- Jul 2020
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www.thelancet.com www.thelancet.com
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2020-07-06
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Pollán, M., Pérez-Gómez, B., Pastor-Barriuso, R., Oteo, J., Hernán, M. A., Pérez-Olmeda, M., Sanmartín, J. L., Fernández-García, A., Cruz, I., Larrea, N. F. de, Molina, M., Rodríguez-Cabrera, F., Martín, M., Merino-Amador, P., Paniagua, J. L., Muñoz-Montalvo, J. F., Blanco, F., Yotti, R., Blanco, F., … Villa, A. V. de la. (2020). Prevalence of SARS-CoV-2 in Spain (ENE-COVID): A nationwide, population-based seroepidemiological study. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)31483-5
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BackgroundSpain is one of the European countries most affected by the COVID-19 pandemic. Serological surveys are a valuable tool to assess the extent of the epidemic, given the existence of asymptomatic cases and little access to diagnostic tests. This nationwide population-based study aims to estimate the seroprevalence of SARS-CoV-2 infection in Spain at national and regional level.Methods35 883 households were selected from municipal rolls using two-stage random sampling stratified by province and municipality size, with all residents invited to participate. From April 27 to May 11, 2020, 61 075 participants (75·1% of all contacted individuals within selected households) answered a questionnaire on history of symptoms compatible with COVID-19 and risk factors, received a point-of-care antibody test, and, if agreed, donated a blood sample for additional testing with a chemiluminescent microparticle immunoassay. Prevalences of IgG antibodies were adjusted using sampling weights and post-stratification to allow for differences in non-response rates based on age group, sex, and census-tract income. Using results for both tests, we calculated a seroprevalence range maximising either specificity (positive for both tests) or sensitivity (positive for either test).FindingsSeroprevalence was 5·0% (95% CI 4·7–5·4) by the point-of-care test and 4·6% (4·3–5·0) by immunoassay, with a specificity–sensitivity range of 3·7% (3·3–4·0; both tests positive) to 6·2% (5·8–6·6; either test positive), with no differences by sex and lower seroprevalence in children younger than 10 years (<3·1% by the point-of-care test). There was substantial geographical variability, with higher prevalence around Madrid (>10%) and lower in coastal areas (<3%). Seroprevalence among 195 participants with positive PCR more than 14 days before the study visit ranged from 87·6% (81·1–92·1; both tests positive) to 91·8% (86·3–95·3; either test positive). In 7273 individuals with anosmia or at least three symptoms, seroprevalence ranged from 15·3% (13·8–16·8) to 19·3% (17·7–21·0). Around a third of seropositive participants were asymptomatic, ranging from 21·9% (19·1–24·9) to 35·8% (33·1–38·5). Only 19·5% (16·3–23·2) of symptomatic participants who were seropositive by both the point-of-care test and immunoassay reported a previous PCR test.InterpretationThe majority of the Spanish population is seronegative to SARS-CoV-2 infection, even in hotspot areas. Most PCR-confirmed cases have detectable antibodies, but a substantial proportion of people with symptoms compatible with COVID-19 did not have a PCR test and at least a third of infections determined by serology were asymptomatic. These results emphasise the need for maintaining public health measures to avoid a new epidemic wave.
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10.1016/S0140-6736(20)31483-5
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Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study
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www.sciencedirect.com www.sciencedirect.com
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2020-07-03
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Fontana, M., Iori, M., Montobbio, F., & Sinatra, R. (2020). New and atypical combinations: An assessment of novelty and interdisciplinarity. Research Policy, 49(7), 104063. https://doi.org/10.1016/j.respol.2020.104063
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Novelty indicators are increasingly important for science policy. This paper challenges the indicators of novelty as an atypical combination of knowledge (Uzzi et al., 2013) and as the first appearance of a knowledge combination (Wang et al., 2017). We exploit a sample of 230,854 articles (1985 - 2005), published on 8 journals of the American Physical Society (APS) and 2.4 million citations to test the indicators using (i) a Configuration Null Model, (ii) an external validation set of articles related to Nobel Prize winning researches and APS Milestones, (iii) a set of established interdisciplinarity indicators, and (iv) the relationship with the articles’ impact. We find that novelty as the first appearance of a knowledge combination captures the key structural properties of the citation network and finds it difficult to tell novel and non-novel articles apart, while novelty as an atypical combination of knowledge overlaps with interdisciplinarity. We suggest that the policy evidence derived from these measures should be reassessed.
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10.1016/j.respol.2020.104063
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New and atypical combinations: An assessment of novelty and interdisciplinarity
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twitter.com twitter.com
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2020-07-01
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Dr. Angela Rasmussen on Twitter: “@jan7681 If I was asked to comment on the intricacies of the luxury electric car market or how to secure NASA contracts, I’d defer to him.” / Twitter. (n.d.). Twitter. Retrieved July 7, 2020, from https://twitter.com/angie_rasmussen/status/1278346632254259200
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If I was asked to comment on the intricacies of the luxury electric car market or how to secure NASA contracts, I'd defer to him.
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When multiple people with infectious disease/epidemiology/virology experience point out that a billionaire celebrity CEO with zero knowledge of any of the above fundamentally doesn't understand how tests work, I'd defer to those with actual expertise.
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Therefore he is sand blasted because you believe others over him how do you know who to believe @jan7681
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That's not intended to "break his spirit." It is intended to correct the false and dangerous misinformation that he is spreading. Hospitalizations are not decreasing. Deaths are beginning to increase in the most heavily affected states.
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you guys are counter productive insulting helps no one do u really believe this is going to break his spirit i hope not rock on Elon @jan7681
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If Elon apparently doesn't understand the difference between PCR (false negatives are bad) and serology tests (false positives are bad), he shouldn't make epidemiological pronouncements about why hospitalizations are increasing. Go back to BSing about space travel or whatever
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twitter.com twitter.com
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2020-07-04
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Trisha Greenhalgh 😷 #BlackLivesMatter on Twitter: “Mask steaming up your glasses? Fix here. https://t.co/Yn3wf7remH” / Twitter. (n.d.). Twitter. Retrieved July 7, 2020, from https://twitter.com/trishgreenhalgh/status/1279413188367454209
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Mask steaming up your glasses? Fix here.
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www.healthline.com www.healthline.com
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2020-07-04
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Why Hanging Out at a Bar During the Pandemic Is a Terrible Idea. (2020, July 4). Healthline. https://www.healthline.com/health-news/why-hanging-out-at-a-bar-during-the-pandemic-is-a-terrible-idea
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Medical experts say bars are places with a high risk of easily spreading COVID-19.Among other factors, this is primarily due to the fact that they’re spots where large numbers of people gather indoors with little ventilation over long periods of time.When people are drinking in a bar, they can often become too relaxed, leading to safety rules and protocols falling by the wayside.Experts also point out that activities like going to church meet a lot of the same risk level criteria as going to a bar.
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Why Hanging Out at a Bar During the Pandemic Is a Terrible Idea
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www.bmj.com www.bmj.com
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2020-07-02
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Loder, E. (2020). Getting it right in the pandemic. BMJ, 370. https://doi.org/10.1136/bmj.m2637
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The pandemic is far from over, but it’s already obvious some countries have done better than others. Germany is one, with fewer infections and lower mortality from covid-19 than many of its European neighbours. Well timed lockdown measures and an extensive, community based system of testing and contact tracing have paid off, says Ralph Reintjes.1 There’s still time to get this right in the UK, argue Peter Roderick and colleagues.2 They emphasise the need to “think local” and reintegrate testing and contact tracing into established regional systems. Meanwhile, the current centralised approach and reliance on commercially run tests mean that results are not reliably communicated to patients’ GPs or those doing local contact tracing.
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10.1136/bmj.m2637
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Getting it right in the pandemic
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theconversation.com theconversation.com
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2020-07-02
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A cornerstone of containing the COVID-19 pandemic is widespread testing to identify cases and prevent new outbreaks emerging. This strategy is known as “test, trace and isolate”. The standard test so far has been the swab test, in which a swab goes up your nose and to the back of your throat. But an alternative method of specimen collection, using saliva, is being evaluated in Victoria and other parts of the world. It may have some benefits, even though it’s not as accurate.
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Explainer: what’s the new coronavirus saliva test, and how does it work?
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www.theguardian.com www.theguardian.com
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2020-07-05
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Spiegelhalter, D. (2020, July 5). Risks, R numbers and raw data: How to interpret coronavirus statistics. The Observer. https://www.theguardian.com/world/2020/jul/05/risks-r-numbers-and-raw-data-how-to-interpret-coronavirus-statistics
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Covid-related facts and definitions are confusing, and as lockdown is eased, clarity is more important than ever
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Risks, R numbers and raw data: how to interpret coronavirus statistics
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www.scientificamerican.com www.scientificamerican.com
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2020-06-19
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Though hotter, humid weather can dampen transmission, it is not enough to significantly curtail the pandemic
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Summer Weather Won’t Save Us from Coronavirus
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www.fastcompany.com www.fastcompany.com
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2020-06-16
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Architects and urban planners from Gensler, Harvard, and Bloomberg Associates explain the changes coming to our shared spaces.
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Six experts on how we’ll live, work, and play in cities after COVID-19
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www.nytimes.com www.nytimes.com
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2020-06-30
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Randomized controlled trials remain the gold standard, but natural experiments can help doctors who need answers now.
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What Coronavirus Researchers Can Learn From Economists
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2020-06-30
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10.1038/d41586-020-01976-4
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If your lab is still shuttered and work is a struggle, technology researcher Sun Sun Lim offers advice on how to switch off.
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How to get away from work mode during the coronavirus lockdown
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www.newscientist.com www.newscientist.com
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2020-07-03
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Taylor, L. (n.d.). How Cuba and Uruguay are quashing coronavirus as neighbours struggle. New Scientist. Retrieved July 6, 2020, from https://www.newscientist.com/article/2247740-how-cuba-and-uruguay-are-quashing-coronavirus-as-neighbours-struggle/
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As coronavirus cases soar in the US, Brazil and other countries in the Americas, some countries have found strategies to contain the virus and limit deaths. More than 5 million confirmed cases of covid-19 and nearly 250,000 related deaths have been reported in the Americas as of 29 June, around half of the world total. The coronavirus is spreading exponentially in many countries, warned Carissa Etienne, the director of the Pan American Health Organization (PAHO) on 9 June. But in a few places, the picture is very different. Cuba, an island of 11.3 million people is an unlikely exemplar of how to manage a pandemic, according to Michael Bustamante at Florida International University. Its infamously long queues for state-provided goods make social distancing and self-isolation difficult, he says, and the country’s healthcare system, “suffers from scarcities and material shortages that are characteristic of the Cuban economy as a whole”.
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How Cuba and Uruguay are quashing coronavirus as neighbours struggle
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www.newscientist.com www.newscientist.com
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2020-07-01
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Liverpool, C. W., Jessica Hamzelou, Adam Vaughan, Conrad Quilty-Harper and Layal. (n.d.). Covid-19 news: Almost 20,000 care home deaths in England and Wales. New Scientist. Retrieved July 6, 2020, from https://www.newscientist.com/article/2237475-covid-19-news-almost-20000-care-home-deaths-in-england-and-wales/
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The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
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Covid-19 news: Almost 20,000 care home deaths in England and Wales
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www.bloomberg.com www.bloomberg.com
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2020-07-01
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Tech’s Embrace of Remote Work Sends San Francisco Rents Plunging. (2020, July 1). Bloomberg.Com. https://www.bloomberg.com/news/articles/2020-07-01/tech-s-embrace-of-remote-work-sends-san-francisco-rents-plunging
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America’s priciest apartment-rental market suddenly has more bargains.Rents for a San Francisco one-bedroom apartment have dropped about 12% from this time last year, a record monthly decline for the city, according to a report from listing site Zumper. Silicon Valley hubs such as Mountain View and Palo Alto also saw rents plunge -- a sign residents of the tech-heavy region are taking advantage of remote work arrangements to flee to cheaper areas.
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Tech’s Embrace of Remote Work Sends San Francisco Rents Plunging
Tags
- price decrease
- rent
- ann:summary
- COVID-19
- ann:title
- has:date
- has:context
- lang:en
- is:news
- USA
- housing
- relocating
- market
- San Francisco
- remote work
Annotators
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books.google.com books.google.com
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2015-02-05
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Risk often gets a bad press. From the seemingly unnecessary actions of extreme sportspeople to the excessive risk appetites of serial entrepreneurs, the term 'risky' is often seen as synonymous with 'reckless', 'foolhardy' or even downright dangerous.But could any of us live in a world without risk, and would it be desirable to do so?Through a series of nine wonderfully rich pen portraits, Polly Morland takes us on a journey through the world of risk, looking not at the extremes or exceptions, but at the routine risks we accept and embrace as part of our everyday lives, often unconsciously.Meet the families who have lived happily on the slopes of Mount Vesuvius for generations; the Paris Opera ballet dancer facing up to the physical, psychological and reputational risks her profession demands; the New York City forensic engineer for whom being first on the scene is just part of the day job. And marvel at the parents and playworkers who every day balance the risks and rewards of how much autonomy and independence to afford growing children.The stories in Risk Wise address fundamental questions about risk and our perceptions about risk-taking. It argues that being risk wise - the ability to understand and accept risk as a force for good - is an essential part of the human experience and a route to living a full and rewarding life.
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Risk Wise: Nine Everyday Adventures
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www.newscientist.com www.newscientist.com
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2020-05-27
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THE coronavirus is still circulating yet many countries are taking steps to relax restrictions. If you have been asked to return to work or send your children back to school, how can you minimise the risk of infection to yourself and your family? Although there are still many unknowns about the virus, a growing amount of data on how it transmits and survives on surfaces can guide our decisions.
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At work, school and seeing friends: How to lower your coronavirus risk
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tamino.wordpress.com tamino.wordpress.com
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2020-07-03
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That means that, on their best behavior with full measures in place, it took New York state roughly 19 days to cut the case load in half. But unchecked, it took less than two days for it to double.
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COVID-19: Doing It Right
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www.nytimes.com www.nytimes.com
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2020-07-04
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Mandavilli, A. (2020, July 4). 239 Experts With One Big Claim: The Coronavirus Is Airborne. The New York Times. https://www.nytimes.com/2020/07/04/health/239-experts-with-one-big-claim-the-coronavirus-is-airborne.html
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The W.H.O. has resisted mounting evidence that viral particles floating indoors are infectious, some scientists say. The agency maintains the research is still inconclusive.
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239 Experts With One Big Claim: The Coronavirus Is Airborne
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twitter.com twitter.com
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2020-07-03
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brief video describing the http://scibeh.org initiative here:
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scibeh.org scibeh.org
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www.biorxiv.org www.biorxiv.org
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2020-06-11
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Corbett, K. S., Edwards, D., Leist, S. R., Abiona, O. M., Boyoglu-Barnum, S., Gillespie, R. A., Himansu, S., Schäfer, A., Ziwawo, C. T., DiPiazza, A. T., Dinnon, K. H., Elbashir, S. M., Shaw, C. A., Woods, A., Fritch, E. J., Martinez, D. R., Bock, K. W., Minai, M., Nagata, B. M., … Graham, B. S. (2020). SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness. BioRxiv, 2020.06.11.145920. https://doi.org/10.1101/2020.06.11.145920
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10.1101/2020.06.11.145920
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A SARS-CoV-2 vaccine is needed to control the global COVID-19 public health crisis. Atomic-level structures directed the application of prefusion-stabilizing mutations that improved expression and immunogenicity of betacoronavirus spike proteins. Using this established immunogen design, the release of SARS-CoV-2 sequences triggered immediate rapid manufacturing of an mRNA vaccine expressing the prefusion-stabilized SARS-CoV-2 spike trimer (mRNA-1273). Here, we show that mRNA-1273 induces both potent neutralizing antibody and CD8 T cell responses and protects against SARS-CoV-2 infection in lungs and noses of mice without evidence of immunopathology. mRNA-1273 is currently in a Phase 2 clinical trial with a trajectory towards Phase 3 efficacy evaluation.
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SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness
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www.frontiersin.org www.frontiersin.org
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Cai, X., Ma, Y., Li, S., Chen, Y., Rong, Z., & Li, W. (2020). Clinical Characteristics of 5 COVID-19 Cases With Non-respiratory Symptoms as the First Manifestation in Children. Frontiers in Pediatrics, 8. https://doi.org/10.3389/fped.2020.00258
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2020-05-12
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An outbreak of the novel coronavirus disease 2019 (COVID-19) occurred in Wuhan, China, in December 2019, which then rapidly spread to more than 80 countries. However, detailed information on the characteristics of COVID-19 in children is still scarce. Five patients with non-respiratory symptoms as the first manifestation were hospitalized from the emergency department, and were later confirmed to have COVID-19, between 23 January and 20 February 2020, at the Wuhan Children's Hospital. SARS-CoV-2 nucleic acid detection was positive for all the patients. Four of the patients were male and one was female, and their ages ranged from 2-months to 5.6 years. All lived in Wuhan. One patient had a clear history of exposure to SARS-CoV-2, one had a suspected history of exposure, while the others had no exposure history. For three of the five patients, the primary onset disease required an emergency operation or treatment, and included intussusception, acute suppurative appendicitis perforation with local peritonitis, and traumatic subdural hemorrhage with convulsion, while for the other two it was acute gastroenteritis (including one patient with hydronephrosis and a stone in his left kidney). During the course of the disease, four of the five patients had a fever, whereas one case had no fever or cough. Two patients had leukopenia, and one also had lymphopenia. In the two cases of severe COVID-19, the levels of CRP, PCT, serum ferritin, IL-6, and IL-10 were significantly increased, whereas the numbers of CD3+, CD4+, CD8+ T lymphocytes, and CD16 + CD56 natural killer cells were decreased. We also found impaired liver, kidney, and myocardial functions; the presence of hypoproteinemia, hyponatremia, and hypocalcemia; and, in one case, abnormal coagulation function. Except for one patient who had a rotavirus infection, all patients tested negative for common pathogens, including the influenza virus, parainfluenza virus, respiratory syncytial virus, adenovirus, enterovirus, mycoplasma, Chlamydia, and Legionella. Chest CT images of all the patients showed patches or ground-glass opacities in the lung periphery or near the pleura, even large consolidations. This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children.
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10.3389/fped.2020.00258
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Clinical Characteristics of 5 COVID-19 Cases With Non-respiratory Symptoms as the First Manifestation in Children
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www.biorxiv.org www.biorxiv.org
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2020-06-12
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Zhang, L., Jackson, C. B., Mou, H., Ojha, A., Rangarajan, E. S., Izard, T., Farzan, M., & Choe, H. (2020). The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity. BioRxiv, 2020.06.12.148726. https://doi.org/10.1101/2020.06.12.148726
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SARS coronavirus 2 (SARS-CoV-2) isolates encoding a D614G mutation in the viral spike (S) protein predominate over time in locales where it is found, implying that this change enhances viral transmission. We therefore compared the functional properties of the S proteins with aspartic acid (SD614) and glycine (SG614) at residue 614. We observed that retroviruses pseudotyped with SG614 infected ACE2-expressing cells markedly more efficiently than those with SD614. This greater infectivity was correlated with less S1 shedding and greater incorporation of the S protein into the pseudovirion. Similar results were obtained using the virus-like particles produced with SARS-CoV-2 M, N, E, and S proteins. However, SG614 did not bind ACE2 more efficiently than SD614, and the pseudoviruses containing these S proteins were neutralized with comparable efficiencies by convalescent plasma. These results show SG614 is more stable than SD614, consistent with epidemiological data suggesting that viruses with SG614 transmit more efficiently.
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10.1101/2020.06.12.148726
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The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity
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www.frontiersin.org www.frontiersin.org
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Zhou, Q., Chen, V., Shannon, C. P., Wei, X.-S., Xiang, X., Wang, X., Wang, Z.-H., Tebbutt, S. J., Kollmann, T. R., & Fish, E. N. (2020). Interferon-α2b Treatment for COVID-19. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.01061
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2020-05-15
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10.3389/fimmu.2020.01061
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The global pandemic of COVID-19 cases caused by infection with SARS-CoV-2 is ongoing, with no approved antiviral intervention. We describe here the effects of treatment with interferon (IFN)-α2b in a cohort of confirmed COVID-19 cases in Wuhan, China. In this uncontrolled, exploratory study, 77 adults hospitalized with confirmed COVID-19 were treated with either nebulized IFN-α2b (5 mU b.i.d.), arbidol (200 mg t.i.d.) or a combination of IFN-α2b plus arbidol. Serial SARS-CoV-2 testing along with hematological measurements, including cell counts, blood biochemistry and serum cytokine levels, and temperature and blood oxygen saturation levels, were recorded for each patient during their hospital stay. Treatment with IFN-α2b with or without arbidol significantly reduced the duration of detectable virus in the upper respiratory tract and in parallel reduced duration of elevated blood levels for the inflammatory markers IL-6 and CRP. These findings suggest that IFN-α2b should be further investigated as a therapy in COVID-19 cases.
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Interferon-α2b Treatment for COVID-19
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Su, Q., Hu, J., Lin, H., Zhang, Z., Zhu, E. C., Zhang, C., Wang, D., Gao, Z., & Cao, B. (2020). Prevalence and risks of severe events for cancer patients with COVID-19 infection: A systematic review and meta-analysis. MedRxiv, 2020.06.23.20136200. https://doi.org/10.1101/2020.06.23.20136200
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2020-06-24
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Background The corona virus disease 2019 (COVID-19) pandemic poses a severe challenge to public health, especially to those patients with underlying diseases. In this meta-analysis, we studied the prevalence of cancer among patients with COVID-19 infection and their risks of severe events. Methods We searched the Pubmed, Embase and MedRxiv databases for studies between December 2019 and May 3, 2020 using the following key words and terms: sars-cov-2, covid-19, 2019-ncov, 2019 novel coronavirus, corona virus disease-2019, clinical, clinical characteristics, clinical course, epidemiologic features, epidemiology, and epidemiological characteristics. We extracted data following PICO (patient, intervention, comparison and outcome) chart. Statistical analyses were performed with R Studio (version 3.5.1) on the group-level data. We assessed the studies risk of bias in accordance to the adjusted Joanna Briggs Institute. We estimated the prevalence or risks for severe events including admission into intensive care unit or death using meta-analysis with random effects. Findings Out of the 2,551 studies identified, 32 studies comprising 21,248 participants have confirmed COVID-19. The total prevalence of cancer in COVID-19 patients was 3.97% (95% CI, 3.08% to 5.12%), higher than that of the total cancer rate (0.29%) in China. Stratification analysis showed that the overall cancer prevalence of COVID-19 patients in China was 2.59% (95% CI, 1.72% to 3.90%), and the prevalence reached 3.79% in Wuhan (95% CI, 2.51% to 5.70%) and 2.31% (95% CI, 1.16% to 4.57%) in other areas outside Wuhan in China. The incidence of ICU admission in cancer patients with COVID-19 was 26.80% (95% CI, 21.65% to 32.67%) and the mortality was 24.32% (95% CI, 13.95% to 38.91%), much higher than the overall rates of COVID-19 patients in China. The fatality in COVID patients with cancer was lower than those with cardiovascular disease (OR 0.49; 95% CI, 0.34 to 0.71; p=0.39), but comparable with other comorbidities such as diabetes (OR 1.32; 95% CI, 0.42 to 4.11; p=0.19), hypertension (OR 1.27; 95% CI, 0.35 to 4.62; p=0.13), and respiratory diseases (OR 0.79; 95% CI, 0.47 to 1.33; p=0.45). Interpretation This comprehensive meta-analysis on the largest number of patients to date provides solid evidence that COVID-19 infection significantly and negatively affected the disease course and prognosis of cancer patients. Awareness of this could help guide clinicians and health policy makers in combating cancer in the context of COVID-19 pandemic
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10.1101/2020.06.23.20136200
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Prevalence and risks of severe events for cancer patients with COVID-19 infection: a systematic review and meta-analysis
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Flushing “can propel viral infection 3ft into air.” (2020, June 16). BBC News. https://www.bbc.com/news/health-53047819
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2020-06-16
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Flushing the toilet with the lid up creates a cloud of spray that can be breathed in and may spread infection, such as coronavirus, say researchers.
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Flushing 'can propel viral infection 3ft into air'
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aip.scitation.org aip.scitation.org
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2020-06-16
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Coronavirus cases may be linked to brain complications, study finds. (n.d.). Thetowntalk. Retrieved July 5, 2020, from https://www.usatoday.com/story/news/health/2020/06/27/coronavirus-cases-may-linked-brain-complications-study-finds/3270615001/
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Currently, a novel coronavirus named “SARS-CoV-2” is spreading rapidly across the world, causing a public health crisis, economic losses, and panic. Fecal–oral transmission is a common transmission route for many viruses, including SARS-CoV-2. Blocking the path of fecal–oral transmission, which occurs commonly in toilet usage, is of fundamental importance in suppressing the spread of viruses. However, to date, efforts at improving sanitary safety in toilet use have been insufficient. It is clear from daily experience that flushing a toilet generates strong turbulence within the bowl. Will this flushing-induced turbulent flow expel aerosol particles containing viruses out of the bowl? This paper adopts computational fluid dynamics to explore and visualize the characteristics of fluid flow during toilet flushing and the influence of flushing on the spread of virus aerosol particles. The volume-of-fluid (VOF) model is used to simulate two common flushing processes (single-inlet flushing and annular flushing), and the VOF–discrete phase model (DPM) method is used to model the trajectories of aerosol particles during flushing. The simulation results are alarming in that massive upward transport of virus particles is observed, with 40%–60% of particles reaching above the toilet seat, leading to large-scale virus spread. Suggestions concerning safer toilet use and recommendations for a better toilet design are also provided
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10.1063/5.0013318
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Can a toilet promote virus transmission? From a fluid dynamics perspective
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eu.thetowntalk.com eu.thetowntalk.com
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2020-06-29
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A new study found evidence of a correlation between severe cases of COVID-19 and brain complications, but researchers aren't sure whether those complications are directly caused by the disease.
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COVID-19 may be linked to brain complications, study finds. But does it cause them?
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www.thelancet.com www.thelancet.com
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2020-06-25
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Varatharaj, A., Thomas, N., Ellul, M. A., Davies, N. W. S., Pollak, T. A., Tenorio, E. L., Sultan, M., Easton, A., Breen, G., Zandi, M., Coles, J. P., Manji, H., Al-Shahi Salman, R., Menon, D. K., Nicholson, T. R., Benjamin, L. A., Carson, A., Smith, C., Turner, M. R., … Plant, G. (2020). Neurological and neuropsychiatric complications of COVID-19 in 153 patients: A UK-wide surveillance study. The Lancet Psychiatry. https://doi.org/10.1016/S2215-0366(20)30287-X
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BackgroundConcerns regarding potential neurological complications of COVID-19 are being increasingly reported, primarily in small series. Larger studies have been limited by both geography and specialty. Comprehensive characterisation of clinical syndromes is crucial to allow rational selection and evaluation of potential therapies. The aim of this study was to investigate the breadth of complications of COVID-19 across the UK that affected the brain.MethodsDuring the exponential phase of the pandemic, we developed an online network of secure rapid-response case report notification portals across the spectrum of major UK neuroscience bodies, comprising the Association of British Neurologists (ABN), the British Association of Stroke Physicians (BASP), and the Royal College of Psychiatrists (RCPsych), and representing neurology, stroke, psychiatry, and intensive care. Broad clinical syndromes associated with COVID-19 were classified as a cerebrovascular event (defined as an acute ischaemic, haemorrhagic, or thrombotic vascular event involving the brain parenchyma or subarachnoid space), altered mental status (defined as an acute alteration in personality, behaviour, cognition, or consciousness), peripheral neurology (defined as involving nerve roots, peripheral nerves, neuromuscular junction, or muscle), or other (with free text boxes for those not meeting these syndromic presentations). Physicians were encouraged to report cases prospectively and we permitted recent cases to be notified retrospectively when assigned a confirmed date of admission or initial clinical assessment, allowing identification of cases that occurred before notification portals were available. Data collected were compared with the geographical, demographic, and temporal presentation of overall cases of COVID-19 as reported by UK Government public health bodies.FindingsThe ABN portal was launched on April 2, 2020, the BASP portal on April 3, 2020, and the RCPsych portal on April 21, 2020. Data lock for this report was on April 26, 2020. During this period, the platforms received notification of 153 unique cases that met the clinical case definitions by clinicians in the UK, with an exponential growth in reported cases that was similar to overall COVID-19 data from UK Government public health bodies. Median patient age was 71 years (range 23–94; IQR 58–79). Complete clinical datasets were available for 125 (82%) of 153 patients. 77 (62%) of 125 patients presented with a cerebrovascular event, of whom 57 (74%) had an ischaemic stroke, nine (12%) an intracerebral haemorrhage, and one (1%) CNS vasculitis. 39 (31%) of 125 patients presented with altered mental status, comprising nine (23%) patients with unspecified encephalopathy and seven (18%) patients with encephalitis. The remaining 23 (59%) patients with altered mental status fulfilled the clinical case definitions for psychiatric diagnoses as classified by the notifying psychiatrist or neuropsychiatrist, and 21 (92%) of these were new diagnoses. Ten (43%) of 23 patients with neuropsychiatric disorders had new-onset psychosis, six (26%) had a neurocognitive (dementia-like) syndrome, and four (17%) had an affective disorder. 18 (49%) of 37 patients with altered mental status were younger than 60 years and 19 (51%) were older than 60 years, whereas 13 (18%) of 74 patients with cerebrovascular events were younger than 60 years versus 61 (82%) patients older than 60 years.InterpretationTo our knowledge, this is the first nationwide, cross-specialty surveillance study of acute neurological and psychiatric complications of COVID-19. Altered mental status was the second most common presentation, comprising encephalopathy or encephalitis and primary psychiatric diagnoses, often occurring in younger patients. This study provides valuable and timely data that are urgently needed by clinicians, researchers, and funders to inform immediate steps in COVID-19 neuroscience research and health policy.
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10.1016/S2215-0366(20)30287-X
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Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study
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www.nbcnews.com www.nbcnews.com
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Does air conditioning spread the coronavirus? (n.d.). NBC News. Retrieved July 5, 2020, from https://www.nbcnews.com/health/health-news/does-air-conditioning-spread-coronavirus-n1232175
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2020-06-26
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The question comes as states are allowing indoor businesses to reopen, as well as allowing increasingly large gatherings of people.
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Does air conditioning spread the coronavirus?
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2020-06-28
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These Canadians say they suffered COVID-19 symptoms for months. (n.d.). Global News. Retrieved July 5, 2020, from https://globalnews.ca/news/7107137/coronavirus-long-term-symptoms/
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A handful of mostly small studies have described the existence of cases where patients had symptoms or were shedding virus for longer than 20 days, though they appear to be a fairly small percentage.A recent preprint, not yet peer-reviewed study of patients in Atlanta, Georgia, noted that reported symptoms “remained common” after three weeks. The study “highlights the persistence of symptoms that may interfere with usual activity, such as shortness of breath with exertion,” the authors wrote.In many of these patients, symptoms “appear to wax and wane,” Jenne said.“So they’ll have sort of attacks or flares and then it’ll go away. And throughout this time, people have been shown to test positive for the virus. So it seems as though that they don’t actually clear all the virus.”
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These Canadians say they suffered COVID-19 symptoms for months
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www.siliconrepublic.com www.siliconrepublic.com
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2020-06-29
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RCSI is set to begin clinical trials for a promising drug therapy that could benefit those with severe Covid-19 infections.
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RCSI team to start trial for promising Covid-19 therapy for severe infections
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www.news-medical.net www.news-medical.net
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2020-06-29
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SARS-CoV-2 circulating in Italy in December 2019. (2020, June 29). News-Medical.Net. https://www.news-medical.net/news/20200629/SARS-CoV-2-circulating-in-Italy-in-December-2019.aspx
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Researchers at the Istituto Superiore di Sanità (Italian National Institute of Health) have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had already been circulating in Italy many weeks before the first autochthonous (native) case was documented on February 21st this year. The team conducted a retrospective search for genomic traces of the virus in sewage samples taken from wastewater treatment plants (WTPs) in northern Italy before the first autochthonous case had been recorded. Eight samples tested positive for SARS-CoV-2, with the earliest case dating all the way back to December 18th, 2019.
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SARS-CoV-2 circulating in Italy in December 2019
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psyarxiv.com psyarxiv.com
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2020-07-03
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Kim, H., & Florack, A. (2020). When Social Interaction Backfires: Frequent Social Interaction during the COVID-19 Pandemic Period Is Associated with Decreased Well-Being and Higher Panic Buying. https://doi.org/10.31234/osf.io/sg5vx
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10.31234/osf.io/sg5vx
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The present research investigated a backfiring effect of social interaction on well-being and general confidence in Western populations during the COVID-19 pandemic period. Across two studies, we observed that stronger self-other connectedness and frequent social communication with others during the first few weeks into the quarantine period led to worsened well-being and decreased general confidence. In study 1 (n = 331), we showed that people who reported higher social connectedness and more frequent social interaction experienced declined well-being. In study 2 (n = 327), we replicated the backfiring effect and showed that those who engaged in frequent social interaction, especially in COVID-19 related conversations, reported decreased general confidence, which mediated the accelerating effect of social interaction on panic buying. Overall, our findings indicated that frequent social interaction under a highly novel and uncertain crisis can induce negative consequences on mental health and behavior.
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When Social Interaction Backfires: Frequent Social Interaction during the COVID-19 Pandemic Period Is Associated with Decreased Well-Being and Higher Panic Buying
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www.nytimes.com www.nytimes.com
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2020-07-01
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Resuming classroom instruction is crucial. Infection control inside and outside classrooms can let it happen.
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We Have to Focus on Opening Schools, Not Bars
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www.dailymail.co.uk www.dailymail.co.uk
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2020-06-10
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Stickings, T. (2020, June 10). Secondary schools resume in Spain, Netherlands and South Africa. Mail Online. https://www.dailymail.co.uk/news/article-8406723/Secondary-schools-resume-Spain-Netherlands-South-Africa.html
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Spain, the Netherlands and South Africa are among the countries where secondary schools have resumedSwiss and Dutch authorities both say there is only a very small risk of younger pupils spreading the diseaseThe issue is a political battleground in Britain where Boris Johnson and Keir Starmer squabbled at PMQs today
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Secondary schools re-open in Spain and South Africa while ALL primary-age children resume lessons in the Netherlands and Switzerland... as politicians squabble in Britain
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www.timesofisrael.com www.timesofisrael.com
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2020-06-04
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staff, T. O. I. (n.d.). Over 20 more schools closed as Israel sees largest daily virus rise in a month. Retrieved July 4, 2020, from https://www.timesofisrael.com/over-20-more-schools-closed-as-israel-sees-largest-daily-virus-rise-in-a-month/
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Education Ministry says 301 students, teachers have tested positive for COVID-19 during fresh outbreak, leading to shuttering of 87 educational institutions across country
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Over 20 more schools closed as Israel sees largest daily virus rise in a month
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www.folkhalsomyndigheten.se www.folkhalsomyndigheten.se
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Det är av vikt att identifiera grupper i befolkningen som har en ökad risk att drabbas av allvarlig sjuklighet och dödlighet i covid-19 i syfte att bedriva riktade insatser och förebygga fortsatt smittspridning. För att få kunskap om insjuknande i covid-19 skiljer sig mellan olika yrkesgrupper har persondata från anmälningarmed bekräftad covid-19 samkörts med register över yrkesklassificering vid SCB. De som har diagnostiserats under perioden 13 mars – 27 maj har inkluderats i analyserna. Den högsta relativa förekomsten av covid-19 återfanns bland yrkesgruppen taxiförare m.fl., 4.8 gånger högre i jämförelse med övriga yrkesgrupper, följt av yrkesgrupperna pizzabagare m.fl. och buss- och spårvagnsförare. Personal inomskola har inte någon högre relativ förekomst i jämförelse med övriga yrken.
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Förekomst av covid-19 i olika yrkesgrupper
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2020-05
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medium.com medium.com