8,784 Matching Annotations
  1. Mar 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuropixels Opto: Combining high-resolution electrophysiology and optogenetics
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838571/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    APOE4 exacerbates glucocorticoid stress hormone-induced tau pathology via mitochondrial dysfunction
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838549/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Active zone maturation state controls synaptic output and release mode and is differentially regulated by neuronal activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838553/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nutritionally responsive PMv DAT neurons are dynamically regulated during pubertal transition
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838509/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Listeria monocytogenes cell-to-cell spread bypasses nutrient limitation for replicating intracellular bacteria
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838505/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Higher throughput assays for understanding the pathogenicity of variants of unknown significance (VUS) in the RPE65 gene
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838478/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi-kinesin clusters impart mechanical stress that reveals mechanisms of microtubule breakage in cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838454/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Sensitive Soma-localized Red Fluorescent Calcium Indicator for Multi-Modality Imaging of Neuronal Populations In Vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838422/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Roles Played by Enhancer of Split Transcription Factors in Drosophila R7 Photoreceptor Specification
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838290/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Haplotype rather than single causal variants effects contribute to regulatory gene expression associations in human myeloid cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838257/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838264/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838303/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular determinants of RNase MRP specificity and function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838342/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838310/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838358/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785141/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comprehensive mutational characterization of the calcium-sensing STIM1 EF-hand reveals residues essential for structure and function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785200/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Co-Conservation of Synaptic Gene Expression and Circuitry in Collicular Neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785205/
  20. www.biorxiv.org www.biorxiv.org
    Exploring Antibiotic Resistance in Diverse Homologs of the Dihydrofolate Reductase Protein Family through Broad Mutational Scanning
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    biorxiv.org/content/10.1101/2025.01.23.634126v1
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Accessible and accurate cytometry analysis using fluorescence microscopes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785219/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Convergent flow-mediated mesenchymal force drives embryonic foregut constriction and splitting
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785243/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785193/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785186/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proximity labeling of the Tau repeat domain enriches RNA-binding proteins that are altered in Alzheimer’s disease and related tauopathies
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785194/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The E2F4 transcriptional repressor is a key mechanistic regulator of colon cancer resistance to irinotecan (CPT-11)
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785039/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of SQSTM1/p62 oligomerization and Keap1 sequestration by the Cullin-3 adaptor SHKBP1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785107/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Type-I nNOS neurons orchestrate cortical neural activity and vasomotion
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785022/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Generative modeling for RNA splicing predictions and design
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785043/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Druggable genome CRISPRi screen in 3D hydrogels reveals regulators of cortactin-driven actin remodeling in invading glioblastoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785026/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A cholinergic spinal pathway for the adaptive control of breathing
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785070/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761689/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785074/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ventral hippocampus to nucleus accumbens shell circuit regulates approach decisions during motivational conflict
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761569/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785044/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fentanyl blockade of K+ channels contribute to Wooden Chest Syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761417/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Insights into the Absence of Lymphoma Despite Fulminant Epstein-Barr Virus Infection in Patients with XIAP Deficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761029/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785118/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetically encoded mechano-sensors with versatile readouts and compact size
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    pmc.ncbi.nlm.nih.gov/articles/PMC11760715/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multilayer regulation underlies the functional precision and evolvability of the olfactory system
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761423/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Quantifying protein unfolding kinetics with a high-throughput microfluidic platform
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761748/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Crb3 and NF2: A dynamic duo that controls assembly of the apical junctions and barrier function via Rho/ROCK signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11760739/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761117/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Keratin intermediate filaments mechanically position melanin pigments for genome photoprotection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761041/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Harnessing Extracellular Vesicles for Stabilized and Functional IL-10 Delivery in Macrophage Immunomodulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761701/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Extensive length and homology dependent chimerism in pool-packaged AAV libraries
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761685/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The PST repeat region of MDC1 is a tunable multivalent chromatin tethering domain
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761366/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC11863645/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies
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    pmc.ncbi.nlm.nih.gov/articles/PMC11741351/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution
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    pmc.ncbi.nlm.nih.gov/articles/PMC11741287/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ChromBPNet: bias factorized, base-resolution deep learning models of chromatin accessibility reveal cis-regulatory sequence syntax, transcription factor footprints and regulatory variants
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    pmc.ncbi.nlm.nih.gov/articles/PMC11741299/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mapping cell-cell fusion at single-cell resolution
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    pmc.ncbi.nlm.nih.gov/articles/PMC11785005/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dnmt3a-dependent de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11642886/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional dissection of metabolic trait-associated gene regulation in steady state and stimulated human skeletal muscle cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11642805/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Viral vector-mediated SLC9A6 gene replacement reduces cerebellar dysfunction in the shaker rat model of Christianson syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC11760745/
  56. www.biorxiv.org www.biorxiv.org
    Cardiolipin deficiency disrupts CoQ-complex III interface in steatohepatitis
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    biorxiv.org/content/10.1101/2024.10.10.617517v3
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Directed Evolution of a Plant Immune Receptor for Broad Spectrum Effector Recognition
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838462/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11463411/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of Human Pathways Acting on Nuclear Non-Coding RNAs Using the Mirror Forward Genetic Approach
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    pmc.ncbi.nlm.nih.gov/articles/PMC11463631/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optical photothermal infrared imaging using metabolic probes in biological systems
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    pmc.ncbi.nlm.nih.gov/articles/PMC11430027/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gradients of Recognition Molecules Shape Synaptic Specificity of Visuomotor Transformation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838220/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chemogenetic Activation of Medial Prefrontal Cortex Projections to the Nucleus Accumbens Shell Suppresses Cocaine-Primed Reinstatement in EcoHIV Infected Mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838193/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Programmed ribosomal frameshifting during PLEKHM2 mRNA decoding generates a constitutively active proteoform that supports myocardial function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11451614/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De novo design of Ras isoform selective binders
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838417/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838211/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC11360998/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen and Identifies Co-Treatment Strategies in Estrogen Receptor Positive Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838206/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Hippo pathway effector YAP inhibits NF-κB signaling and ccRCC growth by opposing ZHX2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11230290/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex
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    pmc.ncbi.nlm.nih.gov/articles/PMC11212875/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses
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    pmc.ncbi.nlm.nih.gov/articles/PMC11185768/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11092754/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural and Dynamic Impacts of Single-atom Disruptions to Guide RNA Interactions within the Recognition Lobe of Geobacillus stearothermophilus Cas9
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    pmc.ncbi.nlm.nih.gov/articles/PMC11092435/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast
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    pmc.ncbi.nlm.nih.gov/articles/PMC11092495/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiplex, multimodal mapping of variant effects in secreted proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838247/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11844385/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    T-cells specific for KSHV and HIV migrate to Kaposi sarcoma tumors and persist over time
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    pmc.ncbi.nlm.nih.gov/articles/PMC10871354/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC10793438/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Unexplored regions of the protein sequence-structure map revealed at scale by a library of foldtuned language models
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    pmc.ncbi.nlm.nih.gov/articles/PMC10769378/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Visualizing PIEZO1 Localization and Activity in hiPSC-Derived Single Cells and Organoids with HaloTag Technology
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    pmc.ncbi.nlm.nih.gov/articles/PMC10769387/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trans-synaptic molecular context of NMDA receptor nanodomains
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    pmc.ncbi.nlm.nih.gov/articles/PMC10769418/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Attenuating ABHD17 isoforms augments the S-acylation and function of NOD2 and a subset of Crohn’s disease-associated NOD2 variants
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    pmc.ncbi.nlm.nih.gov/articles/PMC10769251/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Animal septins contain functional transmembrane domains
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    pmc.ncbi.nlm.nih.gov/articles/PMC10690161/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Programming megakaryocytes to produce engineered platelets for delivering non-native proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC10592833/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential encoding of odor and place in mouse piriform and entorhinal cortex
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    pmc.ncbi.nlm.nih.gov/articles/PMC11741242/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    New submission 10/11/2023, 08:55:25
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    pmc.ncbi.nlm.nih.gov/articles/PMC10418107/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas
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