With your Kokuyo Binder- do you know of a way to bind relatively large numbers of pages together? I want to use something like this as my commonplace book and archive as I go, but once I get enough archived on a given subject, I'd like to bind it as a sort of compendium. Does that seem possible with these or are they not good for larger numbers of pages?

Translocation to a cell’s surface utilizes a signal peptide (for inner membrane translocation) and AIDAc as an outer membrane autotransporter pore

Agreements are subjected to climate agreements and not the other way around that could be 00:53:10 an option

In Bound to Read, Jeffrey Todd Knight excavates this culture of compilation—of binding and mixing texts, authors, and genres into single volumes—and sheds light on a practice that not only was pervasive but also defined the period's very ways of writing and thinking.

In this early period of print, before the introduction of commercial binding, most published literary texts did not stand on shelves in discrete, standardized units. They were issued in loose sheets or temporarily stitched—leaving it to the purchaser or retailer to collect, configure, and bind them.

Creating more legally binding licenses and contracts just perpetuates the problem of law – a.k.a. state force – intruding where it doesn’t belong.

That ♡copyheart isn’t a legally binding license is not a bug – it’s a feature!

(5) contain any article requested by petition signed by at least 10 percent of the voters and filed with the Town Clerk at least 45 days prior to the day of the meeting; and

§ 19-412. Petitions (a) Number of signatures. Initiative and referendum petitions must be signed by at least five percent of the legal voters of the City. (b) Form and content. All papers of a petition shall be uniform in size and style and shall be assembled as one instrument for filing. Each signature shall be executed in ink or indelible pencil and shall be followed by the address of the person signing. Petitions shall contain or have attached thereto throughout their circulation the full text of the ordinance proposed or sought to be reconsidered. (c) Affidavit of circulator. Each paper of a petition shall have attached to it when filed an affidavit executed by the circulator thereof stating that he or she personally circulated the paper, the number of signatures thereon, that all the signatures were affixed in his or her presence, that they are believed to be the genuine signatures of the persons whose names they purport to be, and that each signer had an opportunity before signing to read the full text of the ordinance proposed or sought to be reconsidered. (d) Time for filing referendum petitions. Referendum petitions must be filed within 30 days after adoption by the Council of the ordinance sought to be reconsidered. (Added 2015, No. M-19 (Adj. Sess.), § 2, eff. May 17, 2016.)

(2) Petition for inclusion in the warning of an article to adopt an ordinance. (A) Such petition shall be signed by at least 10 percent of the voters of the Town and shall state that it is to be binding.

§ 107-3.5. Recall (a) The voters of the Town may recall any of the elected Town or Town School District officers listed in subchapter 2, section 2.1 of this charter. (b) A recall petition, signed by at least 25 percent of the legal voters of the Town, and bearing their addresses, shall be filed with the Town Clerk within 15 calendar days of its issue. The Town Clerk upon receipt of a valid petition shall, between 45 and 60 calendar days, hold a special election with voting by Australian ballot to consider the recall of an elected Town officer. (c) When such a petition is approved by a majority of the ballots cast at such special election, the Town officer named in the petition shall thereupon cease to hold the office. (d) A vacancy resulting from the recall of an officer shall be filled in the manner prescribed by law. (e) A recall petition shall not be brought against an individual more than once within 12 months. (Amended 2011, No. M-10 (Adj. Sess.), § 2, eff. April 27, 2012.)

§ 107-3.4. Referendum The voters of the Town may petition for a referendum, by Australian ballot of all voters of the Town, on a final vote on a warned article taken by Representative Town Meeting. Such petition shall be filed within 10 days after adjournment of the meeting. (1) A petition for referendum shall be signed by at least five percent of the voters of the Town; or (2) A petition for referendum shall be signed by at least 50 Representative Town Meeting members. (Amended 2011, No. M-10 (Adj. Sess.), § 2, eff. April 27, 2012.)

The warning shall also contain any article or articles requested by a petition signed by at least five percent of the legal voters of the municipality and filed with the legislative branch not less than 40 days before the day of such meeting.

The Clerk of the City shall at any time when directed by the City Council, or when petitioned in writing by at least five percent of the registered voters of the City and filed with the City Clerk no less than 40 days before the day of such meeting, call a special meeting of the legal voters of the City, for any legal purpose, in the same manner as is provided for the annual meeting, except as is hereinafter provided: (1) Whenever a petition is brought for a meeting to rescind or reconsider the action taken at a previously held City meeting, the number of names required shall be 10 percent of the legal voters, and the petition shall be filed with the City Clerk within 30 days following the date of that meeting.

(c) Initiative. Any lawful ordinance may be enacted by vote of the Town as follows:  A petition signed by not less than five percent of the registered voters shall be filed with the Town Clerk requesting enactment of the ordinance and accompanied by the text thereof. The warning for the next annual Town meeting shall include the text of the proposed ordinance and shall provide for a "yes" or "no" vote.

(f) Referendum. (1) A Town ordinance may be repealed by vote of the Town as follows: A petition requesting a vote on the question of repealing the ordinance shall be signed by not less than five percent of the registered voters and shall be filed with the Town Clerk within 40 days following the date of adoption of the ordinance by the Selectboard. The Selectboard shall call a special Town meeting to be held within 60 days of the date of filing the petition to vote by Australian ballot on whether or not the ordinance shall be repealed. The warning shall include the text of the proposed ordinance and shall provide for a "yes" or "no" vote.

(c) The warning for annual and special City meetings shall, by separate articles, specifically indicate the business to be transacted, including the offices and the questions to be voted upon. The warning also shall contain any legally binding article or articles requested by 10 percent of the registered voters of the City. Petitions requesting that an article or articles be placed on the warning shall be filed with the City Clerk on or before the filing deadline set forth in 17 V.S.A. § 2642(a)(3). (Amended 2005, No. M-7, § 4; 2007, No. M-5, § 2; 2017, No. M-10, § 2, eff. May 30, 2017.)

Any lawful ordinance may be enacted by vote of the Town as follows:  A petition signed by not less than 15 percent of the registered voters shall be filed with the Town Clerk requesting enactment of the ordinance and accompanied by the text thereof. The selectmen shall call a special Town meeting to be held within 60 days of the date the petition is filed, unless prior to such meeting, the selectmen shall have enacted the ordinance. The warning for the meeting shall include a summary of the text of the proposed ordinance, its effective date and penalty provision for violation thereof, and shall be posted and published as the law of this State requires for special meeting generally. The warning shall provide for a "yes" and "no" vote by ballot as to its enactment. Copies of the proposed ordinance shall be posted in its entirety in at least five locations in Town for at least 30 consecutive days to the date of said special Town meeting. In the discretion of the selectmen, the enactment of such ordinance may be proposed as an article in the warning for the next ensuing annual Town meeting, providing that such annual meeting shall be held within 120 days of the filing of such petition for enactment.

§ 124-6. Removal of elected Town officers Any elected Town officer may be removed from office subject to the following conditions and procedures: (1) A written petition, signed by not less than 15 percent of the registered voters of the Town, seeking the removal of such Town officer or officers, and requesting a vote of the Town at a regular or special meeting called for the purpose, shall be filed with the Selectboard and the Town Clerk. (2) Within 15 days after receipt of the petition, the Selectboard shall warn a special Town meeting, or if the annual meeting is to occur within 45 days of the filing of the petition, include an article in the warning for the annual meeting, for the purpose of voting, by Australian ballot, on whether the officer or officers shall be removed from office. (3) The officer or officers shall be removed from office only if at least as many registered voters of the Town cast votes in the special Town meeting or annual meeting as voted in the election wherein the officer subject to the vote of removal was originally elected. (4) Removal shall require a majority of the votes cast at the regular or special Town meeting. (5) If an officer is removed according to the foregoing procedure, the officer shall forthwith cease to hold office and the office shall become vacant. The vacancy shall be filled as provided by law and this charter. (6) Only one petition for removal may be filed against any given elected officer during any 12-month period of his or her term of office. (Added 2005, No. M-9 (Adj. Sess.), § 2, eff. Feb. 24, 2005.)

The warning also shall contain any legally binding article or articles requested by 10 percent of the registered voters of the City. The warning shall also include any nonlegally binding articles, including matters of State, national, or international importance requested by five percent of the voters.

133-103. Recall Any elected official or official appointed to elective office holding a Town office may be recalled by the following process: (1) A petition signed by not less than 35 percent of the number of registered voters voting in the last annual Town meeting shall be filed with the Town Clerk. (2) The petition shall request a special Town meeting for the purpose of recalling a specific person or persons and shall state the office that they hold. (3) The selectmen shall act upon the petition within seven days by warning a special Town meeting. (4) The Town meeting shall be held not less than 30 days and not more than 40 days from the date of the receipt of the petition. (5) The special Town meeting shall be warned as provided by the general law of this State. (6) At least four days but not more than 15 days prior to the voting, an informational meeting shall be held at which time both the elected official and the proponents for the recall shall have the opportunity to discuss the issue of recall. The informational meeting shall be warned in conjunction with the warning for the special Town meeting. (7) Voting on the issue of recall shall be by Australian ballot. A majority of the legal votes cast shall be needed to effect a recall of that official.

§ 151-21. Recall Any Town officer, as defined by 17 V.S.A. § 2646, may be recalled by the following process: (1) A petition shall be filed with the Town Clerk signed by not less than twenty-five percent of the number of registered voters at the time the petition is submitted. (2) The petition shall request a meeting of the voters of the Town for the purpose of recalling a Town officer and shall set forth the name of the person to be recalled, the reason for the recall, and shall identify the office he or she holds.

Binding In a nutshell, the purpose of this is to update the variable programmatically or when the DOM element/components updates it.

We are the species that has invented itself the most, by creating the exogenetics of language and culture which carry our continual further inventions to each other over time and space to invent and reinvent our futures.

histone acetylation

Single-strand binding proteins

Channel binding: Depending on the DH functions, it might be possible for a malicious party to engage in multiple sessions that derive the same shared secret key by setting public keys to invalid values that cause predictable DH output (as in the previous bullet). It might also be possible to set public keys to equivalent values that cause the same DH output for different inputs. This is why a higher-level protocol should use the handshake hash (h) for a unique channel binding, instead of ck, as explained in Section 11.2.

Thus it's an incomplete fix, and the correct solution is binding the transcript.

It's well-understood nowadays that channel binding must cover the session transcript.

We shall not cease from exploration, and the end of all our exploring will be to arrive where we started, and know the place for the first time

Token binding makes session hijacking harder by creating an identifier that is based on a private key. The client generates a public/private key pair for every site that it wants to use token binding on. When it connects to the server it signs something and sends this signature along with the public key to the server. The server verifies the signature against the public key. This way, the server knows that this client is in possession of the private key. After this verification step, the public key is passed to the application. This public key uniquely identifies the client, just as a session cookie would. However, it is no longer possible to simply steal the identifier and impersonate someone. The private key is kept secret and the identifier is checked against it. Without access to the private key it is not possible to reproduce a valid identifier. Even if an attacker intercepts the signature, he can’t use this in another connection. The signature is over the public key and the keying material of the current TLS connection. When a new TLS connection is created, a new signature is needed. This means that if the attacker intercepts the signature, he can’t reuse it in a new connection to the server.

This NGINX module provides mechanism to cryptographically bind HTTP cookies to client's HTTPS channel using Token Binding, as defined by following IETF drafts:

This document specifies version 1.0 of the Token Binding protocol. The Token Binding protocol allows client/server applications to create long-lived, uniquely identifiable TLS bindings spanning multiple TLS sessions and connections. Applications are then enabled to cryptographically bind security tokens to the TLS layer, preventing token export and replay attacks. To protect privacy, the Token Binding identifiers are only conveyed over TLS and can be reset by the user at any time.

Motif models for RNA-binding proteins

A Large-Scale Binding and Functional Map of Human RNA Binding Proteins

Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements

De Novo Prediction of PTBP1 Binding and Splicing Targets Reveals Unexpected Features of Its RNA Recognition and Function

Transcription factor–DNA binding: beyond binding site motifs

Blinatumomab is a murine BiTE® antibody construct combining dual specificities for the human pan-B-cell antigen CD19 and the human CD3ε chain of the TCR complex on a single polypeptide chain, with binding affinities of approximately 10−9 M and 10−7 M, respectively