absolut lächerlich, wie die netzfrequenz geheim gehalten wird, obwohl die jeder depp zu hause messen kann, mit jedem gerät mit audio eingang (samplerate 48KHz)

16:08 During the war, the USA moved 50% of the nations production to WAR. It woudl take a simple political decison to move 50% of the nations production to peace if peace is as profitable as war

14:22 The government spends money into existence

for - stats - earth system boundary - biodiversity - intact natural systems - 50 to 60% global land need to be intact

for - stats - climate crisis intervention - urgency - reduce emissions by 50% in 5 years!

Eine extreme hitzewelle in marokko hat in einer stadt im landesinneren an einemTag meh als 20 Todesopfer gefordert. Vorausgegangen. waren mehrere andere Hitzewellen. Sie sind laut einer Studie mit höchster Wahrscheinlichkeit der Erderhitzung durch Treibhausgase zuzuschreiben. https://www.liberation.fr/environnement/climat/maroc-une-vague-de-chaleur-sans-precedent-entraine-la-mort-de-plus-de-20-personnes-en-24-heures-20240725_YHPM3UEXSFDYLB7PYXNA5LO5F4/

• for: 1.5 Deg C target - 50/50 chance

• comment

  • What most people don't recognize and pay attention to is 50/50 chance that is part of the 1.5 Deg C target.
  • The world is up in arms about the 1.5 Deg C target when it ONLY GIVES US A 50/50 CHANCE!
  • These are not great odds! In fact, THESE ODDS ARE TERRIBLE! What if you were given those chances in your cancer treatment? You would be concerned, wouldn't you?
  • So what would an intervention closer to 90% chance of staying under 1.5 Deg C look like? If people consider today's intervention impossible, then a 90% chance would be beyond impossible. This is the nature of the challenge we face!

• for: do people know? - 50% chance, 1.5 Deg. C target - is still a crap shoot

• new trailmark: do people know?

• do people know?: 50% chance

  • the well known 1.5 Deg C. target, which currently seems almost impossible to achieve, is still a crap shoot! There is a 50% chance that if be we achieve it, we can still trigger very harmful impacts like tipping points

• for: science-based societal transformation, whole system change, overnight change, 50 year project, radical change
• paraphrase
  • this is not an overnight project
  • radical change would be dangerous
• comment
  • the word "radical" is subjective here
  • how does John view the latest earth system science about the need to reach zero emissions in less than a decade and likely 6 years in order to stay within 1.5 Deg C carbon budget?
    • is that considered radical change or not?

ReconfigBehSci. (2021, October 13). RT @PaulMainwood: Wales is first with their vaccine stock data this week, with a solid 1.6m new doses made available to the UK roll-out pro… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1448311825557118977

Peeples, L. (2021). COVID reinfections likely within one or two years, models propose. Nature. https://doi.org/10.1038/d41586-021-02825-8

via https://www.theglobeandmail.com/arts/books-and-media/nancy-pearls-rule-of-50-for-dropping-a-bad-book/article565170/

En este reportaje que hace El Tiempo, hace un recuento de su vida, analizando el apego de dos culturas muy distintas, pero son vecinas y que con el paso del tiempo se han vuelto casi opuestas. La cultura latina, en ese tiempo estaba muy desvalorizada contra la cultura americana y Selena en compañía de su familia que era su misma banda instrumental llamada "Los Dinos", recorrieron Estados Unidos y México, dándose a conocer con una mezcla de ambas culturas, debido al origen de la familia de Selena que se había independizado en Texas.

DOI: 10.7554/eLife.35796

Resource: (ZFIN Cat# ZDB-GENO-100113-50,RRID:ZFIN_ZDB-GENO-100113-50)

Curator: @evieth

SciCrunch record: RRID:ZFIN_ZDB-GENO-100113-50

What is this?

DOI: 10.1016/j.celrep.2015.07.064

Resource: (ZFIN Cat# ZDB-GENO-100412-50,RRID:ZFIN_ZDB-GENO-100412-50)

Curator: @mpairish

SciCrunch record: RRID:ZFIN_ZDB-GENO-100412-50

What is this?

DOI: 10.1371/journal.pgen.1005798

Resource: (ZFIN Cat# ZDB-GENO-100412-50,RRID:ZFIN_ZDB-GENO-100412-50)

Curator: @mpairish

SciCrunch record: RRID:ZFIN_ZDB-GENO-100412-50

What is this?

AssayResult: 3.9

AssayResultAssertion: Indeterminate

StandardErrorMean: 0.04

HGVS: NM_024675.3:c.3073G>A p.(Ala1025Thr)

AssayResult: 56.67

AssayResultAssertion: Not reported

ReplicateCount: 4

StandardErrorMean: 12.4

Comment: Exact values reported in “Source Data” file.

AssayResult: 21.79

AssayResultAssertion: Abnormal

ReplicateCount: 2

StandardDeviation: 1.84

StandardErrorMean: 1.3

Comment: Exact values reported in “Source Data” file.

HGVS: NM_024675.3:c.3209T>C p.(L1070P)

AssayResult: 0.2

AssayResultAssertion: Abnormal

ReplicateCount: 25

StandardErrorMean: 0.2

Comment: This variant had loss of function of peak current (<10% of wildtype), therefore it was considered abnormal (in vitro features consistent with Brugada Syndrome Type 1). (Personal communication: A. Glazer)

HGVS: NM_198056.2:c.4140C>A p.(Asn1380Lys)

AssayResult: 69

AssayResultAssertion: Normal

Comment: See Table S2 for details

AssayResult: 7.1

AssayResultAssertion: Abnormal

Comment: See Table S2 for details

HGVS: NM_000546.5:c.904G>A p.(Gly302Arg)

29% in 50 years? That means in the next 50 years half of the bird population could decrease!

DOI: 10.7554/eLife.54935

Resource: (ZFIN Cat# ZDB-GENO-100412-50,RRID:ZFIN_ZDB-GENO-100412-50)

Curator: @evieth

SciCrunch record: RRID:ZFIN_ZDB-GENO-100412-50

What is this?

§.50 of the Constitution Act, 1867.

§.50 of the Constitution Act, 1867.

§.50 of the Constitution Act, 1867.